| Sequence 1: | NP_572888.2 | Gene: | Set2 / 32301 | FlyBaseID: | FBgn0030486 | Length: | 2362 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_075447.1 | Gene: | NSD3 / 54904 | HGNCID: | 12767 | Length: | 1437 | Species: | Homo sapiens |
| Alignment Length: | 1457 | Identity: | 314/1457 - (21%) |
|---|---|---|---|
| Similarity: | 504/1457 - (34%) | Gaps: | 482/1457 - (33%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 493 VVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVET--KATCGEVVPR 555
Fly 556 PEMVTEDV-YITEGIAATLEKSAVVTK----------------------PTT---EMIAETKLSD 594
Fly 595 EVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLL 659
Fly 660 ETSLS----TEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAED 720
Fly 721 EMMKCNNQKGQKQTPLPEMKE--PEKPVAETVSKKE---------------KAMENP-----ARS 763
Fly 764 SPAI-VDKKVRA-GEMEKKVV----KSTKGTVPEKKM----DSKKSCAAVTPAKQKESGKSAKEA 818
Fly 819 ILKKETEKEKSS-------------------------AKLDSSSPNTLDKKGKDTAQWSPQLQT- 857
Fly 858 LPKS--STKPPQESAPSVISKTTS----------------NQPAPKE---EQHAAKKGLSDNSPP 901
Fly 902 SV------LKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAV 960
Fly 961 PVPGQK-----KSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSK--------- 1011
Fly 1012 -VKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSS-----------KRNGSKR 1064
Fly 1065 TTSDLD----------------GGSKLDQRRYTICE--DRQPETAIP----------------VP 1095
Fly 1096 LTKRRF-------SMHP----KASANPLHDTLLQTAGK----------------KRGRKEGKESL 1133
Fly 1134 SRQNSLDSSSSASQG-------APKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPEL 1191
Fly 1192 EAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFA----------QRVANM 1246
Fly 1247 ETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIK----------QKPQG-------- 1293
Fly 1294 ---------------------------PRA----------------------------SQGRGVA 1303
Fly 1304 SVALAPISMDEQLAELANIEAINEQFLRS--EGLNTFQLLKENFYRCARQVSQENAEMQ------ 1360
Fly 1361 ---------------------------CDCFLTGDEEAQGHLSCG--AGCINRMLMIECGP-LCS 1395
Fly 1396 NGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKD 1460
Fly 1461 RNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITF 1525
Fly 1526 DYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSA 1590
Fly 1591 KAKAKSKLKAKLPLATGRKRKEQTKPK 1617 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Set2 | NP_572888.2 | AWS | 1358..1410 | CDD:197795 | 21/87 (24%) |
| SET | 1414..1533 | CDD:214614 | 51/118 (43%) | ||
| PostSET | 1535..1551 | CDD:214703 | 6/15 (40%) | ||
| WW | 2014..2043 | CDD:278809 | |||
| SRI | 2270..2348 | CDD:285448 | |||
| NSD3 | NP_075447.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 121..157 | 12/55 (22%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 181..252 | 18/78 (23%) | |||
| PWWP domain; Pfam PF00855 | 264..324 | 10/59 (17%) | |||
| MSH6_like | 267..383 | CDD:99898 | 20/115 (17%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 344..365 | 5/20 (25%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 406..465 | 13/58 (22%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 540..696 | 31/157 (20%) | |||
| TNG2 | <602..746 | CDD:227367 | 30/149 (20%) | ||
| PHD type zinc finger motif | 697..738 | 8/44 (18%) | |||
| PHD1_NSD3 | 703..746 | CDD:277119 | 5/42 (12%) | ||
| PHD type zinc finger motif | 745..795 | 7/49 (14%) | |||
| PHD2_NSD3 | 751..797 | CDD:277122 | 6/45 (13%) | ||
| PHD3_NSD3 | 798..850 | CDD:277125 | 9/51 (18%) | ||
| PHD type zinc finger motif | 858..945 | 18/123 (15%) | |||
| PHD4_NSD3 | 917..952 | CDD:277128 | 5/34 (15%) | ||
| PWWP domain; Pfam PF00855 | 954..1013 | 2/58 (3%) | |||
| WHSC1_related | 958..1051 | CDD:99899 | 14/99 (14%) | ||
| AWS | 1094..1144 | CDD:197795 | 20/55 (36%) | ||
| SET | 1145..1268 | CDD:214614 | 51/122 (42%) | ||
| SET domain | 1149..1255 | 46/105 (44%) | |||
| PHD type zinc finger motif | 1317..1364 | 1/1 (100%) | |||
| PHD5_NSD3 | 1323..1365 | CDD:277131 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165158031 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D507784at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4489 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.880 | |||||