Protein Alignment Set2 and Ehmt1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_006498485.1
• Gene: Ehmt1 / 77683
• MGIID: 1924933
• Length: 1312
• Species: Mus musculus
• Alignment Length: 1502
• Identity: 300/1502 - (19%)
• Similarity: 496/1502 - (33%)
• Gaps: 482/1502 - (32%)

  Fly   358 LAKQEPTPD---PEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEP-AAD----- 413
            |||||...|   ..|.|.|       |..:..:||:.:.|:::         |:.| |||
Mouse    25 LAKQETKQDCCMKTELLRE-------GKDTPMAADEGSTEKQE---------GETPMAADGETNG 73

  Fly   414 SCS--------SAPRRSR---RSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHI 467
            ||.        :||:.::   |::|..|::|..:..|...:|...|..||            .|:
Mouse    74 SCEKSGDPSHLNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQ------------NHV 126

  Fly   468 LIDLIEDTLSESEVTSS----VSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESD 528
            ..|   |.:..|.:.|:    ..|.::...:....:..:.|...|.:.|....        |:..
Mouse   127 TAD---DFMQTSVIGSNGYFLNKPALQGQPLRTPNILTSSLPGHAAKTLPGGA--------SKCR 180

  Fly   529 NIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS 593
            .::|........|.|..:.:......:|.....||.:... ..|:.||.:      .:.|.:|..
Mouse   181 TLSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRA-RKTMPKSIL------GLHAASKDH 238

  Fly   594 DEVVIEPPLKDESDPKQT---------EVELPESKPAV--NIPKSERILSAEVETTSSPLVPPEC 647
            .||      :|..:||:.         ..:|..:.||:  ::|:::..::    ||.|
Mouse   239 REV------QDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMA----TTKS------- 286

  Fly   648 CTLESVSGPVLLETSLSTEEKSNENV--------------------------ETTPLKTEAAKED 686
               ::...|.:|..::|.::|.....                          .|...|.|.|.:|
Mouse   287 ---QTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKALDD 348

  Fly   687 SP--------PAAPEEEASNSSEEPN---------FLLEDYESNQEQVAE-DEMMKCNNQKGQKQ 733
            |.        ....|:|.|:..|:..         |..||..:::|.::| |...|.:....::|
Mouse   349 SALHVNGESLEMDSEDEDSDELEDDEDHGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQ 413

  Fly   734 TPLPEMKE-----PEKPVAETVSKKEKAMENPARS-SPAIVDKKVRAGEMEKKVVKSTKGTVPEK 792
            .. |:..|     .|..::...|.|:|.::...:: ||.|...:.|.....||         |..
Mouse   414 ES-PDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKK---------PSS 468

  Fly   793 KMDSKKSCAAVTPAKQKESGKSA-------------KEAILKKETEKEKSSAKLDSSSPNTLDKK 844
            .:.|:...::....:|...|.||             ...||..:||.|..     :|.|:.|...
Mouse   469 MLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGL-----ASGPDVLGTD 528

  Fly   845 GKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNS---------- 899
            |         ||.:|..|.:  .|:..|....|.:|......|....:.|...||
Mouse   529 G---------LQEVPLCSCR--METPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPS 582

  Fly   900 ---PPSVL-------KAKEKAVSG---------FVEC------------DAMFKAMDLANAQLRL 933
               |..||       ..|.:...|         |:||            |...:..:.:......
Mouse   583 NKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCG 647

  Fly   934 DEKNKKK---LKKVPTKVEAPPKVEPPTAVPVPGQKKSLS--GKTSLRRNTVYEDSPNLERNSSP 993
            :|.:|.|   :.|..|         ..|....|||:|||:  |:......:: ..:|..||:.|.
Mouse   648 EEASKAKEVTIAKADT---------TSTVTLAPGQEKSLAAEGRADTTTGSI-AGAPEDERSQST 702

  Fly   994 SSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSK 1058
            :..:.:....||   |:.:   :.|             :|..|..|.:|...|:.::..|:...|
Mouse   703 APQAPECFDPAG---PAGL---VRP-------------TSGLSQGPGKETLESALIALDSEKPKK 748

  Fly  1059 ------------RNG----------------------SKRTTSD--------------LDGGSKL 1075
                        |.|                      |||:...              :..|:.:
Mouse   749 LRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANI 813

  Fly  1076 DQRRYTICED-RQP--ETAIPVPLTKRRFSMHPKASANPLH---DTLLQTAGKKRGRKEGKESLS 1134
            |    |..|| |.|  |.|....|...::.:...|..:|..   .|.|..|.|| |..:..:.|.
Mouse   814 D----TCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKK-GHYDVVQYLL 873

  Fly  1135 RQNSLDSSSSASQG-APKKKALKSAEILSAALLETESSESTSSGSKMS---RW-------DV--- 1185
            ....:|.:.....| .|...|.:...:....||.::.|:.....::.:   .|       |:
Mouse   874 SNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 938

  Fly  1186 --QTSPELEAANPFGDIAKFIEDGVN-------LLKRDKVDEDQRKEGQDEVKREADPEEDEFAQ 1241
              ....:|.|.|..||....|....|       .|.||.....:.|||
Mouse   939 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEG----------------- 986

  Fly  1242 RVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVA-SV 1305
                 |||.            :.::.::.|...|:....:|.|  ...||.....:..|.:| ..
Mouse   987 -----ETPL------------QCASLSSQVWSALQMSKALRDS--APDKPVAVEKTVSRDIARGY 1032

  Fly  1306 ALAPI----SMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ-CDCFL 1365
            ...||    ::|.:|..                 ..::.:.:|.......:.:....:| |.|.
Mouse  1033 ERIPIPCVNAVDSELCP-----------------TNYKYVSQNCVTSPMNIDRNITHLQYCVCV- 1079

  Fly  1366 TGDEEAQGHLSCGA-----------------GCINRMLMIECGPLCSNGARCTNKRFQQHQCWPC 1413
              |:.:.....||.                 ......|:.||...||....|.|:..|.......
Mouse  1080 --DDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARL 1142

  Fly  1414 RVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA- 1474
            :::||:..|.|:.:...||.|.|:.|||||:|...|.:.|:   :|:..|..        .||.
Mouse  1143 QLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNK--------DGEVY 1199

  Fly  1475 VIDATSKGNISRYINHSCDPN-AETQKWTVNGEL---RIGFFSVKPIQPGEEITFDYQYLRYGRD 1535
            .|||...||:||:|||.|:|| ...:.:..:.:|   ||.|||.:.||.||::.|||
Mouse  1200 CIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDY-------- 1256

  Fly  1536 AQR----------CYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEA--EPEE-GQPR 1587
            .:|          |.|.::.||                   .|.|.:.:.:..|  ||:| |.|.
Mouse  1257 GERFWDVKGKLFSCRCGSSKCR-------------------HSSAALAQRQASAAQEPQENGLPD 1302

  Fly  1588 KSAKAKA 1594
            .|:.|.|
Mouse  1303 TSSAAAA 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	29/142 (20%)
		AWS	1358..1410	CDD:197795	14/69 (20%)
		SET_SETD2	1410..1551	CDD:380949	51/158 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Ehmt1	XP_006498485.1	EHMT_ZBD	530..660	CDD:411018	24/131 (18%)
		ANKYR	734..990	CDD:440430	51/282 (18%)
		ANK repeat	788..817	CDD:293786	4/32 (13%)
		ANK repeat	819..850	CDD:293786	8/30 (27%)
		ANK repeat	852..884	CDD:293786	8/32 (25%)
		ANK repeat	886..917	CDD:293786	6/30 (20%)
		ANK repeat	919..950	CDD:293786	4/30 (13%)
		ANK repeat	952..983	CDD:293786	7/30 (23%)
		SET_EHMT1	1050..1280	CDD:380933	66/267 (25%)