DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and ash1l

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_005159540.1 Gene:ash1l / 563799 ZFINID:ZDB-GENE-030131-6101 Length:2988 Species:Danio rerio


Alignment Length:3151 Identity:571/3151 - (18%)
Similarity:935/3151 - (29%) Gaps:1246/3151 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SGPPSNPSPVASRGRGRGRPPKVALSALGNTP-PHINPSLKHADAEASPTAPEDQDSGQSECRRS 67
            :|......|..:||..:.     |.:...:|| |.:.|:..:.....:..||..:...:..|:..
Zfish   142 NGKEGEKKPSVNRGASQS-----AAAPAASTPSPSLPPASINTVTPVNGNAPAKRGPPKLACKSE 201

  Fly    68 SRKKIIKFDVRDLLNKNR--KAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAAS----- 125
            .     |.||:.:.:..:  ..|:...|::..|:....|.....:|.:.|......:|.|     
Zfish   202 G-----KADVKSVASSEKPLNLHRPTTESKSHSSGKKNHVPQTNSAPAPSPPAVPPAATSQQDPK 261

  Fly   126 ----------------------ASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSL 168
                                  .||..|.:....:.::.....|...|.|.|.::  .|.|..| 
Zfish   262 IDGILKTPQCNFLEGQKEQERGISSWGTPTVTEKLAQLIATCPPSKCPKPKARKV--SPAPAHS- 323

  Fly   169 IVAQVTSEPSAVGGAHPVQTMA-----------GLPPVTPRKRGRPRKSQLADAAI--------- 213
                 :|.|.......|.:.||           ..||...|..|||..|:..|:.:         
Zfish   324 -----SSPPLISNLQRPERAMANRNTYSRAVHLAQPPPVSRPPGRPYGSKNKDSILEKFSGTSKK 383

  Fly   214 ----------------IPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKR 262
                            ..|....:.|.:.:..|:||::|.|:|.....|   .|.:|:|      
Zfish   384 EESDGLSKGVSGSSSTTTTTTSSALSQNSSRLTTTTSTNESTDINNTDG---MKSQSRL------ 439

  Fly   263 LKLGGRL---ESSDSGNSPSSSSPEVEPPALQDEN-----AMDERPKQEQNLSRMVD-AEENSDS 318
                |..   .||.:.:.|.|||..||.......|     ::..|||...  ||:.| :|::.:.
Zfish   440 ----GHCPSHSSSAAASPPFSSSSSVERIGSTSCNIGLPGSLTSRPKASP--SRIEDFSEKDKER 498

  Fly   319 DSQIIFIEIETESPK-----------GEEEQEE--------------GRPVEVEPQDLIDIDMEL 358
            |.     |.:|:||:           |:::.:|              ..||:..|.       :.
Zfish   499 DR-----EKDTDSPRDLSKGITPAITGKQDAKERCSLSAPRNDRGKSSSPVKRSPN-------QE 551

  Fly   359 AKQEPTPDPEEDLD-EIMVEVLSG----PPSLWSADDEAEEEEDATVQRATPPGKEPAADSCSSA 418
            ::....|.|.|... .|.....||    ||.|  .||..          |..|......||....
Zfish   552 SRVSGVPSPAESTKCTISPSYPSGASRSPPPL--CDDTG----------AISPASPSEQDSKPLK 604

  Fly   419 PRRSRRSAPLSGSSRQGKTLEE----------------TFAEIAAESSKQILEAEESQDQEEQHI 467
            .||.||.......||..|:|.|                :|:....||.:|.|  .:|....|...
Zfish   605 KRRGRRPRWTKAVSRTHKSLHESPSNHQQIPTPMPSGLSFSSPIRESVEQPL--SDSYTSPEDSD 667

  Fly   468 LID----------------------LIEDTLSESEVTSSV-------SPTIEHMVVE-------- 495
            :.|                      ...:.|:.|:..||:       .|.:.|..|:        
Zfish   668 IFDSSPKKRGRPKTKMPRLDAPAHGCTPNKLAPSKSFSSLLKSKEEQDPPVLHPEVDFNPPKMMA 732

  Fly   496 ----------EVVVEENQ---LVDEADEILDSKQEF--------VIKKVFSESDNIAA-----SL 534
                      ..:.:|.|   |..|:.|....::.|        ::|.:..:.:.:..     .|
Zfish   733 RKRGRPKRSPPTLPQETQPPTLAPESGEASVGEKPFRNKGNGQLIMKTIIGKINKMKTVKRKRLL 797

  Fly   535 NKDIFEPKVETKATCGE--------VVPRPEMVTEDVYITEGIAAT----------LEKSAVV-- 579
            ::.:..||...:..|..        |..:|:.:|       .:|||          :.|...:  
Zfish   798 SQILLGPKPAEEQECSRSSGPTGSPVATKPQSLT-------SLAATFGGKLGPQINVSKKGTIYM 855

  Fly   580 -----TKPTTEMIAETKLSDEVVIEPP----LKDESDPKQTEVELPESKPAVNIPKSERILSAEV 635
                 .||.|    .|..|......||    ..:.|.|...:|:..:::|. .:|.||...|..:
Zfish   856 GKRRGRKPKT----STNPSPGAPTPPPEPFLSPNTSSPHHHQVQALQNQPH-QLPPSEVFPSPSL 915

  Fly   636 ETTSSPLVP-----------------PECC--------------TLESVSGPVLLETSLSTEEKS 669
            ..:|....|                 |.|.              |..:.|...:...:.||...|
Zfish   916 SQSSGGQSPISDASFVEPGSVHFSSHPHCSHSHQVHHSFSFPPPTFSAPSARSVASAATSTAHPS 980

  Fly   670 NEN----------------------------VETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFL 706
            .:.                            :.|:|......||.:|....|..:..:....:.:
Zfish   981 QKKSSCRGYHHHHHHYRQHYHYRKFSPPRPLLPTSPAPLSELKEATPSPVSESHSEETVPSDSGI 1045

  Fly   707 LEDYESNQEQ------------VAEDEMMKCN-----------------NQKGQKQTPLPEMKEP 742
            ..|..|..::            |...:.|...                 :.:|:::.....:.|.
Zfish  1046 GTDNNSTSDRGEKAGSANGLPGVGVSQGMAGGLLMPGVIGPGIGTGIGLSSRGRRRHSSSVLLER 1110

  Fly   743 EKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAK 807
            ..|....:.  .:|..:|.||.|| .......|..||                .|..|      |
Zfish  1111 PSPTPSPLG--VRASPDPRRSHPA-APSSALVGHKEK----------------HKHKC------K 1150

  Fly   808 QKESGKSAKEAILKKETEKEKSSAKLDS--SSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQE-- 868
            ::..|..:.:.:.:::.:::|...:|.|  ..|:.|    .|..:...||..:..|...|...  
Zfish  1151 RRGHGCPSYDKLKRQKRKRKKKYLQLRSRRQDPDFL----ADLDEICVQLSDIRISHRTPTLRLG 1211

  Fly   869 --------SAPSVISKTTSNQPAPKEEQHAAKKGLSDNSP----------PSVLKAKEKAVSGFV 915
                    :.|...|...|.:|       ::..|...|.|          |::.:..   .||:.
Zfish  1212 SSIGLGAGAGPGRGSGLGSTRP-------SSSLGGGTNPPPHHYLHRDLLPTIFRIN---FSGYY 1266

  Fly   916 E------CDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKV-EPPTAVP-VPGQKKSLSGK 972
            .      ||:             |....|..|||   |...|||: |..:.|| |||....||. 
Zfish  1267 SPHPAYPCDS-------------LHYVRKPDLKK---KRGRPPKLRESISEVPFVPGLGFPLSS- 1314

  Fly   973 TSLRRNTVYEDSPNLERNSSP---------SSDSA-------QANTSAGK--------------- 1006
                 ...|..|..:..:|:|         :..||       ||..|...               
Zfish  1315 -----GGFYHPSYGVPYSSTPLGLGYYRGYTPPSALYPHPHHQAPHSGPSHHVHSPSFPPPPPPS 1374

  Fly  1007 -----------LKPSKVKKK---------INPRRSTI---------------------------- 1023
                       |.|||..||         :...||::                            
Zfish  1375 YVHHHHPSHLLLNPSKFHKKKHKLLRQEYLGGGRSSMLYPAMSSELSFGWHHKHKHRHKHRDRCG 1439

  Fly  1024 ---------------------------------------CEAAKDLRSSSSSSTPTREVAASSPV 1049
                                                   |...:|  .|:.|.|..:..:|:|| 
Zfish  1440 EEEGDDGGGVLGGIGGRGVGGEGLGAGRGERGSVESLQHCRFGRD--GSADSRTNKQSASANSP- 1501

  Fly  1050 STSSDSSSKRNGSKRTTSDLDGGSKLD---------------------------QRRYTI----- 1082
            |:||.||::|...|..:....|.|:|.                           .|..:.     
Zfish  1502 SSSSTSSAERYKRKEASMSCLGPSRLSLGTASRGHHPVDSWFRMGSSDTDYSKLSRNQSFSGSGA 1566

  Fly  1083 -----------CEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSR- 1135
                       |.:...|.|.. |:.:...|.|....|:.|..|.|:.:..|:|......|||| 
Zfish  1567 FSEGHVQNPVDCSESDEEDAAS-PIEEPEISHHTNLFASALSRTSLKGSRSKKGGPLESPSLSRL 1630

  Fly  1136 -----------------------QNSLDSSS--SASQG--------------------------- 1148
                                   ||.:..||  ..|:|                           
Zfish  1631 DRTVRRDRSTSSEKREIGNVSSLQNRVGQSSVPDVSEGLHHRHHHHHHPPLSLSHAASCLPHCTL 1695

  Fly  1149 ----------------------------------------APKKKALKSAEILSAALLETES--- 1170
                                                    .||...|...:||.|..|:.::   
Zfish  1696 DQPGNTAPLRPSSRQASPSTCSSQPACCLDSPPSHLSHRPPPKNNLLHVNKILRAKKLQRQARTG 1760

  Fly  1171 ------------------SESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLL------ 1211
                              |...:...:.|..|....||...|....: |..:.|.:..:      
Zfish  1761 NNMVKKRGPGRPRKNPLPSPPATPPPQTSEQDNHPLPERHRATALWE-ADTVVDAIEAVVQNQRK 1824

  Fly  1212 ---KR----------DKVDEDQRKEGQ--DEVKREADPEEDEFAQR----VANMET--------- 1248
               ||          |:.:||..:|.|  ||.:.|.:.:|.:.|.|    ::.:.|         
Zfish  1825 KGRKRKHWERETEGGDEEEEDAEEERQVEDEEEEEDEEQEQQSAAREDDVMSRVRTEGSRQWLTQ 1889

  Fly  1249 ----------------------PATT-PTPSPTQSNPEDSASTTTVLKELETGG--------GVR 1282
                                  |||: |||:|:.::..:........|:.:..|        ...
Zfish  1890 EEVHCFRSALEGKPDGSPERPGPATSEPTPNPSVTSQREKRVARPPKKKFQKAGLYSDVYKTDDP 1954

  Fly  1283 RSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAI-------------NEQFLRSEG 1334
            ||..::.|.:....:.|.....:..|||.:.:.|.:    :.|             ::|..:...
Zfish  1955 RSQLLQLKKEKLEYTPGEHDYGLLPAPIHVGKYLRQ----KRIDFQLPYDILWLWKHDQLYKRPD 2015

  Fly  1335 LNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGA 1398
            :..::.::.|.|...:.:|...| ..|:|.|..|...:|   |...|:|||:..||.| .|....
Zfish  2016 VPLYKKIRSNVYVDVKPLSGYEA-TTCNCRLPDDSSEKG---CQDDCLNRMIYAECSPSTCPCSD 2076

  Fly  1399 RCTNKRFQQHQCWPC-RVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDR- 1461
            :|.|:|.|:|:...| ..||.|.||.||..:..:..|:||:||:|||:..:||  |:::.|..| 
Zfish  2077 QCDNQRIQKHEWVQCLERFRAEGKGWGIRTKQPLRAGQFIIEYLGEVVSEQEF--RKYIASDCRL 2139

  Fly  1462 --------------------------NRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQK 1500
                                      :..:|.:.|....|||:...||.:|::||||:||.|.||
Zfish  2140 HQVKIPMLGENKKQIGVSRMMEQYFSHSGHYCLNLDSGMVIDSYRMGNEARFVNHSCEPNCEMQK 2204

  Fly  1501 WTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR-CYCEAANCRGWIGGEPDSDEGEQLDE 1564
            |:|||..|||.|::|.|..|.|:|:||.:..:..:.|: |.|.:..|||.|||            
Zfish  2205 WSVNGVYRIGLFALKDINSGTELTYDYNFHSFNTEEQQVCKCGSEGCRGIIGG------------ 2257

  Fly  1565 ESDSDAEMDEEELEAEPEEGQPRKSA----KAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGR 1625
                         :::...|.|.|.|    .|:...:||.|      ||.|...|.::.|     
Zfish  2258 -------------KSKRINGLPAKGAGSGGGARRLGRLKEK------RKSKHSLKKREEE----- 2298

  Fly  1626 WLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLL 1690
                     ||.:.|        .:|.:|..|             :.|::          |..:|
Zfish  2299 ---------SSDSSK--------FYQHLLMKP-------------MSNRE----------RNFVL 2323

  Fly  1691 KTRLALLR-----------VLTHGELPCRRLFLDYHGLRLLHAW---ISENGNDDQLREALLDTL 1741
            |.|:.|||           :...||..     .:..||.|...|   |.::||   ::..:..|.
Zfish  2324 KHRVFLLRNWEKMREKQELLKREGERE-----RENSGLSLYTRWGGVIRDDGN---IKSDVFLTQ 2380

  Fly  1742 ESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQ-------ALPE 1799
            .|       .|..||..::.:|  .:.|:...|....:.|.:.|.:..::..::       |.| 
Zfish  2381 FS-------ALQTSRSVRTRRL--AAAEENTEVTRTARLAHIFKEICDMITSYKDSSGQPLAAP- 2435

  Fly  1800 IFRIPKRERIEQMKEHERE------ADRQQKHVHASTALEDQRERESSNDRFRQDRFRRDTTSSR 1858
            :..:|.|:|..|..|...:      .|:|....|..|           ::.|..|..:       
Zfish  2436 LLNLPSRKRNTQYYEKVTDPLDLSTIDKQILSGHYKT-----------DEAFDADMLK------- 2482

  Fly  1859 IGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNR---RRSDIGPPSEQRRTLSKELRRSLF-- 1918
                                         :.||..:   |:|.:|      |.:.: ||::.:  
Zfish  2483 -----------------------------VFRNAEKYYGRKSAVG------RDVCR-LRKAYYGA 2511

  Fly  1919 --ERKVALDEAERRVCTE----DRLEHE-------------------LRC-----EFFGADINTD 1953
              |..|.:||......:|    |.||.:                   :||     :..|..|..:
Zfish  2512 RHEAAVQIDEIVGETASEADSSDSLERDHAHHHHHDGGGSHDKDDDVIRCICGMYKDEGLMIQCE 2576

  Fly  1954 PKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLSPDIDVGQGATDVEYKLPPGVDPLP--- 2015
            ...:          |.:.|.:.:.|                       |||:.|....||.|   
Zfish  2577 KCMV----------WQHCDCMRLEA-----------------------DVEHYLCEQCDPRPVDR 2608

  Fly  2016 -------PAWNWQVTSDGDIYY----------------YNLRE--RISQWEPPSPEQRLQTLLEE 2055
                   |::    ...|.|||                |.:|:  |.::.:|.....||.:.:..
Zfish  2609 EVPMVPQPSY----AQSGFIYYICLLRDDLLLHQGDCVYLMRDSRRTTEGQPVRQSYRLLSHINR 2669

  Fly  2056 NTTQ-----------------------QPLHELQIDPA--VLENELIQVD-------TDYVGSLS 2088
            :...                       :| ||....|:  ...|||.:|.       ...||:..
Zfish  2670 DKLDIFRIEKLWKNEKGERFAFGHHYFRP-HETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCC 2733

  Fly  2089 AKSLAQYIEAK---VRERR----DLRRSKLVSI----------------------RLISPRRDED 2124
            ...|..|.:.:   |:|:.    |.|..|...:                      :.::|:||..
Zfish  2734 VLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFNHFPKRLTPKRDFS 2798

  Fly  2125 RLYNQLESRKYKENKEKIRRRKELYR-----------RRKIEVLPDAVDE--------------- 2163
            ..|   ....||.|..:...:.|..:           .|.....|...||               
Zfish  2799 PHY---VPDNYKRNGGRSAWKSERPKDEEPSSSSTSCERLSSSFPREGDEDGGRGAEGDAEAAQE 2860

  Fly  2164 ---IPVPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGKAVAQ-PT 2224
               .|.|.::.|:          |::.|..|..|.|||...................||.|| |.
Zfish  2861 GSSTPRPQRSSPL----------ESRTAGEEDEAEEEEDRERRREMQEEEEEEGCREKAGAQEPI 2915

  Fly  2225 GLGTVGK-RKLPMPPSVTVKKHRQEQRSKKV 2254
            ....... ...|:.|::..::..|.:|..|:
Zfish  2916 DAQCSSSISSSPLHPAILGRREAQRERLNKI 2946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 19/52 (37%)
SET 1414..1533 CDD:214614 52/145 (36%)
PostSET 1535..1551 CDD:214703 6/16 (38%)
WW 2014..2043 CDD:278809 9/56 (16%)
SRI 2270..2348 CDD:285448
ash1lXP_005159540.1 CytochromB561_N <529..>674 CDD:286826 35/165 (21%)
AWS 2037..2088 CDD:197795 20/54 (37%)
SET 2091..2238 CDD:214614 53/148 (36%)
COG5076 2281..>2500 CDD:227408 59/340 (17%)
Bromo_ASH1 2408..2513 CDD:99955 23/159 (14%)
PHD_ASH1L 2559..2601 CDD:277023 11/74 (15%)
BAH_polybromo 2633..2772 CDD:240068 23/139 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593859
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.880

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