back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setdb1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001157113.1	Gene:	Setdb1 / 84505	MGIID:	1934229	Length:	1308	Species:	Mus musculus

Alignment Length:	1565	Identity:	291/1565 - (18%)
Similarity:	498/1565 - (31%)	Gaps:	498/1565 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLK--LGGRLESSDSGNSPSSS 281
            :|.|       .|...:..::||.|:.... |....:|.:|::.|:  :...||..|........
Mouse     4 LPGC-------MSLAAAPAAADSAEIAELQ-QAVVEELGISMEELRQYIDEELEKMDCIQQRKKQ 60

  Fly   282 SPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEV 346
            ..|:|...||.|:.:....:...:.||.|   .|.:|..:..:.::..:......|.|..||.|:
Mouse    61 LAELETWVLQKESEVAYVDRLFDDASREV---TNCESLVKDFYSKLGLQYHDSSSEDEASRPTEI 122

  Fly   347 EPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPA 411
                 |:|            |:||.|.:.::         |.|..:...:|..::.|....::.|
Mouse   123 -----IEI------------PDEDDDVLSID---------SGDAGSRTPKDQKLREAMAALRKSA 161

  Fly   412 ADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAES----SKQILEAEESQDQEEQHIL-IDL 471
            .|........:::|:  |....:| ||.:...|::.:.    |.:||..:.::...:..:: |..
Mouse   162 QDVQKFMDAVNKKSS--SQDLHKG-TLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQT 223

  Fly   472 I--------------EDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK 522
            :              :..||.:.:.....|..:.:.|...||.:.:         |..|.::...
Mouse   224 VGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYK---------DGNQVWLYAG 279

  Fly   523 VFSESDNIAASLNKDI-FEPKVETKATCGEVVP--RPEMVTEDVYITEGIAATLEKSAVVTKPTT 584
            :.:|:.|:...|...| |:....:..|..|:.|  ||                       .|.|.
Mouse   280 IVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRP-----------------------LKKTW 321

  Fly   585 EMIAETKLSD---EVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETT--SSPLVP 644
            |.|.::...|   |.:...|                ::|.| :.||.:::..|.|.|  .|
Mouse   322 EDIEDSSCRDFIEEYITAYP----------------NRPMV-LLKSGQLIKTEWEGTWWKS---- 365

  Fly   645 PECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTE---AAKEDSPPAAPEEEASNSSEEPNFL 706
                .:|.|.|.  |...|..::|..|.:.....:.|   :.|..|..|..:::.......||..
Mouse   366 ----RVEEVDGS--LVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASAMEKKQGGQLRTRPNMG 424

  Fly   707 LEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPA-----RSSPA 766
            ....:....|..:|     ....|.:..|:    ||.:|:|.           ||     ..||.
Mouse   425 AVRSKGPVVQYTQD-----LTGTGIQFKPM----EPLQPIAP-----------PAPLPIPPLSPQ 469

  Fly   767 IVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSA 831
            ..|.:    .:|.::.:|       :|..:||| .:..|........|...:.|.:.....|...
Mouse   470 AADTE----SLESQLAQS-------RKQVAKKS-TSFRPGSVGSGHSSPTSSTLSENVSAGKLGI 522

  Fly   832 KLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLS 896
            .....||  |.......|..:|.:..:|.....||...||          |.|...  .|..|:.
Mouse   523 NQTYRSP--LASVTSTPASAAPPVPPVPPGPPTPPGPPAP----------PGPLAP--PAFHGML 573

  Fly   897 DNSP--PSVLKAKEKA-----VSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKV 954
            :.:|  ||.....||.     |..:. |.:..:.|  .|.|.|  .||
Mouse   574 ERAPAEPSYRAPMEKLFYLPHVCSYT-CLSRIRPM--RNEQYR--GKN----------------- 616

  Fly   955 EPPTAVPVPGQKKSLSGKTSLRR----NTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSK---- 1011
              |..||:....:.::.:..:.|    :.:|:....|...:....:.....|....|....
Mouse   617 --PLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLD 679

  Fly  1012 ----VKKKINPRRS-----TICEAAKDLRSS---SSSSTPTREVAASSP--------VSTSSD-- 1054
                |.:|..|.:.     .|....:|:..|   ...:||..:||.|..        ::|..:
Mouse   680 PYVLVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFL 744

  Fly  1055 -----SSSKRNGSK--------RTTSDLDGGSKLDQRRYTICEDRQPETAIPVPL--TKRRFSMH 1104
                 ....|:.||        :.|:...||.......|   :.::.|..:|..:  ..:|.:..
Mouse   745 VGCDCKDGCRDKSKCACHQLTIQATACTPGGQVNPNSGY---QYKRLEECLPTGVYECNKRCNCD 806

  Fly  1105 PKASANPL--HD-----TLLQTAGKKRGRKEGKESLSRQNSLDSSSSAS-----------QGAPK 1151
            |....|.|  |.     .|.:|..|..|.:          .||..:..|           .....
Mouse   807 PNMCTNRLVQHGLQVRLQLFKTQNKGWGIR----------CLDDIAKGSFVCIYAGKILTDDFAD 861

  Fly  1152 KKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKV 1216
            |:.|:..:...|.|...||.|:...|.:.   ||.||.:              ..||::    |.
Mouse   862 KEGLEMGDEYFANLDHIESVENFKEGYES---DVPTSSD--------------SSGVDM----KD 905

  Fly  1217 DEDQRKEGQDEVKREADPEEDEFAQ-------------------------RVANMET-------- 1248
            .||.....:|..:...|..:|.|.:                         .::.|.:
Mouse   906 QEDGNSGSEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENELSEMTSKDSRPPDL 970

  Fly  1249 -PATTPTPS----------PTQSNPEDSASTTTVLKELETGG----GVRRSHRIKQKPQGPRASQ 1298
             |...|.||          .::..|::..::......:..||    ..|.|.:..:...| ||..
Mouse   971 GPPHVPIPSSVSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDG-RAGG 1034

  Fly  1299 GRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDC 1363
            |||.              ||.|:...::   .:.||.|             :|..:|:.|.:
Mouse  1035 GRGE--------------AERASTSGLS---FKDEGDN-------------KQPKKEDPENR--- 1066

  Fly  1364 FLTGDEEAQGHLSCGAGCINRMLMIECG--------PLCSNGARCTNKRFQ--QHQCWPCRVF-- 1416
                               |:|.::..|        |:.|.|.|.:..:..  |.|    ||.
Mouse  1067 -------------------NKMPVVTEGSQNHGHNPPMKSEGLRRSASKMSVLQSQ----RVVTS 1108

  Fly  1417 -------------RTEKKG---------CGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSK 1459
                         .||.:|         .|.|:...:...:  ::.:....|.::||.:::| |.
Mouse  1109 TQSNPDDILTLSSSTESEGESGTSRKPTAGHTSATAVDSDD--IQTISSGSDGDDFEDKKNL-SG 1170

  Fly  1460 DRNRHYYFMALRGEA----------------------------------------VIDATSKGNI 1484
            ...|.....:.||.|                                        :|||..:||:
Mouse  1171 PTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNL 1235

  Fly  1485 SRYINHSCDPNAETQKWTVN-GELR---IGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEA 1543
            .||:||||.||...|...|: .:||   :.||:.|.|:.|.|:|:||.|.....:.:.  |.|.|
Mouse  1236 GRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGA 1300

  Fly  1544 ANCRG 1548
            ..|||
Mouse  1301 IECRG 1305

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.