Protein Alignment Set2 and EFS

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_177854.6
• Gene: EFS / 844066
• AraportID: AT1G77300
• Length: 1805
• Species: Arabidopsis thaliana
• Alignment Length: 2195
• Identity: 461/2195 - (21%)
• Similarity: 770/2195 - (35%)
• Gaps: 753/2195 - (34%)

  Fly   271 SSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRM----VDAEE---NSDSDSQIIFIEIE 328
            ||...|..|.||.|:...|....:.::.:.|....:.:|    .:::|   |:|.|..:.:...:
plant    38 SSRGQNLDSVSSLEIPQTASSVNHTIEGQRKCFTEIEQMGYGNSNSQEDAGNTDDDLYVCYNADD 102

  Fly   329 TESP---KGEEEQEEGRPVEVEPQDLI-DIDMELAKQEPTPDPEE--DLDEIMVEVLSGPPSLWS 387
            |:..   .||.||.         |:|| |.|: |.......|.:|  |.:..:|.:.||
plant   103 TQEQGVVSGELEQS---------QELICDTDL-LVNCNKLDDGKESQDTNVSLVSIFSG------ 151

  Fly   388 ADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQ 452
                :.:|::|      |..||...        ....:.|:.||   |...|.||...|.|..:.
plant   152 ----SMQEKEA------PQAKEDEG--------YGGTTLPIGGS---GIDTESTFVNDAPEQFES 195

  Fly   453 ILEAEESQDQEEQHILIDLIE-----------------------DTLSESEVTSSVSPTIEHMVV 494
            :        :..:||..|.:|                       ||.|..:::.|
plant   196 L--------ETTKHIKPDEVESDGISYRFDDGGKEGRNGPSSDLDTGSSDDISLS---------- 242

  Fly   495 EEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEM- 558
                    |.....|.:|||       .||      ..|..:...|..::.:.. |.:|..|.:
plant   243 --------QSFSFPDSLLDS-------SVF------GCSATESYLEDAIDIEGN-GTIVVSPSLA 285

  Fly   559 VTEDVYITEG--IAATLEKSAV--VTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESK 619
            :||.:...:|  .:..|.|..|  ...|..:::.|.:|..::.:
plant   286 ITEMLNNDDGGLCSHDLNKITVTETINPDLKLVREDRLDTDLSV--------------------- 329

  Fly   620 PAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPL--KTEA 682
                  .:|::|...|..:||          ||....:.:...::.:.::....:::|:  ||..
plant   330 ------MNEKMLKNHVGDSSS----------ESAVAALSMNNGMAADLRAENFSQSSPIDEKTLD 378

  Fly   683 AKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVA 747
            .:.:||       .::||...||.| ::.|...:|       ||               ||..|
plant   379 MEANSP-------ITDSSLIWNFPL-NFGSGGIEV-------CN---------------PENAV- 412

  Fly   748 ETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSK-------KSCAAVTP 805
                       .|.|    |||...|.|   .:|..::.....|..|.|.       |.|..|
plant   413 -----------EPLR----IVDDNGRIG---GEVASASGSDFCEAGMSSSRRKARDGKQCKVV-- 457

  Fly   806 AKQKESGKSAKEAILKKETEKE-KSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTK----- 864
             :.|.|.:..:::..||::|:: :|..|......::|.|..: :::|.     ||..:|:
plant   458 -QTKTSARHLRKSSRKKQSERDIESIFKCSKQKRSSLLKTSR-SSEWG-----LPSKTTEIFLQS 515

  Fly   865 --PPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLA 927
              .|.:..|....:.:.......|...::..|..:.|..::     :|.||  .|
plant   516 NNIPYDGPPHHEPQRSQGNLNNGEHNRSSHNGNVEGSNRNI-----QASSG--SC---------- 563

  Fly   928 NAQLRLDEKNKKKLKKVPTKVEAPPKVE----PPTAVPVPGQKKSLSGKTSL---RRNTVYEDSP 985
               |||..|..|...:.|..:.. .||.    |...:...|....|.|....   :..|| |...
plant   564 ---LRLKVKFGKSGGQNPLNITV-SKVSGNSLPGNGIVKAGTCLELPGSAHFGEDKMQTV-ETKE 623

  Fly   986 NLERNSSP--------SSDS---AQANTSAGKLKPSKVKKKI---NPRRSTI-----CEAAKDLR 1031
            :|...|:|        ||||   .:.|..||.| ..||...:   :|..|:|     ||.|...:
plant   624 DLVEKSNPVEKVSYLQSSDSMRDKKYNQDAGGL-CRKVGGDVLDDDPHLSSIRMVEECERATGTQ 687

  Fly  1032 SSSSSSTPTREVAASSP--VSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIP- 1093
            |..:.::|..||..|.|  :..........:|...|..|:     :.:.|....||....:..|
plant   688 SLDAETSPDSEVINSVPDSIVNIEHKEGLHHGFFSTPEDV-----VKKNRVLEKEDELRASKSPS 747

  Fly  1094 ------VPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKK 1152
                  :|..|:  :.|||:.:|              |.|:||...|........:.:.:|..::
plant   748 ENGSHLIPNAKK--AKHPKSKSN--------------GTKKGKSKFSESAKDGRKNESHEGVEQR 796

  Fly  1153 KALKSA---------EI-------LSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIA 1201
            |:|.::         |:       .:.|||:.:..:::::...:|. || |..|:..     |:.
plant   797 KSLNTSMGRDDSDYPEVGRIESHKTTGALLDADIGKTSATYGTISS-DV-THGEMVV-----DVT 854

  Fly  1202 KFIEDGVNL----LKRD--------------KVDEDQR---KEGQDEVKREADPEEDEFAQRVAN 1245
              |||..:.    ::.|              .:||..|   ....|  ||.||..:   :|.::|
plant   855 --IEDSYSTESAWVRCDDCFKWRRIPASVVGSIDESSRWICMNNSD--KRFADCSK---SQEMSN 912

  Fly  1246 METPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSH------RIKQKPQGPRASQGRGVAS 1304
            .|                       :.:||..|.....::      |.|:|.|..:...|:..|
plant   913 EE-----------------------INEELGIGQDEADAYDCDAAKRGKEKEQKSKRLTGKQKA- 953

  Fly  1305 VALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAE-MQCDCFLTGD 1368
                                            .|:.:|.|.:....:.||...| |.|.|..:.|
plant   954 --------------------------------CFKAIKTNQFLHRNRKSQTIDEIMVCHCKPSPD 986

  Fly  1369 EEAQGHLSCGAGCINRMLMIEC-GPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIP 1432
                |.|.||..|:||||.||| ...|..|..|:|::||:.:......|::.|||.|:.....:.
plant   987 ----GRLGCGEECLNRMLNIECLQGTCPAGDLCSNQQFQKRKYVKFERFQSGKKGYGLRLLEDVR 1047

  Fly  1433 PGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAE 1497
            .|:|::||||||:|.:.:|.||..|:....:|:|||.|.|..||||.:|||:.|:|||||:||..
plant  1048 EGQFLIEYVGEVLDMQSYETRQKEYAFKGQKHFYFMTLNGNEVIDAGAKGNLGRFINHSCEPNCR 1112

  Fly  1498 TQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLR-YGRDAQRCYCEAANCRGWIGGEP------- 1554
            |:||.||||:.:|.||::.::.|:|:||||.|:| :|..|::|||.:::|||:|||:|
plant  1113 TEKWMVNGEICVGIFSMQDLKKGQELTFDYNYVRVFGAAAKKCYCGSSHCRGYIGGDPLNGDVII 1177

  Fly  1555 DSDEGEQL-------DEES--------------DSDAEMDE--EEL----EAEPEEGQPRKSAKA 1592
            .||..|:.       |:||              |:|.:|.:  |::    :..|:..|.:.|...
plant  1178 QSDSDEEYPELVILDDDESGEGILGATSRTFTDDADEQMPQSFEKVNGYKDLAPDNTQTQSSVSV 1242

  Fly  1593 K----------------------------------AKSKLKAKLPLA------------------ 1605
            |                                  |:.|.|:..|.:
plant  1243 KLPEREIPPPLLQPTEVLKELSSGISITAVQQEVPAEKKTKSTSPTSSSLSRMSPGGTNSDKTTK 1307

  Fly  1606 --TGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAM----LEDPDV----V 1660
              :|..:|...:|:.|       :|.|.:..||..:|....|.|||.|.:    |:...:    .
plant  1308 HGSGEDKKILPRPRPR-------MKTSRSSESSKRDKGGIYPGVNKAQVIPVNKLQQQPIKSKGS 1365

  Fly  1661 EELS-------------LLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFL 1712
            |::|             |...||:..::|:.:        ..||  |.||...:.|        .
plant  1366 EKVSPSIETFEGKLNELLDAVGGISKRRDSAK--------GYLK--LLLLTAASRG--------T 1412

  Fly  1713 DYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQ 1777
            |..|       |..|.:...:.:|||.|      .::::|.|......:|:..|.::|...   .
plant  1413 DEEG-------IYSNRDLSMILDALLKT------KSKSVLVDIINKNGLQMLHNIMKQYRG---D 1461

  Fly  1778 EKQAALHKRMVALLQ-----KWQALPEIFRIPKRERIEQMKEHE---READRQQKHVHASTALED 1834
            .|:..:.::::.:|:     |..||..|.|.|....:|..|:..   .|.|....|..|
plant  1462 FKRIPIIRKLLKVLEYLATRKILALEHIIRRPPFAGMESFKDSVLSFTEHDDYTVHNIA------ 1520

  Fly  1835 QRERESSNDRFRQDRFRRDTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRSDI 1899
                .|..||:....||         ||.|:                           ||
plant  1521 ----RSFRDRWIPKHFR---------KPWRI---------------------------NR----- 1540

  Fly  1900 GPPSEQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTD 1964
                |:|    .|..||...|:.       |...|.|.:|:
plant  1541 ----EER----SESMRSPINRRF-------RASQEPRYDHQ------------------------ 1566

  Fly  1965 TNEWFNSDDVPVPAPPRTELLTKALLSPD-IDVGQGATDVEYKLPPGVDPLPPAWNWQVTSDGDI 2028
                     .|.||.|...:.:....:|: ..|.:|.::....||.
plant  1567 ---------SPRPAEPAASVTSSKAATPETASVSEGYSEPNSGLPE------------------- 1603

  Fly  2029 YYYNLRERISQWEPPS--PEQRLQTLLEENTTQQPLHELQIDPAVLENELIQVD---------TD 2082
              .|.|:|.|:|:.||  .|||:.|:|.:.|.:           ...|:.:|.|         ||
plant  1604 --TNGRKRKSRWDQPSKTKEQRIMTILSQQTDE-----------TNGNQDVQDDLPPGFSSPCTD 1655

  Fly  2083 YVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLI----SPRRDEDRLYNQLESRK-YKENKEKI 2142
            ...:::|:...:::..       |..|..:.:.::    ||.:::...::...... |.......
plant  1656 VPDAITAQPQQKFLSR-------LPVSYGIPLSIVHQFGSPGKEDPTTWSVAPGMPFYPFPPLPP 1713

  Fly  2143 RRRKELYRRRKIEVLPDAVDEIPVPGKALPIQPY-----------LFSSD 2181
            ....|.:.:|.:.....::..:....:.||..|.           |||||
plant  1714 VSHGEFFAKRNVRACSSSMGNLTYSNEILPATPVTDSTAPTRKRELFSSD 1763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	27/130 (21%)
		AWS	1358..1410	CDD:197795	23/53 (43%)
		SET_SETD2	1410..1551	CDD:380949	65/141 (46%)
		WW	2014..2043	CDD:459800	5/28 (18%)
		SRI	2266..2355	CDD:462404
EFS	NP_177854.6	zf-CW	865..910	CDD:462181	10/49 (20%)
		AWS	975..1025	CDD:197795	23/53 (43%)
		SET_SETD2	1025..1167	CDD:380949	65/141 (46%)