DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and EHMT1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_011517323.1	Gene:	EHMT1 / 79813	HGNCID:	24650	Length:	1301	Species:	Homo sapiens

Alignment Length:	1472	Identity:	295/1472 - (20%)
Similarity:	478/1472 - (32%)	Gaps:	464/1472 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 ATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHI 467
            |.|...||..|.|.        ...|.|        |||  .:||:      |....:...|.|:
Human    11 AVPARGEPQQDCCV--------KTELLG--------EET--PMAAD------EGSAEKQAGEAHM 51

  Fly   468 LIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAA 532
            ..|...:...|:...||.:...:|       .:::..|:..|.  .:....:.:...||.|:.||
Human    52 AADGETNGSCENSDASSHANAAKH-------TQDSARVNPQDG--TNTLTRIAENGVSERDSEAA 107

  Fly   533 SLNKDIFEPKVETK--ATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDE 595
            ..|....:..|:|.  .:.|.::.:|.:..:.:..|..:|::|...|..|.|.......|
Human   108 KQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRT----- 167

  Fly   596 VVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLE 660
                                |.:.|                  .:|..||          ..|.|
Human   168 --------------------PSAFP------------------QTPAAPP----------ATLGE 184

  Fly   661 TSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKC 725
            .|..||::... .....:|...|::..|.:.....|  :|::|.   |..|:...:..::|:.|.
Human   185 GSADTEDRKLP-APGADVKVHRARKTMPKSVVGLHA--ASKDPR---EVREARDHKEPKEEINKN 243

  Fly   726 NNQKGQKQ--TPLPEMKE--PEKP----------------VAETVSKKEKAMEN-----PARSSP 765
            .:..|::|  .|.|.:.:  |:..                :|..||:|:|....     |.:.:.
Human   244 ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTK 308

  Fly   766 AIVDKKVRAGEMEKKVVKSTKGTVPEK--------------KMDSKK--------------SCAA 802
            .:..:.|.  ||.|.:..||.|:..||              :|||.:              ..||
Human   309 VLKQRTVI--EMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAA 371

  Fly   803 VTPAK---------------QKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDK-----KGKD 847
            ..|.:               ||..|:|.:|.......|:|:...:.|.||.:::.|     |||.
Human   372 AFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKT 436

  Fly   848 TAQWSPQLQTLPKSSTKPPQESAPSVISKT---TSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEK 909
            .:.|....:...:.|.|.|..:..|...|:   ::.|.||.:     ..|..:.|    |.:.:.
Human   437 DSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGD-----STGYMEVS----LDSLDL 492

  Fly   910 AVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQ---KKSLSG 971
            .|.|.:..    :|..|||....|:....:::.....::|.|...|..|.  ...|   .:|:..
Human   493 RVKGILSS----QAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTL--ANNQCMATESVDH 551

  Fly   972 KTSLRRNTV--YEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSS 1034
            :.....|:|  ||    |.|.|:.:..........|::    ||.:..|.....|.|...:....
Human   552 ELGRCTNSVVKYE----LMRPSNKAPLLVLCEDHRGRM----VKHQCCPGCGYFCTAGNFMECQP 608

  Fly  1035 SSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVP---- 1095
            .||...|         ...|.:|:.|.:.......:..||  .:..||.:.....|..|||
Human   609 ESSISHR---------FHKDCASRVNNASYCPHCGEESSK--AKEVTIAKADTTSTVTPVPGQEK 662

  Fly  1096 ---LTKRRFSMHPKASANPL-HDTLLQ---------------------TAGKKRGRKEGKESL-S 1134
               |..|..:....|:..|| .|..||                     |.|..:|  .|||:| |
Human   663 GSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQG--PGKETLES 725

  Fly  1135 RQNSLDSSSSASQGAPKK-----KAL----KSAEILSAALLETESSESTSSGSKMSRWDVQTSPE 1190
            ...:|||..      |||     |.|    :..|:....|:..:..:   ...||...: :.||
Human   726 ALIALDSEK------PKKLRFHPKQLYFSARQGELQKVLLMLVDGID---PNFKMEHQN-KRSP- 779

  Fly  1191 LEAANPFG--DIA-KFIEDGVNLLKRDKVDEDQR---KEGQDEVKREA-----------DPEEDE 1238
            |.||...|  ||. ..::.|.|:   |...||||   .|..:....||           ||::.|
Human   780 LHAAAEAGHVDICHMLVQAGANI---DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAE 841

  Fly  1239 ------FAQRVANMETPATTPTPSPTQSNPEDSASTTTVL-----------KELETGGG------ 1280
                  .|.:..:.|......:......|.:|....|.::           |.|.:.|.
Human   842 GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 906

  Fly  1281 ------------------------------------------VRRSHR---------------IK 1288
                                                      ..|.:|               :|
Human   907 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK 971

  Fly  1289 QKPQGPRASQGRGVASVALAPISMDEQLAELAN-------------------------IEAINEQ 1328
            .| :|....|...:.|...:.:.|.:.|.:.|.                         :.|::.:
Human   972 NK-EGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSE 1035

  Fly  1329 FLRSEGLNTFQLLKENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGA------------- 1379
            ...|    .::.:.:|.......:.:....:| |.|.   |:.:..:..||.
Human  1036 PCPS----NYKYVSQNCVTSPMNIDRNITHLQYCVCI---DDCSSSNCMCGQLSMRCWYDKDGRL 1093

  Fly  1380 ----GCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEY 1440
                ......|:.||...||....|.|:..|.......:::||...|.|:.:...||||.|:.||
Human  1094 LPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEY 1158

  Fly  1441 VGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AETQK 1500
            |||:|...|.:.|:   :|:..|..        .||. .|||...||:||:|||.|:|| ...:.
Human  1159 VGELISDSEADVREEDSYLFDLDNK--------DGEVYCIDARFYGNVSRFINHHCEPNLVPVRV 1215

  Fly  1501 WTVNGEL---RIGFFSVKPIQPGEEITFDYQYLRYGRDAQR----------CYCEAANCRGWIGG 1552
            :..:.:|   ||.|||.:.|:.||::.|||        .:|          |.|.:..||
Human  1216 FMAHQDLRFPRIAFFSTRLIEAGEQLGFDY--------GERFWDIKGKLFSCRCGSPKCR----- 1267

  Fly  1553 EPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKA 1594
                       ..|.:.|:......:...|:|.|..|:.|.|
Human  1268 -----------HSSAALAQRQASAAQEAQEDGLPDTSSAAAA 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	14/69 (20%)
		SET	1414..1533	CDD:214614	46/126 (37%)
		PostSET	1535..1551	CDD:214703	5/25 (20%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
EHMT1	XP_011517323.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840