Protein Alignment Set2 and ehmt2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001428432.1
• Gene: ehmt2 / 569250
• ZFINID: ZDB-GENE-010501-6
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1281
• Identity: 253/1281 - (19%)
• Similarity: 411/1281 - (32%)
• Gaps: 465/1281 - (36%)

  Fly   588 AETKLSDEVVIEPPLKDESDPKQTEVEL----PESKPAVNIPKSERILSAEVETTSSPLVPPECC 648
            :.::.|.||.:.|.:|.    ||.| :|    .:.:|:.    |.:..:..:..:||   |....
Zfish    15 SSSQSSHEVEVNPAVKG----KQME-DLTGRQDDGRPST----STKTFTGVINKSSS---PSSSS 67

  Fly   649 TLESVSGPVLLETSLSTEEKSNENV----ETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLED 709
            :|.|.|      :|.|...::..:|    ..||..:.::...:.|.|....|..:...|
Zfish    68 SLSSSS------SSSSASGRAKMSVCGPGSKTPSSSSSSSSSAGPPAKVHRARKTMNRP------ 120

  Fly   710 YESNQEQVAEDEMMKCNNQKGQKQTPLPEMK-----------EP---EKPVAETVSKKEKA---- 756
                                     |||::|           :|   |||.|:||.||.||
Zfish   121 -------------------------PLPQIKPVESISPAAAEKPAGGEKPDADTVVKKRKAGLDV 160

  Fly   757 ---------------MENPARSSPAI------------------VDKKVRAGEMEKKVV------ 782
                           .|.|..:|||:                  .|....|.|.:..::
Zfish   161 SATPSGTPEKVLKPQTEPPMTASPAVGKAEPVATATKDSHSRWMEDLDEEADEEDFHLLYNSYCG 225

  Fly   783 --------KSTKGTVPEKK-----MDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLD 834
                    ||.:|...|..     .|...|.....||.::.|            :|:|:
Zfish   226 DDVIYSDSKSDEGMTEEPMGAGHLSDHSSSSDPPLPAYKRNS------------SEREE------ 272

  Fly   835 SSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLS--D 897
                ||..::||..|:  .:.....:..|:...|||...:..|...:........:|...||  |
Zfish   273 ----NTWKRQGKGKAR--DRAAAGGEQDTEKGAESASVAVGSTDYTEVPLDSLDISAADSLSHAD 331

  Fly   898 NSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPV 962
            .|.....:.:|..:     |....:|.       |||..:.:..:..........::...|.|.:
Zfish   332 GSDAETERLEELPL-----CSCRMEAP-------RLDSSSVRSSRTCMAIQSINGELVGCTNVIM 384

  Fly   963 PGQKKSLSGKTSLR------------------------RNTVYEDSPNL---------------- 987
            .|:....|.:.||.                        ..|..|..|::
Zfish   385 KGETMRPSSRVSLMVLCETHRSHMVKHHCCPGCGYFCLSGTFLECCPDVHITHRFHRSCVSVLGS 449

  Fly   988 --ERNSSPSSDSAQAN-TSAGKLKPSKVKKKINPRRSTI------C-EAAKDLRSSSSSSTPTRE 1042
              .|.::..||...|. ||:|:            .|.|:      | ...:|...:.:.|.|...
Zfish   450 GRSRGAAGGSDDQWAEPTSSGR------------SRGTVGVGLLFCPHCGEDASEARTVSIPPEA 502

  Fly  1043 VAASSPVSTSSDSSSKRNG--------SKRTTSDL------------------------------ 1069
            ..|.|.|.|:|.||:..:.        .:|||.:|
Zfish   503 PPAGSHVVTASASSTTASNHTQHTPQTHRRTTDNLNARMRCRGDARKGAELQSQPTNGAAAGSGE 567

  Fly  1070 -------DGG------SKLDQRRYTICEDRQP--------ETAIPVPLTKRR--FSMHPKASANP 1111
                   |||      |.:......:|....|        :.||....::||  ...||:.
Zfish   568 EDVVAVGDGGVDSVGPSLVLPNGKPVCPSALPAGDRRAALQRAILTQDSERRKKLRFHPRQ---- 628

  Fly  1112 LHDTLLQTAGKKRGRKEGKESLSRQNSLDSS-SSASQGAPKKKALKSAE---ILSAALLETESSE 1172
                 |..|. |:|..: :..|.....:|.| .|.||.  ::.||.:|.   :|....|..::..
Zfish   629 -----LYPAA-KQGEAQ-RVLLMLMEGMDPSYQSDSQN--RRCALHAAAQRGLLEICYLLVQAGA 684

  Fly  1173 STSSGSKMSRWDVQTSPELEA-ANPFGDIAKFI-----------EDG----------------VN 1209
            ...:..|..|     :|.||| .|...|:.|::           :||                :.
Zfish   685 KVDAQDKSLR-----TPLLEAIVNNHVDVVKYLIQSGACVYHAEDDGSTGLHHAAKLGNLEVVML 744

  Fly  1210 LLKRDKVDEDQR------------------------KEGQDEVKREADPE----------EDEFA 1240
            ||...:||.:.:                        ..|.|...|:.:..          ..|.|
Zfish   745 LLSTGQVDINAQDSGGWTPVIWAAEHRHIEVIRALLNRGADVTLRDKEMNVCLHWASFAGSAEIA 809

  Fly  1241 QRVANMETPAT-------TPTPSPTQSNPED--------SASTTTVLKELETGGGVRRSH----- 1285
            :.|.|...|.:       ||.....:....|        .|....|.||.:|...:.|..
Zfish   810 ELVLNAGCPLSSVNVHGDTPLHISAREGYSDCVTLFLSRGADIDIVNKEGDTPLSLARGETPVWV 874

  Fly  1286 --RIKQKPQGPRASQGRGVAS-------VALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLL 1341
              :|.:|.:       ||:|:       :..:.::...:...:..:..::::...|:    ::.:
Zfish   875 ALQINRKLR-------RGIANRIVRTERIICSDVAQGYENVPIPCVNGVDDEGCPSD----YKYI 928

  Fly  1342 KENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGAGCI--------------NRM---LMI 1388
            .||....|..:.:....:| |.|   .|:.:..:..||...|              |::   |:.
Zfish   929 AENCETSAMNIDRNITHLQHCSC---TDDCSSSNCLCGQLSIRCWYDKDHRLLQEFNKIEPPLIF 990

  Fly  1389 ECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERR 1453
            ||...||....|.|:..|.......:::||||.|.|:.|...||.|.||.|||||:|...|.:.|
Zfish   991 ECNMACSCHKTCKNRVVQAGIKVRLQLYRTEKMGWGVRALQDIPQGSFICEYVGELISDAEADVR 1055

  Fly  1454 Q---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AETQKWTVNGEL---RIG 1510
            :   :|:..|..        .||. .|||...|||||:|||.|||| ...:.:.::.:|   ||.
Zfish  1056 EDDSYLFDLDNK--------DGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIA 1112

  Fly  1511 FFSVKPIQPGEEITFDY---------QYLRYGRDAQRCYCEAANCR 1547
            |||.:.|..|:|:.|||         :|.       .|.|.:..|:
Zfish  1113 FFSSRDIFTGQELGFDYGDRFWDIKSKYF-------TCQCGSEKCK 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	34/192 (18%)
		AWS	1358..1410	CDD:197795	16/69 (23%)
		SET_SETD2	1410..1551	CDD:380949	55/155 (35%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
ehmt2	NP_001428432.1	None