DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and PHF20L1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_011515377.1	Gene:	PHF20L1 / 51105	HGNCID:	24280	Length:	1023	Species:	Homo sapiens

Alignment Length:	1096	Identity:	215/1096 - (19%)
Similarity:	354/1096 - (32%)	Gaps:	376/1096 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   795 DSKKSCAAVTPAKQKESGK--------SAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQ- 850
            ||.:......||.:||..|        .|.|.:|.:.|:.....||:::     ::|:|..|.|
Human    61 DSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEA-----INKEGTFTVQF 120

  Fly   851 WSPQLQTLPKSSTKP-PQESAPSVISKTTSNQP----APKEEQHAAKKGLSDNSPPSVLK----- 905
            :...::.|.:...|. |:::....:.:..|..|    .|.:...:..:.:......:::|
Human   121 YDGVIRCLKRMHIKAMPEDAKGQFLFQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAA 185

  Fly   906 -AKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVE------APPKVEP----PTA 959
             ||.|..|         |....||:....| |:::|..|||:|.|      |.|.||.    ||:
Human   186 AAKNKTGS---------KPRTSANSNKDKD-KDERKWFKVPSKKEETSTCIATPDVEKKEDLPTS 240

  Fly   960 -----------VP---VPGQKKSLSGK-------------------TSL------------RRNT 979
                       ||   .|..:.:||.|                   |.|            ::..
Human   241 SETFVGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKED 305

  Fly   980 VYEDSPNLERNSSPSSD---------SAQANT----------SAGKLKPSKVKKK-------INP 1018
            ..|.:|.||:..||...         |:.|||          |:||.:..|.|.:       |.|
Human   306 YNETAPMLEQAISPKPQSQKKNEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSSGCIKP 370

  Fly  1019 RRSTICE---AAKDLR-SSSSSSTPTREVAASSPVSTS---SDSSSKRNGSKRTTSDL--DGGSK 1074
            .:|.:..   ..:||. .|..||:...:.:...||:..   ..|..:|...:..|..:  |...|
Human   371 PKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEK 435

  Fly  1075 L-------DQRRYTICEDRQPETAIP----------------VPLTKRRFS--MHPKASANPLHD 1114
            :       |.:.::|....|.|:::|                :||...|.|  ..|.||.:...:
Human   436 VSSPSPATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRN 500

  Fly  1115 TLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSK 1179
            ..      .|..||..:.|...:|  .:.:..:|||....:...|    ..::.|...||:.|.:
Human   501 EC------PRAEKEDTQMLPNPSS--KAIADGRGAPAAAGISKTE----KKVKLEDKSSTAFGKR 553

  Fly  1180 MSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEED------- 1237
            ..:                       |.....|||| |..:.|:.:.:.|::...:.|
Human   554 KEK-----------------------DKERREKRDK-DHYRPKQKKKKKKKKKSKQHDYSDYEDS 594

  Fly  1238 --EFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRA---- 1296
              ||.:|.:   :|.|..:.|...|....:..|||.                    |.|||
Human   595 SLEFLERCS---SPLTRSSGSSLASRSMFTEKTTTY--------------------QYPRAILSV 636

  Fly  1297 -SQGRGVASVALAPISMDEQLAELANIEAINEQFLRS---EGLNTFQLLKENFYRCARQVSQENA 1357
             ..|..::.|.....|..|.|  |.:.:..|:.|..:   |..:....|.| ..||..::.:||.
Human   637 DLSGENLSDVDFLDDSSTESL--LLSGDEYNQDFDSTNFEESQDEDDALNE-IVRCICEMDEENG 698

  Fly  1358 EM-QCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARC----TNKRFQQHQCWPCR--- 1414
            .| ||:                          ||  ||...:.|    .....:|:.|:.||
Human   699 FMIQCE--------------------------EC--LCWQHSVCMGLLEESIPEQYICYICRDPP 735

  Fly  1415 ------VFRTEK------KGCGIT----------AELLIPPGEFIMEYVG--EVIDSEEFERRQH 1455
                  .:|.:|      :.||::          |:.::.....:.:..|  ||:...:.:
Human   736 GQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLK---- 796

  Fly  1456 LYSKDRNRHY---YFMALRG-----EAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFF 1512
             ....:|:|:   :..|..|     :.:|....|......:|.      |.:|:..|       .
Human   797 -IGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNR------EEKKYVQN-------H 847

  Fly  1513 SVKPIQP----GEEITFDYQYLR---YGRDAQRCYCEAANCRGWIG-GEPDSDEGEQLDEESDSD 1569
            ...|..|    |..||.::.|.:   :|:|          |:.... |..|.|:...|:||.:..
Human   848 KEPPRLPLKMEGTYITSEHSYQKPQSFGQD----------CKSLADPGSSDDDDVSSLEEEQEFH 902

  Fly  1570 AEMDEEELEAEPEEGQPRKSAKAKAK----------------SKLKAKLPLAT--GRKRKEQTKP 1616
            .........:..|.|.|.|...|:..                |.|:.:|.|.|  ...:.|.|..
Human   903 MRSKNSLQYSAKEHGMPEKKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSR 967

  Fly  1617 KDREYK----AGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRR 1668
            .|...|    ...||                     .|...||.||.:..|..|:|
Human   968 MDLIEKEVDVLESWL---------------------DFTGELEPPDPLARLPQLKR 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	9/56 (16%)
		SET	1414..1533	CDD:214614	25/160 (16%)
		PostSET	1535..1551	CDD:214703	2/15 (13%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
PHF20L1	XP_011515377.1	MBT	3..68	CDD:302657	2/6 (33%)
		TUDOR	90..135	CDD:119391	10/49 (20%)
		DUF3776	214..322	CDD:289391	25/107 (23%)
		PHD20L1_u1	323..388	CDD:293265	14/64 (22%)
		PHD_PHF20L1	688..733	CDD:277103	15/72 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030