DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and kmt2ca

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_005162602.1 Gene:kmt2ca / 560793 ZFINID:ZDB-GENE-080520-3 Length:4958 Species:Danio rerio


Alignment Length:1977 Identity:368/1977 - (18%)
Similarity:617/1977 - (31%) Gaps:689/1977 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 GRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNK 83
            |..|..|.||||...|...........|||......|.|...|.:..:              :.|
Zfish  3225 GAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKNVTEQQSVVQKQLEQ--------------IRK 3275

  Fly    84 NRKAHKIQIEA-RIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLP 147
            .:|.|...||. |:.........|:|......:|...                        |..|
Zfish  3276 QQKEHAELIEEYRVKQQQQQQRLQTGMMGPMKTMPVM------------------------QGQP 3316

  Fly   148 P---PPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQT--MAG--LPPVTPRKRGRPRK 205
            |   |..||.|..:.....|.|.....:.:..|| :.|.||..|  ::|  :||..|.:...|..
Zfish  3317 PGMMPVGPPMAQPMMGSMLPMQHPHFGKPSRMPS-MPGWHPGTTGPISGPRMPPHLPPQMALPNP 3380

  Fly   206 SQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLE 270
            :|...|. .|..|.|              ......||.:.|                        
Zfish  3381 AQPLQAQ-PPAPIAP--------------GGKPGQSGTVAG------------------------ 3406

  Fly   271 SSDSGNSPSSSSPEVEPPALQDENAMDE-----------RPKQE-QNLSRMVDAE---------- 313
              .:|...|||:|.|:   ..|.|...|           |.:|| |.:..|.:.|          
Zfish  3407 --GNGGGASSSAPHVK---FDDNNPFSEGFQERERRERLREQQEKQRVQLMQEVERQRALQRLEL 3466

  Fly   314 ----------ENSDSDSQIIFIEIE-----TESPKGEEEQEEGRPVEVE----PQDLI---DIDM 356
                      .|.||.:|:.|...:     .::|:.:::|::..|:..:    |.|.:   ...|
Zfish  3467 EQQSLGLGPDNNGDSLAQMPFYNSDLSQEFMQTPRPQQQQQQLGPLFPQQGNVPCDFVGQGSAFM 3531

  Fly   357 ELAKQEPTP-----DPEEDLDEIMVEVLSGP------PSL--WSADDEAEEEEDATVQRATPP-- 406
            :..:..|.|     .||           .||      |.:  :||.            |..||  
Zfish  3532 QGGEHRPIPGNGSFGPE-----------MGPNFQPKNPMMPGFSAG------------RPRPPGF 3573

  Fly   407 ---------GKEPAADSCSSAPRRSRRSAPL----SGSSRQGKTLEETFAE-IAAESSKQILEAE 457
                     |.||::...:|       :.||    .||   |::|.:.::. |..|..|:....:
Zfish  3574 GGTRMPHHGGGEPSSFGMNS-------TTPLPPNFPGS---GQSLIQLYSNIIPEEKGKKKRSRK 3628

  Fly   458 ESQDQEEQHI-------------LIDLIEDT------------------------------LSES 479
            :.:|.:...:             |...:.||                              .||.
Zfish  3629 KKRDDDADSVKTPSTPHSDITAPLTPCVSDTSSTPTRSVAIMGDQDTSEFSNPLGSMTGLPSSEL 3693

  Fly   480 EVT----------SSVSPTIEHMVVEEVVVE--ENQLVDEAD---EILDSKQEFVIKKVFSESDN 529
            |::          :|||...||.::.::.:|  |:.:..:|:   .:..|.:|..|.|  :|..|
Zfish  3694 EISLSGSTPLRRQTSVSSEAEHGLLHDIKLEKLESSVCQKAEGEAPVGHSAEETGIIK--TEEVN 3756

  Fly   530 IAASLNKDIFEPKVETKATCGEVV-----------PRP-----------EMVTEDVYITEGIAAT 572
            ...|.|:....|...||...|..:           |.|           .:.:||    ||:.  
Zfish  3757 EIISHNRTSQSPAQSTKGEPGNELLKHLLKNKNTPPPPSAPLMHQMSNESLRSED----EGLN-- 3815

  Fly   573 LEKSAVVTKPTTEMIA--ETKLSDEVVIEPPLKDESDPKQTEVELPES---KPAVNIPKSER--- 629
             :....:.:.:|:.::  .::|:|   :||.|.::...||.....|::   ||.....|.::   
Zfish  3816 -DSKGYLRQDSTDSMSGINSRLTD---LEPSLPEQCKKKQRNKRTPKNGVDKPPSRWKKRKKDED 3876

  Fly   630 ------------ILSAEVETTSSPLVPPECCTLESV---------SGPVLLETSLSTEEKS---- 669
                        :...:.:.:..||:.|    |..|         ||.:..|..||....|    
Zfish  3877 ERQAIYTNTDTLMTQLKQQLSMLPLMEP----LIGVNFAHFPPYGSGQLNGENRLSGSFGSASLD 3937

  Fly   670 ------------NENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEM 722
                        ..|:...|....:.....||.|.::           ||..:.:.:|...:.|:
Zfish  3938 GVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPVARQK-----------LLNGFATAEELARKAEV 3991

  Fly   723 MKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKG 787
            | .:...||||. ....|..:..:..|:::..|.::.||                          
Zfish  3992 M-VSKSLGQKQL-TASFKAEDDLLGHTITQGPKTVDVPA-------------------------- 4028

  Fly   788 TVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWS 852
            ::|             ||....:.....:|..:.::|    ..:.:.||||.::  .|.:.::: 
Zfish  4029 SLP-------------TPPHNNQEDLRGQEHCIDRDT----PDSFVPSSSPESV--VGMEISRY- 4073

  Fly   853 PQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVEC 917
            |.|..:.:   :||..:...||       |....:...|::......|||...|     |.|.:.
Zfish  4074 PDLSRVKE---EPPSPAVSPVI-------PILDCKGSEARRWEVKTEPPSNFFA-----SQFGQL 4123

  Fly   918 DAMFKAMDLANAQLRLDEKNKKKLKKVPTK------VEAPPKVEPPTAVPVPGQKKS---LSGKT 973
            ....:. ||....:.|:......::.|.:.      |..|...| .|..|.|..:.|   |||..
Zfish  4124 STCLRT-DLVPVSITLNPVAAMNIQGVVSALANMLCVSIPGNYE-VTRSPGPEHRSSIDMLSGLK 4186

  Fly   974 SLRRNTVYEDSPNLERNSSP------SSDSAQANTSAGKLKPSKVKKKINPRRSTIC-------- 1024
            .....:::...|.:..:..|      |..:|......|::..|.:..|  |:..:.|        
Zfish  4187 VPHPTSLFHQQPGMRLHRPPLPHQTFSDGTAMVRRDYGQMHGSSLGSK--PQWCSHCRVVVLGNG 4249

  Fly  1025 --EAAKDLRSSS---------------------SSSTPTREVAASSPVSTSSDSSSKRNGSK--- 1063
              ::.|:|..:.                     |:|..::.:.........|:|..|:|.:|   
Zfish  4250 VRKSTKELPMNKLGHGGAVESLVFCSNNCLVLYSASMQSKLLDGKPNFPPPSESGDKQNPTKVLH 4314

  Fly  1064 ---RTTSDLD------------------------------GGSKLDQRRYTICEDRQPETAIP-- 1093
               ...||||                              |..|.|..:.|:....:|.....  
Zfish  4315 QYNNNISDLDVHCLAQLQPKQSPPPTPIISFPSITSEMLRGDCKPDTLKVTVKLKPRPRAVHNGG 4379

  Fly  1094 -----------VPLTKRRFSMH---PKASAN-PLH---DTLLQTAGKKRGRKEGKESLSRQNSLD 1140
                       ..|..||:|:.   ||.:.: |:.   |.||:..|.....:...:.:.|.....
Zfish  4380 DEPRYLSGKRWKALRWRRWSVQIIVPKGNYHLPVEEEIDALLKKLGTSLRPEPMPKDMRRCCFCH 4444

  Fly  1141 SSSSASQGAPKKKALKSAEI---LSAALLETESSESTSSGSKMS-------------RWDVQTSP 1189
            .........|.:......::   |:.||..||..| |.:|:.::             .:..||..
Zfish  4445 EEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYE-TQAGALINVELALRRGLSVRCAYCQQTGA 4508

  Fly  1190 -----ELEAANPFGDI------AKFIED-----------GVNLL-----------------KRDK 1215
                 .|...|.:...      ..|.:|           |.:|:                 :|..
Zfish  4509 TSGCHRLRCTNAYHFTCALKAQCTFFKDKTMLCHLHRPRGTSLIGGGLLGTEHELRCFAVFRRVY 4573

  Fly  1216 VDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETG-- 1278
            |..|:.::....::|    .|.|...||.::...|.      .|..|:...:..::......|  
Zfish  4574 VQRDESRQIASIIQR----GEREHTFRVGSLVLHAV------GQLLPQQMLAFHSMTAIFPVGYE 4628

  Fly  1279 ---------GGVRRSH---RIKQKPQGPR----------------ASQGRGVASVALAPISMDEQ 1315
                     .|.||.|   .|.:....|.                .|..:||....|.|::    
Zfish  4629 ASRIYWSMRHGNRRCHYVCSINENDGSPEFVIRVVEQGYDDLILTGSSPKGVWDKVLEPVA---- 4689

  Fly  1316 LAELANIEAINEQ-FLR-----SEGLNTFQLLKENFYR----------CARQVSQ--ENAEMQCD 1362
                   |..||. |||     .:|.:.|.|......|          |.|...:  .|..||..
Zfish  4690 -------ERRNETGFLRLFPVYLKGEDLFGLTVSAVTRIVESLPGVEACERYTFRYGRNPLMQLP 4747

  Fly  1363 CFLTGDEEAQGHLSCGAGC----------INRMLM------------------IECG--PLCSNG 1397
            ..:.           .:||          |.|.::                  .|.|  |...:.
Zfish  4748 LAIN-----------PSGCARSEPKACTHIKRFVLRPHTLTSTSKALQSPGNPAEIGVPPYSKHF 4801

  Fly  1398 ARCTNKRFQQHQC-WPCRVF--RTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSK 1459
            ....:.::::... |...|:  |:..:|.|:.|...|.....::||:|.:|.||...|::.:| :
Zfish  4802 VHSKSAQYRRMNAEWKSNVYLARSRIQGLGLYAARDIEKYTMVIEYIGTIIRSEVANRKEKMY-E 4865

  Fly  1460 DRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEIT 1524
            .:||..|...:..|.|||||..|..:|||||||.||..|:...:....:|...|.:.||.|||:.
Zfish  4866 AQNRGVYMFRIDSEHVIDATITGGPARYINHSCAPNCITEVVALERGHKIIISSNRRIQRGEELC 4930

  Fly  1525 FDYQY-LRYGRDAQRCYCEAANCRGWI 1550
            :||:: |...:....|:|.|.|||.|:
Zfish  4931 YDYKFDLEDDQHKIPCHCGAVNCRKWM 4957

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 9/81 (11%)
SET 1414..1533 CDD:214614 44/121 (36%)
PostSET 1535..1551 CDD:214703 7/16 (44%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
kmt2caXP_005162602.1 PHD_SF 263..346 CDD:304600
PHD1_KMT2C_like 360..404 CDD:276984
PHD2_KMT2C 406..451 CDD:277069
PHD_SF 484..535 CDD:304600
PHD4_KMT2C 973..1029 CDD:277071
PHD5_KMT2C_like 1030..1076 CDD:276988
PHD_SF 1108..1157 CDD:304600
HMG 1707..1760 CDD:197700
CITED 2586..>2683 CDD:282356
ePHD2_KMT2C 4440..4544 CDD:277167 15/104 (14%)
FYRN 4599..4649 CDD:283589 8/55 (15%)
FYRC 4656..4736 CDD:283590 18/90 (20%)
SET 4819..4940 CDD:214614 44/121 (36%)
SET <4820..4958 CDD:225491 51/139 (37%)
PostSET 4942..4958 CDD:214703 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593896
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.870

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