back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and NSD2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens

Alignment Length:	1627	Identity:	344/1627 - (21%)
Similarity:	570/1627 - (35%)	Gaps:	512/1627 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 FPIQKPKSKLRVSLK--RLKLGGRLESSDSGNSPSSS--------------SPEVEPPALQDENA 295
            |.|::....::..:|  ::|....:..|.:|.:||..              |..::...:|..|.
Human     3 FSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNG 67

  Fly   296 MDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAK 360
            .|..|        .:.|::..|..|::...|......|...|.:|.:.:...|
Human    68 HDALP--------FIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPP------------ 112

  Fly   361 QEPTP----DPEEDLDEIMVEVLSGPPSLW------SADDEAEEEEDATVQRATPPGKEPAADSC 415
             ..||    .||..| :|....::|.|...      ||.|.::.||:         |::|.
Human   113 -NTTPIKNGSPEIKL-KITKTYMNGKPLFESSICGDSAADVSQSEEN---------GQKPE---- 162

  Fly   416 SSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEES---QDQEEQHILIDLIEDTLS 477
            :.|.|..:||........||.......::|::.|.|:|...:||   ..:::.|:|...:.|.
Human   163 NKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDL-- 225

  Fly   478 ESEVTSSVS--PTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK---------VFSESDNIA 531
               |.|.||  |....||             .||.:|.|..:...:|         .|.::...|
Human   226 ---VWSKVSGYPWWPCMV-------------SADPLLHSYTKLKGQKKSARQYHVQFFGDAPERA 274

  Fly   532 ASLNKDI--FEPKVETKATCGEVVPRPEMVTEDVYITEGIAATL----EKSAVVTKPTTEMIAET 590
            ....|.:  ||.:.:.:..|.|...:.....|.:.:.:.|:..|    |...|..:....|..|.
Human   275 WIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEE 339

  Fly   591 K--------LSDEVVIEPPL-KDESDPKQTEVELPE----SKPAVNIPKSERILSAEVETTSSPL 642
            :        :.|::.:.|.: |:.....::..|:.|    |:.|...|||.|
Human   340 RKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVR------------- 391

  Fly   643 VPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKE----DSPP-------AAPEEEA 696
              .||..::......|. :|..|.|...:..::||.||..|..    .|||       :.|....
Human   392 --EECIPMKRRRRAKLC-SSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRK 453

  Fly   697 SNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPA 761
            .:::.:  ||:...:...|.|||..     :..|:      |::|..:.....:|:|::|..|..
Human   454 GDAASQ--FLVFCQKHRDEVVAEHP-----DASGE------EIEELLRSQWSLLSEKQRARYNTK 505

  Fly   762 RSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEK 826
            .:..|.|..:..:|.:..|....|| .:.:...|::   |..||.|:.   ::.|.::.|::|..
Human   506 FALVAPVQAEEDSGNVNGKKRNHTK-RIQDPTEDAE---AEDTPRKRL---RTDKHSLRKRDTIT 563

  Fly   827 EKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAA 891
            :|::                             ::|:....|:|.|:.|:             ||
Human   564 DKTA-----------------------------RTSSYKAMEAASSLKSQ-------------AA 586

  Fly   892 KKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEP 956
            .|.|||...|  ||.:.:|.:.             |::.|
Human   587 TKNLSDACKP--LKKRNRASTA-------------ASSAL------------------------- 611

  Fly   957 PTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP--SSDSAQANTSAGKLKPSKVKKKINPR 1019
                   |..||.|...||..|.| .|||..|.:.||  |:|..|...|   :...|.::.:..:
Human   612 -------GFSKSSSPSASLTENEV-SDSPGDEPSESPYESADETQTEVS---VSSKKSERGVTAK 665

  Fly  1020 RSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSS----SKRNGSKRTTSDLDGG-------- 1072
            :..:|:..:         .|...:....|...:...:    |:|...:.|.|:...|
Human   666 KEYVCQLCE---------KPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCK 721

  Fly  1073 -SKLDQRR--YTICEDRQPETAI-PVPLT---KRRFSMHPKASANPLHDTLLQTAGKKRGRKEGK 1130
             ||.|.:|  .|.|.....|..: ..|||   .|.|..       |||..:...|......:..|
Human   722 ESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRC-------PLHSCVSCHASNPSNPRPSK 779

  Fly  1131 ESLSR-------QNSLDSSSSASQGAPKKKALKSAEILSAALLETESSE-------------STS 1175
            ..:.|       .:|.|:..:|.     ...:.|..|:..|.......:             .:.
Human   780 GKMMRCVRCPVAYHSGDACLAAG-----CSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSK 839

  Fly  1176 SGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRD------KVDEDQRKEGQDEVKREADP 1234
            .||.:.   .::.|           |.|..|.:|:...|      .....::...||.:
Human   840 GGSLLC---CESCP-----------AAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDII------ 884

  Fly  1235 EEDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKP------- 1291
                 ..::.|.. .||....|.....|.:                  :..|.|.:.|
Human   885 -----WVKLGNYRWWPAEVCHPKNVPPNIQ------------------KMKHEIGEFPVFFFGSK 926

  Fly  1292 --------------QGPRASQGRGVASVA-LAPISMDEQLAELANIEAINEQFLRSEGLNT---- 1337
                          :|.|.|:.:||..:. :...::.|..|....|:      |:.|...|
Human   927 DYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIK------LQREARETQESE 985

  Fly  1338 -----FQLLKENF-YRCARQVSQENAEM-QCDCFLTGDEEAQGHLSCG--AGCINRMLMIECGP- 1392
                 ::.:|.|. |...:..:.:.:|: :|:|..| ||.     .||  :.|:|||||.||.|
Human   986 RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPT-DEN-----PCGFDSECLNRMLMFECHPQ 1044

  Fly  1393 LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEE-FERRQHL 1456
            :|..|..|.|:.|.:.|....::.:|:.||.|:.|:..|..|||:.|||||:||.|| ..|.:|.
Human  1045 VCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHA 1109

  Fly  1457 YSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGE 1521
            :..|.. |:|.:.:..:.:|||..|||.||::||||.||.||.||||||:.|:|.|:|..|..|.
Human  1110 HENDIT-HFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGT 1173

  Fly  1522 EITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQP 1586
            |:||:|.....|.:...|.|.|:||.|::|..|.:                 ...|.:| |:|:
Human  1174 ELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKT-----------------STTLSSE-EKGK- 1219

  Fly  1587 RKSAKAKAKSKLKAKLPLATGRKRKE----------QTKPKDREY--KA-------------GRW 1626
                  |.|.|.:.:.....|:::.|          |....||::  ||             |:|
Human  1220 ------KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKW 1278

  Fly  1627 L----------KPS--------------------------------------ATGSSSSAEKPPK 1643
            .          |||                                      |:..|:..||||.
Human  1279 ECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPP 1343

  Fly  1644 KP 1645
            :|
Human  1344 EP 1345

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.