DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set2 and setd1ba

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001038599.2	Gene:	setd1ba / 567970	ZFINID:	ZDB-GENE-050309-289	Length:	1844	Species:	Danio rerio

Alignment Length:	1833	Identity:	366/1833 - (19%)
Similarity:	584/1833 - (31%)	Gaps:	577/1833 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EESGPPSNPSPVASRGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPT--APEDQDSGQSEC 64
            :..|.|..|.|                   ..||  .:....::..:.:|.  |...:.||..:.
Zfish   300 QSQGTPHTPRP-------------------SGTP--FSQDSSYSSRQGTPAFQANRAESSGGYKS 343

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSM---------STAT 120
            ||...|      .:|..|:..:...:.           |.:|.|.|....|.         |.|.
Zfish   344 RRHETK------FQDAYNRRPERRYVH-----------GPTQRGNTEQPPSFKQHQPPEPPSPAF 391

  Fly   121 ASAASASSAATVSRLFSMF-------------------EMSHQSLPPPPPPPTALEIFAKPRPTQ 166
            .......::|.....:|.:                   |:.::..|..||||:...:..:.|||.
Zfish   392 THTPPPPTSANFKTAYSQYQPPIPQEYTVASYHQPVQRELDYRRPPQAPPPPSTDFLPVRDRPTT 456

  Fly   167 SLI-------VAQVTSEPSAVGGAHPVQT-------------------------------MAGLP 193
            ..|       ..|.|:.||:.....|..|                               |.|.|
Zfish   457 PPIPEPPPAPETQPTTPPSSTPEPCPSPTQESERNSLDSRIEMLLKPFLNERGDSDAEVRMDGSP 521

  Fly   194 ---------PVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSD---------TNSTSTTTSNMSSD 240
                     |:.|::..||..:.|.|  |.||.: |...|.:         .||...:.:||.|.
Zfish   522 ISSSSSQLSPIPPQRPSRPSSTGLED--ISPTPL-PDSEDDEPIRGTASLLANSRGMSPTNMHSK 583

  Fly   241 S--GELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQE 303
            |  ||        |::             .::..|:|:..|....|:..         ||.|...
Zfish   584 SCVGE--------PRT-------------AIDKMDTGHQSSGEDMEISD---------DEMPGTP 618

  Fly   304 QNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDL--IDIDMELAKQEPTPD 366
               ....|.::|...:|.:..|:.....|.|...........:.|..|  ......|....|...
Zfish   619 ---IASGDCDKNIVVNSALSLIQTIPMPPPGFPPLPHAAGFPLPPHHLPHHSTVSHLPSHHPMLH 680

  Fly   367 PEED---LDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEP-AADSCSSA--------P 419
            |...   :..:.|::||..|.|.....:.:.:..:.:.::..|...| .|.|.:.|        |
Zfish   681 PLHSYGMMHFLPVDLLSSLPQLLQMPFQMQTQMLSRMAQSQHPYAYPYPAPSANPAAMPFGGPYP 745

  Fly   420 RRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEA-----EESQDQEEQHILIDLIEDTLSES 479
            ..|..|||......|...|         .|..|...|     .|.|.::.....||.:...:.:
Zfish   746 PLSVVSAPADTLHGQPWPL---------PSMPQFNPAVPPPGYEPQKEDPHKATIDGVLMAIVK- 800

  Fly   480 EVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVE 544
            |:.:.:...:...:||.|...      :.||..| |||...|...:.   :.....||..:.:.:
Zfish   801 ELKAIMKKDLNRKMVEVVAFR------KFDEWWD-KQELSAKATLTP---VKTGEGKDEEKERAK 855

  Fly   545 TKATCGEVVPRPE---MVTEDVYITEGI-AATLEKSAVVTKPTTEMIAETKLSDEVVIEP--PLK 603
            .|.|....:|..:   :..|.:.:..|: ...|....|..|...|   .|..||...:.|  |:.
Zfish   856 PKETMSSHLPWNKGEGLGFEGMGLGIGLRGIRLPSFKVKRKQPPE---PTSTSDNKRVRPSTPVD 917

  Fly   604 DESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCT----LESVSGPVLLETSLS 664
            ||.:.:::|        .:......|:..|...:...|..|.|..:    .|..||..  |:|||
Zfish   918 DELEDEESE--------RMGRTDGSRVDPAGSSSKRRPARPLELDSEGEEEEETSGKE--ESSLS 972

  Fly   665 TEE--------------KSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEP------NFLLED 709
            ..|              |..|..:....::.:::.:|..::.:|.:|:||.:.      :....|
Zfish   973 DHEEEPVDDASERLSSGKDLEEEDEKKSESHSSESESSDSSDDEASSSSSSKSGSDSSGSESSSD 1037

  Fly   710 YESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAET----------VSKKEKAMENPARSS 764
            |||:.|:..|:|         :::..:..|.:.|...|.|          .|.:|:.:|..|.|:
Zfish  1038 YESSSEEEEEEE---------EEEERIVGMDDEEDVDARTSTSSSTTSTSSSDEEEVVEVKAPST 1093

  Fly   765 PA---IVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKE------SGKSAKEAIL 820
            |.   ..::....|.:|         .|.|.::|.|.|..::...|.:|      .|..|.|..:
Zfish  1094 PTGPPPEEEPNELGRLE---------AVDEAEIDHKPSMVSLIKTKVEEVRPPSPKGLPADELDV 1149

  Fly   821 KKET-----EKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTK-----PPQESAPSVIS 875
            ..|.     :.|.|..::.:..|.|......|:.|     .|.||..|:     |..|....:.|
Zfish  1150 DLEVKIPVPKTEASLEEVGNLRPPTPTGSFADSDQ-----DTRPKIPTEDFPRTPGHEGPVPLES 1209

  Fly   876 KTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKK 940
            :||..:..|....|..........|.|:|...|                .|.:..:|
Zfish  1210 ETTVPRSLPTPSMHLPLPPSHVPDPQSLLPPPE----------------TLPDMPVR-------- 1250

  Fly   941 LKKVPTKVEAP--------------PKVEPPTAVPV-PGQKKSLSGKTSLRRNTVYEDSPNLERN 990
             .::||:.:.|              .|::....||| ||....|:|.:.        .||::  .
Zfish  1251 -GRLPTEEDIPRTPGRDLMDRARGLGKLQSTDTVPVTPGSDTPLTGNSL--------SSPHI--L 1304

  Fly   991 SSPSSDSAQ-------------------------ANTSAGKLKPSKVKKKINPRRSTICEAAKDL 1030
            .||.|..||                         |..|||.....|...:|...:....|..  |
Zfish  1305 GSPFSYPAQSPVLSAGIPRTPGRDLTFAPAFPDSAGLSAGLPIHRKASSEILEEKPLFKEPL--L 1367

  Fly  1031 RSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIP-- 1093
            .:|..:|.|..  |||||..          |....|:.|                  ||.|:|
Zfish  1368 SASPQASLPNN--AASSPFP----------GPPLPTASL------------------PEPALPPQ 1402

  Fly  1094 --VPLT-KRRFSMHPKASANPLHDT---LLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKK 1152
              .|.: :..|...||....|:.|.   |..|..||:        |.|..:             |
Zfish  1403 GSPPASIENSFPASPKELPVPMIDVPVPLDDTPSKKK--------LVRSKN-------------K 1446

  Fly  1153 KALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVD 1217
            |.::.:|.....|:|..|                 .|||...|.:.|:..
Zfish  1447 KGIQDSEEPQVTLIEASS-----------------LPELPVNNQYPDLPS--------------- 1479

  Fly  1218 EDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGV- 1281
                         |:..|||                 ..|..|..|:|...|.:.|..||...|
Zfish  1480 -------------ESIKEED-----------------GEPAFSEKEESQVPTIIPKVEETSFYVE 1514

  Fly  1282 ------RRSHRIKQK----PQGPRASQGRGVASVALAPISMDEQLAELANI--EAINEQFLRSEG 1334
                  ||..|..|:    ...|.||..|    .:..|.|..|::..|.:|  :.|:|:.:|...
Zfish  1515 EPIQKTRRQRRGWQELLLSMHSPVASPRR----PSFMPRSDFEEMTILYDIWNDGIDEEDIRYLK 1575

  Fly  1335 LNTFQLL--------------------------------KENFYR-----CAR-----QVSQENA 1357
            :...::|                                ||:..|     |||     ::.:::.
Zfish  1576 ITYDKMLQQDNAHDWLNDTLWVHHPPTNMGSATGVKKKRKEDGIRDHVTGCARSEGYYKIDKKDK 1640

  Fly  1358 EMQCDCFLTGDEE-----------AQGHLSCGAGCINR------MLMIECGPLCSNGARCTNKRF 1405
            ....:......||           ||..:|..||...|      :....|.   |:..:....:|
Zfish  1641 MKYLNSSRLQSEEPDVDTQGKSIPAQPQVSTRAGSERRSEQRRLLSSFSCD---SDLLKFNQLKF 1702

  Fly  1406 QQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMAL 1470
            ::.:   .|..|:.....|:.|...|...|.::||||:.|.....:.|:..|..:.....|...:
Zfish  1703 RKKK---IRFCRSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRV 1764

  Fly  1471 RGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRD 1535
            ..:.:||||..||.:|:|||||:||...:..||..:.:|..:|.:||...||||:||:: ....:
Zfish  1765 DHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDYKF-PIEDE 1828

  Fly  1536 AQRCYCEAANCRG 1548
            ...|.|.|.||||
Zfish  1829 KIPCLCGAENCRG 1841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	11/68 (16%)
		SET	1414..1533	CDD:214614	40/118 (34%)
		PostSET	1535..1551	CDD:214703	7/14 (50%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
setd1ba	NP_001038599.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..58
		RRM_SF	136..228	CDD:302621
		RRM	<144..>232	CDD:223796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..562		54/302 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..871		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	890..1108		48/239 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1160..1341		42/220 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1367..1499		47/244 (19%)
		N-SET	1556..1695	CDD:288597	22/141 (16%)
		SET	<1619..1844	CDD:225491	62/230 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1647..1678		7/30 (23%)
		SET	1705..1828	CDD:214614	40/126 (32%)
		PostSET	1828..1844	CDD:214703	7/14 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870