DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and nsd1a

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_683890.4 Gene:nsd1a / 556086 ZFINID:ZDB-GENE-080519-3 Length:2055 Species:Danio rerio


Alignment Length:1853 Identity:386/1853 - (20%)
Similarity:620/1853 - (33%) Gaps:665/1853 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEA----RIDSNP--------------STGHSQSGTTA 111
            |...::|..|:.|...|..:.||..::.||    :::|.|              ...|.::....
Zfish   366 RGRQKEKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLTLIQDVCVPITEDKAHKKNPACP 430

  Fly   112 ASTSMSTATASAASASSAATV-SRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQ--- 172
            .||::||.::|..|....|:| :||               .|.||    :|.:.|:.:|.:|   
Zfish   431 KSTTLSTPSSSLLSNGLNASVKNRL---------------KPGTA----SKKKATKKMIQSQSIK 476

  Fly   173 VTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTN-------ST 230
            ::..||.      .::.:......|.....|..|..:|...:|.::.....|....       ||
Zfish   477 LSETPSL------FKSKSNPSSDKPSIATDPLDSPYSDIDSVPRILCSKRIDESLQVELEKELST 535

  Fly   231 STT----TSNMSSDSGELPG----------FPIQK--PKSK-LRVSLKRLKLGGRLESSDSGNS- 277
            .||    ....|.:|.:.||          ..::|  ||.| |:.:..|||     |||..|:| 
Zfish   536 KTTKVQACKKTSKNSVDKPGKKTDVKCLKNSKLKKSTPKDKTLKATSSRLK-----ESSSPGSSD 595

  Fly   278 ----------PSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESP 332
                      |:||...|...|..:|.       :|::||.    |.||             .||
Zfish   596 GSFAMHSHYLPASSGLIVRALAAGEET-------KEKDLSH----EPNS-------------HSP 636

  Fly   333 KGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEED 397
            ..|...:...              ||:||.                       |...:.:|..|:
Zfish   637 SSEHSSQTNH--------------ELSKQN-----------------------WEVKNNSESSEE 664

  Fly   398 ATVQRATPPG--------KEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEET-FAEIAAES--SK 451
            :.....:||.        |.|..:.....|      .|.|....:.|...|: |::.::.|  |.
Zfish   665 SVDASDSPPNPTSIKRIKKRPQKNGIHKDP------PPKSHEESESKVNNESMFSDTSSSSIPSP 723

  Fly   452 QILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSP----------------------------- 487
            .|...:..||.:|      |...:|.:.|.:|..||                             
Zfish   724 SISPMDAFQDIKE------LSFRSLVKEECSSGESPLRADSNYKFSTFLMLLKDLHDSREKEGKP 782

  Fly   488 -TIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNI--AASLNKDIFEPKVETKATC 549
             |:.......::.||..|:...:|   ...|.:.:|.|:|..::  ..|...:..:.|.:.|:|.
Zfish   783 LTLPPTSPSSLIKEEPSLIPVGEE---PPNEVLCEKEFAEQSSLPGKTSTPNNSKQSKAKLKSTV 844

  Fly   550 GEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVE 614
            .:...:|::|.:.|                                    .|||....|...:| 
Zfish   845 KKESQKPDVVIDSV------------------------------------SPLKKPISPVGLDV- 872

  Fly   615 LPESKPAV-NIPKSERILSAEVET----TSSPLVPPE-CCTLESVSGPVLLETSLSTEEKSNENV 673
            |.:|.|.: ::|||..:.:|..:.    |.|.:.|.: ..|.||       |...|.:.||:: |
Zfish   873 LDKSLPLLGDLPKSSDVSAAVTDVCAKGTISKVAPKKRWKTFES-------ELGKSIKPKSDQ-V 929

  Fly   674 ETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPE 738
            ::|                .:|..:.|.|||.:.:|  ..||....|                  
Zfish   930 DST----------------LDEVKSVSTEPNGVFKD--GLQESAHSD------------------ 958

  Fly   739 MKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKK--SCA 801
                       |..|:.|.||.....|:  .:.:..||..:::..|.|.|  :|..:|.|  ||.
Zfish   959 -----------VPNKKDASENKRLRKPS--KRLIECGEEYEQIFPSKKKT--KKSTESCKTGSCI 1008

  Fly   802 AVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPP 866
            :.|..:|..|.:...:|:.....||.......:...|              |....:|.|:.|.|
Zfish  1009 SNTTPEQPASDQITLDAVSSSSAEKPLDHVVAEEQKP--------------PADVLVPPSAPKSP 1059

  Fly   867 QESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQL 931
             ..|.|:.::....:.||.|.:...|         ||.|..:.|:.|  |...:.|..:....:.
Zfish  1060 -SCATSLETEPCEKKSAPLERKRPRK---------SVHKVLDCAIEG--ESVKIPKKGESRQHKT 1112

  Fly   932 RLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNT-VYEDSPNLER------ 989
            ..:|...:.|:|   :.||.|....|.||       |...:..||.:: :..|.|::.:      
Zfish  1113 NPEESGVRDLEK---QEEAGPPPSSPCAV-------SAQSEGELRTSSPIQPDVPSVSQIPVEGE 1167

  Fly   990 NSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEA-AKDLRSSSSSSTPTREVAASSPVSTSS 1053
            .||||                  |.:||...|.|.|. |..|..|          |.||..|.|.
Zfish  1168 QSSPS------------------KPQINNEDSLISEGFAAGLNDS----------AFSSRDSLSG 1204

  Fly  1054 D----SSSKRNGSKRTTSDLDGGSKLDQRRYTICED----------------------------- 1085
            |    |::||:..:      .||:.|.:....:||.                             
Zfish  1205 DLSGLSTNKRSVER------GGGASLKENVCQVCEKTGELLLCEGQCCGAFHLQCIGLTETPKGR 1263

  Fly  1086 ----------------RQPETAI---------------------PVPLTKRRF--SMHPKAS--- 1108
                            ::|:..:                     |.....|.|  |:|...|   
Zfish  1264 FICQECKMGVHTCFVCKKPDKEVRRCMIPVCGKFYHMDCILKYSPTVAQNRGFRCSIHVCLSCYI 1328

  Fly  1109 ANPLHDTLLQTAGKKRGR------------------KEGKESLSRQNSLDSSSSASQGAPKKKAL 1155
            .||      ...|..:||                  ..|...|:..:.|    ..:...| :|..
Zfish  1329 TNP------NNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFL----CPNHFTP-RKGC 1382

  Fly  1156 KSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQ 1220
            |:.|.::.:....    .:..||.:.   .::.|           |.|..:.:|:         :
Zfish  1383 KNHEHINVSWCFV----CSEGGSLLC---CESCP-----------AAFHRECLNI---------E 1420

  Fly  1221 RKEGQ---DEVKREADPE-EDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLKELETGGG 1280
            ..:|.   ::.:....|. :|....:|.... .||....|   :|.||:.:              
Zfish  1421 MPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQP---KSVPENIS-------------- 1468

  Fly  1281 VRRSHRIKQKP---------------------QGP---RASQGRGVASVALAPISMDEQLAELAN 1321
             |..|.:.:.|                     :|.   :...|:|               |:...
Zfish  1469 -RMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKG---------------ADAVY 1517

  Fly  1322 IEAINEQFLRSEGLNTFQLLKENFYRCARQ-------------------------VSQENAEM-Q 1360
            .:|:||...|..     :||||...|..::                         ::.:.:|: :
Zfish  1518 KKALNEAADRFR-----ELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIITADLSEIPR 1577

  Fly  1361 CDCFLTGDEEAQGHLSCG--AGCINRMLMIEC-GPLCSNGARCTNKRFQQHQCWPCRVFRTEKKG 1422
            |:|..| ||.     .||  :.||||||:.|| ..:|..|.||.|:.|.:.|.....:|||..:|
Zfish  1578 CNCKAT-DEN-----PCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRG 1636

  Fly  1423 CGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRY 1487
            .|:.:...|..|.|:.||||||||.||...|......:...::|.:.|..:.:|||..|||.||:
Zfish  1637 WGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRF 1701

  Fly  1488 INHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGG 1552
            :||||.||.|||||||||:.|:|.|:::.|..|.|:||:|.....|.....|.|.|.||.|::|.
Zfish  1702 MNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGV 1766

  Fly  1553 EPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPK 1617
            .|                            :.||....|.:   ||:.|:   :|:::.:....|
Zfish  1767 RP----------------------------KNQPPSDDKTR---KLRRKV---SGKRKSQSEVTK 1797

  Fly  1618 DRE---YKAGRWLKPSATGSSSSAEKPPKKPKV 1647
            :||   :..|       .|....:.|.|..|||
Zfish  1798 EREDECFYCG-------DGGQIVSCKKPGCPKV 1823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 22/55 (40%)
SET 1414..1533 CDD:214614 53/118 (45%)
PostSET 1535..1551 CDD:214703 6/15 (40%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
nsd1aXP_683890.4 PWWP 285..382 CDD:295359 4/15 (27%)
TNG2 <1108..1270 CDD:227367 41/205 (20%)
PHD1_NSD1_2 1228..1270 CDD:277118 2/41 (5%)
PHD_SF 1275..1321 CDD:304600 5/45 (11%)
PHD3_NSD1 1322..1375 CDD:277123 9/62 (15%)
PHD4_NSD1 1392..1431 CDD:277126 7/65 (11%)
WHSC1_related 1437..1531 CDD:99899 20/131 (15%)
AWS 1574..1624 CDD:197795 22/55 (40%)
SET 1626..1748 CDD:214614 53/121 (44%)
PHD5_NSD1 1802..1844 CDD:277129 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593804
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.850

Return to query results.
Submit another query.