DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and kmt2cb

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_009296384.1 Gene:kmt2cb / 568162 ZFINID:ZDB-GENE-070705-340 Length:4892 Species:Danio rerio


Alignment Length:1931 Identity:368/1931 - (19%)
Similarity:595/1931 - (30%) Gaps:637/1931 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 GRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNK 83
            |..|..|.||||...|...........|||......|.|...|.:..:              :.|
Zfish  3199 GAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQGVVQKQLEQ--------------IRK 3249

  Fly    84 NRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPP 148
            .:|.|...||.                                         :.:.:....:|.|
Zfish  3250 QQKEHAELIEE-----------------------------------------YRVKQQQQGALQP 3273

  Fly   149 P-----PPPPTALEIFAKPRPTQSLI-----------VAQVTSEPSAVG---GAHPVQTMAGLPP 194
            |     .||...:::  .|...||::           ...||..|:..|   || ||.|...:|.
Zfish  3274 PIMPGMQPPAGMMQV--GPPINQSMVGPMMPIRLHSNQPDVTKMPNTAGWHPGA-PVPTGPRMPG 3335

  Fly   195 VTPRKRGRPRKSQLADAAIIPTVI-----VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKS 254
            |.|.:..:|:  .|..||..||.:     .|..:..|||..|             .||..::.|.
Zfish  3336 VMPAQVVQPQ--PLQPAAARPTQVQAGGESPHVNFDDTNPFS-------------EGFQERERKE 3385

  Fly   255 KLRVSLKRLKL----------------GGRLESSDSGNSPSSSS--------PE--VEPPALQDE 293
            :||...:|.::                ..::.:...|.....|.        |:  ::||.||.:
Zfish  3386 RLREQQERQRMQIIKEVERQHVKHCVEQQQVSNCQDGTMRGLSQMPFYNQELPQDFMQPPRLQQQ 3450

  Fly   294 NAMDERPKQE------------------------------QNLS----RMVDAEENSDSDSQIIF 324
            ......|:|:                              |||:    .::.|:......|  :.
Zfish  3451 IQGPTFPQQQGTQQGYIGGPPRPLLGNGPFPQEMGSGFAPQNLAVHGPNLIQAQTRPQRYS--VP 3513

  Fly   325 IEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSAD 389
            ..:....|:|.....|| |..:.|.              .|.|...|.::...::.........:
Zfish  3514 HMMAQNPPQGHPFPMEG-PTPLPPN--------------FPGPGPSLIQLYSNIIPEEKGKKKRN 3563

  Fly   390 DEAEEEEDATVQRA--TP--PGKE------PAADSCSSAPRRS----------RRSAPLSGSSRQ 434
            .:.:::||....||  ||  |..:      |.....||.|.|:          ..|.|  |||..
Zfish  3564 QKKKKDEDCESLRAPSTPHTPHSDMTAPLTPCVSDTSSTPTRNPMVFGDHEFCETSQP--GSSTP 3626

  Fly   435 GKTLEETFAEIAAESSKQILEA------EESQDQEEQH------ILIDLIEDTLSESEVTSSVSP 487
            |....:..:|:    .:|:.|.      |.:...||.|      |.::.:|...........:..
Zfish  3627 GSMSSQPHSEL----ERQLSEGSCGGGPESAMGHEEMHDRILSNIKLEKVEANDCHGHKPIDMEI 3687

  Fly   488 TIEHMVVE-EVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGE 551
            .|..:.|| |:::........|:   .||:|.                ..::.:..::.|.|...
Zfish  3688 RIGMVKVEREIMLHHPSSQSPAN---SSKEEG----------------GNELLKHLLKNKRTPPH 3733

  Fly   552 VVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELP 616
            .:|...  :||...:|...:| |..|...:.:.:.......|:......||..|...||.....|
Zfish  3734 ALPHQR--SEDSLRSEEEGST-ESKAFFRQNSMDSTGTFSDSNHQDFPGPLILEDKKKQRNKRTP 3795

  Fly   617 ES--KPAVNIP--KSERILSAEVETTSSPLVPP-------------------------------- 645
            :|  :||....  |.|...|..|.:::.|::.|                                
Zfish  3796 KSGDRPAPRCKKRKKEEDESQAVYSSTDPMITPLKQQHLSLLPLMEPLVGVNFAHLMPYGGGQLD 3860

  Fly   646 ---------ECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASN--- 698
                     ...:|:.||.   ..:.|..::.:..|..|.|    |:...:||....::..|   
Zfish  3861 GENRLSGTFGSASLDGVSD---YYSQLIYKQNNLSNPPTPP----ASLPPTPPPVARQKLLNGFA 3918

  Fly   699 SSEE---PNFLLEDYESNQ-------EQVAEDEMM--------------------KCNNQ---KG 730
            ::||   ...|:..::..:       |..||:|::                    ..|||   :|
Zfish  3919 TTEELARKGGLIAGHDVTKGLLARPLEFKAEEELLAQALAQGPKTVNVPASLPTPPHNNQEELRG 3983

  Fly   731 Q-----KQTP---LPEMKEPEKPVAETVSK-------KEKAMENPARSS-----PAIVDKKVRAG 775
            |     :.||   :|. ..||..|...:|:       ||:. .:||.|.     |...||.|:..
Zfish  3984 QEHCEDRNTPDSFVPS-SSPESVVGMEISRYPDLSLVKEEP-PSPAMSPVIPMFPVFRDKDVKLQ 4046

  Fly   776 EMEKK----VVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSS 836
            |::.:    ...|:..:|.........|.|.:......|:......||......|..||.::.|.
Zfish  4047 EVKTEPSSVFFDSSFRSVQNGSNTGLVSIAIMLKPAAAENITDVVAAIADLIRVKIPSSYEVSSG 4111

  Fly   837 SPNTLD--KKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSN-------------QPAPKE 886
            ...:..  |...|....:..|...|::..:.||.    ::.:...|             :|..|:
Zfish  4112 PGGSFGAIKTSVDPQCLASALPNGPRALRQAPQH----LLLQHNHNKNIGGEQYRDGQVRPGSKQ 4172

  Fly   887 E--QH----AAKKGLSDNSPPSVLKAKEKAV---SGFVECDAMFKAMDLANAQLRLDEKNK---- 938
            :  ||    ...||:...:....:|.:|..:   .|.|.|......:..:::|...:..||    
Zfish  4173 QWCQHCKVVVLGKGVRKITKDEEVKPQESRLCSDGGLVFCSHSCLILHSSSSQSNGNADNKASVP 4237

  Fly   939 ----KKLKKVPTKVE-------------APPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPN 986
                ..||:..:||:             ...:::|..:.|.|            ..:..:..:..
Zfish  4238 LLSESALKQSFSKVQHQYSNNMSSLDVHCLAQLQPKPSSPAP------------YLHMAFAPAKA 4290

  Fly   987 LERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAA--------KDLRSSSSSSTPTREV 1043
            ::..|.|.|      .|.|.|   ||..|:.||..:..|..        |.||....    |.::
Zfish  4291 IKTESKPRS------ISEGHL---KVTVKLKPRLHSHLEDKQWHHGKRWKGLRWRKW----TIDI 4342

  Fly  1044 AASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICE------------------------ 1084
            |.......||:|..:....:.|||.....:..||||...|:                        
Zfish  4343 AMPKVAPQSSESELEERLKQLTTSLRPCLTIRDQRRCCFCQQIGDGMTDGPARLLNLDLDTWVHL 4407

  Fly  1085 ----------DRQPETAIPVPLTKRR---------------FSMHPKASANPLHDTLLQTAG--- 1121
                      :.|....|.|.|.::|               ...|.....|..|.|....||   
Zfish  4408 NCALWSSEVYETQAGALINVGLARQRGQTVVCAFCQRLGATSGCHRLRCLNIYHFTCALQAGCTF 4472

  Fly  1122 ---------KKRGRKEGKES-LSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSS 1176
                     :.|.|..|..: |..::.|...|...:...::..|:.   |:||:.:.|...:...
Zfish  4473 FKDKTMLCHQHRPRGAGAAAGLHVEHQLRCFSVFRRVYVQRDELRQ---LAAAVQQPERGHTFRV 4534

  Fly  1177 GSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQR-----KEGQDEVKREADPEE 1236
            ||.:.....|..|.|...  |.........|.         |..|     :.||...:.....||
Zfish  4535 GSLLFHAMGQLPPALMPT--FHSSTAIFPPGY---------EATRLYWSMRHGQKRCRYVCSVEE 4588

  Fly  1237 D----EFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRAS 1297
            .    ||:.||              .:...||...|.|..|            .:.:|..||.|.
Zfish  4589 HEGRAEFSIRV--------------IEQGYEDLVLTDTSAK------------GVWEKVLGPVAE 4627

  Fly  1298 QGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCD 1362
            :......:.|.||                  :|:.|.|  |.|......|.|             
Zfish  4628 RRAETGMLRLFPI------------------YLKGEDL--FGLTISAVTRIA------------- 4659

  Fly  1363 CFLTGDEEAQGHLSCGAGCI----NRMLMIECGPLCSNGARCTNKRFQQHQ------CWPCRVFR 1417
                  |...|..:|.....    |.:|::......|..||...:.:.||:      .|| |:.|
Zfish  4660 ------ESLPGVEACSRYRFRYGRNPLLVLPLSMNSSGSARSELQTYPQHERVKILSSWP-RISR 4717

  Fly  1418 -----------------------------------------TEKKGCGITAELLIPPGEFIMEYV 1441
                                                     :..:|.|:.|...|.....::||:
Zfish  4718 CIQNSTVAASASSHSKHFVHSKSSQYRRLASDWKSNVYLAHSRIQGLGLFAARAIEKQTMVIEYM 4782

  Fly  1442 GEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGE 1506
            |:::.:|...||:.|| |.:||..|...:..|.|||||:.|:.:|||||||.||...:..|....
Zfish  4783 GDILRTEVAMRRELLY-KAKNRPAYMFCIDSERVIDATNSGSPARYINHSCSPNCVAEVVTFERG 4846

  Fly  1507 LRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANCRGWI 1550
            .:|...:...|:.|||:.:||: |....|..:  |:|.||.||.||
Zfish  4847 YKIIISAACRIERGEELCYDYK-LTPVNDQSKIPCHCGAAKCRKWI 4891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 10/61 (16%)
SET 1414..1533 CDD:214614 43/159 (27%)
PostSET 1535..1551 CDD:214703 9/18 (50%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
kmt2cbXP_009296384.1 PHD_SF 232..319 CDD:304600
PHD1_KMT2C_like 332..377 CDD:276984
PHD2_KMT2C 379..424 CDD:277069
PHD3_KMT2C 459..507 CDD:276986
PHD_SF 947..1003 CDD:304600
PHD5_KMT2C_like 1004..1050 CDD:276988
PHD_SF 1081..1131 CDD:304600
HMG 1691..1744 CDD:197700
DUF4200 3168..3262 CDD:290574 19/117 (16%)
Med15 3255..>3659 CDD:255446 85/485 (18%)
PHD_SF 4379..4483 CDD:304600 12/103 (12%)
FYRN 4536..4586 CDD:283589 10/60 (17%)
FYRC 4594..4673 CDD:283590 26/143 (18%)
SET 4753..4868 CDD:214614 39/115 (34%)
PostSET 4877..4892 CDD:214703 8/15 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593895
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

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