Protein Alignment Set2 and SDG14

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_191733.3
• Gene: SDG14 / 825347
• AraportID: AT3G61740
• Length: 1018
• Species: Arabidopsis thaliana
• Alignment Length: 1289
• Identity: 236/1289 - (18%)
• Similarity: 403/1289 - (31%)
• Gaps: 456/1289 - (35%)

  Fly   392 AEEEEDATVQRATPPGKEPAADSCSSAPRRSR---RSAPLSGSSRQGKTLEETFAEIAAESSKQI 453
            ::|.|..|...::...||.:...||...:.||   |:.|    ||...::..|:     :||::.
plant    49 SKEPELLTSSSSSLTSKEESQQVCSDQSKSSRGRVRAVP----SRFKDSIVGTW-----KSSRRK 104

  Fly   454 LEAEESQDQEEQHILIDLIEDTLSESEV----TSSVSPTIEHMVVEEVVVE--ENQL-VDEADEI 511
            .|:.||...::...|...::.....|::    .|.|.|..::....||..:  :.|: .|:|:..
plant   105 GESTESSHDDDDVSLGKKVKGFSGSSKLHRSKDSKVFPRKDNGDSSEVDCDYWDVQISYDDANFG 169

  Fly   512 LDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETK-----ATCGEVVPR-PEMVTEDV-YITEGI 569
            :..|.:               :..|.:::|:..|.     |.||:..|. |.:|.:.: ...:|:
plant   170 MPKKSD---------------ASRKGVYKPEEFTVGDLVWAKCGKRFPAWPAVVIDPISQAPDGV 219

  Fly   570 AATLEKSAV------VTKPTTEMIAETKLSDEVVIEP----PLKDESDPKQTEVELPESKPA-VN 623
            .......|:      .:|..|:       .|...:..    |..:..|..|.:..|...|.: .|
plant   220 LKHCVPGAICVMFFGYSKDGTQ-------RDYAWVRQGMVYPFTEFMDKFQDQTNLFNYKASEFN 277

  Fly   624 IPKSERILSAEVETTSSPLVPPECCTLESVS--GPVLLETSLSTEEKSNENVET-------TPLK 679
            ....|.:|:.......:.::.|:....||..  ||     :...:...:|::.|       .|||
plant   278 KALEEAVLAENGNFGDAEIISPDSSATESDQDYGP-----ASRFQGSYHEDIRTCDGCGSVMPLK 337

  Fly   680 TEAAKEDSPPAAPEE---------EASNS-----------SEEPNFL------------LEDYES 712
            :....:||   .|||         ..||.           |::.:::            .::..:
plant   338 SLKRTKDS---QPEELLCKHCSKLRKSNQYCGICKRIWHPSDDGDWVCCDGCDVWVHAECDNITN 399

  Fly   713 NQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEM 777
            .:.:..|.....|.:.|.|.:. .|.:.|.:..|.::.   ||..|.....:..:
plant   400 ERFKELEHNNYYCPDCKVQHEL-TPTILEEQNSVFKST---EKTTETGLPDAITV---------- 450

  Fly   778 EKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKES---------GKSAKEAILKKET--EKEKSSA 831
               |....:||...|....:..|.:....||..|         .|..|.::..|:|  ..||..|
plant   451 ---VCNGMEGTYIRKFHAIECKCGSCGSRKQSPSEWERHTGCRAKKWKYSVRVKDTMLPLEKWIA 512

  Fly   832 KLDSSSPNT--LDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKG 894
            :..:.:..|  |||:         ::.:|.:...:|       |.:|.|:       |:.|..:.
plant   513 EFSTYTLETQMLDKQ---------KMLSLLEEKYEP-------VRAKWTT-------ERCAVCRW 554

  Fly   895 LSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTA 959
            :.|.....::......|:...||..:.|:.||.:...|..|
plant   555 VEDWEENKMIICNRCQVAVHQECYGVSKSQDLTSWVCRACE------------------------ 595

  Fly   960 VPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKK---------- 1014
                                    :|::||      |........|.||||.|:.
plant   596 ------------------------TPDIER------DCCLCPVKGGALKPSDVEGLWVHVTCAWF 630

  Fly  1015 -------------------KINPRRS--TICEAAKDLRSS----SSSSTPTREVAASSPVSTSSD 1054
                               || |..|  .:|...|....|    ...:|....:.||........
plant   631 RPEVGFLNHENMEPAVGLFKI-PANSFLKVCTICKQTHGSCVHCCKCATHFHAMCASRAGYNMEL 694

  Fly  1055 SSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQ---PETAIPVPLTKRRFSMHPKASANPLHDTL 1116
            ...::||.:||            |:...|...:   |::.:.|......|     .|.|     |
plant   695 HCLEKNGVQRT------------RKSVYCSFHRKPDPDSVVVVHTPSGVF-----GSRN-----L 737

  Fly  1117 LQTAGKKRGRKEGKE-SLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKM 1180
            ||   .:.||.:|.. .|:::..|....:.:| |.:.:...|   ||||.....|..:|..
plant   738 LQ---NQYGRAKGSRLVLTKKMKLPGFQTQTQ-AEQSRVFDS---LSAARCRIYSRSNTKI---- 791

  Fly  1181 SRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVAN 1245
                     :|||.
plant   792 ---------DLEAI--------------------------------------------------- 796

  Fly  1246 METPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPI 1310
                                                  |||:|    ||
plant   797 --------------------------------------SHRLK----GP---------------- 803

  Fly  1311 SMDEQLAELANIEAINEQF-LRSEGLNTFQLLKENFYRCARQ-------VSQENAEMQCDCFLTG 1367
             ....|:.:.|:.:....| .|:..::.|..|...|....|:       |:.:.|:      .|.
plant   804 -SHHSLSAIENLNSFKASFSFRAPFMSVFCFLGATFSEYLRKILISIYLVTHQEAD------FTS 861

  Fly  1368 DEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIP 1432
            ..|...||.                      |..|.|.    |:.    ::...|.|:.|...|.
plant   862 FRERLKHLQ----------------------RTENFRV----CFG----KSGIHGWGLFARKSIQ 896

  Fly  1433 PGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAE 1497
            .||.|:||.|..:.....:.|:..| :.:.:..|...:..|.|||||..|||:|.|||||.||..
plant   897 EGEMIIEYRGVKVRRSVADLREANY-RSQGKDCYLFKISEEIVIDATDSGNIARLINHSCMPNCY 960

  Fly  1498 TQKWTV-NGE-LRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANCR 1547
            .:..:: :|| .||...:...:..|||:|:||.:.....:..:  |.|:|.|||
plant   961 ARIVSMGDGEDNRIVLIAKTNVAAGEELTYDYLFEVDESEEIKVPCLCKAPNCR 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	24/133 (18%)
		AWS	1358..1410	CDD:197795	7/51 (14%)
		SET_SETD2	1410..1551	CDD:380949	47/142 (33%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
SDG14	NP_191733.3	PWWP_AtATX3-like	188..292	CDD:438971	20/110 (18%)
		PHD_TCF19_like	365..415	CDD:276992	3/49 (6%)
		COG5141	<518..>765	CDD:227470	59/349 (17%)
		ePHD_ATX3_4_5_like	603..714	CDD:277133	22/123 (18%)
		SET_SETD1-like	862..1014	CDD:380916	51/182 (28%)