Protein Alignment Set2 and kmt2bb

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_002664717.2
• Gene: kmt2bb / 566825
• ZFINID: ZDB-GENE-080521-1
• Length: 3772
• Species: Danio rerio
• Alignment Length: 1780
• Identity: 350/1780 - (19%)
• Similarity: 591/1780 - (33%)
• Gaps: 557/1780 - (31%)

  Fly    38 INPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDS-NPS 101
            :.|:::....|.||...|:.....|.|.:|..:                    .:|..:.| |||
Zfish  2282 VRPAVQEKQVEESPDHGENCTIAHSPCPQSECE--------------------ALELGLSSTNPS 2326

  Fly   102 T-GHSQSGTTAASTSMST---ATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTA------- 155
            | .:..||:..|...:..   .|:...:...|..:||          .||.|...|:.
Zfish  2327 TEANFTSGSVFAKPDLGARPKITSYPQNRRPAGGLSR----------PLPSPGAAPSKPHHILTI 2381

  Fly   156 --LEIFAKPR---------PTQSLIVAQVTSE-----PSAVGGAHPVQTMAGLPPVTP------- 197
              ||...:||         .|:|.:.:.....     ||..||:|..::.....|:.|
Zfish  2382 SDLEDTRRPRRHSPHTQNSGTRSHMTSPTLGSPAGPIPSRAGGSHHPKSSQTTSPMFPLGATENL 2446

  Fly   198 ------RKRGRPRKSQLADAAIIPTVIVPSCSDSD----------TNSTSTTTSNMSS------- 239
                  |..||...|......:.|.......|.|.          ||.:.|:.:::|:
Zfish  2447 LTSSSARPVGRSASSVRGTGILTPHSTSGLFSQSTKQGGIGSTPCTNRSLTSPTHLSTRPRPFDF 2511

  Fly   240 ---DSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPK 301
               ||.|||...|..|:..|               |::|..|           |.|..:|   ||
Zfish  2512 NPIDSLELPHNFIASPQEHL---------------SETGALP-----------LGDALSM---PK 2547

  Fly   302 QEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLID--IDMELAKQEPT 364
            .....         ||.|.....|.:|.:.....|.:.|   :|:| :.:::  :.|..:.|
Zfish  2548 VNHLC---------SDRDFPYTSIHLEADLTVAPELRTE---LEIE-ESVVNEGVAMNCSAQ--- 2596

  Fly   365 PDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCS------------- 416
                     |:||........|..||...:.....:.....|.:|...:|.|
Zfish  2597 ---------IVVEGEDNQEDFWEPDDNKSKMSSQRLSCTVDPCREDWGNSSSDEDMENYFNFTRT 2652

  Fly   417 ----SAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEE-----SQDQEEQHILIDLI 472
                .|.|.|.:.:|   |.||...|:.  .:...||...:..::.     |...::.|..:..:
Zfish  2653 VVTCKAQRDSSKKSP---SVRQISQLDG--VDDGTESDTSLANSDNHAMKLSNQTQKPHKSLSAV 2712

  Fly   473 --EDTLSE----------SEVTSSVSPTIEHMVVEEVVVEEN-----QLVDEADEILDSKQEFVI 520
              |.|.|.          |:: ||::...|.:...||:.:::     |:::.:..:...:|:.:|
Zfish  2713 PHEQTASNGLCLTFPSPLSDI-SSINCCFESVPNSEVLTDQDSFGLTQILESSSGVCGPQQDTLI 2776

  Fly   521 KKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTE 585
            ..|.|:|.|...|...:.::...|.:...  ::.|.:.::.:.:.||.:
Zfish  2777 NFVESKSSNPTFSTYGNDYQSLAEPETPL--ILERCDPLSPNAHFTELV---------------- 2823

  Fly   586 MIAETKLSDEVVIEPPLKDE-SDPKQTEVELPESKPAVNIPKSERILSAEVETT--SSPLVPPEC 647
                           |::|. .||:       |||.....|.|...:|:..:.|  .:..:..:.
Zfish  2824 ---------------PVQDSPCDPQ-------ESKELYLDPSSGHFVSSVDDATVYQNSHLQDDS 2866

  Fly   648 CTLESVSG--------PV----------LLETSLSTE--------EKSNENVETTPLKTEAAKED 686
            ..|..|:|        ||          |||.|.|.:        :.:..||...|::|.|.|..
Zfish  2867 LNLNQVNGIQFSLQQNPVPSTELLKPAPLLEPSSSVQVPFVAFPNQTTPTNVSLFPVQTSAGKTI 2931

  Fly   687 SPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPV----- 746
            .||                 :|.:.:                   |..|.||.:.|...|
Zfish  2932 LPP-----------------MESFRT-------------------KLNPHPEQRHPAPSVPGGAL 2960

  Fly   747 ----AETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAK 807
                |....|.|..:..|:.:.                |...|.|.:      |......:.|..
Zfish  2961 PYVPANIPQKPESMLSVPSATG----------------VPLGTYGPI------SGTVSVPLHPTY 3003

  Fly   808 QKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPS 872
            .:..|.:....:               |||.:.       |:|.|.|.|.:| |:.:|  .|||.
Zfish  3004 MQPIGSTTVGVV---------------SSSTSV-------TSQPSAQCQAMP-SAIQP--ASAPC 3043

  Fly   873 VISKTTSNQPAPKEEQHAAKKGLSDN--SPPSVLKAKEKAVSGFVECDAMFKAMDLANAQL---- 931
            ||:   .....|.:...|..:.:|.|  :|.|.::.:::.|:..:...|:....::....:
Zfish  3044 VIN---GYNTMPMQRDSAPGRTISINFSTPRSAVEPQQQLVTQALPGHAILTVKEVGGPNVDPTP 3105

  Fly   932 ------RLDE---KN-KKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGK------------TS 974
                  ||.:   || :....::||  ...|.....|.:....|..:||..            .:
Zfish  3106 HVLLVNRLGQIFVKNPESNTFQLPT--PNSPSFSCVTQIASLLQSNALSATLAAAGSLPAVAGAT 3168

  Fly   975 LRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRST--ICEAAKDLRSSSSSS 1037
            :.....:..:|.::.:::.:...|..|..|....|:.|||   |||:|  ..|..|..|:...||
Zfish  3169 IPTQVSHIVTPLVQTSNTITQLLATNNNEAAPPPPADVKK---PRRNTKSTGEKVKKPRTKKESS 3230

  Fly  1038 TPTREVAASS-------PVSTSSDSSSKRNGSK--------------RTTSDLDGGSK------L 1075
            ||.|..:.|:       .|.||||..::.:.::              :|.|::...|.      :
Zfish  3231 TPRRTKSTSTSGKQSTGQVITSSDKFNQLDSAQAIINQAMAGYYDPNKTVSNILPSSSPCNTKPV 3295

  Fly  1076 DQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANP----------LHDTLLQTAGKKRGRKEGK 1130
            .|.:.|: ....|||.:..|..|....:.|:.:..|          |.|.:   |.||  .|...
Zfish  3296 GQTQTTV-SPVLPETLLVKPEKKSSPPVTPEVAPRPKQVRMKRVSCLSDRI---ATKK--SKSDF 3354

  Fly  1131 ESLSRQNSLD-----SSSSASQGAPKKKALKSAEILSAALLETE-SSES---------------T 1174
            ..:.|.::|:     ||.|||:...:.|......||....|..| ||:|               |
Zfish  3355 LDMERPSALEEPHKSSSVSASRYGVRIKTPTVKGILDLDKLNEEPSSDSESARPGPWDRLSLPRT 3419

  Fly  1175 SSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREAD------ 1233
            ...:|.|.||......|...|.:..:....:           ||....:|::.|....|
Zfish  3420 GESNKPSTWDPANRSGLSDLNKYSGMLSCSD-----------DELSPSDGEEHVPLSRDQPHLRF 3473

  Fly  1234 --PEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTT----------------VLKELETGGG 1280
              ..:|.|:....::|...:.......::.........|                |:..:|...|
Zfish  3474 EIASDDGFSIEADSIEVAWSAVLEGVQEARAAAGLRLLTMCGMSGARVMGMLHDAVVYLVEQLQG 3538

  Fly  1281 VRRSHR-----IKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQL 1340
            .:|.||     .||      |||              |:.|....:..|.:|.:||....:.|..
Zfish  3539 AKRCHRHTFRFHKQ------ASQ--------------DDDLPVNPSGCARSEVYLRKSTFDMFNF 3583

  Fly  1341 LKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTN--- 1402
            |          .||.......|.:   |||                  |...|..:..|.|:
Zfish  3584 L----------ASQHRQLPDTDLY---DEE------------------EDEVLLKSTRRATSLEL 3617

  Fly  1403 ------KRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDR 1461
                  :..::.......|:|:...|.|:..:..|..||.::||.|.||.|...::|:..|. .:
Zfish  3618 PMAMRFRHLERTSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYD-GK 3681

  Fly  1462 NRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFD 1526
            ....|...:....|:|||..||.:|:|||||:||..::...|.|:..|..|:::.|..|||:|:|
Zfish  3682 GIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYD 3746

  Fly  1527 YQY-LRYGRDAQRCYCEAANCRGWI 1550
            |:: :....:...|.|.|..||.::
Zfish  3747 YKFPIEDASNKLGCNCGAKRCRRFL 3771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	16/131 (12%)
		AWS	1358..1410	CDD:197795	8/60 (13%)
		SET_SETD2	1410..1551	CDD:380949	46/142 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
kmt2bb	XP_002664717.2	PTZ00121	<466..919	CDD:173412
		rne	<710..817	CDD:236766
		zf-CXXC	1407..1452	CDD:366873
		PHD1_KMT2B	1654..1700	CDD:277064
		PHD2_KMT2B	1702..1750	CDD:277066
		PHD3_KMT2B	1787..1843	CDD:277068
		Bromo_ALL-1	1857..1979	CDD:99925
		ePHD_KMT2A_like	2081..2185	CDD:277134
		FYRN	2232..2279	CDD:461787
		Atrophin-1	<2876..>3077	CDD:460830	54/286 (19%)
		PHA03247	<2945..3337	CDD:223021	87/447 (19%)
		FYRC	3468..3550	CDD:461788	10/81 (12%)
		SET_KMT2A_2B	3619..3772	CDD:380947	46/154 (30%)