Protein Alignment Set2 and ezh1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001035072.2
• Gene: ezh1 / 664754
• ZFINID: ZDB-GENE-050114-1
• Length: 756
• Species: Danio rerio
• Alignment Length: 964
• Identity: 186/964 - (19%)
• Similarity: 303/964 - (31%)
• Gaps: 368/964 - (38%)

  Fly   661 TSLSTEEKSNENVETTPLKTEAAKEDSP---------PAAPEEEA---------------SNSSE 701
            |.|..||.|...:::.||.|.:....|.         |:.|.:..               |.|..
Zfish    59 TELLNEEWSKLRIQSIPLSTSSGSLPSKKLCMVEFGFPSFPNQAVAMRPLTTVAGIPFMYSWSPL 123

  Fly   702 EPNFLLED--YESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSS 764
            :.||::||  :..|...:.:                  |:.|.::...|.:......:.....|.
Zfish   124 QQNFMVEDETFLHNIPYMGD------------------EVLEQDEAFLEELIDNYDGVHGDRVSC 170

  Fly   765 PAIVDKKVRAGEMEKKVVKS-TKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEK 828
            ..:::......|:.|::|:: ::.:.||::.:.|:      |....|:         |:|.|||
Zfish   171 TFLIEGGFINDEIFKELVEALSQYSDPEEEEEEKE------PTDAAEN---------KQEEEKE- 219

  Fly   829 SSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKK 893
                                         :.||:.:.|:||..:...:...| .|...|..|.||
Zfish   220 -----------------------------MQKSAAEAPEESKTAFFKRKWRN-TAEGRELSANKK 254

  Fly   894 GLSDNSPPSVLKAKEKAVSGFVECDAMF-----------KAMDLANAQLRLDEKNKKKLKKVPTK 947
            ...|..              |....:||           |.:||      |:..|..||..:.|
Zfish   255 IPHDKI--------------FTAIASMFPYKGTMQELKDKYLDL------LEPSNHVKLPPLCT- 298

  Fly   948 VEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTV--------YEDSPNLERNSSPS---------- 994
                |.::.|.|..|..::...|..|...|...        :..|||:.:..|..
Zfish   299 ----PNMDGPFAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHSSPNVYKRKSKEIHMETEPCGL 359

  Fly   995 -----SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSD 1054
                 ...|:.......::..:.:::....|.          |||...||           ..|.
Zfish   360 DCFLLQKGAKEFADQNMMRSQRTRRRRRQPRP----------SSSCGHTP-----------PDSS 403

  Fly  1055 SSSKRNGS-KRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQ 1118
            ...|..|| ..|||..:|.|:        |         |.|:     .|.|
Zfish   404 EKGKEGGSDHETTSSSEGNSR--------C---------PSPI-----KMKP------------- 433

  Fly  1119 TAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRW 1183
                  |.:|.||          |.|..|.:..:::|  ..:|.........|.:...|:|..|
Zfish   434 ------GEEESKE----------SKSPPQWSGAEESL--FRVLHGTYYNNFCSIARLIGTKTCR- 479

  Fly  1184 DVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDED----QRKEGQDEVKREADPEEDEFAQRVA 1244
                           ::.:|....| |:.|..:::.    |:|:.:..:..:...::|..:.:|.
Zfish   480 ---------------EVYEFAVKEV-LIDRMPLEDSGISPQKKKRKHRLWAKIQLKKDNSSNQVY 528

  Fly  1245 NMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAP 1309
            |.:       |.....:|.||:...
Zfish   529 NYQ-------PCDHPEHPCDSSCPC---------------------------------------- 546

  Fly  1310 ISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQV----------SQENAEMQCDCF 1364
                          .|.:.|.            |.|.:|.|:.          :|.|.: ||.|:
Zfish   547 --------------VITQNFC------------EKFCQCDRECQNRFPGCRCKTQCNTK-QCPCY 584

  Fly  1365 LTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKK------- 1421
            |.                    :.||.| ||.......:...:|..|..|.:.|..||
Zfish   585 LA--------------------VRECDPDLCMTCGAADHWDSKQVSCKNCSIQRGLKKHLLLAPS 629

  Fly  1422 ---GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGN 1483
               |.|...:..:...|||.||.||:|..:|.:||..:|  |:....:...|..:.|:|||.|||
Zfish   630 DVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIY--DKYMSSFLFNLNNDFVVDATRKGN 692

  Fly  1484 ISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY-----LRY 1532
            ..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|     |:|
Zfish   693 KIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKY 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	19/125 (15%)
		AWS	1358..1410	CDD:197795	10/52 (19%)
		SET_SETD2	1410..1551	CDD:380949	52/138 (38%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
ezh1	NP_001035072.2	EZH2_WD-Binding	45..74	CDD:463308	5/14 (36%)
		PRC2_HTH_1	164..286	CDD:436286	32/187 (17%)
		SANT	447..489	CDD:238096	7/59 (12%)
		preSET_CXC	569..600	CDD:408079	11/51 (22%)
		SET_EZH1	617..752	CDD:380994	50/132 (38%)