Protein Alignment Set2 and setd1bb

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_009302386.1
• Gene: setd1bb / 571274
• ZFINID: ZDB-GENE-080522-1
• Length: 1859
• Species: Danio rerio
• Alignment Length: 1628
• Identity: 337/1628 - (20%)
• Similarity: 557/1628 - (34%)
• Gaps: 453/1628 - (27%)

  Fly   112 ASTSMSTATASAASASSAATVSRLF--SMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVT 174
            ||.:..|.|||...:.:...|::..  |..:.||..:|         ::.:.|..|:.:
Zfish   491 ASENTLTQTASPVPSKTTYDVNQNHYPSQAQSSHSYVP---------KLCSSPETTEDI------ 540

  Fly   175 SEPSAVGGAHPVQTMAGLPPVTPRKRGRP-----RKSQLADAAIIPTVIVPSCSDSDTNSTSTTT 234
            |||          |:....|..|....:|     |...|..|.   :.::|..:...::|.||..
Zfish   541 SEP----------TVECPSPEFPAPESKPDSLDTRIQMLLSAG---SPVLPLLNQDSSDSESTEE 592

  Fly   235 SNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGN--SPSSSSP--------EVEPPA 289
            ::....|...|. |.|.           |..|..|...|..:  ..:||.|        :|.|.|
Zfish   593 NDHHQRSSRAPS-PTQS-----------LTTGVSLNYDDISSVVRDTSSYPRENLSGMEDVNPTA 645

  Fly   290 LQDENAMD--ERPKQEQNLSRM-----VDAEENSDSDSQ-----IIFIEIETESPKGEEEQEEGR 342
            |.|. |.|  |.|..::.||:|     |:..|:.|:..|     :|.....|.:|...|......
Zfish   646 LYDV-AEDKHELPSPKKPLSKMPSSTIVNPNEDQDTSDQPSSIPVICTNRSTSTPPMSEIPPPPM 709

  Fly   343 P----------------VEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDE 391
            |                ..:.|..:|   .::.::...|.....| .|...:..|..||    ..
Zfish   710 PSVHYPFLPGYSLPTSSCSLYPPSII---KQVCRRSNWPTSLAPL-PIPTRITQGQTSL----SP 766

  Fly   392 AEEEEDATVQRATPPGKEPAADSCSSAPRRSR-------------RSAPLSG-----SSRQGKTL 438
            :...:..:.....||...|   .|||...|.|             .|.|..|     .|....|:
Zfish   767 SFLPQSFSFMTHRPPYPSP---GCSSTMLRYRPPWPPPPPIPRFDPSVPPPGYVPIKESPHKATV 828

  Fly   439 EETFAEIAAESSKQILEAEESQDQEEQHILI---DLIEDTLSESEVTSSVS-PTIEHMVVEEV-- 497
            :...|.:|:|     |.|...:|...:.|.|   ...:....:.|..:.|| |.::.:..:::
Zfish   829 DGVLAVVASE-----LRAIVKKDIHRRMIEIMAFKAFDQWWDDKEQAAKVSAPAVKSVGNKDIKL 888

  Fly   498 -VVEENQLVDEADE---ILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGE------- 551
             |:|::..:..|..   ||||.:   ||           ||:..|..|..:.|...|:
Zfish   889 RVMEQSLRLGTAGGEGCILDSGK---IK-----------SLHGAIKLPSFKRKGPSGQGSTDVKR 939

  Fly   552 --VVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKL---SDEVVIE----PPLKDESD 607
              ..|.||. :||           |:|...|.|  :.:.||.:   |::.:::    .||..:|:
Zfish   940 ICPSPGPEH-SED-----------EESEQQTAP--DCVDETTVLNASEDTMVKRRHSRPLALDSE 990

  Fly   608 PKQTEVELPESKPAVNIPKSERILSAE--------VETTSSPLVPPECCTLESVSGPVLLETSLS 664
            .:..|    |:......||.|::.:.:        .:.||.|.|             ::.:....
Zfish   991 EEDDE----ENSEKAEDPKPEQVHACDRVDIKKVTKDQTSDPCV-------------IVDDEDTD 1038

  Fly   665 TEEKSNENVETTPLKTEAAKED------SPPAAPEEEA-------SNSSEEPNFLLED---YESN 713
            ||..|:.|       :.|:|..      ||.:|....|       |..|..|.|:..|   .||:
Zfish  1039 TETLSHSN-------SSASKSQGYDSLASPRSASHYSACSPSVIDSPVSSRPVFVSSDDRSDESS 1096

  Fly   714 QEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAET--VSKKEKAMEN-PARSSPAIVDKKVRAG 775
            ....|||:     ...||..   ||....::.|.||  :|..|...|| ....:|..:.......
Zfish  1097 SVSSAEDD-----QSDGQSS---PETPREDRRVVETIWISSDEDDDENQETLHTPVFLPSPHSEE 1153

  Fly   776 EMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETE-KEKSSAKLDSSSPN 839
            :::..|..|...::   :.|.......:.||:.::..:.....:..:..: .|.....|.....:
Zfish  1154 DLQPPVTPSAPDSI---ESDVDNDFFDLDPAQMEDPEEELSVRVYMQGLKLPEPLRYTLQDPVKH 1215

  Fly   840 TLDKKGK---DTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSD---- 897
            .|..|.|   ....:|.|...||    .||..:...:.....:......|:|....:.|.|
Zfish  1216 CLTNKLKLPDPVIFFSDQESELP----SPPSPTYRGLSDDLETQYTTDSEDQRVIMEALEDPVHL 1276

  Fly   898 ----------NSPPSVLKAKEKAVSGFVECDAMFKAMDLANA-----QLRLDEKNKKKLKKVPTK 947
                      :|.|.:...::.:.....|       :||.:.     :|..||.|
Zfish  1277 RPITPTGFLSDSDPDIEMGRKFSPPAIEE-------VDLPHTPGRCLELEDDENN---------- 1324

  Fly   948 VEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKL----- 1007
             ..||  .|||.:|.|   .|.:|...|..:.:|...|.|  :|.|..:  :...:.|::
Zfish  1325 -ILPP--GPPTPLPPP---PSPTGIKELPSSPLYYGIPLL--SSYPGYE--EIPKTPGRVNDPGF 1379

  Fly  1008 -----------KPSK-VKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSK-- 1058
                       :||: ::...||..|:..:       |....||.|:::.|.||....:...:
Zfish  1380 VFHSERITPPQEPSRTLESPCNPFLSSFAD-------SGIPRTPGRDMSLSPPVLNHRERHVQHR 1437

  Fly  1059 ---RNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTA 1120
               :.|.:...||. ..|.:....:                           |.|..|.....||
Zfish  1438 ELLKYGQRHRNSDF-AQSDVQTNNF---------------------------SKNNSHTPRSDTA 1474

  Fly  1121 GKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDV 1185
            ..|| |:|..:...|...|..|...:.                  |.|.||...||.:
Zfish  1475 RLKR-RRERLKKRQRMIELQRSRRCTD------------------LNTHSSLQVSSAT------- 1513

  Fly  1186 QTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPA 1250
             |.|..::..|.        |.|:.::.::.:..|    |.|.:|.:   |..:.:|.::: ||.
Zfish  1514 -TKPTNQSLEPL--------DRVSNIRTEESNNSQ----QIETQRLS---ESSYVRRDSSL-TPH 1561

  Fly  1251 TTPTPSPTQS-------------NPED----SASTTTVLKELETGGGVRRSHRIKQKPQGPRASQ 1298
            ...||...:.             |.|:    .||...::.|......:||:..|...|......:
Zfish  1562 LIFTPRSKRREKLVLHAVWTKGVNEEEIRHLKASYERLVVEDNEYDWLRRTRWIPHPPTSTSDDR 1626

  Fly  1299 GR----GV--------ASVALAPISMDEQLAELANIEAINEQFLR-SEGLNTFQLLKENFYRCAR 1350
            .|    ||        .|.....||..|:|..|.|...::|:|.. |:|.:....:..:
Zfish  1627 PRRWLDGVRNHLTGCARSEGYYFISKREKLQYLCNERTVSEEFTADSQGKSVSAQVSHS------ 1685

  Fly  1351 QVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRV 1415
              |:..:|::.:         |..|.....|.:.:|..       |..:...||.        |.
Zfish  1686 --SRSGSELRAE---------QRRLLSSFSCDSDLLKF-------NQLKFRKKRL--------RF 1724

  Fly  1416 FRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATS 1480
            .::.....|:.||..|...|.|:||||:.|.....:.|:..|..:.....|...:..:.:||||.
Zfish  1725 GKSRIHDWGLFAEEPIAADEMIIEYVGQSIRQVIADMRERRYETEGIGSSYLFRVDHDTIIDATK 1789

  Fly  1481 KGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAAN 1545
            .||::|:|||||:||...:..||..:.:|..:|.:||...||||:||:: ....:...|.|.|.|
Zfish  1790 CGNLARFINHSCNPNCYAKVITVEAQKKIVIYSRQPITVNEEITYDYKF-PIEDEKIPCLCAAEN 1853

  Fly  1546 CRG 1548
            |||
Zfish  1854 CRG 1856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	24/129 (19%)
		AWS	1358..1410	CDD:197795	8/51 (16%)
		SET_SETD2	1410..1551	CDD:380949	48/139 (35%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
setd1bb	XP_009302386.1	RRM_SF	104..195	CDD:473069
		N-SET	1580..1714	CDD:463344	29/157 (18%)
		SET_SETD1	1708..1855	CDD:380946	49/162 (30%)