Protein Alignment Set2 and setd2

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_009290459.1
• Gene: setd2 / 794199
• ZFINID: ZDB-GENE-030131-2140
• Length: 2737
• Species: Danio rerio
• Alignment Length: 3118
• Identity: 626/3118 - (20%)
• Similarity: 1025/3118 - (32%)
• Gaps: 1196/3118 - (38%)

  Fly     9 NPSPVASRGRGRGRPPKVALSALGNTPPHIN-----PSLKHADAEASPTA-----PEDQDSGQSE 63
            |.:.|....:||   .||:.|......|..|     ||.:.:.:|.|.|:     |....:||:
Zfish    47 NKTKVNLEEQGR---QKVSFSLTQTKKPRQNVFLPPPSPEKSASEHSSTSQAGPVPVSVQAGQT- 107

  Fly    64 CRRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSN-PSTGHSQSGTTAASTSM----------- 116
                       ::.::                :|:| |:.|.:|:..| .|.|:
Zfish   108 -----------YETKN----------------VDTNTPAVGETQTAPT-VSFSLRSRHVLGKMHF 144

  Fly   117 ------STATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTS 175
                  ||.....::.|:|:.        |:|.     |..|...:...||.....||   |.:.
Zfish   145 KKQILSSTVVGDKSTVSTASA--------EISE-----PVVPSDKITSSAKVETENSL---QQSH 193

  Fly   176 EPSAVGGA--------HPVQTMAGLPPVTPRKRGRPRKSQL----ADAAII----PTVIVPSCSD 224
            :.|.|.|:        :|.:.:|..      .:| |..|.:    .|::||    .:.....|||
Zfish   194 KNSVVDGSSEKVSKEENPQEKIASC------LKG-PDSSHIGKEDTDSSIISEHEESRKSKQCSD 251

  Fly   225 S-------DTNSTSTTTSNMSSD----------SGELPGFPIQKPK-SKLRVSLKRLKLGGRLES 271
            |       |..||.|::|..|:|          |.|:......|.: .|.|...|..:.|.|...
Zfish   252 SKLAGLETDGQSTRTSSSQKSNDRRNKTKSESHSNEVKRSSNSKTELDKSRTDRKDEEKGIRHSK 316

  Fly   272 SDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEE 336
            ||..:...||.        ...:..|.|..:.::.||...:..:|.|.|:....|.::.:.:...
Zfish   317 SDRDSRHMSSR--------SSRSDRDRRRTKSRSRSRSRGSRTSSYSRSERSRSERQSRTDRSHY 373

  Fly   337 EQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQ 401
            .:.|.|.....|.      .|........|..                   :.|.::.|:|.  :
Zfish   374 HESERRFHRSSPH------RERRSSRSRTDGR-------------------SRDSSDSEDDH--R 411

  Fly   402 RATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQH 466
            |....|.:.:..|..|:.::..:|:..|.|.|..|   .|....::||.|:   |:.|:.:..:.
Zfish   412 RTRTRGSDSSRSSTYSSSQKDSKSSTHSRSHRDSK---PTDCSRSSESDKR---AQHSKSESNRR 470

  Fly   467 ILIDL--------------IEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQE 517
            ...::              :.|.:|.|.:|:| |.|.|..:.:              ...||.:|
Zfish   471 SSSEIDAVHKKSSARTKLEVNDKISNSNLTTS-SRTSEKKIHK--------------TSSDSDEE 520

  Fly   518 FVIKKVFSESD-----NIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSA 577
            ...|:....||     ..::|...|:.:   ......|....|..        |:.:....:.|.
Zfish   521 HRRKRQSQGSDRSPRSGTSSSRKNDLVD---HNSFNIGTGTERQS--------TDRLNTNAKDSQ 574

  Fly   578 VVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTE----VELPE-SKPAVNIPKSERILSAEVET 637
            :|....|.....:.:.|:..  ||....|..:..|    |.|.| :|.|.:.|.::.:.|.|..|
Zfish   575 LVFVTVTSQKESSNIDDQCT--PPKSKNSSQQMHEATHKVNLCETNKKAEHQPSNQDLSSLEKCT 637

  Fly   638 TSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVE------TTPLKTEAAKEDSPPA-----A 691
            .    ||....|.|.::..:.: ||...|.:|...|:      |.|:::|........:     |
Zfish   638 N----VPESKKTTERLTESISI-TSGKLEVRSPTEVDEPGMKVTVPIQSEVLTVGQTESICVGPA 697

  Fly   692 PEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKA 756
            |.|....|       |.|..|.:|...|..::.  |.|..:.:.:  :.:...||..||...||.
Zfish   698 PSEHTMGS-------LTDSLSVKELPPEGSLIL--NTKSDESSLI--ISQISTPVTLTVQPCEKD 751

  Fly   757 ME----NPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKE 817
            .|    :|.:.:..|..|...|.:....:|    |.|..:.....|   .|.|        ..|:
Zfish   752 SEQNIGSPEQPNTGISKKDASAKKSRWDIV----GQVTSEYQSPAK---LVNP--------DVKK 801

  Fly   818 AILKK-----ETEKEKSSAKLDSSSPN--TLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVIS 875
            .:|.:     :|..:..|.|||...|:  :::...:||            ::.:..||     ||
Zfish   802 VMLAQKIEFSDTTPDNCSQKLDPEVPSEKSVEVHARDT------------TAAESHQE-----IS 849

  Fly   876 KTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKK 940
            ..|||         ...||..|.            :...||......|:.:::.|...::.|..|
Zfish   850 SFTSN---------FGTKGTHDE------------LQKTVEIPQSTSALVVSDFQPSKEKVNVDK 893

  Fly   941 LKKVPTKVEAPPKVEPPTAVPVPGQ------------KKSLSGKTSLRR---------NTVYEDS 984
            .|         |:::.|.::...|:            ..|..|:.||:|         |:.....
Zfish   894 TK---------PEIQDPDSLNHDGKCHSDDSESEESDSDSDDGRVSLKRLHSVVVVPKNSTIALE 949

  Fly   985 PNLERNSSPSSDSAQANTSAGKLKPSKVKKKINP-------RRSTICEAAKDLRSSSSSSTPTRE 1042
            .|.:...:|:|.....|      :.:...:.||.       .:||:.|::..|...|:      :
Zfish   950 TNDKAEPAPASSLFSGN------QQTDTHESINKEFPYGFNNQSTLKESSAALYKGSA------Q 1002

  Fly  1043 VAASSP----VSTSS-----DSSS---------KRNGSKRTTSDLDG--GSKLDQRRYTICEDRQ 1087
            .|..||    ||..|     ||:|         .:|.|.:...::.|  ..:..|.....||  :
Zfish  1003 AACQSPNVKGVSYQSQSNMVDSTSHLEVMSAHVDKNWSAQERPNISGQINQEYVQNFEKTCE--K 1065

  Fly  1088 PETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSL--DSSSSASQGAP 1150
            |||.            |.:....|         ....||| |..|:.|.:||  |.:.|
Zfish  1066 PETD------------HHQYHGRP---------DSWNGRK-GDFSVGRGDSLVWDFNQS------ 1102

  Fly  1151 KKKALKSAEILSAALLETESSESTSSG--SKMSRWDVQTSPELEAAN-------PFGDIAKFIED 1206
                    |..|:...:.:||.||...  ..:.|.|....|.:...:       ||.     ..|
Zfish  1103 --------EQPSSTFQQPDSSYSTPQPLFDSVHREDPWAQPAISKTSRTVNTHVPFQ-----YHD 1154

  Fly  1207 GVNLLKRDKV--DEDQRKEGQDEVKREADPEEDEFAQRVANME----TPATTPTPSPTQSNPEDS 1265
            .|:.:..|.:  |.|..:||                 |:..::    ..|..|.|||....||.|
Zfish  1155 LVHQIHPDSLTNDHDDDREG-----------------RILGIKQASLLSAGLPGPSPFVQAPEIS 1202

  Fly  1266 ASTTTVLKELETGGGVR----RSHRIKQKPQGPR---ASQGRGVASVALA----------PI--- 1310
            ::.:...:........|    :.||.:..|:..|   .|:....|...|:          |:
Zfish  1203 SNCSFTTESQNISEAPRDDNQKPHRGRGPPKKRRQEFESESDNEAEAGLSKRECFDESSRPLKDA 1267

  Fly  1311 -----SMDEQLAELANIEAINEQFLRSEGLNT------FQLLKENFYRCARQVSQENAE---MQC 1361
                 .:.|....|.:::..::.|:..:....      |.|::||.|...|:.::.:.:   |||
Zfish  1268 KESFHQIQEVQRPLLSLKEFSDPFVWRDKAKQKKMPPYFDLIEENLYLTERKKNKSHRDIKRMQC 1332

  Fly  1362 DC-FLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGI 1425
            :| .|:.:|.|:|.|:||..|:||:|||||...|.|||.|:|:|||..|.....|..||.||.|:
Zfish  1333 ECAILSKEERARGILACGEDCLNRLLMIECSSRCLNGAYCSNRRFQMKQHADYEVILTESKGWGL 1397

  Fly  1426 TAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINH 1490
            .|...:.|..|::||.|||:|..||:.|...|::::|.|||||||:...:||||.|||.||::||
Zfish  1398 RAAKDLQPNTFVLEYCGEVLDHREFKARVKEYARNKNIHYYFMALKNNEIIDATLKGNCSRFMNH 1462

  Fly  1491 SCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPD 1555
            ||:||.|||||||||:||||||:.|.:..|.|:|||||:.|||::||:|:|.|.:|||.||||
Zfish  1463 SCEPNCETQKWTVNGQLRIGFFTTKAVTAGTELTFDYQFQRYGKEAQKCFCGAPSCRGLIGGE-- 1525

  Fly  1556 SDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDRE 1620
                                          .|.|.:|            |.|:|::|:::.||
Zfish  1526 ------------------------------TRVSVRA------------AGGKKQRERSRKKD-- 1546

  Fly  1621 YKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRG--GLKNQQDTLRFSRC 1683
                       |.|:.:.                    :.|||..|:..  ||..:::.:...|.
Zfish  1547 -----------TDSALTT--------------------LDEELEALQENGEGLCGEKEVISLCRL 1580

  Fly  1684 LVRAKLLKTRLALLRVLTHGELP-CRRLFLDYHGLRLLHAWI---------SENGNDDQLREALL 1738
            :||.:.::.||..|:::.:.:.| |.:.|||:|||.||  ||         :.:.|:.:|:..::
Zfish  1581 MVRVETMEQRLTCLKLIQNTQNPLCLKQFLDHHGLSLL--WIFMVELSEAKTNSVNNIKLQLEIM 1643

  Fly  1739 DTLESLPIPNRTMLSDSRVYQSVQLWS-------------------------------------- 1765
            ..|..|||..:.||.:|||.|.:|.|:
Zfish  1644 KALSVLPISTKNMLEESRVLQFIQRWAQSRSLSQPAEQDGYSSESTSRAQTPLNTPDGPPAKLAT 1708

  Fly  1766 --------------------NSLEQQL-------------------------------------- 1772
                                |||:..|
Zfish  1709 ELDGDTPKRAVYRRLKIISENSLDSALSDASKASDGKEEEDEEEEEMEDEPSKLESTTERKIKVE 1773

  Fly  1773 ----------------------------------------------------------------- 1772
                                                                             
Zfish  1774 STEAPPVSQAELEVELKQEAPETVEIPRLMPEAVGSEGETLETQEPEEKLLCTPEGQLKDEKTVE 1838

  Fly  1773 ----------------------------------------------------------------- 1772
                                                                             
Zfish  1839 ETKSDEPSENQTESAAVKEDPLVTDTTSAADISNDVVADAETPVTETQVENASSEQSTSEEDASC 1903

  Fly  1773 ----------------------------------------------------------------- 1772
                                                                             
Zfish  1904 STAEITSAQPAEVIIEGISSDSAAIVIKSTPKESPSVSVKTPPTGSDVVSNGNAPSEAVFAPSEA 1968

  Fly  1773 -------AVVPQEKQAALHKRMVA----------------------------------------- 1789
                   ||.|.|..|:..:.:.:
Zfish  1969 VAAPLEAAVAPSEAVASFPEAVASLPETVAAPAEAVDEPAEAVADPAEAVADPAEAVADPAEAVA 2033

  Fly  1790 ----------------------------------------------------------------- 1789
                                                                             
Zfish  2034 EPAEAVAAPAEAVAAPPEAVAAPPEAVAAPVSADVSALAIVPVPAEGAAVGTPSQDEEEGVSDVE 2098

  Fly  1790 --------------------LLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHASTALED 1834
                                ||..|:.|.|::||||:.::|: :.::|..||:......:::...
Zfish  2099 SERSQEPQIRASDISDMAARLLDSWKDLKEVYRIPKKSQVEK-ESNDRSRDRESLMTPRTSSSSR 2162

  Fly  1835 QRERESSNDRFRQDRFR---------RDTTSSRIG-KPIRMSGNNTICTITTQQKGSNG-----A 1884
            :||||...:|.| ||.|         ||....|.| :|...|.:.      .:::||..     |
Zfish  2163 ERERERDKERDR-DRDRDWEREREWDRDRERDRDGERPTLRSADR------KRRRGSTSPLPPPA 2220

  Fly  1885 PDGMTRNDNRRRSDIGPPS-------EQRRTLSKELRRSLFERKVALDEAER------------- 1929
            .:...|||:  |.::...|       |.|..||.|.||.|||::||..||::
Zfish  2221 YERSRRNDD--RYELSSSSKKKLHTKEARTKLSTEERRKLFEQEVAQREAQKQQQQQLQQQQQQQ 2283

  Fly  1930 -----------------------RVCTEDRLEHELRCEFFGADINTD-------PKQLPFYQKTD 1964
                                   :...:.:.:.:|:...|.....|.       |...|.....|
Zfish  2284 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQTLAFNPLAYTSSPNFMNYPPGYPIQTYVD 2348

  Fly  1965 -TNEWFNSDDVPVPAPP--------------RTELLTKALLSPDIDVGQG--ATDVEY-----KL 2007
             ||.  |:..|.:|.||              :...|...:.||.....|.  |:.:.:     :|
Zfish  2349 PTNP--NAGKVLLPTPPVEPICVTPAAGTFEQPPALDLGIASPSSTTTQAGPASSLAHIPAPLEL 2411

  Fly  2008 PPG-----VDPLPPAWNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTTQQPLHELQI 2067
            ..|     |.|..||      .|..:...::..:.:  .|..|.|:..|.|.:..|||.: .:|.
Zfish  2412 SSGTQTQFVQPAVPA------QDPSVAVLSVPAQAA--SPQIPSQQGYTTLWDPNTQQAV-TVQT 2467

  Fly  2068 DPAVLENELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLES 2132
            .|           |....:.|....|.|.:.:..:       .:.||....|:.      |....
Zfish  2468 QP-----------TQQYSTTSQPQAAIYYQGQPCQ-------TIYSIPAGYPQT------NPPVI 2508

  Fly  2133 RKYKENKEKIRRRKELYRR-------------RKIEVLPDAVDEIPVPG----KALPIQP-YLFS 2179
            :.|.|........:::|.:             ::..::|:.:.::|.|.    |.:.:.| :..:
Zfish  2509 QAYTEPAANYLHSQQVYTQGGTVTTIVTSQPVQQEMIVPNNIIDLPPPSPPKPKTIILPPSWKVA 2573

  Fly  2180 SDEEE--------TKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGKAVAQPTGLGTVGKRKLPM 2236
            .|.|.        |:....:.|:    .|......|..|.|...||    .||
Zfish  2574 RDPEGRIYYYHIITRQTQWDPPS----WDGTTEEASVEHEAEMDLG----TPT------------ 2618

  Fly  2237 PPSVTVKKHRQEQRSK-KVKSSQSPLTATSAREAHEKFRFEISGHVANFLRPYRKESCTLGRITS 2300
                     ..|..|| ..|::::..::..|:::.|.||.|:|..:...|.||||..|.||||::
Zfish  2619 ---------YDENPSKFSTKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKLGRISN 2674

  Fly  2301 DEDYKFLVNRLSYHITTKEMRYCEVSGNP--LSCTESVKHKSYDFINQYMRQKGPVYKKPAEN 2361
            .||:|.|..:|::.:..||::.|:   ||  |.|.|:||||:.::|.:||::.|.|| :|.|:
Zfish  2675 TEDFKHLARKLTHGVMNKELKSCK---NPEDLECNENVKHKTKEYIKKYMQKFGSVY-RPKED 2733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	28/55 (51%)
		SET	1414..1533	CDD:214614	66/118 (56%)
		PostSET	1535..1551	CDD:214703	8/15 (53%)
		WW	2014..2043	CDD:278809	3/28 (11%)
		SRI	2270..2348	CDD:285448	33/79 (42%)
setd2	XP_009290459.1	AWS	1328..1382	CDD:197795	28/53 (53%)
		SET	1383..1506	CDD:214614	67/122 (55%)
		WW	2566..2595	CDD:278809	4/28 (14%)
		SRI	2642..2721	CDD:285448	33/81 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4828
eggNOG	1	0.900	-	-		E2759_KOG4442
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	1	1.000	-	-		FOG0002762
OrthoInspector	1	1.000	-	-		oto40815
orthoMCL	1	0.900	-	-		OOG6_102278
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.680