DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and ASH1L

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens


Alignment Length:2854 Identity:561/2854 - (19%)
Similarity:947/2854 - (33%) Gaps:979/2854 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 INPSLKHADAEASPTAPEDQDSGQSECRRSSRKKII-KFDVR-DLLNKNRKAHKIQIEARIDSNP 100
            ::.|||  |:..|.|.       :....|.:::.|: ||.|| :::|..::...   |.......
Human   452 LSESLK--DSATSKTF-------EKNVVRQNKESILEKFSVRKEIINLEKEMFN---EGTCIQQD 504

  Fly   101 STGHSQSGTTAASTSMSTATASAAS-------ASSAATVSRLFSMFEMSHQSLPPP--------- 149
            |...|:.|:...|...........|       ||..:|....||....|:...|.|         
Human   505 SFSSSEKGSYETSKHEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLTR 569

  Fly   150 PPPPTALEIFAKPRP-------------TQSLIVAQVTSEPS-------AVGGAHPVQ------- 187
            .||.|:.::  .|.|             ::|:...|.|||.:       :||.:..::       
Human   570 SPPETSSQL--APNPLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKE 632

  Fly   188 ------TMAGLPPVTPRKRGRPR-KSQLADAAIIPTVI---------------VPSCSD-----S 225
                  |...:|.::.....:|. .|:.:...|.|:|:               ..|.||     :
Human   633 VNDSKTTHIDIPRISSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVA 697

  Fly   226 DTNSTSTTTSNMSSDSGELPGFPIQKPKSKLR----VSLKRLKLGGRLESSDSGNS---PSSSSP 283
            ::.|||..:..:....|..|.:.....:|..|    :.|:|.:|...:..|...||   |:....
Human   698 ESLSTSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMK 762

  Fly   284 EVEPPALQDENAMDER-PKQEQ----NLSRMVDAEENSD--------SDSQIIFIEIETE--SPK 333
            .:.||:..|.:.:..| ||..:    :|:.:.|:|:.|.        |.|..:..::.::  .||
Human   763 NIGPPSFVDHDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPK 827

  Fly   334 GEEEQEEGRPVEVE-PQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPP---------SLWSA 388
                  .|||...| ||                             |.|||         .::|.
Human   828 ------RGRPKSKEMPQ-----------------------------LEGPPKRTLKIPASKVFSL 857

  Fly   389 DDEAEEEEDATVQRATPPGKEPAAD--------SCSSAPRRSRRSAPLSGSSRQGKTLEETFAEI 445
            ..:.|:|         ||..:|..:        |.|..|::..|......|..:.|....:.|..
Human   858 QSKEEQE---------PPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPF 913

  Fly   446 AAESSKQILEAE-----------ESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVV 499
            .|..|...||:|           ||:||.:.       .|.|.:|...|..|.:...|..::.:.
Human   914 VATESPSKLESESDNHRSSSDFFESEDQLQD-------PDDLDDSHRPSVCSMSDLEMEPDKKIT 971

  Fly   500 EENQ------LVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETK---------ATC 549
            :.|.      ::.:.:::...|::.::.::.|.|   ..|.||.    ||::|         ||.
Human   972 KRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSS---VESSNKG----KVQSKLHNTVSSLAATF 1029

  Fly   550 GEVVPRPEMVTE--DVYI-----------TEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPP 601
            |..:.:...|::  .:||           ..||.:....|..|.:.|.:..|.:.|..   |.||
Human  1030 GSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQ---ILPP 1091

  Fly   602 LKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVP-PECCTLESVSG---PV----- 657
            |            ||.|                  .:||.::| |.|......||   ||     
Human  1092 L------------LPSS------------------ASSSEILPSPICSQSSGTSGGQSPVSSDAG 1126

  Fly   658 LLETS----LSTEEKSNENVETTPLK--TEAAKEDSPPAAPEEEASNSSE-------EPNFLLED 709
            .:|.|    |....:....::|..:|  ::..:..|||.......|:.||       .|:.:.|.
Human  1127 FVEPSSVPYLHLHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPISES 1191

  Fly   710 YESNQEQVAEDEMMKCNNQK---------GQKQ----------------TPLPEMKEP------- 742
            :  :.|.:..|..:..:|..         |||:                |.|..:||.       
Human  1192 H--SDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKR 1254

  Fly   743 --------EKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEK--------KVVKSTKGTVPE 791
                    :|...:...:|:|..:...|..|..:      .|:|:        ::...:...:|.
Human  1255 RNHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFI------AELEELISRLSEIRITHRSHHFIPR 1313

  Fly   792 ----------------------------KKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEK 828
                                        :|.|.||...  .|.|.:|:        :.:......
Human  1314 DLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRG--RPPKMREA--------MAEMPFMHS 1368

  Fly   829 SSAKLDSS----------SPNTLDKKGKDTA---------QWSPQLQTLPKS---STKPPQES-- 869
            .|..|.|:          ||:.|      ||         ::.|.|...|.|   :|..|..|  
Human  1369 LSFPLSSTGFYPSYGMPYSPSPL------TAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYM 1427

  Fly   870 -------APSVISK------------TTSNQP---------APKE------------EQHAAKKG 894
                   .|:...|            |||..|         .|.|            .:|..::.
Human  1428 HAGHLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREH 1492

  Fly   895 LSDNSPP---------SVLKAKEKAVSG----------------FVECDAMFKAMDLANAQLRLD 934
            .|...|.         |||::.::...|                .:.|..:..:..|.|.:.:..
Human  1493 RSSEQPQVSMDTGSSRSVLESLKRYRFGKDAVGERYKHKEKHRCHMSCPHLSPSKSLINREEQWV 1557

  Fly   935 EKNKKKLKKVPTKVEAPPKVEPPTAVP-------VPGQKKSLSGK-TSLRRNTV----------- 980
            .:...:...:...::.|.:::...:.|       .|..:.:.|.: |:|..:.:           
Human  1558 HREPSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNSS 1622

  Fly   981 ----YEDSPNL------------ERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKD 1029
                ..|||.|            .:.|.||::.| ..|.||. :|:..|....|..||.|...:.
Human  1623 GRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERA-VQTLAGS-QPTSDKPSQRPSESTNCSPTRK 1685

  Fly  1030 LRSSSSSSTPTREVAASSP---------------------------------VSTSS---DSSSK 1058
            ..||.|:|:....|.:.||                                 ::|:|   .||..
Human  1686 RSSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVIATASAPPSSSPG 1750

  Fly  1059 RNGSK-RT------------TSDL--DGGSKLDQRRYTICEDRQPETAIPVPLTK--RRFSMHPK 1106
            |:.|| ||            |||.  :..|.|.::..:.|.....:.::...:.:  |:...:.|
Human  1751 RSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVVEAMQRQARKMCNYDK 1815

  Fly  1107 ASANPLH----DTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKK---KALKSAEILSAA 1164
            ..|...:    :.:|:....:|..:.|...:.|:          .|.|:|   :|:.|.:...||
Human  1816 ILATKKNLDHVNKILKAKKLQRQARTGNNFVKRR----------PGRPRKCPLQAVVSMQAFQAA 1870

  Fly  1165 LLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNL-------LKRD--KVDEDQ 1220
            ............|:.:     ..||:...     |:.:.:...|||       |||.  .::|..
Human  1871 QFVNPELNRDEEGAAL-----HLSPDTVT-----DVIEAVVQSVNLNPEHKKGLKRKGWLLEEQT 1925

  Fly  1221 RKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSH 1285
            ||      |::..|||:|.....:..|.|...|:||.|.:.|.:..||...:..|        ..
Human  1926 RK------KQKPLPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSL--------IP 1976

  Fly  1286 RIKQKPQGPRAS-QGRGVASVALAPISMDEQLAELAN---------------------IEAINEQ 1328
            |.|:.|:.|:.. |..|:.|..........:|.:|..                     :..::.:
Human  1977 REKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGK 2041

  Fly  1329 FLRSEGLNTFQL------------------------LKENFYRCARQVSQENAEMQCDCFLTGDE 1369
            :||.:.:: |||                        ::.|.|...:.:|...| ..|:|....|:
Human  2042 YLRQKRID-FQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEA-TTCNCKKPDDD 2104

  Fly  1370 EAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPC-RVFRTEKKGCGITAELLIP 1432
            ..:|   |...|:|||:..||.| .|..|.:|.|:|.|:|:...| ..||.|:||.||..:..:.
Human  2105 TRKG---CVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLK 2166

  Fly  1433 PGEFIMEYVGEVIDSEEFERRQ----HLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCD 1493
            .|:||:||:|||:..:||..|.    |.:|     .:|.:.|....|||:...||.:|:||||||
Human  2167 AGQFIIEYLGEVVSEQEFRNRMIEQYHNHS-----DHYCLNLDSGMVIDSYRMGNEARFINHSCD 2226

  Fly  1494 PNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR-CYCEAANCRGWIGGEPDSD 1557
            ||.|.|||:|||..|||.:::|.:..|.|:|:||.:..:..:.|: |.|....|||.|||:....
Human  2227 PNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRV 2291

  Fly  1558 EGEQLDEESDSDAEMDEEELEAEPEEGQP----RKSAKAKAKSKLKAKLPLATGRKRKE------ 1612
            .|....:.|                  ||    :||.::|.|.|.|.||....|...:|      
Human  2292 NGLTSSKNS------------------QPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENIN 2338

  Fly  1613 ---------QTKP----------KDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPD 1658
                     |.||          |...:....|            ||..:|.:..|..:     |
Human  2339 TPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNW------------EKIRQKQEEVKHTS-----D 2386

  Fly  1659 VVEELSLLRR--------GGLKNQQDTLRFSRCLVRAKLLKT-RLAL----LRVLTHGELPCRRL 1710
            .:...||..|        |.:|:.....:|| .|..|:.::| |||.    :.|.....|  .::
Human  2387 NIHSASLYTRWNGICRDDGNIKSDVFMTQFS-ALQTARSVRTRRLAAAEENIEVARAARL--AQI 2448

  Fly  1711 FLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVV 1775
            |.:     :....||..   |..|:||...|.:|| |.:   .::..|:.:       ...|.::
Human  2449 FKE-----ICDGIISYK---DSSRQALAAPLLNLP-PKK---KNADYYEKI-------SDPLDLI 2494

  Fly  1776 PQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHASTALEDQRERES 1840
            ..|||         :|..:....|.|                  |.....|..:......|:...
Human  2495 TIEKQ---------ILTGYYKTVEAF------------------DADMLKVFRNAEKYYGRKSPV 2532

  Fly  1841 SND--RFRQDRFR-RDTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRSDIGPP 1902
            ..|  |.|:..:. |...|::|.:.:..:.:....:.|:..:..|    |..::|:..|...|  
Human  2533 GRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKEN----GHEKDDDVIRCICG-- 2591

  Fly  1903 SEQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADI------NTDPKQLPFYQ 1961
                          |::     ||.....|.:..:.....|....:|:      ..||:.:    
Human  2592 --------------LYK-----DEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPV---- 2633

  Fly  1962 KTDTNEWFNSDDVPVPAPPRTELLTK------ALLSPDIDVGQGATDVEY------KLPPGVDPL 2014
                       |..||..||......      .||..|:.:.||  |..|      :.|.|   .
Human  2634 -----------DREVPMIPRPHYAQPGCVYFICLLRDDLLLRQG--DCVYLMRDSRRTPDG---H 2682

  Fly  2015 PPAWNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTTQ---------QPLHELQIDPA 2070
            |...::::.|     :.| |:::..:       |::.|.:....:         :| ||....|:
Human  2683 PVRQSYRLLS-----HIN-RDKLDIF-------RIEKLWKNEKEERFAFGHHYFRP-HETHHSPS 2733

  Fly  2071 --VLENELIQVD-------TDYVGSLSAKSLAQYIEAK---VRERR----DLRRSKLVSI----- 2114
              ...|||.:|.       ...||:.....|..|.:.:   |:|:.    |.|..|...:     
Human  2734 RRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIH 2798

  Fly  2115 -----------------RLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDAVD 2162
                             :.::|::|....|   ....||.|..:...:.|    |....|.|...
Human  2799 RNRYPVCTKPYAFDHFPKKLTPKKDFSPHY---VPDNYKRNGGRSSWKSE----RSKPPLKDLGQ 2856

  Fly  2163 EIPVPGKALP-IQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGKAVAQPTGL 2226
            |    ..||| |:..|.|.::...::.::|:|  |.|..:.|::                     
Human  2857 E----DDALPLIEEVLASQEQAANEIPSLEEP--EREGATANVS--------------------- 2894

  Fly  2227 GTVGKRKLPMPPSVTVKKHRQEQRSKKVKSSQSPLTATSAREAHEKFRFEISGHVANFL 2285
                                 |...|..:|||.|.:..:..|.....|..::..:.|.|
Human  2895 ---------------------EGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLL 2932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 19/52 (37%)
SET 1414..1533 CDD:214614 52/122 (43%)
PostSET 1535..1551 CDD:214703 6/16 (38%)
WW 2014..2043 CDD:278809 4/28 (14%)
SRI 2270..2348 CDD:285448 3/16 (19%)
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583 12/47 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966 22/94 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711 29/132 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991 25/93 (27%)
Catalytic domain 2069..2288 85/227 (37%)
AWS 2092..2143 CDD:197795 20/54 (37%)
SET 2146..2266 CDD:214614 53/124 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346 14/75 (19%)
Bromo_ASH1 2443..2548 CDD:99955 26/152 (17%)
PHD_ASH1L 2586..2628 CDD:277023 8/62 (13%)
BAH_polybromo 2665..2799 CDD:240068 29/152 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919 12/86 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157986
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.880

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