DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and setd1b

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001072649.1	Gene:	setd1b / 780106	XenbaseID:	XB-GENE-5842344	Length:	1956	Species:	Xenopus tropicalis

Alignment Length:	1787	Identity:	347/1787 - (19%)
Similarity:	579/1787 - (32%)	Gaps:	602/1787 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RGRGRPPKVALSALGNTPPH--------INPSLKHADA---EASPTAPEDQDSGQ-------SEC 64
            |..|.|...:.|.|...||:        :.||.:.:..   :.|||...|.|...       |.|
Frog   513 RMEGSPISSSSSQLSPIPPYSSGSRYQDVTPSSRPSSTGLEDISPTPLPDSDDDDEPIPGTASLC 577

  Fly    65 RRSSRKKIIKFDVRDLLNKN-RKAHKIQIEARI--DSNPST-----GHSQSG----TTAASTSMS 117
            :.|.....|     |.:|:: ||...:..:..:  |..|::     ||..||    .:....:.|
Frog   578 QNSRSASPI-----DQINQSGRKTESLDKKELVAGDETPTSEKMDEGHPSSGEDMEISDDEVTPS 637

  Fly   118 TATASAASASSAATVSRLFSMFEMSHQSLP---------------PPPPPPTALEIFAKPRP--- 164
            ..|::..:.:|::.:|.:..:.......||               |||||||...:...|.|
Frog   638 PITSAECAITSSSVISSVIPIPPPGFPPLPPPPPPQPGFPMPPPLPPPPPPTHPSVTVPPPPLPA 702

  Fly   165 --------------------------------------------TQSL--IVAQVTSEP------ 177
                                                        ||.|  ::....|.|
Frog   703 PPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQGSYPYHHFMG 767

  Fly   178 --SAVGGAHPVQTMA-------GLP--------PVTP-----RKRGRP----------------- 203
              ...|..||.:..|       |.|        |..|     .|:..|
Frog   768 GSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYEHKKEDPHKATVDGVLQVIVKELK 832

  Fly   204 -------------------------RKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNM--SSDS 241
                                     :|.:||..::.|.....|..:....:....||::  |.:.
Frog   833 AIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKEEDKQKTKEHITSSLLESWNK 897

  Fly   242 GE------------------LPGFPIQK---PKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEV 285
            ||                  ||.|.:::   |.:.|....||::             ||.|
Frog   898 GEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIR-------------PSHS---- 945

  Fly   286 EPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQD 350
                :.||   ||..::::::|.........|:|:.             ...:...||::.|.::
Frog   946 ----VDDE---DEESERDRDISSTASDLSKKDADAV-------------NNRRRPARPLDSEGEE 990

  Fly   351 LIDI---DMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKE--- 409
            .::.   |.|.:.:|.:...:||.|:..|..||....|: .|.|.::|:|.|    ...|||
Frog   991 EVESEGDDGETSDKEDSSSEKEDQDDGSVSALSSKKQLY-GDKEGDDEDDDT----QSSGKEEDL 1050

  Fly   410 --PAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLI 472
              ...|:.|.|..|    |.:..|....::.|       .|||....|.||..|:||:.:..|
Frog  1051 VSEEEDTTSVASSR----AEMDSSDESEESSE-------YESSSDSDEKEEEDDEEEELVFGD-- 1102

  Fly   473 EDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKD 537
                .:|                    |:..|..|.:...|.:::|     |.|:.:..:||.|
Frog  1103 ----DQS--------------------EDQDLGQEYEVETDREEDF-----FRENLSECSSLPK- 1137

  Fly   538 IFEPKVETKATCGEVVPRPEM--VTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEP 600
                       .|:|....||  |.||                |.:.||:   ||....:..::.
Frog  1138 -----------AGDVELEDEMQKVEED----------------VARQTTQ---ETLHLRKKNLDV 1172

  Fly   601 PLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLST 665
            ||.:..:.||..::..|...||  |..|.:.. |.|...||:
Frog  1173 PLVESKECKQDTLDKVEKLFAV--PMQEEVFK-EHEKAPSPM----------------------- 1211

  Fly   666 EEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKG 730
                ||..|...|:.|..     |..| |.|:.:::||..:              ..:......|
Frog  1212 ----NEEEEYIELQLEPV-----PLVP-EGAAPAAQEPVII--------------RPLTPTGAFG 1252

  Fly   731 QKQTPLPEMKEPEKPVAET---VSKKEKAMENPARSSPAIVDKKV--RAGEMEKKVVKSTKGTVP 790
            : ..|:.:::||:..|..|   ...:|.....|.|.:.|..|.:|  :.|      :|....::|
Frog  1253 E-TGPVLKLEEPKLQVNLTQFATEDEELYPRTPGRDTAAHSDTEVTFQPG------LKVAPSSLP 1310

  Fly   791 EKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQL 855
            .....:|:....:.|  :|.:|......:|.:|            ..|.|   .|:|....|..|
Frog  1311 FLPSHNKEEECLLPP--EKHAGHLTVTKMLSEE------------DLPRT---PGRDIVVKSSHL 1358

  Fly   856 QTLPKSSTKP--PQESAP---SVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFV 915
            .....:.|.|  |...||   |.::.|:.:.|.......:...|:.::..|............|.
Frog  1359 GKSQSTETVPATPGSDAPLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPTFP 1423

  Fly   916 ECDAMFKAMDLANAQLRLDEKNKKKLKKVPT-------KVEAP-PKVEPPTAVPVPGQKKSLSGK 972
            |.:::|.... :..:..:||.::|..|: ||       .|.:| |...||..:|          .
Frog  1424 ESNSIFPCHP-SGKKPSVDEPDEKSFKE-PTSASLTMNSVPSPIPFASPPRGLP----------H 1476

  Fly   973 TSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSS 1037
            ..:|          |..:...|||:           |:.:..|:....|. ||..|...:|:..|
Frog  1477 MDIR----------LGADDLESSDT-----------PAYLSDKLLSEESE-CEFTKVHLTSTDES 1519

  Fly  1038 TPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFS 1102
            .|      |.|:    ..:.||.|.:         ||.....:....::..||:..|.::
Frog  1520 AP------SPPL----PPAEKRKGDR---------SKKPLSAHEFETEKNYETSSAVAMS----- 1560

  Fly  1103 MHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLE 1167
                                     ||  :|.:|..:....:.|  ..|..|....:..:.:|.|
Frog  1561 -------------------------EG--ALGKQMFIGQPDAVS--GIKDPAAVPLDFRNDSLSE 1596

  Fly  1168 TESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREA 1232
            ....|..          :|..|..|..|.:.::.|..||    :.:.|...:.|...:
Frog  1597 NTVHEPI----------IQKVPLKELENQWNEVLKEEED----ITKHKKSRNSRHNNR------- 1640

  Fly  1233 DPEEDEFAQRVANMETPATTPTP--SPTQS--NPEDSASTTTVLKELETGGGVRRSHRIKQKPQG 1293
               .|||          :|.|:|  ||.::  .|.......|:|.::..||       |..:
Frog  1641 ---YDEF----------STVPSPEFSPPRAMFKPRSEFEEMTILYDIWNGG-------IDDE--- 1682

  Fly  1294 PRASQGRGVASVALAPISMDEQLAELANIEAINEQF---------------LRSEGLNTFQLLKE 1343
                      .:....|:.|..|.:...::.:|:..               .|.:|      |:|
Frog  1683 ----------DIKYMCITYDRLLQQDNGMDWLNDTLWVYHPSTSVYSPKKKKRDDG------LRE 1731

  Fly  1344 NFYRCARQ---------------VSQENAEMQCDCFLTGDE-EAQGHLSCGAGC-----INRMLM 1387
            :...|||.               ::..:...:......|.. .||...|..||.     ..|:|.
Frog  1732 HVTGCARSEGYYKIDKKDKLKYLINNRSLTEELPIDTQGKSIPAQPQASTRAGSERRSEQRRLLS 1796

  Fly  1388 IECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFER 1452
            ...|...|:..:....:|::.:   .|..::.....|:.|...|...|.::||||:.|.....:.
Frog  1797 SFTGSCDSDLLKFNQLKFRKKK---LRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIADM 1858

  Fly  1453 RQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPI 1517
            |:..|..:.....|...:..:.:||||..||.:|:|||||:||...:..||..:.:|..:|.:.|
Frog  1859 REKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQYI 1923

  Fly  1518 QPGEEITFDYQYLRYGRDAQ-RCYCEAANCRG 1548
            ...||||:||::..  .|.: .|.|.|.||||
Frog  1924 NVNEEITYDYKFPI--EDVKIPCLCGAENCRG 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	11/57 (19%)
		SET	1414..1533	CDD:214614	38/118 (32%)
		PostSET	1535..1551	CDD:214703	8/15 (53%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
setd1b	NP_001072649.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		RRM_Set1B	119..211	CDD:240993
		RRM	<127..304	CDD:223796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..637		28/128 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..696		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..1148		66/317 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1341..1386		13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1464		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1512..1553		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1627..1655		9/47 (19%)
		N-SET	1669..1807	CDD:288597	26/163 (16%)
		SET	<1732..1956	CDD:225491	60/227 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1766..1790		6/23 (26%)
		SET	1817..1939	CDD:214614	38/126 (30%)
		PostSET	1940..1956	CDD:214703	7/14 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940