Protein Alignment Set2 and SET2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 789
• Identity: 203/789 - (25%)
• Similarity: 309/789 - (39%)
• Gaps: 223/789 - (28%)

  Fly  1310 ISMDEQLAELANIEA---------INEQFLRSEGLNTFQLLKENFYRCARQVSQENAE-MQCDCF 1364
            :|..|...|:.|..|         ..|..|..|.|..|:.|.:..|...|..:.:|.: |:|||:
Yeast     7 VSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCY 71

  Fly  1365 LTGDEEAQG-HLSC--GAGCINRMLMIEC-GPLCSN-GARCTNKRFQQHQCWPCRVFRTEKKGCG 1424
               :|.:.| :.:|  .:.||||:.:||| ..|||: |..|.|:|||:.|..|..:|:|:.||.|
Yeast    72 ---EEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYG 133

  Fly  1425 ITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYIN 1489
            :.||..|...:||.||.||||:..||..|...|.:...:|:|||.|:....||||.||:::|:.|
Yeast   134 VRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCN 198

  Fly  1490 HSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEP 1554
            |||.|||...||.|..:||:|.|:.:.|..||||||||...|||..||:||||..||.|::||:.
Yeast   199 HSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKT 263

  Fly  1555 DSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDR 1619
            .:|....|                       |:..|.|         |.:....::|
Yeast   264 QTDAASLL-----------------------PQNIADA---------LGVTVSMEKK-------- 288

  Fly  1620 EYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDP-----DVVEELSLLRRGGLKNQQDTLR 1679
                  |||..........:...:...:...|::...|     ||.:.:|:|.      |||..
Yeast   289 ------WLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLL------QQDNK- 340

  Fly  1680 FSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGL----RLLHAWISE------NGN---DD 1731
                ::.:||||      |:.|..:...|...:..||.    ::|..:|:|      .||   :|
Yeast   341 ----IIASKLLK------RLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEED 395

  Fly  1732 QLR--EALLDTLESLPIPNRTMLSDSRVYQSV------------------QLWSNSLEQQLAVVP 1776
            .::  :.:||.|..||...|..:..|::...|                  :.|| ..|....:..
Yeast   396 DIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWS-KFETYKRITK 459

  Fly  1777 QEKQAALHK----RMVALLQKWQALPEIFR----------------------------------- 1802
            ::...|..|    |.|.|...|:.:.|..|
Yeast   460 KDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPS 524

  Fly  1803 ---IPKRERIEQMKEH-----EREADRQQKHVHASTALE--DQRERESSNDRFRQDRFRRDTTSS 1857
               |||.......|:|     |.|..:|::..:...|||  .|.|.||...:.:.
Yeast   525 SSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKL---------- 579

  Fly  1858 RIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRS---DIGPPSEQRRTLSKELRRSLFE 1919
                                              :|.|:|   ||...:.:::.|.||..:.|.|
Yeast   580 ----------------------------------ENERKSVLEDIIAEANKQKELQKEEAKKLVE 610

  Fly  1920 RKVALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTEL 1984
            .|.|.....:.|....||||... :||.:.:   |..:   :|...::.|:.:::...|....::
Yeast   611 AKEAKRLKRKTVSQSQRLEHNWN-KFFASFV---PNLI---KKNPQSKQFDHENIKQCAKDIVKI 668

  Fly  1985 LTKALLSPD 1993
            ||...|..|
Yeast   669 LTTKELKKD 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	23/57 (40%)
		SET_SETD2	1410..1551	CDD:380949	68/140 (49%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SET2	NP_012367.2	AWS	64..119	CDD:197795	23/57 (40%)
		SET_SETD2	119..260	CDD:380949	68/140 (49%)
		WW_1	479..505	CDD:375933	3/25 (12%)
		TolA	545..>626	CDD:442298	23/124 (19%)
		SRI	627..703	CDD:462404	14/58 (24%)