DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Kmt2e

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_081260.1	Gene:	Kmt2e / 69188	MGIID:	1924825	Length:	1868	Species:	Mus musculus

Alignment Length:	1709	Identity:	318/1709 - (18%)
Similarity:	540/1709 - (31%)	Gaps:	565/1709 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 GAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGEL-- 244
            ||.|..|    ||.:|...|...|:::.         :.:..:.|..|::||.|  :|:.|..
Mouse    67 GARPPPT----PPASPPPSGLISKNEVG---------IFTTPNFDETSSATTIS--TSEDGSYGT 116

  Fly   245 ------------PGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPE-VEPPALQDENAM 296
                        .|:.|...|..:...:..:.:       |..:.|.:...| .:|.:|..|.|:
Mouse   117 DVTRCICGFTHDDGYMICCDKCSVWQHIDCMGI-------DRQHIPDTYLCERCQPRSLDKERAV 174

  Fly   297 DERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQ 361
            ..:.::.:|:         ||.|:.      .|||.
Mouse   175 LLQRRKRENM---------SDGDTS------ATESG----------------------------- 195

  Fly   362 EPTPDPEEDLDEIMVEVLSG----PPSLWSADDEAEEEEDATVQRATPPG-KEPAADSCSSAPRR 421
                      ||:.||:.:.    |.|:...   |......|.:|....| ||.....|..|.|.
Mouse   196 ----------DEVPVELYTAFQHTPTSITLT---ASRVPKVTDKRRKKSGEKEQNFSKCKKAFRE 247

  Fly   422 -SRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEA---------EESQD-------QEEQHILI 469
             ||:|:.:.||:.:        .:.:::||..:.|.         ||:.:       |.|...|.
Mouse   248 GSRKSSRVKGSAPE--------IDPSSDSSNFVWETKIKAWMDRYEEANNNQYSEGVQREAQRLA 304

  Fly   470 DLI-----EDTLSESEVTSSVS---PTIE-HMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFS 525
            ..:     ...:::||::::.|   |.:| |:...:.:::..:.:.....|::.:.:|::::.|.
Mouse   305 QRLGSGNDSKDMNKSELSTNNSLFRPPVESHIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFE 369

  Fly   526 ESDNIAASLNKDIFEPKVETKATCGEVVPRP-------------EMVTEDVYITEGIAATLEKSA 577
            .:                      |....||             ||..:        |.|....|
Mouse   370 AN----------------------GYFFKRPYPFVLFYSKFHGLEMCVD--------ARTFGNEA 404

  Fly   578 VVTKPTTEMIAETKLS-DEVVIEPPLKD-ESDPKQTEVELP------ESKPAVNIPKSERILSAE 634
            ...:.:....||.:.. :|..|...:.. :|.||.||:.:.      ..|..|
Mouse   405 RFIRRSCTPNAEVRHEIEEGTIHLYIYSIQSIPKGTEITIAFDFDYGNCKYKV------------ 457

  Fly   635 VETTSSPLVPPEC-CTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASN 698
                       :| |..|:...|||..:|.|| |..|...||...|.:..|:.|    .|::..|
Mouse   458 -----------DCACLKENPECPVLKRSSEST-ENINSGYETRRKKGKKEKDTS----KEKDIQN 506

  Fly   699 SS-----EEPNFLLEDYESNQEQVAEDEMMKCNNQKG------QKQTPLPEMKEPEKPVAETVSK 752
            .:     |..|..:...|:.|.:::...:...|||:.      :::||:  ..|.|....|.:::
Mouse   507 QNMTLDCEGTNNKIRSPETKQRKLSPLRLSVSNNQEPDFIDDMEEKTPI--SNEVEMESEEQIAE 569

  Fly   753 KEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKE 817
            :::.|....|...||:....|..:.||:..::.: .:...|.:.|..|        |||...|..
Mouse   570 RKRKMTREERKMEAILQAFARLEKREKRREQALE-RISTAKTEVKPEC--------KESQVIADA 625

  Fly   818 AI----LKKETEKEKSSAKLD-SSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVIS-- 875
            .:    :|:||..:.::||:: :....:..:......|...:.:|:...|..||......|:|
Mouse   626 EVVQEQVKEETAIKPAAAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIPPSSPDIEVLSQQ 690

  Fly   876 --------------KTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDL 926
                          :|...:..|:.|..|..|     .|....|.|:..|:.:
Mouse   691 NEIENTVLAIEPETETAVAEIIPEAEVPALNK-----CPTKYPKTKKHLVNEW------------ 738

  Fly   927 ANAQLRLDEKNKK------KLKKVPTKVEAPPKVEPPTAVPVPG--------------------- 964
                  |.|||:|      .|.:.|.::...|:|.......:||
Mouse   739 ------LSEKNEKTGKPSDSLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPF 797

  Fly   965 --QKK-------SLSG---KTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLK--------- 1008
              :||       ::||   |..|::....|:|..|.|..||..:.:::.|..|:.|
Mouse   798 LSEKKRRKETTENISGSCKKRWLKQALEEENSTILHRYHSPCQERSRSPTVNGENKSPLLLSDSC 862

  Fly  1009 -----PSKVKKKINPRRSTICEAAKDLRSSSSSSTPT--------------REVAASSPVSTSSD 1054
                 .:.:||:   |...:.:.|     .|.|||||              .:.|.::|....||
Mouse   863 SLPDLTTPLKKR---RLYQLLDTA-----YSESSTPTPSPYATPTHTDITPTDPAFATPPRIKSD 919

  Fly  1055 SSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQT 1119
            ..:.|||.|...|                    |.|    |:|       |....|.:|   .:.
Mouse   920 DETYRNGYKPIYS--------------------PVT----PVT-------PGTPGNTMH---FEN 950

  Fly  1120 AGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTS--------- 1175
            ........|.|.....|...|..|:.....|    .:::.:....|.|.::...||
Mouse   951 ISSPESSPEIKRCTYNQEGYDRPSNMLTLGP----FRNSNLTELGLQEIKTIGYTSPRSRTEVNR 1011

  Fly  1176 --SGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDE 1238
              .|.|.|..|:|..  |:|..|           ..|.|..:.....|.|..:::..........
Mouse  1012 PCPGEKESVSDLQLG--LDAVEP-----------AALQKSMETPAHDRTEPSNQLDSTHSGRGTM 1063

  Fly  1239 FAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHR---IKQKPQGPRASQGR 1300
            ::..|   ::|..|.......||..|    .|...:||||||.|.|..   |:|       ...|
Mouse  1064 YSSWV---KSPDRTGVNFSVNSNLRD----LTPSHQLETGGGFRVSESKCLIQQ-------DDTR 1114

  Fly  1301 GVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQ---------LLKENFYRCARQVSQEN 1356
            |:...|....:.::.||.... ..:|:..:  :|..|.|         ||:  :.:..|:..:..
Mouse  1115 GMFLGAAVFCTSEDGLASGFG-RTVNDNLI--DGSCTPQNPPQKKKVSLLE--YRKRQREARKSG 1174

  Fly  1357 AEMQCDCFLTGDEEAQGHL-SCGAGCINRMLMIECGPLCSN------------------GARCTN 1402
            ::.:....::......|.| |.|.||::..   |.|....|                  .|...:
Mouse  1175 SKPENFALISVSPHPSGSLSSSGDGCVHSS---ENGEQAENQASLPLPPPAAAAAATAAAAYSAS 1236

  Fly  1403 KRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFER----RQHLYSKDRNR 1463
            .......|.......:|||.         |..::......|.:....::|    ..|...||..
Mouse  1237 SEEGSSNCPVKDANSSEKKD---------PEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSG- 1291

  Fly  1464 HYYFMALRGEAVIDATSKGNI----SRYINH----------------SCDPNAETQKWTVNGEL- 1507
                    ||:...:.|..::    |.:.||                ..||:||..:.|...|.
Mouse  1292 --------GESPCVSCSPSHVQSPPSSHSNHIPQVHAQSLAPSLSELMADPDAEGTEATSTSECP 1348

  Fly  1508 -----RIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSD-EGEQLDEES 1566
                 :....:.||..||.                   ...|...|.|..:|||. |......|:
Mouse  1349 SPDTSQSPSKTSKPGSPGP-------------------INPAQSHGKILTKPDSHWEATATVSEA 1394

  Fly  1567 DSDAEMDEEELEAEPEEGQPRKSAK-------AKAKSKLKAKLPLATGRKRKEQTKPKDREYKAG 1624
            |:....:.|....:.....|..|..       ..|..:|..|||.|   ..|....|
Mouse  1395 DNSVHQNPEPQHRQLSSNTPALSQNHAPQAHALSANDQLPQKLPSA---PTKLHCPP-------- 1448

  Fly  1625 RWLKPSATGSSSSAEKPPK 1643
                      |...|.|||
Mouse  1449 ----------SPHTENPPK 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	10/70 (14%)
		SET	1414..1533	CDD:214614	25/148 (17%)
		PostSET	1535..1551	CDD:214703	2/15 (13%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Kmt2e	NP_081260.1	HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:Q8IZD2	63..66
		PHD_MLL5	120..163	CDD:277025	6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..197		7/72 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..268		14/58 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..329		3/20 (15%)
		SET_KMT2E	323..451	CDD:380959	24/157 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..504		11/36 (31%)
		Smc	483..>716	CDD:224117	47/247 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..682		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..924		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1038..1068		2/29 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1165..1222		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1236..1315		15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1565		34/164 (21%)
		Herpes_BLLF1	<1350..1609	CDD:282904	29/148 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1585..1842
		PRK03427	<1749..>1857	CDD:235124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030