Protein Alignment Set2 and nsd1a

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_683890.5
• Gene: nsd1a / 556086
• ZFINID: ZDB-GENE-080519-3
• Length: 2053
• Species: Danio rerio
• Alignment Length: 1860
• Identity: 381/1860 - (20%)
• Similarity: 613/1860 - (32%)
• Gaps: 679/1860 - (36%)

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEA----RIDSNP--------------STGHSQSGTTA 111
            |...::|..|:.|...|..:.||..::.||    :::|.|              ...|.::....
Zfish   366 RGRQKEKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLTLIQDVCVPITEDKAHKKNPACP 430

  Fly   112 ASTSMSTATASAASASSAATV-SRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQ--- 172
            .||::||.::|..|....|:| :||               .|.||    :|.:.|:.:|.:|
Zfish   431 KSTTLSTPSSSLLSNGLNASVKNRL---------------KPGTA----SKKKATKKMIQSQSIK 476

  Fly   173 VTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTN-------ST 230
            ::..||.      .::.:......|.....|..|..:|...:|.::.....|....       ||
Zfish   477 LSETPSL------FKSKSNPSSDKPSIATDPLDSPYSDIDSVPRILCSKRIDESLQVELEKELST 535

  Fly   231 STT----TSNMSSDSGELPG----------FPIQK--PKSK-LRVSLKRLKLGGRLESSDSGNS- 277
            .||    ....|.:|.:.||          ..::|  ||.| |:.:..|||     |||..|:|
Zfish   536 KTTKVQACKKTSKNSVDKPGKKTDVKCLKNSKLKKSTPKDKTLKATSSRLK-----ESSSPGSSD 595

  Fly   278 ----------PSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESP 332
                      |:||...|...|..:|.       :|::||.    |.||.|.|.      |..||
Zfish   596 GSFAMHSHYLPASSGLIVRALAAGEET-------KEKDLSH----EPNSHSPSS------EHSSP 643

  Fly   333 KGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEED 397
            ...                     ||:||.                       |...:::|..|:
Zfish   644 TNH---------------------ELSKQN-----------------------WEVKNKSESSEE 664

  Fly   398 ATVQRATPPG--------KEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEET-FAEIAAES--SK 451
            :.....:||.        |.|..:.....|      .|.|....:.|...|: |::.::.|  |.
Zfish   665 SADASDSPPNPTSIKRIKKRPQKNGIHKDP------PPKSHEESESKVNNESMFSDTSSSSIPSP 723

  Fly   452 QILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSP----------------------------- 487
            .|...:..||.:|      |...:|.:.|.:|..||
Zfish   724 SISPMDAFQDIKE------LSFRSLVKEECSSGESPLRADSNYKFSTFLMLLKDLHDSREKEGKP 782

  Fly   488 -TIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNI--AASLNKDIFEPKVETKATC 549
             |:.......::.||..|:...:|   ...|.:.:|.|:|..::  ..|...:..:.|.:.|:|.
Zfish   783 LTLPPTSPSSLIKEEPSLIPVGEE---PPNEVLCEKEFAEQSSLPGKTSTPNNSKQSKAKLKSTV 844

  Fly   550 GEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVE 614
            .:...:|::|.:.|                                    .|||....|...:|
Zfish   845 KKESQKPDIVIDSV------------------------------------SPLKKPISPVGLDV- 872

  Fly   615 LPESKPAV-NIPKSERILSAEVET----TSSPLVPPE-CCTLESVSGPVLLETSLSTEEKSNENV 673
            |.:|.|.: ::|||..:.:|..:.    |.|.:.|.: ..|.||       |...|.:.||:: |
Zfish   873 LDKSLPLLGDLPKSSDVSAAVTDVCAKGTISKVAPKKRWKTFES-------ELGKSIKPKSDQ-V 929

  Fly   674 ETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPE 738
            ::|                .:|..:.|.|||.:.:|  ..||....|
Zfish   930 DST----------------LDEVKSVSTEPNGVFKD--GLQESAHSD------------------ 958

  Fly   739 MKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKK--SCA 801
                       |..|:.|.||.....|:  .:.:..||..:::..|.|.|  :|..:|.|  ||.
Zfish   959 -----------VPNKKDASENKRLRKPS--KRLIECGEEYEQIFPSKKKT--KKSTESCKTGSCI 1008

  Fly   802 AVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPP 866
            :.|..:|..|.:...:|:.....||.......:...|                    |.....||
Zfish  1009 SNTTPEQPASDQITPDAVSSSSAEKPLDHDVAEEQKP--------------------PADVLVPP 1053

  Fly   867 QESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQL 931
              |||...|..||.:..|.|::          |.|...|...|:|...::|
Zfish  1054 --SAPKSPSCATSLETEPCEKK----------SAPLERKRPRKSVHKVLDC-------------- 1092

  Fly   932 RLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSD 996
                           .:|.       .:|.:|.:.:|...||:...:.|.:.....|....|||.
Zfish  1093 ---------------AIEG-------ESVKIPKKGESRQHKTNPEESGVRDLEKQEEAGPPPSSP 1135

  Fly   997 SAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSS---------------STPTREVAAS 1046
            .|.:..|.|:|:.|   ..|.|...::.:...:...||.|               .....:.|.|
Zfish  1136 CAVSAQSEGELRTS---SPIQPDVPSVSQIPVEGEQSSPSKPQMNNEDSLISEGFGAGLNDSAFS 1197

  Fly  1047 SPVSTSSD----SSSKRNGSKRTTSDLDGGSKLDQRRYTICED---------------------- 1085
            |..|.|.|    |::||:..:      .||:.|.:....:||.
Zfish  1198 SRDSLSGDLSGLSTNKRSVER------GGGASLKENVCQVCEKTGELLLCEGQCCGAFHLQCIGL 1256

  Fly  1086 -----------------------RQPETAI---------------------PVPLTKRRF--SMH 1104
                                   ::|:..:                     |.....|.|  |:|
Zfish  1257 TETPKGRFICQECKMGVHTCFVCKKPDKEVRRCMIPVCGKFYHMDCILKYSPTVAQNRGFRCSIH 1321

  Fly  1105 PKAS---ANPLHDTLLQTAGKKRGR------------------KEGKESLSRQNSLDSSSSASQG 1148
            ...|   .||      ...|..:||                  ..|...|:..:.|    ..:..
Zfish  1322 VCLSCYITNP------NNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFL----CPNHF 1376

  Fly  1149 APKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKR 1213
            .| :|..|:.|.::.:....    .:..||.:.   .::.|           |.|..:.:|:
Zfish  1377 TP-RKGCKNHEHINVSWCFV----CSEGGSLLC---CESCP-----------AAFHRECLNI--- 1419

  Fly  1214 DKVDEDQRKEGQ---DEVKREADPE-EDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLK 1273
                  :..:|.   ::.:....|. :|....:|.... .||....|   :|.||:.:
Zfish  1420 ------EMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQP---KSVPENIS------- 1468

  Fly  1274 ELETGGGVRRSHRIKQKP---------------------QGP---RASQGRGVASVALAPISMDE 1314
                    |..|.:.:.|                     :|.   :...|:|
Zfish  1469 --------RMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKG------------- 1512

  Fly  1315 QLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQ-------------------------VSQ 1354
              |:....:|:||...|..     :||||...|..::                         ::.
Zfish  1513 --ADAVYKKALNEAADRFR-----ELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIITA 1570

  Fly  1355 ENAEM-QCDCFLTGDEEAQGHLSCG--AGCINRMLMIEC-GPLCSNGARCTNKRFQQHQCWPCRV 1415
            :.:|: :|:|..| ||.     .||  :.||||||:.|| ..:|..|.||.|:.|.:.|.....:
Zfish  1571 DLSEIPRCNCKAT-DEN-----PCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEI 1629

  Fly  1416 FRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATS 1480
            |||..:|.|:.:...|..|.|:.||||||||.||...|......:...::|.:.|..:.:|||..
Zfish  1630 FRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGP 1694

  Fly  1481 KGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAAN 1545
            |||.||::||||.||.|||||||||:.|:|.|:::.|..|.|:||:|.....|.....|.|.|.|
Zfish  1695 KGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPN 1759

  Fly  1546 CRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKR 1610
            |.|::|..|                            :.||....|.:   ||:.|:   :|:::
Zfish  1760 CSGFLGVRP----------------------------KNQPPSDDKTR---KLRRKV---SGKRK 1790

  Fly  1611 KEQTKPKDRE---YKAGRWLKPSATGSSSSAEKPPKKPKV 1647
            .:....|:||   :..|       .|....:.|.|..|||
Zfish  1791 SQSEVTKEREDECFYCG-------DGGQIVSCKKPGCPKV 1823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	26/124 (21%)
		AWS	1358..1410	CDD:197795	22/55 (40%)
		SET_SETD2	1410..1551	CDD:380949	60/140 (43%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
nsd1a	XP_683890.5	None