Protein Alignment Set2 and SETDB2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_114121.2
• Gene: SETDB2 / 83852
• HGNCID: 20263
• Length: 719
• Species: Homo sapiens
• Alignment Length: 924
• Identity: 161/924 - (17%)
• Similarity: 267/924 - (28%)
• Gaps: 386/924 - (41%)

  Fly   776 EMEKKVVKSTKGTVPEKKMDSKK---------------SCAAVTPAKQKESGKSAKEAILKKETE 825
            |..:.|::|.|..:.:....:|:               |..::..|.|||....:.:.:...:.|
Human    26 EQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKGASQKEVNAQSSDPMPVTQKE 90

  Fly   826 KE-KSSAKLDSSSPNT----------------------LDKKGKDTAQWSPQLQTLPKSSTKPPQ 867
            :| ||:|...:|..|:                      :|.:.||::          .:.:....
Human    91 QENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSS----------SNLSYQSH 145

  Fly   868 ESAPSVISKTTSNQPAPKEEQ-----HAAKKGLSDNSPPSVLKAKEKAVSG-------------- 913
            :.:.:.:.|...|.......|     |..::....||..|.|....|...|
Human   146 DCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLL 210

  Fly   914 FVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLR-- 976
            ..||:.:|......|..::| .:|..|.|:|.:.|:....||   :||:     |...:...|
Human   211 ETECNFLFTDNFSFNTYVQL-ARNYPKQKEVVSDVDISNGVE---SVPI-----SFCNEIDSRKL 266

  Fly   977 -----RNTVYEDSPNLERNSSPSSDSAQA------------------NTSAGKLKPSKVKKKINP 1018
                 |.||:..:.||...||..:||...                  |.....|...|:......
Human   267 PQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKY 331

  Fly  1019 RR------------STICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDG 1071
            :|            |.:|:..:.|       ...|.|.....|......:.::....|...|:|.
Human   332 KRLQRQIPTGIYECSLLCKCNRQL-------CQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDR 389

  Fly  1072 GSKL------------DQRRYTI-----------------------CEDRQPETAIPV-----PL 1096
            |:.:            .::.|.|                       |.|.:.| .:|:     |.
Human   390 GTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVE-VLPLGLETHPR 453

  Fly  1097 TKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGK-ESLSR--QNSL----DSSSSASQGAPKKKA 1154
            |.:.....||.|.||...|:           |.| :::||  .:|:    :|.::..|...||
Human   454 TAKTEKCPPKFSNNPKELTV-----------ETKYDNISRIQYHSVIRDPESKTAIFQHNGKK-- 505

  Fly  1155 LKSAEILSAALLETESSEST----SSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDK 1215
                       :|..||||.    :.|.|..|..:.:..:....:...:.....||.: |::.|.
Human   506 -----------MEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNL-LIESDV 558

  Fly  1216 VDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGG 1280
            :|..:.:|                             .||..::.|...:.....:.|.:|.
Human   559 IDITKYRE-----------------------------ETPPRSRCNQATTLDNQNIKKAIEV--- 591

  Fly  1281 VRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENF 1345
                 :| ||||     :||..|
Human   592 -----QI-QKPQ-----EGRSTA------------------------------------------ 603

  Fly  1346 YRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQC 1410
              |.||        |..|    |||               |:.|.....|:.....||
Human   604 --CQRQ--------QVFC----DEE---------------LLSETKNTSSDSLTKFNK------- 632

  Fly  1411 WPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAV 1475
                                           |.|.                             :
Human   633 -------------------------------GNVF-----------------------------L 637

  Fly  1476 IDATSKGNISRYINHSCDPNAETQKWTVNGELR----IGFFSVKPIQPGEEITFDYQYLRYGRDA 1536
            :|||.:||:.|::||||.||...|...|....|    :.||:.:.::...|:|:||.| ..|...
Human   638 LDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGY-EAGTVP 701

  Fly  1537 QR---CYCEAANCR 1547
            ::   |.|....||
Human   702 EKEIFCQCGVNKCR 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	14/71 (20%)
		AWS	1358..1410	CDD:197795	10/51 (20%)
		SET_SETD2	1410..1551	CDD:380949	29/145 (20%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SETDB2	NP_114121.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..102		8/29 (28%)
		HMT_MBD	164..224	CDD:238689	11/59 (19%)
		SET_SETDB2	222..718	CDD:380921	128/718 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..547		7/38 (18%)