DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Nsd2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001178481.2	Gene:	Nsd2 / 680537	RGDID:	1307955	Length:	1365	Species:	Rattus norvegicus

Alignment Length:	1546	Identity:	322/1546 - (20%)
Similarity:	535/1546 - (34%)	Gaps:	470/1546 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 FPIQKPKSKLRVSLKRLKLGGRLESSDSGN----------------SPSSSSPEVEPPALQDENA 295
            |.|:|....::..:|.:|:....|...|.|                |.:..|..::...:|..|.
  Rat     3 FSIRKSPLSVQKVVKCMKMKQAPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNG 67

  Fly   296 MDERP----KQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDM 356
            .|..|    ::.::|:..|...|....|:::.|   ||:..||........|::
  Rat    68 HDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCF---ETQEVKGIGTPPNTTPIK----------- 118

  Fly   357 ELAKQEPTPDPEEDLDEIMVEVLSGPPSLWS------ADDEAEEEEDATVQRATPPGKEPAADSC 415
                   ...||..| :|....::|.|...|      |.|.::.||:         |::    |.
  Rat   119 -------NGSPEIKL-KITKTYMNGKPLFESSICGDGAADMSQSEEN---------GQK----SD 162

  Fly   416 SSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEES--QDQEEQHILIDLIEDTLSE 478
            :...|..:||........||.......::|::...|:|...:||  ....::.:|:......|..
  Rat   163 NKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPEDKKIPVKKESCPNSGRDRDLLLKYNVGDLVW 227

  Fly   479 SEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK---------VFSESDNIAASL 534
            |:|  |..|....||             .||.:|.:..:...:|         .|.::...|...
  Rat   228 SKV--SGYPWWPCMV-------------SADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIF 277

  Fly   535 NKDI--FEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVV 597
            .|.:  ||.:.:.:..|.|...:.....|.:.:.:.|:..|.
  Rat   278 EKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLR----------------------- 319

  Fly   598 IEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETS 662
                       .|.|:.:.:::.|.::...||............|         .::..|..|..
  Rat   320 -----------AQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQL---------RLNPQVAKEAG 364

  Fly   663 LSTEEKSNENVETTPLKTEAA------KEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDE 721
            ::| |...|.|:::....|||      :|:..|......|..||
  Rat   365 IAT-EPLGEMVDSSVANEEAAVDPGTMREEDIPVKRRRRAKRSS--------------------- 407

  Fly   722 MMKCNNQKG----QKQTPLPEM--KEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKK 780
              ...||:|    :|.|| |:|  .||::.|.....:| ::..:.:||         |.|:...:
  Rat   408 --SAENQEGDPGTEKSTP-PKMADAEPKRGVGSPAGRK-RSTGSASRS---------RKGDSAAQ 459

  Fly   781 VVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKE----TEKEKS----------SA 831
            .:     ...:|..|.       ..|:..::.:...|.:|..:    .||:|:          ||
  Rat   460 FL-----VFCQKHRDE-------VVAEHPDASEEEIEELLGSQWSMLNEKQKARYNTKFSLMISA 512

  Fly   832 KLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQ----ESAPSVISKTTSNQPAPKEEQHAAK 892
            :.:..|.||..||           :|..|.:..||:    |.||....:|         ::|:.:
  Rat   513 QSEEDSGNTSGKK-----------RTHTKRTDDPPEDVDVEDAPRKRLRT---------DKHSLR 557

  Fly   893 K--GLSDNSP-PSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKV 954
            |  .::|.:. .|..||.|.|.|  ::..|..|  :|::|...|.::|:..
  Rat   558 KRETITDKTARTSSYKAIEAASS--LKSQAATK--NLSDACKPLKKRNRAS-------------- 604

  Fly   955 EPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP--SSDSAQANTSAGKLKPSKVKKKIN 1017
              .||....|..||.|...||..|.| .|:|..|.:.||  |:|..|...|   :...|.::.:.
  Rat   605 --ATASSALGFNKSSSPSASLTENEV-SDNPGDEPSESPYESADETQTEAS---VSSKKSERGMA 663

  Fly  1018 PRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGG---------S 1073
            .::..:|:..:     .:.|....|.........:....|:|...:.|.::...|         |
  Rat   664 AKKEYVCQLCE-----KTGSLLLCEGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFVCKES 723

  Fly  1074 KLDQRRYTI--CEDRQPETAI-PVPLT---KRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKES 1132
            |::.:|..:  |.....|..: ..|||   .|.|..       |||..:...|......:..|..
  Rat   724 KMEVKRCMVNQCGKFYHEACVKKYPLTVFESRGFRC-------PLHSCMSCHASNPSNPRPSKGK 781

  Fly  1133 LSR-----------------------QNSLDSSS--SASQG--------------APKKKALKSA 1158
            :.|                       .||:..:.  :|.:|              ..|..:|...
  Rat   782 MMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCC 846

  Fly  1159 EILSAALLETESSESTSSGSKMSRW---DVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQ 1220
            |...||......|.....||    |   |.:...:|.    |.||
  Rat   847 EACPAAFHPDCLSIEMPDGS----WFCNDCRAGKKLH----FQDI-------------------- 883

  Fly  1221 RKEGQDEVKREADPEEDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRS 1284
                              ...::.|.. .||....|.....|.:                  :..
  Rat   884 ------------------IWVKLGNYRWWPAEVCHPKNVPPNIQ------------------KMK 912

  Fly  1285 HRIKQKP---------------------QGPRASQGRGVASVA-LAPISMDEQLAELANIEAINE 1327
            |.|.:.|                     :|.|.|:.:||..:. :...::.|..|.      .||
  Rat   913 HEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEAR------FNE 971

  Fly  1328 QFLRSEGLNT---------FQLLKENF-YRCARQVSQENAEM-QCDCFLTGDEEAQGHLSCGAG- 1380
            ..|:.|...|         ::.:|.|. |...:..:.:.:|: :|:|..| ||.     .||:.
  Rat   972 IKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPT-DEN-----PCGSDS 1030

  Fly  1381 -CINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGE 1443
             |:|||||.||.| :|..|..|.|:.|.:.|....::.:|:.||.|:.|:..|..|||:.|||||
  Rat  1031 ECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGE 1095

  Fly  1444 VIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELR 1508
            :||.||...|.....::...|:|.:.:..:.:|||..|||.||::||||.||.||.||||||:.|
  Rat  1096 LIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTR 1160

  Fly  1509 IGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMD 1573
            :|.|:|..|..|.|:||:|.....|.:...|.|.|:||.|::|..|.:......:|:|
  Rat  1161 VGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTSLSSEEKS------- 1218

  Fly  1574 EEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAG 1624
                              .|||.|.:.:.....|:::.|     |..::.|
  Rat  1219 ------------------KKAKKKTRRRRAKGEGKRQSE-----DECFRCG 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	22/55 (40%)
		SET	1414..1533	CDD:214614	53/118 (45%)
		PostSET	1535..1551	CDD:214703	6/15 (40%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Nsd2	NP_001178481.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850