DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and Set2

DIOPT Version :10

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_061511250.1 Gene:Set2 / 4577900 VectorBaseID:AGAMI1_014733 Length:2662 Species:Anopheles gambiae


Alignment Length:2894 Identity:759/2894 - (26%)
Similarity:1126/2894 - (38%) Gaps:846/2894 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 ASRGRGRGRPPK-VALSALG-NTPPHI---------------------NPSLKHADAEASPTAPE 55
            |.||.||||..: ...|:|| |:||.:                     :.||:....:.|....:
Mosquito    62 AGRGAGRGRGGRGRGASSLGVNSPPPVEETPYADGEMVEMIEILDDETSKSLEGTPGDDSVVVQQ 126

  Fly    56 DQDSGQS----ECRRSSRKKIIKFDVRDLLNKNRKAH-KIQIEAR-----IDSNPSTGHSQSGTT 110
            :::..:.    :|:....|.|:.  ..:.|..|..|. .:.::..     |:..|....|.:||.
Mosquito   127 EEELAEEVQLMDCQTIDGKTIVV--TEETLVGNEPADGTLLVDGETTVVYIEDEPEVADSGAGTR 189

  Fly   111 AASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVA---- 171
            .:...:.              .:..|..|.:. ..||....|.........||.....|.:    
Mosquito   190 KSKRQVK--------------ATNKFRDFVVD-APLPMNQQPVRTYSSGKSPRRVAGTIGSGMLQ 239

  Fly   172 ------QVTSEPSAVGGAHPVQTMAGLPP---------VTPRKRGRPRKSQLADAAIIPTVI--- 218
                  |.||.|:||   :...|....||         .|..||||.:|      .:.|:::   
Mosquito   240 PGTSKQQRTSLPAAV---YETPTKEAPPPSSTAAVRGGSTGAKRGRKKK------PVAPSILDIA 295

  Fly   219 -VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLR-VSLKRLKLGGRLESSDSGNSPSSS 281
             |..|.::                       ||.|:.:.| .||..|::.|.:...|.....|||
Mosquito   296 GVDPCDET-----------------------IQLPRPEERNNSLISLRIDGAVFGDDDSIHSSSS 337

  Fly   282 SPEVEP-PALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEE--EQEEGRP 343
            ...||. |.:........:||                    :..:....|.|.|..  .:....|
Mosquito   338 QELVESGPPIMGGGTRGRKPK--------------------VAAVGSTPERPAGSTFIRRSYKTP 382

  Fly   344 VEV----EPQDLIDIDMELAKQEPTPDPEE----DLDEIMVEVLSGPPSLWSADDEAEEEEDATV 400
            ..|    ||.  ..::.|:...||..|.|:    ..|||:::.               .||..|.
Mosquito   383 ANVNAALEPS--TSVEAEVVAPEPVVDDEDVIVLQADEIIIDA---------------PEERPTS 430

  Fly   401 QRATPPGKEPAADSCSSAPRRSRRS-APLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEE 464
            .|.:..|:.......|...|.||.. ....|...:|:.......|...|.....:|.|..:::| 
Mosquito   431 GRGSRGGRGSRGGRGSRGGRGSRGGRGSRGGRGGRGRGAARGVMEGGEEMVNDSVEGEREKEEE- 494

  Fly   465 QHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDN 529
                 .:.:.:...:||   |...:||  |||.|.|...:    :||::.|.|        :.:.
Mosquito   495 -----SVAQPSEESAEV---VEVAVEH--VEETVPESAMM----EEIVEEKVE--------QPEE 537

  Fly   530 IAASLNKDIFEPKVETKATCGEVVPR-PEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS 593
            :|.       ||:|:     .|:.|: .|.:.:.:..||....|...|.||..| .|.:.|.:.:
Mosquito   538 VAT-------EPEVQ-----AEIAPKEEEEIPDKMDSTEQPTETEPTSMVVETP-VEPVCEVETA 589

  Fly   594 D-EVVIE---PPLK--DESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSP----LVPPECC 648
            . ||.:|   .|::  .|:.|...| |||..:|......|:...:...|.|:.|    :.|||  
Mosquito   590 TVEVCVEEQPAPVEPIPENKPDLPE-ELPHDEPTQKDTPSDTATNKATEQTNLPKEPEITPPE-- 651

  Fly   649 TLESVSGPVLLETSLSTEEKSNEN--------VETTPLKTE-----------AAKEDSPPAAPEE 694
                      ...|:.||:...|:        |||.|.|.:           .:::.|....|.:
Mosquito   652 ----------QNASVETEKPDREDPAPPPKQIVETPPRKEKRDQDTKLTDSGGSRKGSSKERPPK 706

  Fly   695 EASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMEN 759
            |:.:|.::       |.::::...:::..:...:|       .|.|..|:.:.:....|::.|.:
Mosquito   707 ESPSSRDK-------YRASEKSTPDEDRSRGEQRK-------KERKRLEEEMRKRTQSKDRPMGD 757

  Fly   760 PARSSPAIVDKKVRAGEMEKKVV--KSTKGTVPEKKM-------DSKKSCAAVTPAKQKESGK-- 813
            ......|:.|..||..:..|..:  .|:.||..::.:       |.|...     .|.||:.|  
Mosquito   758 ERHEKRAVSDGAVRVKDDRKLSLDRMSSAGTERDQHVPLGTTASDEKDKI-----RKGKEADKRS 817

  Fly   814 -------SAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPP----- 866
                   .|||.|...|:....||.|..||.|...||..|........|:..|.|.||.|     
Mosquito   818 SDVGTAGEAKEKIATAESSIPSSSKKRPSSIPPRPDKPKKCFESEMKALELQPISRTKAPHDESR 882

  Fly   867 --------QESAPSVISKTT--------------------------------------SNQPAPK 885
                    .:|:.|..|..|                                      |::|..|
Mosquito   883 RRAETKDRDDSSSSSSSHRTKEHSRHSSSSGSSKHKSSKSSSSHEGATARRLDTSGHRSSRPKEK 947

  Fly   886 EEQHAAK-KGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVE 949
            ||:...: :|......|:..|:.....|...|.....:::...:::.:..:::..|.|.....||
Mosquito   948 EEEKQQRDRGEGGEKEPTGRKSVSAGGSFLQEETNRDRSIVKKSSKTKDSKRDSSKAKSGVEAVE 1012

  Fly   950 APPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP--SSDSAQANTSAGKLKPSKV 1012
            ..| .|.|.....| |||........|  .|.|..|..:..:.|  :|..|....:...||..|:
Mosquito  1013 EKP-AEKPLVTESP-QKKIEEQPVETR--NVPECPPVEQEPAEPFKASPEAPRIVTKASLKMYKM 1073

  Fly  1013 KKKIN-------------PRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKR 1064
            ::.:.             |....:...|:::..|....|...|:....||               
Mosquito  1074 EECVEAELPTPPPPPQQPPETLQVTPKAEEIHVSEVVQTKVAELPTQLPV--------------- 1123

  Fly  1065 TTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTA--GKKRGRK 1127
                               ::..|.|...||      .|.||.....|.:...:.|  ..:..|.
Mosquito  1124 -------------------KEEPPATLDAVP------PMEPKPETQQLAELKEEEAFSDAETLRS 1163

  Fly  1128 EGKESLSRQNSLDSSSSASQGAPKK--KALKSAEILSAALLETESSESTSSGSKMSRWDVQTS-- 1188
            :....||....|.:.|..|.|.|.:  ..::|.......|:..:..:..|||...|...|..|  
Mosquito  1164 DSVAGLSDSEGLSAPSRCSSGFPSEDDSGVRSGASTPYDLMSCDEPDPASSGGGGSVTVVPPSSV 1228

  Fly  1189 PELEAANPFGD-------------IAKFIEDGVNLLKRDK-----VDEDQRKEGQDEVKREADPE 1235
            |.:|...   |             :..:|:|||  ::|..     ..:.||..|...|:     :
Mosquito  1229 PSVEEVR---DEDRDSQRVDMVRLVESYIDDGV--IRRSTRIKTISSQKQRTSGHGLVR-----D 1283

  Fly  1236 EDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGR 1300
            .|:..::               :.....|:..|...|     .||...|....|  .|.......
Mosquito  1284 RDKLMKK---------------SSGAVGDAYGTAEAL-----AGGYSASEMAMQ--SGGHLQGAA 1326

  Fly  1301 GVASVALAPISMDEQLAELANIEAINEQFLR--SEGLNTFQLLKENFYRCARQVSQENAEMQCDC 1363
            ||:..|. |:..:|  .:.||:| ::|::||  .|.|:.|:.::||.|...|.||:|..:|.|||
Mosquito  1327 GVSGPAW-PVIANE--GDSANVE-LSEEYLRDMEEKLSRFETIRENIYHSDRIVSREAKKMTCDC 1387

  Fly  1364 FLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAE 1428
            |||.:|..:|...||..|:||:||||||..|:.|.||||:|||:.:...|:||||||||.||.|.
Mosquito  1388 FLTHEEIERGEHGCGEDCLNRLLMIECGSRCTVGDRCTNRRFQRQEYAHCQVFRTEKKGFGIQAS 1452

  Fly  1429 LLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCD 1493
            ..|.||||||||||||::|.:|:.|...||:::|:||||||||.:.:||||:||||||:||||||
Mosquito  1453 SAIAPGEFIMEYVGEVLNSAQFDERAEAYSREKNKHYYFMALRSDGIIDATTKGNISRFINHSCD 1517

  Fly  1494 PNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEP---- 1554
            ||||||||||||||||||||.|.|.||||||||||:.||||.||:|||||.:||||||.:|    
Mosquito  1518 PNAETQKWTVNGELRIGFFSTKYILPGEEITFDYQFQRYGRKAQKCYCEAESCRGWIGAKPTGEG 1582

  Fly  1555 -DSD-EGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPK 1617
             ||: |.|..|||.:.:.|..|||...|.|||..:......|.| ::....|..|:..|      
Mosquito  1583 RDSEFEEEDEDEEDEEEGEEGEEEESEEEEEGGEKVDLVETAAS-VQQSAQLDVGKAAK------ 1640

  Fly  1618 DREYKAGRWLKPSAT----------GSSSSA-------EKPPKKPKVNKFQAML---EDPDVVEE 1662
                  |..|..:||          |.|.:|       :|..||....:.|..|   ||||:.||
Mosquito  1641 ------GAALAAAATAAGAGDRPEGGKSDAAPVAPTKVKKTRKKRTTGRKQRRLEIHEDPDLDEE 1699

  Fly  1663 LSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWI--- 1724
            ::.|.:.|||||..||:.||.:||||.:|:|..||.:|..||||||||||||||||||:.||   
Mosquito  1700 INNLLKTGLKNQAHTLKLSRLMVRAKDIKSRSRLLTLLQSGELPCRRLFLDYHGLRLLYGWICES 1764

  Fly  1725 SENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWS--NSLEQQLAVVP----------- 1776
            :|:..|.:.|..:||||:.|||.|:|||.||::..:|:.|:  ...:||..|||           
Mosquito  1765 TESIEDLKFRIQILDTLDRLPISNKTMLKDSKILHTVEKWARVEKGKQQKEVVPGPTAVPKEEPQ 1829

  Fly  1777 ------------------------------------------QEKQAA------------LHKRM 1787
                                                      :.:|||            :.|.|
Mosquito  1830 PQLPPPAPAAVGEKAEKEVSSRTSSPSDSNGAGSDSSSQPATERQQAAAKKDLLGLGSMEVLKNM 1894

  Fly  1788 VALLQ------------------------------------------------------------ 1792
            .|||:                                                            
Mosquito  1895 PALLKLADLGKLKEIISTCDSKEVENKEKAAAAAAAAAAGAAAATATTTLSTDSLTASVLPSDIQ 1959

  Fly  1793 ----------------------------KWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHAS 1829
                                        .|..|.|:|||||:||||||||||||||.:.:.:...
Mosquito  1960 IPEPEDENAPEEQRLGTQIRILSCKLLISWMNLKEVFRIPKKERIEQMKEHEREADMRYQAIGLE 2024

  Fly  1830 TALEDQRERESSNDRFRQDR-------FRRDTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDG 1887
            .  :|::|.:..:.|.|..|       |.|.:     |:|.|           .:......||.|
Mosquito  2025 N--DDEKEEKQQHHRHRDGRGWGDGRGFVRGS-----GEPKR-----------RRSLDDRDAPYG 2071

  Fly  1888 MTRNDNRRRSDIGPPSE----------QRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELR 1942
            .......:|.   ||..          ::..|||:.||.|||.|||.:|||||. .|..|.||..
Mosquito  2072 GGLGGKLKRP---PPGGLAGVGGYAPLKQDNLSKQQRRHLFEMKVAHEEAERRK-KEMWLMHENA 2132

  Fly  1943 CEFFGADIN-TDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTELL----TKALLSPDIDVGQGATD 2002
            |..||.:.: |.|..:|......|.|:|:.||..:|.||.....    .....:||         
Mosquito  2133 CLRFGLNPHLTAPMDIPVRMNPATGEYFSEDDRLLPTPPSHAYFKIQPPPMSTNPD--------- 2188

  Fly  2003 VEYKLPPGVDPLPPAWNWQVTSDGDIYYYNLRERISQWEPP------------------------ 2043
             :|:||  ...|||.|.:.:...|.:|||:::|||.|||||                        
Mosquito  2189 -DYELP--AMKLPPYWRFAIDERGRLYYYHVKERIPQWEPPRKPGASRAAVVADDEDISLSSDSS 2250

  Fly  2044 -------SPEQ---RLQTLLEENTTQQP---LHELQIDPAVLENELIQVDT-------------- 2081
                   |.|:   :.:.||::...||.   |.::...|..:.:::.:...              
Mosquito  2251 TTDTCDTSEEELAAQFEQLLKKKRKQQSSFNLDDVLAKPDDMNDDMSKAPVKRESGESGSPQMLT 2315

  Fly  2082 --DYVGSLSAKSLAQYIEAKVRE---RRDLRRS-KLVSIRLISPRRDEDRLYNQLESRKYKENKE 2140
              :..|..:..|.|...||.:::   ||..:.| |||..|:||||.:||:.|.|:|.::|||.||
Mosquito  2316 LEEIFGESANASTAAVDEATLQQLLPRRKRKHSLKLVQARIISPRTEEDKQYGQMEMKRYKETKE 2380

  Fly  2141 KIRRRKELYRRRKI--------------------------------------------------- 2154
            |:|:|||..:|.:.                                                   
Mosquito  2381 KLRKRKEEAKRLRARSMFSKTLADNPFGGPLLDKPSLAANATATDGAGSGGMGGVGVGGTGDASL 2445

  Fly  2155 ---------EVLPD--AVDEIPVPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPST 2208
                     :::.|  .|||:.:..|...|.||      ||.|  .::|...::.:.:..|   |
Mosquito  2446 MDDDLVVSHKIVEDKCIVDELDILNKKKKISPY------EEWK--KVQQRLGKKRKTAEEM---T 2499

  Fly  2209 SHAAMAALGKAVAQPTGLGTVGKRKLPMPPS----------VTVKKHRQEQRSKKVKSSQSPLTA 2263
            ..:.....|.|||  .|.||.|....|...|          .|.|      .:|:.|||:..|.:
Mosquito  2500 GESGGGGGGAAVA--GGSGTGGPAAAPAQQSAADGGGSSAMATAK------LAKRKKSSKGDLNS 2556

  Fly  2264 TSAREAHEKFRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGN 2328
            ..|::..||||.:|:|.:...|..|||:||.|||||:.:|:|.|..:|::.:..||:::|:.:.:
Mosquito  2557 EEAKKIKEKFRVDIAGVIVQHLSGYRKDSCPLGRITNTDDFKHLARKLTHFVMLKELKHCDNTVH 2621

  Fly  2329 PLSCTESVKHKSYDFINQYMRQKGPVYKKPAEND 2362
            .|..|:|||.|:.:||.:||.:.||||.: .||:
Mosquito  2622 ELEVTDSVKTKAREFIKKYMAKHGPVYVR-GENE 2654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 valS <709..832 CDD:237855 28/140 (20%)
AWS 1358..1410 CDD:197795 29/51 (57%)
SET_SETD2 1410..1551 CDD:380949 102/140 (73%)
WW 2014..2043 CDD:459800 14/28 (50%)
SRI 2266..2355 CDD:462404 37/88 (42%)
Set2XP_061511250.1 None

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