Protein Alignment Set2 and ezh2

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_012820250.1
• Gene: ezh2 / 550047
• XenbaseID: XB-GENE-956215
• Length: 769
• Species: Xenopus tropicalis
• Alignment Length: 649
• Identity: 143/649 - (22%)
• Similarity: 230/649 - (35%)
• Gaps: 177/649 - (27%)

  Fly   974 SLRRNTVYEDSPNLERNSSPSSDSA----------QANTSAGKLKPSKVKKKIN---PRRSTICE 1025
            :|.:.:.|||..:.:.|.....|..          |......|....|:.:.|:   |.:.|:.|
 Frog   198 ALAQYSDYEDDEDGDDNQDDERDDTAKDQDDNMEDQETQPLRKFPSDKIFEAISSMFPDKGTLEE 262

  Fly  1026 AAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDG-GSKLDQRRYTICEDRQPE 1089
            ..:..:..:....|    .|..|               ..|.::|| .:|..||..::
 Frog   263 LKEKYKELTEQQLP----GALPP---------------ECTPNIDGPNAKSVQREQSL------- 301

  Fly  1090 TAIPVPLTKRRFS----MHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAP 1150
            .:......:|.|.    :|      |.|.|              ..:..|:|:..::.....|..
 Frog   302 HSFHTLFCRRCFKYDCFLH------PFHAT--------------PNTYKRKNNEAANDGKPCGPH 346

  Fly  1151 KKKALKSAEILSAALL--ETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKR 1213
            ..:.|:.|...:|||.  ..::.....||.:..|....||   ..:.|          .||:|:.
 Frog   347 CYQLLEGAREFAAALTAERIKTPPKRPSGRRRGRLPNNTS---RPSTP----------TVNVLEA 398

  Fly  1214 DKVDEDQRK------EGQDEVKREADPEEDEFAQRVANMETP-ATTPTPSPTQSNPEDSASTTTV 1271
            ...|.|:..      |..|:.:.|...|....::..:..:|| ...|...|.: |.|.|.:..::
 Frog   399 KDTDSDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPE-NVEWSGAEASL 462

  Fly  1272 LKEL-----ETGGGVRR-----------SHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELA 1320
            .:.|     :....:.|           ..|:|:              |..:||:     :||
 Frog   463 FRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKE--------------SSIIAPV-----IAE-- 506

  Fly  1321 NIEAINEQFLRSEGL-----NTFQLLKE-------NFYRC--ARQ---------VSQENAEMQCD 1362
            :::....:..|...|     ...||.|:       |:..|  .||         ::|...|..|.
 Frog   507 DVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQ 571

  Fly  1363 CFLTGDEEAQGHL---SCGAGCINR-----MLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRT 1418
            |    ..|.|...   .|.|.|..:     :.:.||.| ||.......:...:...|..|.:.|.
 Frog   572 C----SSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRG 632

  Fly  1419 EKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGE 1473
            .||          |.||..:..:...|||.||.||:|..:|.:||..:|  |:....:...|..:
 Frog   633 SKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFLFNLNND 695

  Fly  1474 AVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY-----LRY 1532
            .|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|     |:|
 Frog   696 FVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKY 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	13/60 (22%)
		SET	1414..1533	CDD:214614	51/134 (38%)
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
ezh2	XP_012820250.1	EZH2_WD-Binding	54..82	CDD:288468
		SET	635..756	CDD:214614	47/122 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910