Protein Alignment Set2 and ezh2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001070747.1
• Gene: ezh2 / 768133
• ZFINID: ZDB-GENE-041111-259
• Length: 760
• Species: Danio rerio
• Alignment Length: 980
• Identity: 199/980 - (20%)
• Similarity: 313/980 - (31%)
• Gaps: 363/980 - (37%)

  Fly   626 KSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPA 690
            |..||....:.|..|.|.....||::|           ...|.|.:.:   ||||..|....|..
Zfish    61 KLRRIQPVHIMTPVSSLRGTRECTVDS-----------GFSEFSRQVI---PLKTLNAVASVPVM 111

  Fly   691 APEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEK 755
                 .|.|..:.||::||                                      |||
Zfish   112 -----YSWSPLQQNFMVED--------------------------------------ETV----- 128

  Fly   756 AMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAIL 820
             :.|.......|:|:.   |...::::|:..|     |:...:.|..:......|...:..:...
Zfish   129 -LHNIPYMGDEILDQD---GTFIEELIKNYDG-----KVHGDRECGFINDEIFVELVNALNQYSD 184

  Fly   821 KKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPK 885
            .:|.::|...........:..|  |||.|:                                 ..
Zfish   185 NEEDDEEDDHHDYKFEKMDLCD--GKDDAE---------------------------------DH 214

  Fly   886 EEQHAAKKGLSDNSP--PSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKV 948
            :||.:::...:|.|.  ||               |.:|:|:..........|:.|:|.|:: |:.
Zfish   215 KEQLSSESHNNDGSKKFPS---------------DKIFEAISSMFPDKGSTEELKEKYKEL-TEQ 263

  Fly   949 EAP--------PKVEPPTAVPVPGQKKSLSGKTSLRRNTV--------YEDSPNL--ERNSSPSS 995
            :.|        |.::.|.|..|..::...|..|...|...        ::.:||.  .:|.....
Zfish   264 QLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFQATPNTYKRKNMENLV 328

  Fly   996 DSAQAN-------TSAGKLK--PSKV---KKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSP 1048
            ||....       ...|.::  |:.|   :.|...:|||.....:...|:|..||||
Zfish   329 DSKPCGIYCYMYMVQDGMVREYPAGVVPERAKTPSKRSTGRRRGRLPNSNSRPSTPT-------- 385

  Fly  1049 VSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLH 1113
              .:|:       :|.|.||.:||                                  |..|..:
Zfish   386 --VNSE-------TKDTDSDREGG----------------------------------ADGNDSN 407

  Fly  1114 DTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTS-SG 1177
            |               |:...:::...|||.|:........||         |.:|..|:.. ||
Zfish   408 D---------------KDDDDKKDETTSSSEANSRCQTPVKLK---------LSSEPPENVDWSG 448

  Fly  1178 SKMSRWDVQTSPELEAANPFGDIAKFI-------------EDGVNLLKRDKVDED--QRKEGQDE 1227
            ::.|.:.|......:   .|..||:.|             ::...:.:...|||:  |||:.:..
Zfish   449 AEASLFRVLIGTYYD---NFCAIARLIGTKTCRQVYEFRVKESSIIARAPAVDENTPQRKKKRKH 510

  Fly  1228 VK-----READPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRI 1287
            ..     |:...::|..:..|.|.:     |...|.|  |.||:...
Zfish   511 RLWATHCRKIQLKKDGSSNHVYNYQ-----PCDHPRQ--PCDSSCPC------------------ 550

  Fly  1288 KQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAIN--EQFLR--SEGLNTFQLLKENFYRC 1348
                                              :.|.|  |:|.:  ||..|.|.     ..||
Zfish   551 ----------------------------------VTAQNFCEKFCQCSSECQNRFP-----GCRC 576

  Fly  1349 ARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWP 1412
            ..|.:.:    ||.|:|.                    :.||.| ||.......:...:...|..
Zfish   577 KAQCNTK----QCPCYLA--------------------VRECDPDLCLTCGAAEHWDSKNVSCKN 617

  Fly  1413 CRVFRTEKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYF 1467
            |.:.|..||          |.||..:..:...|||.||.||:|..:|.:||..:|  |:....:.
Zfish   618 CSIQRGAKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFL 680

  Fly  1468 MALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY--- 1529
            ..|..:.|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|
Zfish   681 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQA 745

  Fly  1530 --LRY 1532
              |:|
Zfish   746 DALKY 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	15/122 (12%)
		AWS	1358..1410	CDD:197795	9/52 (17%)
		SET_SETD2	1410..1551	CDD:380949	53/138 (38%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
ezh2	NP_001070747.1	EZH2_WD-Binding	39..68	CDD:463308	3/6 (50%)
		PRC2_HTH_1	159..262	CDD:436286	22/153 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..231		7/55 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..444		30/162 (19%)
		preSET_CXC	573..604	CDD:408079	12/54 (22%)
		SET_EZH2	623..742	CDD:380995	47/120 (39%)