DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and KMT2D

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens


Alignment Length:1954 Identity:338/1954 - (17%)
Similarity:589/1954 - (30%) Gaps:727/1954 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 SHQSL------PPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVG--GAHPVQTMAGLPPVTPR 198
            |||.|      |.||..|..:     ..|.|..::.|  ..|.|:|  |.|....|     ...|
Human  3784 SHQGLLVQQLSPQPPQGPQGM-----LGPAQVAVLQQ--QHPGALGPQGPHRQVLM-----TQSR 3836

  Fly   199 KRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRL 263
            ....|:.:|.....:...::         .:............|.:.|.      |.|:.||   
Human  3837 VLSSPQLAQQGQGLMGHRLV---------TAQQQQQQQQHQQQGSMAGL------SHLQQSL--- 3883

  Fly   264 KLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIE 328
                   .|.||....|:.|......||.:..:.::.:.:|...:.:..::      |:...:::
Human  3884 -------MSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQ------QLQQQQLQ 3935

  Fly   329 TESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAE 393
            .:..:.:.:|::.:.::.:.|.|     :..:|:.....::...:..:.:|:...:|.|...:.:
Human  3936 QQQQQQQLQQQQQQQLQQQQQQL-----QQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQ 3995

  Fly   394 EE-------EDATVQRATPPGK---------------EPAADSCSSAPRRSRRSAPLS-GSSRQG 435
            ::       ....:|..:.||.               :||..|.::....:.:..||: |::.:.
Human  3996 QQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPES 4060

  Fly   436 KTLE--ETFAEIAAESSKQILEAEESQD--------------QEEQHILIDLIEDTLSESEV--- 481
            ...|  |....::.:|...:::.:....              |::|.:.:.......|..::   
Human  4061 MATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSG 4125

  Fly   482 TSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETK 546
            :||.:.::.|::.:..|...:|.......:|..:|..:.:.:.:.:                   
Human  4126 SSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNT------------------- 4171

  Fly   547 ATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQT 611
               |...|:|..|.:......|:.         ..||...: ..:|...:...|.|:..|..:|.
Human  4172 ---GPQPPKPGPVLQSGQGLPGVG---------IMPTVGQL-RAQLQGVLAKNPQLRHLSPQQQQ 4223

  Fly   612 EV-------ELPESKPAVNIPKSERILSAEVETTSSPL--------------------------- 642
            ::       :|.:|:.....|..:     |..|.:|||                           
Human  4224 QLQALLMQRQLQQSQAVRQTPPYQ-----EPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAG 4283

  Fly   643 ----------VPPECCTLESVSGPVLLETSLSTEEKSNENVE----TTPLKTEAAKEDSPPAAPE 693
                      .||...:...|.|||......|:.::.....:    ::.|.|||....:.|..|:
Human  4284 PRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPK 4348

  Fly   694 EEASNSS-------------------------EEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQ 733
            .:.....                         :.|:.|.|..:..|..:....:.:.|.|...:.
Human  4349 PQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEA 4413

  Fly   734 TPLPEMKEP-EKPVA-ETVSKKEKAMENP----------------ARSSPAIVDKKVRAGEMEKK 780
            :.|...:|| |:|.| ...|.|.:|...|                :.:...::.|.:||..::..
Human  4414 SQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLS 4478

  Fly   781 VVKSTKGTVPE--KKMDSK----KSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPN 839
            ..:.::|...|  ..:|||    :.....||:.::::  :|::.:..|....:|:|.:|.||...
Human  4479 TGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKEDA--AARKPLTPKPKRVQKASDRLVSSRKK 4541

  Fly   840 TLDKKGKDTA-----QWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNS 899
            ...:.|...:     |...:|..||  .|:|...:..|:.:...|..|...:.|           
Human  4542 LRKEDGVRASEALLKQLKQELSLLP--LTEPAITANFSLFAPFGSGCPVNGQSQ----------- 4593

  Fly   900 PPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPG 964
                       :.|.....|:....|..:..|     .|..|...||    ||...|||  |.|.
Human  4594 -----------LRGAFGSGALPTGPDYYSQLL-----TKNNLSNPPT----PPSSLPPT--PPPS 4636

  Fly   965 -QKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKIN--------PRR 1020
             |:|.::|.|           |:.|....| .|:|.|..|...|:.:...|.::        |..
Human  4637 VQQKMVNGVT-----------PSEELGEHP-KDAASARDSERALRDTSEVKSLDLLAALPTPPHN 4689

  Fly  1021 STICEAAKDLR--SSSSSSTPTREVAASSPVSTSSDSSSK--RNGSKRTTSDLDGGSKLDQRRYT 1081
            .|     :|:|  |...|.:|...|.||||.|...:.:.:  ..||.|...              
Human  4690 QT-----EDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQ-------------- 4735

  Fly  1082 ICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTL------LQTAGK------KRGRKEGKE--- 1131
              |||.....||         :.|:||.....||.      |:..||      ::|:  |.|   
Human  4736 --EDRALSPVIP---------LIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGK--GSEVSV 4787

  Fly  1132 ----SLSRQNSLDSSSSASQGAPKKKALKSAEIL-----SAALLETESSESTSSGSK---MSRWD 1184
                |.:...:|:....|.......|...|.|:|     :.|..|.:..|:...|.|   :....
Human  4788 MLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKS 4852

  Fly  1185 VQTSP----ELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVAN 1245
            ..|.|    :.:|..| |...|...|.::|||:             |......|.:..:...|:|
Human  4853 PDTGPDWLKQFDAVLP-GYTLKSQLDILSLLKQ-------------ESPAPEPPTQHSYTYNVSN 4903

  Fly  1246 MET------PATTPTPSPTQSNPEDSASTTTVLKELET-----------------GGGVRRSHRI 1287
            ::.      |...|:|.|:...|..::..|..|.||.|                 ....|...|.
Human  4904 LDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRA 4968

  Fly  1288 KQKPQG-----PRASQGRGV------------------------------ASVALAP-------- 1309
            :...:|     ||..:.:||                              ...||.|        
Human  4969 RPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMR 5033

  Fly  1310 -------------------ISMDEQL------------------AELANIE-------------- 1323
                               :::|..|                  ..|.|:|              
Human  5034 RCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLC 5098

  Fly  1324 ----------------------AIN----------------------EQFL-------------- 1330
                                  ||.                      ||.|              
Human  5099 QRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERD 5163

  Fly  1331 ----------RSEGLNTF-----------QLLKENF----------------------------- 1345
                      |.|.|:.|           |||....                             
Human  5164 EVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRR 5228

  Fly  1346 --YRCA---------------------------------RQVSQENAEMQCDC--------FLTG 1367
              |||:                                 .::.:..|.|:.:.        :|.|
Human  5229 CCYRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKG 5293

  Fly  1368 D--------------EEAQGHLSC--------------------GAGC----------------- 1381
            :              |...|..||                    ..||                 
Human  5294 EELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRVFTS 5358

  Fly  1382 ---------------INRMLMIECGPLCSNGARCT--NKRFQQHQCWPCRVFRTEKK-------- 1421
                           :|...|.:.......|...|  :|:|...:....|..|||.|        
Human  5359 IISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARS 5423

  Fly  1422 ---GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGN 1483
               |.|:.|...:.....::||:|.:|.:|...||:.:| :::||..|...:..|.|||||..|.
Human  5424 RIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQNRGIYMFRINNEHVIDATLTGG 5487

  Fly  1484 ISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANC 1546
            .:|||||||.||...:..|.:.|.:|...|.:.|..|||:|:|||: .:..|..:  |:|.|.||
Human  5488 PARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQF-DFEDDQHKIPCHCGAWNC 5551

  Fly  1547 RGWI 1550
            |.|:
Human  5552 RKWM 5555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 15/127 (12%)
SET 1414..1533 CDD:214614 47/129 (36%)
PostSET 1535..1551 CDD:214703 8/18 (44%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
KMT2DXP_011537072.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157992
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.870

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