Protein Alignment Set2 and kmt2a

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_005157640.1
• Gene: kmt2a / 557048
• ZFINID: ZDB-GENE-080521-3
• Length: 4219
• Species: Danio rerio
• Alignment Length: 1952
• Identity: 381/1952 - (19%)
• Similarity: 631/1952 - (32%)
• Gaps: 677/1952 - (34%)

  Fly    12 PVASRGRGRGRPPK----VALSALGNT-----PPHI---NPSLKHADAEASPTA--------PED 56
            |:|...:.:..|.|    .:::||.:|     |..|   :.|.|..|..:.|.|        ...
Zfish  2531 PLAMLPKDKANPNKEGNMTSMAALKDTVKTGSPQRIYNKSGSRKSHDYASGPAAVVAMKPLWSSG 2595

  Fly    57 QDSGQSECRR---------------SSRKK--IIKFDV-RD--------------LLNKNRKAHK 89
            ...|:.:.:|               |:::|  .:|.:| ||              :||.|.|:..
Zfish  2596 AKLGEEDIKRGFQASAGITGSHGTSSTKEKHSKVKMNVSRDVSKERKETPQNRNAVLNSNSKSSN 2660

  Fly    90 IQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFS----MFEMSHQSL---- 146
            ::.:.::   |...:..:..||.|::..:.|..............|.|    .||..|.|.
Zfish  2661 VKTQGQV---PPPHNISNKATALSSNTGSGTVEVNKFDQKEVEKPLKSKERFSFEKKHTSAMDAI 2722

  Fly   147 -----------PPPPPPPTALEI-FAKPRPTQSLIVAQVTSEPS---AVGGAHPVQTMAGLPPVT 196
                       ||...|.::.|: ....:.|:.|.:.....:|:   ||..:...||...   ||
Zfish  2723 QPKAGSERSIRPPQVHPKSSKEVPLVGKKHTERLSLMSQKMDPNRTKAVSISPNTQTYTS---VT 2784

  Fly   197 PRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLK 261
            |..:|..|:|..|      .|..||.               ||:|.|
Zfish  2785 PSNQGPQRRSSRA------MVFSPSA---------------SSESSE------------------ 2810

  Fly   262 RLKLGGRLESSDSGNSPSSSSPEV---------EPPALQDENAMDERPKQEQNLS---------- 307
                      |||...|..|...:         |...|:||.::|:..:::.:.|
Zfish  2811 ----------SDSHIHPDDSEEHLMDHQCADDGEDNNLEDEGSVDKHHEEDSDGSAGSAKRRYPR 2865

  Fly   308 RMVDAEEN------------SDSDSQIIFI---EIETESPKGEEEQE-EGRPVEVEPQDLIDIDM 356
            |...|..|            |..:..|.|.   ||..:...|..::. ||   :|:..|    ||
Zfish  2866 RSARARSNMFFGLTPFYGVRSYGEEDIPFYRSGEISMKKRTGSSKRSAEG---QVDGAD----DM 2923

  Fly   357 ELAKQEPTPDPEE------------DLDEIMVEVLSGPPSLWSAD--------------DEAEEE 395
            ..:....:.:.||            :....::...||.||:...|              |:|:|.
Zfish  2924 STSSSADSGEDEEGGIGSNKDTYYYNFTRTIINPSSGLPSIAGIDQCLGRGSQIHRFLRDQAKEH 2988

  Fly   396 EDAT--VQRATP----------PGKEPAADSCSSAPRRSRRSAPLSGSSRQGKT--------LEE 440
            ||.:  |..||.          .|.:..::|..|....|..:|..| |:::|.|        .|:
Zfish  2989 EDDSDEVSTATKNLELQQIGQLDGVDDGSESDISISTSSTTTATTS-STQKGSTKRKGRESRTEK 3052

  Fly   441 TFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLV 505
            :..:...|:......:.:|:..::.:.|......|..:..:.:.:|.|.:.:..:    .:|...
Zfish  3053 SNVDSGKEAVNTTSNSRDSRKNQKDNCLPLGSVKTQGQDPLETQLSLTTDLLKSD----SDNNNS 3113

  Fly   506 DEADEILDSK-QEFVIKKVFSESDNIAASLNKDIFEPKVE----TKATCGEVVPRPEMVTEDVYI 565
            |:...||.|. .|||:.....:      :|.:....|..|    .::...:|..|.:|:.||
Zfish  3114 DDCGNILPSDIMEFVLNTPSMQ------ALGQQAEAPSAEQFSLDESYGVDVNQRKDMLFED--- 3169

  Fly   566 TEGIAATLEKSAVVTKPTTEM-IAETKLSDEVVIEP----PLKDESDPKQTEVELPESKPAVNIP 625
                         .|:|.... ..|:.:|..:.:|.    ||           |||.
Zfish  3170 -------------FTQPLANAESGESGVSTTIAVEESYGLPL-----------ELPS-------- 3202

  Fly   626 KSERILSAEVETTSSPLVPPECCTLESVSGPVLLETS------LSTEE----KSNENVET-TPLK 679
                  ...|.||.||.|.      ....||::.|||      |:|||    ||.:...| :.:.
Zfish  3203 ------DLSVLTTRSPTVS------NQNHGPLISETSERTMLALATEESEAGKSKKKTRTGSTVS 3255

  Fly   680 TEAAKE---------------------------DSPPAAPEEEASNSS-----------EEPNFL 706
            :::.:|                           .||..||..|..|..           ..|...
Zfish  3256 SKSPQEGCADSQVPEGHMTPEHFIPPSVDGDHITSPGVAPVGETGNQDMTRTSSTPVLPSSPTLP 3320

  Fly   707 LEDYE---------------SNQEQVAEDEMMKCNNQK----GQKQTPLPEMK-------EPEKP 745
            |::.:               |:..|.|..: :|...:|    .|...||..::       .|..|
Zfish  3321 LQNQKFIPATTVTSGPAPITSSAVQAAASQ-LKPGPEKLIVLNQHLQPLYVLQTVPNGVMNPNAP 3384

  Fly   746 VAETVSKKEKAMEN--PARSS---PAIVDKKVRA--GEME---KKVVKSTKGTV----------- 789
            |...:|......::  ||.|.   |.....::.|  |..:   :.|:.||...:
Zfish  3385 VLTGLSGGISTSQSIFPAGSKGLVPVSHHPQIHAFTGTTQTGFQPVIPSTTSGLLIGVTSHDPQI 3449

  Fly   790 ------------PEKKMDSKKSCAAVTPAKQK-ESGKSAKEAILKKETEKEKSSAK--------- 832
                        |...|.|  |.:.:|||... .||...|..|.:.::.|.|..|:
Zfish  3450 GVTEAGHRHDHAPNVAMVS--SASTITPAPSMIPSGHGKKRLISRLQSPKSKKQARPKTQPTLAP 3512

  Fly   833 --------LDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISK----------TTS 879
                    |.:.||:.: ..|........:|.|:    |..|....|::|.:          |..
Zfish  3513 SDVGPNMTLINLSPSQI-AAGIPAQTGLMELGTI----TATPHRKIPNIIKRPKQGVMYLEPTIL 3572

  Fly   880 NQPAPKEEQHAAKKGLSDNSPPSVLKAKEK------AVSGFVECDAMFKAM-------------- 924
            .||.|          :|..:.|.:|.....      .|||.....::...:
Zfish  3573 PQPMP----------ISTTTQPGILGHDSSTHLLPCTVSGLNTSQSVLNVVSVPSSAPGNFLGGS 3627

  Fly   925 -----------------DLANAQLRLDEKNKKKLKKVP------------------TKVEAPPKV 954
                             .|:|..::.:..| ..|.:.|                  |.:.:...|
Zfish  3628 SVSLSAPGLISSTEITGSLSNLLIKANPHN-LSLSEQPMVLHPGTPMMSHLTNPAQTSIASSICV 3691

  Fly   955 EPPT-AVPVP-GQKKSLSGKTSLRR--NTVYED---SPNLERNSSPSSDSAQANTSAGK--LKPS 1010
            .||. ::.|| .|:....|...|:.  :.|..|   .||:              :|||:  |.|:
Zfish  3692 FPPNQSITVPVNQQVEKEGTVHLQHAVSRVLADKTLDPNV--------------SSAGQVALAPN 3742

  Fly  1011 KVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKL 1075
            .:.:::| :...:....:..|:|..|....:..|:..|...||.:..|              .|.
Zfish  3743 PISQELN-KGHVVSVLTQSSRTSPISRPQHQHQASKLPAGASSVAFGK--------------GKH 3792

  Fly  1076 DQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDT-LLQTAGKKRGRKEGKESLSRQNSL 1139
            ..:|...|.|:..        .|:...:|   |..|..|| .:|.:..|     |.:.||....:
Zfish  3793 KAKRPRPCPDKSS--------GKKHKGLH---SDTPTVDTSAIQLSYIK-----GDQELSSPEPM 3841

  Fly  1140 DSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFI 1204
            |:..|...|:.|:                :|:..|::.|.:.|..|....  |..:..|..:|
Zfish  3842 DTGQSNETGSKKR----------------DSTTMTTNSSALKRKTVDAVD--EKPSTAGLPSK-- 3886

  Fly  1205 EDGVNLLKRDKVD-EDQRKEGQDEVKREADPE---------EDEFAQRVANMET--PATTPTPSP 1257
            .||.. .|...|| .|||..|:|. ..:..|:         :|.|..|..::|.  .:.|.....
Zfish  3887 GDGTG-NKAFSVDTPDQRDSGRDS-SLDHKPKKGLIFEICSDDGFQIRCESIEEAWKSLTDKVQE 3949

  Fly  1258 TQSNPEDSAST--------------TTVLKELETGGGVR--RSHRIK-QKPQ-------GPRASQ 1298
            .:||....|.:              ..|:..||...|.|  |::|.: .||:       .|..|
Zfish  3950 ARSNARLKALSFDGVNGLKMLGVVHDAVVFLLEQLYGARHCRNYRFRFHKPEETDYLPVNPHGS- 4013

  Fly  1299 GRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDC 1363
                                     |..|.:.|...|:.|..|....    ||....|.:.:
Zfish  4014 -------------------------ARAEVYHRKSVLDMFNFLASKH----RQPPVYNPQEE--- 4046

  Fly  1364 FLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTN------KRFQQHQCW---PCRVFRTE 1419
                |||.....|                    ..|.|:      ::|:|.:..   ...|:|:.
Zfish  4047 ----DEEEMQQKS--------------------ARRATSTDLPLPEKFRQLKKASRDAVGVYRSA 4087

  Fly  1420 KKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNI 1484
            ..|.|:.....|.|||.::||.|.||.|...::|:..|. |:....|...:....|:|||..||.
Zfish  4088 IHGRGLFCRKNIEPGEMVIEYSGNVIRSVLTDKREKYYD-DKGIGCYMFRIDDYEVVDATIHGNS 4151

  Fly  1485 SRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRG 1548
            :|:|||||:||..::...|:|:..|..|:.:.|..|||:|:||:: :....:...|.|.|..||.
Zfish  4152 ARFINHSCEPNCYSRVVNVDGQKHIVIFATRKIYKGEELTYDYKFPIEEPGNKLPCNCGAKKCRK 4216

  Fly  1549 WI 1550
            ::
Zfish  4217 FL 4218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	34/182 (19%)
		AWS	1358..1410	CDD:197795	8/57 (14%)
		SET_SETD2	1410..1551	CDD:380949	48/145 (33%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
kmt2a	XP_005157640.1	zf-CXXC	1312..1359	CDD:366873
		PHD1_KMT2A	1627..1673	CDD:277063
		PHD2_KMT2A	1675..1724	CDD:277065
		PHD3_KMT2A	1762..1818	CDD:277067
		Bromo_ALL-1	1841..1971	CDD:99925
		ePHD_KMT2A	2066..2178	CDD:277163
		FYRN	2219..2266	CDD:461787
		Atrophin-1	3221..>3709	CDD:460830	87/506 (17%)
		FYRC	3919..4002	CDD:197781	17/82 (21%)
		SET_KMT2A	4066..4219	CDD:380983	50/154 (32%)