DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setd5

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_006506740.1	Gene:	Setd5 / 72895	MGIID:	1920145	Length:	1467	Species:	Mus musculus

Alignment Length:	1528	Identity:	281/1528 - (18%)
Similarity:	471/1528 - (30%)	Gaps:	520/1528 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSM--- 138
            :||.:.||..          :|.|    :|||.:..::.:  ....:..||.|.....::|.
Mouse     4 LRDPIKKNSS----------ESKP----AQSGFSRGNSPL--CCPESVEASPAVNEKSVYSTHNY 52

  Fly   139 ------------FEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAG 191
                        :...:...||||.||      |.| |.|::|               |...:.|
Mouse    53 GTTQRHGCRGLPYADHNYGAPPPPTPP------ASP-PVQTII---------------PRSDLNG 95

  Fly   192 LP-PVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTS----NMSSDSGELPGFPIQK 251
            || ||..|                       |.||..:...|..:    .:|.|     ||.:..
Mouse    96 LPSPVEER-----------------------CGDSPNSEGETVPTWCPCGLSQD-----GFLLNC 132

  Fly   252 PKSKLRVSLKRLKLGGRLESSDSGNSPSSS---SPEVEPPALQDENAMDERPKQEQNLSRMVDAE 313
            .|.:.....|.::|..|.:.:.||...|::   ..|:.|..:                  :..|.
Mouse   133 DKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTV------------------LYTAT 179

  Fly   314 ENSDSDSQIIFIEIETESPKGEEEQ-EEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVE 377
            :::.:.   |.:.:....||..::. |:||...           :..|.:.:|...::|||...|
Mouse   180 QHTPTS---ITLTVRRTKPKKRKKSPEKGRAAP-----------KTKKIKNSPSEAQNLDENTTE 230

  Fly   378 VLSGPPSLWSADDEAEE----EEDATVQRATPP---------GKEPAAD-------SCSSAPRRS 422
            .......||:  |:.||    :..|.||.|...         ||....|       :|::....|
Mouse   231 GWENRIRLWT--DQYEEAFTNQYSADVQNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGS 293

  Fly   423 RRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSP 487
            :....|...:|             .:..::||.|..           ||..|||
Mouse   294 QMQLQLGRVTR-------------VQKHRKILRAAR-----------DLALDTL----------- 323

  Fly   488 TIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEV 552
                                   |::.:.:.::::.|        .:|...|:.
Mouse   324 -----------------------IIEYRGKVMLRQQF--------EVNGHFFKK----------- 346

  Fly   553 VPRP-----------EMVTEDVYITEGIAATLEKSAVVTKPTTEMIAE----------TKLSDEV 596
             |.|           ||.. |.......|..:.:|.........|||:          :.::.:.
Mouse   347 -PYPFVLFYSKFNGVEMCV-DARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDA 409

  Fly   597 VIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
            .:......|......:|:....|...|.|..:|..:|    ...||.||.  :..::........
Mouse   410 EVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNA----AELPLPPPP--SFPTIGAETRRRK 468

  Fly   662 SLSTE---EKSNENVETTPLKTEAAKEDSPPAAPE--------EEASNSSEEPNFLLEDYESNQE 715
            :...|   |:.||..|..|       :..|...||        ||..|..|:|.      |..:|
Mouse   469 ARRKELELEQQNEVPEENP-------DPQPQEVPEKVTVSNEHEEVDNPEEKPE------EEEKE 520

  Fly   716 QVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKK 780
            :..:|:    .|....::|......|......|::.|::|..:.|...|.:  |.::.....|..
Mouse   521 EATDDQ----ENSAHSRRTREDRKVEAIMHAFESLEKRKKRRDQPVEQSSS--DIEITTSSSEIV 579

  Fly   781 VVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKG 845
            |.:.||...||.::.|..|..|: |:..:.:|.:.:.:....:...||...|...:.|:....|.
Mouse   580 VGEETKTAAPESEVSSPVSNVAI-PSTPQSTGVNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPKS 643

  Fly   846 KDTAQWSPQLQTLPK----------------------SSTKPPQE--------------SAPSVI 874
            :.:...:...|.|.:                      :|..||:.              |.|:||
Mouse   644 RISRYRTSSAQRLKRQKQAIAQQAELSQAALEEGGSNNSVTPPEAGNTDSSGENRQLTGSDPTVI 708

  Fly   875 SKTTS--NQPA---PKEEQHAAKKGLSD---------------NSPPSVLKAKEKAVSGFVECDA 919
            |.|.|  |:.|   ||.:::...:.|:|               .:.|:||......:.|.:....
Mouse   709 SVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPL 773

  Fly   920 M---------FKAMDLANAQLR--LDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSL--SG 971
            :         |.:..:...:.|  |.:......||...|......:...::||...:.:.|  |.
Mouse   774 ICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSN 838

  Fly   972 KTSLRRNTVYEDSPNL-------------ERNSS-------------PSSDSAQAN-TSAGKLKP 1009
            :|| ..:::.:|:.:|             |:|.:             |||.|.... |:.|:..|
Mouse   839 ETS-NSSSICKDNADLLSPLKKWKSRYLMEQNITKLLQPLSPVTPPPPSSGSKSPQLTTPGQTHP 902

  Fly  1010 SKVKKKINPRRSTICEAAKDLRSSSSSSTP----------------------TREVA-------- 1044
            .  :::.....|.:......|.::|.|:||                      |...|
Mouse   903 G--EEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKDLDLTKVGFPDSSTHSCADRPSLLNC 965

  Fly  1045 -----ASSP--VSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIP--------V 1094
                 ||.|  |.||......|:|....|. |....:..:..:.:.....|..|:|        .
Mouse   966 NHPDLASHPSVVPTSEAGFPSRSGDGPQTL-LRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGS 1029

  Fly  1095 PLTKRRFSMH----------------------------------------PKASANPLHDTLLQT 1119
            ||...|..:|                                        |.|..||.....:..
Mouse  1030 PLVGDRKPLHLDGGYCSPAEGFSSRYEHGFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSL 1094

  Fly  1120 AGKKRGRKEGKESLSRQNSLDSSSSASQGA--------------------------PKKKALKSA 1158
            ...::.::|.||:....|....|.|.|.||                          |.||...|.
Mouse  1095 LEYRKRKQEAKENSGGGNDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSSPHKKFSPSH 1159

  Fly  1159 EILSAALLETES---SESTSSG------SKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRD 1214
            .  ||:.||..|   |..|||.      :..|||.|.||  :|.....|.|.|.:...|.:.::
Mouse  1160 S--SASHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTS--VERLREGGSIPKVLRSSVRVAQK- 1219

  Fly  1215 KVDEDQRKEGQDEVKREADPEEDEFAQRVAN-METPATTPTPS--PTQSNPEDSASTTTVLKELE 1276
              .|.......:..::|:||.:.|..:.::: :...||..:||  ..|....||..|.: ...|:
Mouse  1220 --GEPSPTWESNITEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTES-QSLLQ 1281

  Fly  1277 TGGGVRRSHRIKQKPQGPRASQGRGVASVALAP 1309
            ......|.|        |..|.|....:.||.|
Mouse  1282 QSSSPFRGH--------PTQSPGYSYRTTALRP 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setd5	XP_006506740.1	SET_SETD5	292..441	CDD:380958	30/227 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030