DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and Kmt2b

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_001277502.1 Gene:Kmt2b / 75410 MGIID:109565 Length:2722 Species:Mus musculus


Alignment Length:2423 Identity:469/2423 - (19%)
Similarity:727/2423 - (30%) Gaps:850/2423 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SGPPSNPSPVASRGRGRGRPPKV----ALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSEC 64
            :|..|.|.|.::|||..|||...    .....||....:..:|:.....|.|...|..:.     
Mouse     5 AGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVRVALRRGGGAAGPGGAEPGED----- 64

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARI--------------------DSNPSTGHSQ--- 106
              ::..:::     .|....|:..::...||:                    :...|.|.|:   
Mouse    65 --TALLRLL-----GLRRGLRRLRRLWAGARVQRGRGRGRGRGWGPNRGCMPEEESSDGESEEEE 122

  Fly   107 -----SGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPP--------PP--PT-- 154
                 |....|.:|:.:|..|....:......:        |::.|.||        ||  ||  
Mouse   123 FQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRK--------HKTTPLPPRLADVTPVPPKAPTRK 179

  Fly   155 -----------AL-EIFAK---PRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRK-RGRP 203
                       || |:..:   |:|.:|...|:   |||                 |||: ||||
Mouse   180 RGEEGTERMVQALTELLRRSQAPQPPRSRARAR---EPS-----------------TPRRSRGRP 224

  Fly   204 --------RKSQ----LADAAII------PTVIVP--------SCSDSDTNSTSTTTSNMSSDSG 242
                    ||.|    ||:||:.      |..:||        .|.:.......|.........|
Mouse   225 PGRPAGPCRKKQQAVVLAEAAVTIPKPEPPPPVVPVKNKAGSWKCKEGPGPGPGTPKRGGQPGRG 289

  Fly   243 -------ELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPE-VEPPALQDENAMDE- 298
                   ...|.|:.   .|.....|::|:|...:..:||......... .:.|..:|.:..:. 
Mouse   290 GRGGRGRGRGGLPLM---IKFVSKAKKVKMGQLSQELESGQGHGQRGESWQDAPQRKDGDEPERG 351

  Fly   299 --RPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAK- 360
              |.||||.|....:.||....:.:   .:.:.|....:||:||......|.:.::..:.|.|| 
Mouse   352 SCRKKQEQKLEEEEEEEEKEGEEKE---EKDDNEDNNKQEEEEETERAVAEEEAMLAKEKEEAKL 413

  Fly   361 -----QEPTPDPEEDLD----------EIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEP 410
                 ..|.|.|...|.          ..:...:|.||.|......|.|:     |..:|| ..|
Mouse   414 PSPPLTPPVPSPPPPLPPPSTSPPPPASPLPPPVSPPPPLSPPPYPAPEK-----QEESPP-LVP 472

  Fly   411 AADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDT 475
            |  :||    |.|...||:.|.|                    .|.|.::...|     ..:..|
Mouse   473 A--TCS----RKRGRPPLTPSQR--------------------AEREAARSGPE-----GTLSPT 506

  Fly   476 LSESEVTSSV---SPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKD 537
            .:.|..|.|.   |||:               |.::...|.:.::|::..|.:.|..:..:..:.
Mouse   507 PNPSTTTGSPLEDSPTV---------------VPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRF 556

  Fly   538 IFE-----PKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVV 597
            :.|     ||||                          |::.:..|.|.|...            
Mouse   557 MDEDPPKPPKVE--------------------------ASIVRPPVATSPPAP------------ 583

  Fly   598 IEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETS 662
             :.|:...|.|:   |..|.|.| |.:|:..|.:..|                     |....||
Mouse   584 -QEPVPVSSPPR---VPTPPSTP-VPLPEKRRSILRE---------------------PTFRWTS 622

  Fly   663 LSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFL-----------LEDYESNQEQ 716
            |:.        |..|.........|||.||    :..|..|..|           |:.|||    
Mouse   623 LTR--------ELPPPPPAPPPAPSPPPAP----ATPSRRPLLLRAPQFTPSEAHLKIYES---- 671

  Fly   717 VAEDEMMKCNNQKGQKQTPLP----EMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEM 777
                           ..||.|    |..|||.|              ||..|||         |.
Mouse   672 ---------------VLTPPPLGALETPEPELP--------------PADDSPA---------EP 698

  Fly   778 EKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLD 842
            |.:.|..|      ..:...:....||...:.|.......|:      .|....:| ...|..| 
Mouse   699 EPRAVGRT------NHLSLPRFVPVVTSPVKVEVPPHGAPAL------SEGQQLQL-QQPPQAL- 749

  Fly   843 KKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAK 907
                       |.|.||::  .|||:  |..       || |...||         :||     .
Mouse   750 -----------QTQLLPQA--LPPQQ--PQA-------QP-PPSPQH---------TPP-----L 777

  Fly   908 EKA---------VSGFVECDAMFKAMDLANAQL-RLDEKNKKKLKKVPTKVEAPPKVEPPTAVPV 962
            |||         :||..|  .||..:..|..|| ::|::.:   :||...:...|.|:...||  
Mouse   778 EKARVASLGSLPLSGVEE--KMFSLLKRAKVQLFKIDQQQQ---QKVAASMPLSPAVQTEEAV-- 835

  Fly   963 PGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAA 1027
             |..|....:..:|              |...|..|:.:.::|...|.:     .||...:|..|
Mouse   836 -GTVKQTPDRGCVR--------------SEDESMEAKRDRASGPESPLQ-----GPRIKHVCRHA 880

  Fly  1028 ------------KDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDG-GSKLDQRR 1079
                        :|:...|:.....|:..|:...|::|::.|..:.|:|...:..| |...:...
Mouse   881 AVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAGPGGDSEPTG 945

  Fly  1080 YTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSS 1144
            .|......|..::|        |.|.|...       :...|..||....::..|..|.||....
Mouse   946 STGALAHTPRRSLP--------SHHGKKMR-------MARCGHCRGCLRVQDCGSCVNCLDKPKF 995

  Fly  1145 ASQGAPKKK----ALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIE 1205
               |.|..|    ..:..:.:.|..:|..:.:..:....:..||...|||.....| |.......
Mouse   996 ---GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPP-GPRRGAGA 1056

  Fly  1206 DGVNLLKRDKV-------DED----QRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPS--- 1256
            .|    .|::|       ::|    |||..:..||:.  |..|.|..  ::...|...|.|.   
Mouse  1057 GG----SREEVGATPGPEEQDSLLLQRKSARRCVKQR--PSYDVFED--SDDSEPGGPPAPRRRT 1113

  Fly  1257 ------PTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAP-----I 1310
                  |.....|.|......|:.:......||..:....| ||.||...|......:|     :
Mouse  1114 PREHELPVLEPEEQSRPRKPTLQPVLQLKARRRLDKDALAP-GPFASFPNGWTGKQKSPDGVHRV 1177

  Fly  1311 SMD-EQLAELANIEAINEQFLRSEGLNTFQ----------LLKENFYRCARQVSQENAEMQ--CD 1362
            .:| ::..:|.|:..:.       ||:...          ||      ||.:...|....|  ||
Mouse  1178 RVDFKEDCDLENVWLMG-------GLSVLTSVPGGPPMVCLL------CASKGLHELVFCQVCCD 1229

  Fly  1363 -----CFLTGDEEAQGHLS------------CGAGCINRMLMIEC-------GPLC---SNGARC 1400
                 |....:..:..|..            ||........::||       .|.|   |...|.
Mouse  1230 PFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRA 1294

  Fly  1401 TNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGE-FIMEYVGEVIDSEEFERRQHLYSK----- 1459
            |.:|  :|  |.|... ...|.||.|      ||: :.:|:.|   |.....|...||.|     
Mouse  1295 TRRR--RH--WICSAC-VRCKSCGAT------PGKNWDVEWSG---DYSLCPRCTELYEKGNYCP 1345

  Fly  1460 -------DRN-----------RHYYFMALRGEAVIDATSKGNISRYINHSCDP--NAETQKW--T 1502
                   |.:           .|:......|.:..|......:...:.::|.|  .|...:|  .
Mouse  1346 ICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQPRWREA 1410

  Fly  1503 VNGELRIGFFSV-----------------------KPIQPG-----------EE----------- 1522
            ::|.|:.|...|                       |.:.||           ||           
Mouse  1411 LSGALQGGLRQVLQGLLSSKVAGPLLLCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFME 1475

  Fly  1523 --ITFDYQYLRYGRDAQR------------------CYCEAANCRGW-------IGGEPDSDEGE 1560
              :....::...|...:|                  |:.:|.:.:.|       .|..|::....
Mouse  1476 DVVAILMRHSEEGETPERRAGSQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNAVLPP 1540

  Fly  1561 QLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLP-LATGRKRKEQTKPKDREYK-A 1623
            .||...   |:..::|.|. ||.|||.....|..:||..|... |...|:.....|..|.:.| |
Mouse  1541 SLDHVY---AQWRQQESET-PESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEA 1601

  Fly  1624 GRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLR--------- 1679
            ||.|   ..|.:....       ||   ..:...:|.||    ..|.|||....:.         
Mouse  1602 GRLL---YIGQNEWTH-------VN---CAIWSAEVFEE----NDGSLKNVHAAVARGRQMRCEL 1649

  Fly  1680 -----------FSRCLVRAKLLKTRLALLRVLTHGELPC---------------------RRLFL 1712
                       .|.||.....:..|.:........::.|                     ||:::
Mouse  1650 CLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVTPDGFDVLRRVYV 1714

  Fly  1713 DYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSD------------SRVYQSVQLWS 1765
            |:.|:.....:::  |.:..:...|:.::....:...:.|||            ||:|     ||
Mouse  1715 DFEGINFKRKFLT--GLEPDVINVLIGSIRINSLGTLSDLSDCEGRLFPIGYQCSRLY-----WS 1772

  Fly  1766 NSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHAST 1830
                     ....::...::..:...:.|.        |:.|.:     |...|:..|..||:.|
Mouse  1773 ---------TVDARRRCWYRCRILEYRPWG--------PREEPV-----HLEAAEENQTIVHSPT 1815

  Fly  1831 ALEDQRERESSNDR--------------------FRQDRFR------RDTTSSRIGKPIRMSGNN 1869
            ...:....:...|.                    .|.|...      |..:.:||..|.......
Mouse  1816 PSSEPPNHDDLPDTDSLIPGDPVHHSPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRR 1880

  Fly  1870 TICTITTQQKGSNGAPDGMTRN-----DNRRRSDI-GPPSEQRRTLSKELRRSLFERKVALDEAE 1928
            .:..::.....|.|:|..:|.:     |    ||. .||...||......|          ....
Mouse  1881 PLGGVSFGPLPSPGSPSSLTHHIPTVGD----SDFPAPPRRSRRPSPLATR----------PPPS 1931

  Fly  1929 RRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTN-EWFNSDDVPVPAPPRTELLTKALLSP 1992
            ||..:..|...:||     ..::|....|     |.|: |....|..|.|.||..:      |.|
Mouse  1932 RRTSSPLRTSPQLR-----VPLSTSVTAL-----TPTSGELAPPDLAPSPLPPSED------LGP 1980

  Fly  1993 DID-----VGQGATDVEY 2005
            |.:     .|..|.|:::
Mouse  1981 DFEDMEVVSGLSAADLDF 1998

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 16/80 (20%)
SET 1414..1533 CDD:214614 30/193 (16%)
PostSET 1535..1551 CDD:214703 4/40 (10%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
Kmt2bNP_001277502.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65 16/66 (24%)
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6 17..36 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..524 108/527 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..783 83/409 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..872 10/62 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..964 15/72 (21%)
zf-CXXC 963..1010 CDD:251032 11/56 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1076 11/48 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1088..1138 10/53 (19%)
PHD1_KMT2B 1209..1255 CDD:277064 10/51 (20%)
PHD2_KMT2B 1257..1306 CDD:277066 13/52 (25%)
PHD3_KMT2B 1343..1399 CDD:277068 5/55 (9%)
Bromo_ALL-1 1380..1522 CDD:99925 18/141 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1572 8/22 (36%)
ePHD_KMT2B 1587..1691 CDD:277164 22/120 (18%)
FYRN 1740..1786 CDD:283589 8/59 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2125..2169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2391..2417
FYRC 2420..2504 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6 2515..2520
SET <2566..2722 CDD:225491
SET 2584..2704 CDD:214614
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:Q03164 2659..2660
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848407
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.