DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and KMT2E

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_061152.3	Gene:	KMT2E / 55904	HGNCID:	18541	Length:	1858	Species:	Homo sapiens

Alignment Length:	1540	Identity:	295/1540 - (19%)
Similarity:	502/1540 - (32%)	Gaps:	539/1540 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1037 STPT-REVAASSPVSTSSDSSSKRNGSKRT------TSDLDGGSKLDQRRYTIC----------- 1083
            :||. .|.::::.:|||.|.|   .|:..|      |.| ||        |.||
Human    93 TTPNFDETSSATTISTSEDGS---YGTDVTRCICGFTHD-DG--------YMICCDKCSVWQHID 145

  Fly  1084 ---EDRQ--PETAI-----PVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNS 1138
               .|||  |:|.:     |..|.|.|             ..|||.      ||       |:|.
Human   146 CMGIDRQHIPDTYLCERCQPRNLDKER-------------AVLLQR------RK-------RENM 184

  Fly  1139 LDSSSSASQGAPKKKALKSAEI---LSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDI 1200
            .|..:||::...        |:   |..|...|.:| .|.:.|::|:
Human   185 SDGDTSATESGD--------EVPVELYTAFQHTPTS-ITLTASRVSK------------------ 222

  Fly  1201 AKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDS 1265
                   ||       |:.::|.|:.|             |.::..:
Human   223 -------VN-------DKRRKKSGEKE-------------QHISKCK------------------ 242

  Fly  1266 ASTTTVLKELETGGGVRRSHRIK-QKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQF 1329
                ...:|     |.|:|.|:| ..|:...:|.|............||..      .||.|.|:
Human   243 ----KAFRE-----GSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRY------EEANNNQY 292

  Fly  1330 LRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLC 1394
              |||      ::....|.|.::...|.:.:.:                ...:|...::...|:.
Human   293 --SEG------VQREAQRIALRLGNGNDKKEMN----------------KSDLNTNNLLFKPPVE 333

  Fly  1395 SNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSK 1459
            |:        .|:::    ::.::.|.         :||...|:||.|:.:..|:||...:.:.:
Human   334 SH--------IQKNK----KILKSAKD---------LPPDALIIEYRGKFMLREQFEANGYFFKR 377

  Fly  1460 DRNRHYYFMALRG-EAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEI 1523
            ......::....| |..:||.:.||.:|:|..||.||||.:....:|.:.:..:|:..|..|.||
Human   378 PYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEI 442

  Fly  1524 T----FDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEG 1584
            |    |||...:|..|   |.|...|           .|...|...|:| .|......|...::|
Human   443 TIAFDFDYGNCKYKVD---CACLKEN-----------PECPVLKRSSES-MENINSGYETRRKKG 492

  Fly  1585 QPRKSAKAKAKSKLKAKLPL----ATGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEK----- 1640
            :..|.. :|.|......:.|    .|.:.:..:||.        |.|.|.....|::.|.
Human   493 KKDKDI-SKEKDTQNQNITLDCEGTTNKMKSPETKQ--------RKLSPLRLSVSNNQEPDFIDD 548

  Fly  1641 -PPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRV---LT 1701
             ..|.|..|:.: |..:..:.|....:.|...|.:.....|:|...|.|  :...||.|:   .|
Human   549 IEEKTPISNEVE-MESEEQIAERKRKMTREERKMEAILQAFARLEKREK--RREQALERISTAKT 610

  Fly  1702 HGELPCRRLFLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIP---NRTMLSDS-------- 1755
            ..:..|:...:           :|:   .:.::|...:...|.|.|   |||....|
Human   611 EVKTECKDTQI-----------VSD---AEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHI 661

  Fly  1756 ----RVYQSVQLWS---------------NSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIF 1801
                |.:::|.:.|               |.:|..:..:..|.:.||     |.:.....:|.:.
Human   662 GQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETAL-----AEIITETEVPALN 721

  Fly  1802 RIPKRERIEQMKEH---EREADRQQKHVHASTALEDQRERESSNDRFRQDRFRRDTTSSRIGKPI 1863
            :.|  .:..:.|:|   |..:::.:|....|..|.:                          :|:
Human   722 KCP--TKYPKTKKHLVNEWLSEKNEKTGKPSDGLSE--------------------------RPL 758

  Fly  1864 RMSGNNTICTITTQQKGSNGAPDGMT-------------------RNDNRRRSDIGPPSEQRRTL 1909
            |::.:..:  :.||   .|..| |:|                   .::.|||.:   |:|.....
Human   759 RITTDPEV--LATQ---LNSLP-GLTYSPHVYSTPKHYIRFTSPFLSEKRRRKE---PTENISGS 814

  Fly  1910 SKE--LRRSLFERKVALDEAERRVCTEDRLEHELR------------CEFFGADINTDPKQLPFY 1960
            .|:  |:::|.|...|:.......|.|......:.            |..  .|:.|..|:..||
Human   815 CKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDSCSL--PDLTTPLKKRRFY 877

  Fly  1961 QKTDTNEWFNSDDVPVPAPPRTELLTKALLSPDIDVGQGATDVEYKLPPGV-------------- 2011
            |..|:  .::....|.|:|..|.  |...::|        .|..:..||.:
Human   878 QLLDS--VYSETSTPTPSPYATP--THTDITP--------MDPSFATPPRIKSDDETCRNGYKPI 930

  Fly  2012 -DPLPPAWNWQVT--SDGDIYYYNLRERISQWEPPSPEQRLQTLLEE-----------------N 2056
             .|:.|     ||  :.|:..::   |.||..| .|||.:.:|..:|                 |
Human   931 YSPVTP-----VTPGTPGNTMHF---ENISSPE-SSPEIKRRTYSQEGYDRSSTMLTLGPFRNSN 986

  Fly  2057 TTQ----------------------------QPLHELQ-----IDPAVLENEL-----------I 2077
            .|:                            :|:.:||     ::|..|...|           .
Human   987 LTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDRAEPNS 1051

  Fly  2078 QVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISP----------RRDEDRLYNQLES 2132
            |:|:.:.|  .....:.::  |..:|..:..|...::|.::|          |..|.:...|.::
Human  1052 QLDSTHSG--RGTMYSSWV--KSPDRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQDDT 1112

  Fly  2133 R-KYKENKEKIRRRKELYRRRKIEVLPDAVDEIPVPGKALPIQPYLFSSDEEETKVAAIE----Q 2192
            | .:.|..........|     :......|::..:.|...|..|      .::.||:.:|    |
Human  1113 RGMFMETTVFCTSEDGL-----VSGFGRTVNDNLIDGNCTPQNP------PQKKKVSLLEYRKRQ 1166

  Fly  2193 PAAEEEQDSLNMAP--STSHAAMAAL-----GKAVAQPTGLGTVGKRKLPMPPSVTVKKHRQEQR 2250
            ..|.:........|  |.|..|..:|     |.|.:...|........||:|...||.....|:
Human  1167 REARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEE- 1230

  Fly  2251 SKKVKSSQSPLTATSAREAHEKFRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHI 2315
                .|:..|:...:|.|.:|.   |:....:..:...|:.|.....:.||            |.
Human  1231 ----TSNNCPVKDATASEKNEP---EVQWTASTSVEQVRERSYQRALLLSD------------HR 1276

  Fly  2316 TTKEMRYCEVSGNP---LSCTESVKHKSYDFINQYMRQ---KGPV 2354
            ..|:      ||..   :||:.|....|....:.::.|   ||||
Human  1277 KDKD------SGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPV 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	4/51 (8%)
		SET	1414..1533	CDD:214614	34/123 (28%)
		PostSET	1535..1551	CDD:214703	4/15 (27%)
		WW	2014..2043	CDD:278809	8/30 (27%)
		SRI	2270..2348	CDD:285448	14/80 (18%)
KMT2E	NP_061152.3	HCFC1-binding motif (HBM). /evidence=ECO:0000269\|PubMed:23629655	63..66
		PHD_MLL5	120..163	CDD:277025	12/51 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..269		17/123 (14%)
		SET	343..452	CDD:214614	34/117 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..530		13/64 (20%)
		ARGLU	550..>605	CDD:330370	13/57 (23%)
		ERM	<561..>669	CDD:330563	23/123 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..687		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..960		20/91 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1068		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1561		39/178 (22%)
		DUF4045	<1310..>1502	CDD:330572	4/6 (67%)
		Med15	1442..>1829	CDD:312941
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1835
		Atrophin-1	<1741..1846	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030