DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and setdb1b

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_005158070.2	Gene:	setdb1b / 768131	ZFINID:	ZDB-GENE-061013-224	Length:	1242	Species:	Danio rerio

Alignment Length:	1534	Identity:	290/1534 - (18%)
Similarity:	496/1534 - (32%)	Gaps:	521/1534 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SDTNSTSTTTSNMSSDSGELPGFPIQ-KP--KSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVE 286
            :|..|...:...|..|:|...|..:: :|  :.:|.|||..|:.... |..||..:......::|
Zfish    17 NDRASHLNSVQCMEVDAGLNSGMEMELEPELEEELGVSLDELRKWIE-EQVDSSEAVQKRKADLE 80

  Fly   287 PPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKG---EEEQEEGRPVEVEP 348
                |.:..:::|.|:..::..:  ....|:|..|...:..|..|..|   .|...:....:..|
Zfish    81 ----QLQEWVEQREKEVADIDAL--CSNASESVVQCEALVKEVYSNMGLVYRESSSDDEGGKANP 139

  Fly   349 QDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPP--SLWSADDEAEEEEDATVQRAT------- 404
            .::|:||            ::|.|:::......||  ||..|.|.|.:|..|.:||.:
Zfish   140 SEVIEID------------DDDDDDVIAVGCLVPPKKSLTQAKDPALKEASAALQRTSQQVQNLA 192

  Fly   405 -------------------PPGKEPAADSC---SSAPRRS--------RRSAPLSGSSRQGKTLE 439
                               |||:.|.|...   |||||.:        ::.:.....:..||...
Zfish   193 QTVNRTAQSGVTTPVKTGGPPGQGPLAVPAVFMSSAPRNTPTQPNPNIKQDSIKINMTLLGKKRT 257

  Fly   440 ETFAEIAAESSKQI---LEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEE 501
            :|:......:.||:   |:.:...:.:.:.:        ||.:.|.....||:|.:.|...||..
Zfish   258 KTWHRGTLVAIKQVGNNLKYKVRFENKGKSL--------LSGNHVAFEYHPTLERLFVGARVVAR 314

  Fly   502 NQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYIT 566
            .:         |..|.::...|.:|..|   |.|:..|.                      ::..
Zfish   315 YK---------DGNQVWLYAGVVAEMPN---SKNRMRFL----------------------IFFD 345

  Fly   567 EGIAA--TLEKSAVVTKP---TTEMIAETKLSD---EVVIEPPLKDESDPKQTEVELPESKPAVN 623
            :|.|:  .|.:...:.:|   |.|.|.:....|   |.:...|                ::|.|
Zfish   346 DGYASYVGLPELYPICRPLKKTWEDIEDASCRDFIEEYITSYP----------------NRPMV- 393

  Fly   624 IPKSERILSAEVETT--SSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKED 686
            :.|..:|:..|.|.|  .|        .:|.|.|.  |...|..::|.:|.:
Zfish   394 LLKPGQIIKTEWEGTWWKS--------RVEEVDGS--LVKMLFLDDKRSEWI------------- 435

  Fly   687 SPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVS 751
                    ...::..||.|.|:...:|.::      .|...|  |:|.|.......:.||.:..|
Zfish   436 --------YRGSTRLEPMFNLKMNTANSQE------KKMAGQ--QRQRPNMGALRTKGPVVQYTS 484

  Fly   752 KKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAK 816
                  :|.|.:|..       .|       .:|.|| |.:.:..:   .|..|...:....|.|
Zfish   485 ------DNSAAASTG-------GG-------AATPGT-PTRPVAPQ---PAGPPQPSRTESPSFK 525

  Fly   817 EAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSS------------TKPPQES 869
            ..:.||.|.:.....:  ...|:.|..|        |.:..|..::            |..|...
Zfish   526 SQMAKKSTGQLALQPR--QGMPSDLQPK--------PIINALQTNTSRLFLLQSGPVHTLTPITP 580

  Fly   870 APSVIS---KTTSNQPAPKEEQHAAKKG----LSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLA 927
            ||..:.   .|.:|:..|:|..:.|...    |:.|..|              ||
Zfish   581 APQTVQTAISTYTNERVPQEPSYQAPNDRLFYLTHNCSP--------------EC---------- 621

  Fly   928 NAQLRLDEKNKKKLKKV-PTKVEAPPKV---EPPTAVPVPGQKKSLSGKTSLRR----NTVYEDS 984
                         ||:: ||:    |.:   ..|...|:..:.:.::|:..|.|    :.:|:
Zfish   622 -------------LKRIRPTR----PNLHRGRNPLLTPLLYEFRRMTGRRRLNRKMSFHVIYK-- 667

  Fly   985 PNLERNSSPSSDSAQANTSAGK----------------LKP-SKVKKKINPRR-----STICEAA 1027
                   ||...|.:..|...:                |.| ..|.::..|:|     ..|....
Zfish   668 -------SPCGLSLRNMTEIQRYLFQTQCDFIFLEMFCLDPYVLVDRRFQPQRPFYFIRDITSGR 725

  Fly  1028 KDLRSS---SSSSTPTREVAASSP--------VSTSSD-------SSSKRNGSK--------RTT 1066
            :|:..|   ...:||...||.|..        ::||:|       :...|:.||        :.|
Zfish   726 EDIPLSCVNEIDNTPPPSVAYSKERIPEDGVYINTSADFLVGCDCTDGCRDKSKCSCHQLTLQAT 790

  Fly  1067 SDLDGG----------SKLDQRRYT--------------ICEDRQPETAIPVPLTKRRFSMHPKA 1107
            ....||          .:||:...|              :|.:|..:..:.|.|  :.|....|.
Zfish   791 GCTPGGQINPNAGYHYKRLDECLPTGIYECNKRCRCNMQMCTNRLVQHGLQVRL--QLFKTQNKG 853

  Fly  1108 SANPLHDTLLQ------TAGK--------KRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSA 1158
            ......|.:.:      .|||        |.|.:.|.|..:..:.::|..:..:|...
Zfish   854 WGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYES------- 911

  Fly  1159 EILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRK- 1222
                    |...|:|..||..|||      .:|.|::..|             |.:|::|....
Zfish   912 --------EAHCSDSEGSGVDMSR------VKLPASSRHG-------------KSNKMEERNSST 949

  Fly  1223 --EGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSAST--TTVLKELETGGGVRR 1283
              :.||:...|:|.|:|:                    .||.:||.|:  |.|.....|...|.|
Zfish   950 TGKSQDDSSEESDDEKDD--------------------DSNEDDSDSSDDTFVKDTYYTTSSVWR 994

  Fly  1284 SHRIKQKPQG----------------------PRASQGRGVASVALAPISMDEQLAELANIEAIN 1326
            |:..:::.:|                      |...:..|.:.||   ..:..|.:..||.....
Zfish   995 SYTTRRQAKGLKEESQDSKDGMSVSAGEDRKPPHMPEETGKSKVA---SWLTNQSSTSANQSVKV 1056

  Fly  1327 EQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECG 1391
            |..:::|..:...|...:..:.....|.:|.|.:.........:.....:.|....:..:|::.|
Zfish  1057 EGGIKTEKKDVMTLSDSDDVQTISSGSDDNKEREKKTQAVVKRQVAVKSTRGIALKSHSMMVKSG 1121

  Fly  1392 PLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHL 1456
            ...:.|.                       |.|                            ..|.
Zfish  1122 GGGAGGG-----------------------GSG----------------------------PSHG 1135

  Fly  1457 Y------SKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVN-GELR---IGF 1511
            :      :..:|...:|.......:|||..:||:.||:||||.||...|...|: .:||   :.|
Zfish  1136 HGGGGGDNGPKNTRLFFDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAF 1200

  Fly  1512 FSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANCRG 1548
            |:.|.|:.|.|:|:||.|.....:.:.  |.|.:..|||
Zfish  1201 FASKRIRAGTELTWDYNYEVGSVEGKELLCCCGSTECRG 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	5/51 (10%)
		SET	1414..1533	CDD:214614	32/128 (25%)
		PostSET	1535..1551	CDD:214703	5/16 (31%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
setdb1b	XP_005158070.2	TUDOR	305..364	CDD:295375	14/92 (15%)
		TUDOR	395..446	CDD:197660	15/81 (19%)
		HMT_MBD	638..699	CDD:238689	10/69 (14%)
		Pre-SET	721..834	CDD:282838	21/112 (19%)
		SET	842..>905	CDD:214614	13/64 (20%)
		SET	<1142..1219	CDD:214614	28/76 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840