Protein Alignment Set2 and SWN

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_567221.1
• Gene: SWN / 828165
• AraportID: AT4G02020
• Length: 856
• Species: Arabidopsis thaliana
• Alignment Length: 950
• Identity: 195/950 - (20%)
• Similarity: 330/950 - (34%)
• Gaps: 240/950 - (25%)

  Fly   697 SNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETV-SKKEKAMENP 760
            ||||......::|.:..:|:  ||.:....|:       |.|:|  .|...|.| |.|||...|
plant     6 SNSSGRIKSHVDDDDDGEEE--EDRLEGLENR-------LSELK--RKIQGERVRSIKEKFEAN- 58

  Fly   761 ARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMD---SKKSCAAVTPAKQKESGKSAKEAILKK 822
                                          .||:|   |..|.||.:.|..:::|.|.     ..
plant    59 ------------------------------RKKVDAHVSPFSSAASSRATAEDNGNSN-----ML 88

  Fly   823 ETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPP--------------------- 866
            .:.......||:..|....|:....|.........||.:...||
plant    89 SSRMRMPLCKLNGFSHGVGDRDYVPTKDVISASVKLPIAERIPPYTTWIFLDRNQRMAEDQSVVG 153

  Fly   867 -------QESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSV-LKAKEKAVSGFVECDAMFKA 923
                   |....::|...:..:|.|:||    |:..|:.....: |..:|..:...|: ||:.:.
plant   154 RRQIYYEQHGGETLICSDSEEEPEPEEE----KREFSEGEDSIIWLIGQEYGMGEEVQ-DALCQL 213

  Fly   924 MDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSL------------R 976
            :.:..:.: |:..|:.|||......|....          |.|..:|.:..|            |
plant   214 LSVDASDI-LERYNELKLKDKQNTEEFSNS----------GFKLGISLEKGLGAALDSFDNLFCR 267

  Fly   977 RNTVYEDSPNLERNSSP--SSDSAQANTS--AGKLKPS--------KVKKKINPRRSTICEAAKD 1029
            |..|::  ..|...|.|  |:...|...|  .|..||.        |..:::....|.....|::
plant   268 RCLVFD--CRLHGCSQPLISASEKQPYWSDYEGDRKPCSKHCYLQLKAVREVPETCSNFASKAEE 330

  Fly  1030 LRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQ-------RRYTICED-- 1085
            ..|....|   :.|::..|.:.:|..|.:...:.....::|..|.::|       |...|.:|
plant   331 KASEEECS---KAVSSDVPHAAASGVSLQVEKTDIGIKNVDSSSGVEQEHGIRGKREVPILKDSN 392

  Fly  1086 -------RQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSS 1143
                   ::.:||  ...||..|    ..|...|...|..|.|.:.|..:.|  ::|.:..| :.
plant   393 DLPNLSNKKQKTA--ASDTKMSF----VNSVPSLDQALDSTKGDQGGTTDNK--VNRDSEAD-AK 448

  Fly  1144 SASQGAPKKKALKSAEIL--------SAALLETESSESTSSGSKMSRWD-VQTSPELEAANPFG- 1198
            ...:..|..........:        :.|::..|.||::...::   |: ::....|:....||
plant   449 EVGEPIPDNSVHDGGSSICQPHHGSGNGAIIIAEMSETSRPSTE---WNPIEKDLYLKGVEIFGR 510

  Fly  1199 -----------------DIAKFI-EDGVNLLKRDK-----VDEDQRKEGQDEVKREADPEEDEFA 1240
                             |::.:: |:.|::.:|..     :|:.:...|.|  ..|..|....|.
plant   511 NSCLIARNLLSGLKTCLDVSNYMRENEVSVFRRSSTPNLLLDDGRTDPGND--NDEVPPRTRLFR 573

  Fly  1241 QRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASV 1305
            ::....:...:|           .||...:|.|.:  .||..:|.: :..|.|..:..|:.
plant   574 RKGKTRKLKYST-----------KSAGHPSVWKRI--AGGKNQSCK-QYTPCGCLSMCGKD---- 620

  Fly  1306 ALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTG--- 1367
              .|...:|...|              :.....:..|..|..|....||..:. ||.||..|
plant   621 --CPCLTNETCCE--------------KYCGCSKSCKNRFRGCHCAKSQCRSR-QCPCFAAGREC 668

  Fly  1368 --DEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELL 1430
              |......:|||.|.:..      .|....| :|.|.|....|.....:.:::..|.|...:..
plant   669 DPDVCRNCWVSCGDGSLGE------APRRGEG-QCGNMRLLLRQQQRILLGKSDVAGWGAFLKNS 726

  Fly  1431 IPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPN 1495
            :...|::.||.||:|...|.::|..:|  ||....:...|..:.|:||..||:..::.|||..||
plant   727 VSKNEYLGEYTGELISHHEADKRGKIY--DRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPN 789

  Fly  1496 AETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRD 1535
            ...:...|.|:.|:|.|:.:.|:..||:.:||   |||.|
plant   790 CYAKVMFVAGDHRVGIFANERIEASEELFYDY---RYGPD 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	26/126 (21%)
		AWS	1358..1410	CDD:197795	15/56 (27%)
		SET_SETD2	1410..1551	CDD:380949	37/125 (30%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SWN	NP_567221.1	SANT	492..536	CDD:238096	5/46 (11%)
		preSET_CXC	646..677	CDD:408079	9/31 (29%)
		SET_EZH	707..823	CDD:380917	34/120 (28%)