DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setdb1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_006232975.1	Gene:	Setdb1 / 689883	RGDID:	1308370	Length:	1322	Species:	Rattus norvegicus

Alignment Length:	1555	Identity:	279/1555 - (17%)
Similarity:	484/1555 - (31%)	Gaps:	484/1555 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLK--LGGRLESSDSGNSPSSS 281
            :|.|       .|...:..::||.|:.... |....:|.:|::.|:  :...||..|........
  Rat    24 LPGC-------MSLAAAPAAADSAEIAELQ-QAVVEELGISMEELRQFIDEELEKMDCIQQRKKQ 80

  Fly   282 SPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEV 346
            ..|:|...||.|:.:....:...:.||.|   .|.:|..:..:.::..:......:.|..:|.|:
  Rat    81 LAELETWVLQKESEVAYVDRLFDDASREV---TNCESLVKDFYSKLGLQYHDSSSDDEASQPTEI 142

  Fly   347 EPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPA 411
                 |:|            |:||.|.:.::         |.|..:...:|..::.|....::.|
  Rat   143 -----IEI------------PDEDDDVLSID---------SGDAGSRTPKDQKLREAMAALRKSA 181

  Fly   412 ADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAES----SKQILEAEESQDQEEQHIL-IDL 471
            .|........:::|:  |....:| ||.:...|::.:.    |.:||..:.::...:..:: |..
  Rat   182 QDVQKFMDAVNKKSS--SQDLHKG-TLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQT 243

  Fly   472 I--------------EDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK 522
            :              :..||.:.:.....|..:.:.|...||.:.:         |..|.::...
  Rat   244 VGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYK---------DGNQVWLYAG 299

  Fly   523 VFSESDNIAASLNKDI-FEPKVETKATCGEVVP--RPEMVTEDVYITEGIAATLEKSAVVTKPTT 584
            :.:|:.|:...|...| |:....:..|..|:.|  ||                       .|.|.
  Rat   300 IVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRP-----------------------LKKTW 341

  Fly   585 EMIAETKLSD---EVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETT--SSPLVP 644
            |.|.::...|   |.:...|                ::|.| :.||.:::..|.|.|  .|
  Rat   342 EDIEDSSCRDFIEEYITAYP----------------NRPMV-LLKSGQLIKTEWEGTWWKS---- 385

  Fly   645 PECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTE---AAKEDSPPAAPEEEASNSSEEPNF- 705
                .:|.|.|.  |...|..::|..|.:.....:.|   :.|..|..|..:::.......||.
  Rat   386 ----RVEEVDGS--LVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASAMEKKQGGQLRTRPNMG 444

  Fly   706 ----------LLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENP 760
                      ..:|..|...|....|.:         |..:|....|..|::......|......
  Rat   445 AVRSKGPVVQYTQDLTSTGIQFKPMEPL---------QPIVPPAPLPMLPLSPQAGDSESLESQL 500

  Fly   761 ARSSPAIVDKKV--RAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKE 823
            |:|...:..|..  |.|.:.......|..|:.|.          |.|.|           |...:
  Rat   501 AQSRKQVAKKSTSFRPGSVSSGHSSPTSPTLSEN----------VPPGK-----------IGMNQ 544

  Fly   824 TEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQ 888
            |.:..|::...:.:|                  ..|.....||...||       ...|||
  Rat   545 TYRSPSASVTSTPAP------------------AAPSGPPAPPGPLAP-------PGPPAP---- 580

  Fly   889 HAAKKGLSDNSP--PSVLKAKEKA-----VSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPT 946
             .|..|:.:.:|  ||.....||.     |..:. |.:..:.|  .|.|.|  .||
  Rat   581 -PAFHGMLERAPAEPSYRAPMEKLFYLPHVCSYT-CLSRIRPM--RNEQYR--GKN--------- 630

  Fly   947 KVEAPPKVEPPTAVPVPGQKKSLSGKTSLRR----NTVY-------------------------- 981
                      |..||:....:.::.:..:.|    :.:|
  Rat   631 ----------PLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFL 685

  Fly   982 ---------------------------------EDSPNLERNSSPSSDSAQANTSAGKLKPSKVK 1013
                                             ||.|....|...::...|...|..::....|.
  Rat   686 YLEMFCLDPYVLVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVF 750

  Fly  1014 KKINPRRSTICEAAKDLRSSSSSSTP--TREVAASSPVSTSSDSSSKRNGSKRTTSDLDGG---- 1072
            ....|.....|:.....|..|..:..  |.:..|.:|....:.||..::  ||....|..|
  Rat   751 INTGPEFLVGCDCKDGCRDKSKCACHQLTVQATACTPGGQINPSSGYQH--KRLEECLPTGVYEC 813

  Fly  1073 ---SKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQ------TAGK------ 1122
               .|.|.   .:|.:|..:..:.|.|  :.|....|.......|.:.:      .|||
  Rat   814 NKRCKCDP---NMCTNRLVQHGLQVRL--QLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDF 873

  Fly  1123 --KRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDV 1185
              |.|.:.|.|..:..:.::|..:..:|........|    .::.::.:..|..:|||:
  Rat   874 ADKEGLEMGDEYFANLDHIESVENFKEGYESDVPSSS----DSSGVDMKDQEDGNSGSE------ 928

  Fly  1186 QTSPELEAANPFGDIAKFIEDGVNLLKRDKVDED-------------QRKEGQDEVKREADPEED 1237
              .||....:...|         |..|    |||             ::..||.|.:......:|
  Rat   929 --DPEESNDDSSDD---------NFCK----DEDFSTSSVWRSYATRRQTRGQKESELSEVTSKD 978

  Fly  1238 EFAQRVANMETPATTP------TPSPTQSNPEDSASTTTVLKELETGG----GVRRSHRIKQKPQ 1292
            ..|........|.|..      .|..::..|::..::......:..||    ..|.|.:..:...
  Rat   979 SRAPDRGPPHVPITPSGSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGD 1043

  Fly  1293 GPRASQGRGVAS-VALAPISM----DEQLAELANIEAINEQFLRSEGLNTF----QLLKENFYRC 1348
            | ||..|||.|. .:.:.:|.    |.:.::..:.|..|:..:.:||....    .:..|...|.
  Rat  1044 G-RAGGGRGEAERASTSGLSFKDEGDSKQSKKEDPEDRNKMSVVTEGSQNHGHNPPMKSEGLRRP 1107

  Fly  1349 ARQVSQ-------ENAEMQCDCFLT--GDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKR 1404
            |.::|.       .:.:...|..||  ...|::|               |.|
  Rat  1108 ASKISMLQSQRVVTSTQSNPDDILTLSSSTESEG---------------ESG------------- 1144

  Fly  1405 FQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMA 1469
                        .:.|...|.|:...:...:  ::.:....|.::||.:::| |....|.....:
  Rat  1145 ------------TSRKPTTGQTSATAVDSDD--IQTISSGSDGDDFEDKKNL-SGPTKRQVAVKS 1194

  Fly  1470 LRGEA----------------------------------------VIDATSKGNISRYINHSCDP 1494
            .||.|                                        :|||..:||:.||:||||.|
  Rat  1195 TRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSP 1259

  Fly  1495 NAETQKWTVN-GELR---IGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANCRG 1548
            |...|...|: .:||   :.||:.|.|:.|.|:|:||.|.....:.:.  |.|.|..|||
  Rat  1260 NLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRG 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	7/53 (13%)
		SET	1414..1533	CDD:214614	39/162 (24%)
		PostSET	1535..1551	CDD:214703	6/16 (38%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setdb1	XP_006232975.1	YlqD	<44..118	CDD:287979	17/77 (22%)
		TUDOR	277..337	CDD:197660	15/91 (16%)
		TUDOR	368..420	CDD:197660	14/61 (23%)
		MBD	629..704	CDD:128673	7/93 (8%)
		Pre-SET	714..827	CDD:282838	23/117 (20%)
		SET	835..>898	CDD:214614	13/64 (20%)
		SET	<1237..1299	CDD:214614	26/61 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840