Protein Alignment Set2 and LOC4577143

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_313355.5
• Gene: LOC4577143 / 4577143
• VectorBaseID: AGAMI1_013464
• Length: 851
• Species: Anopheles gambiae
• Alignment Length: 1021
• Identity: 213/1021 - (20%)
• Similarity: 328/1021 - (32%)
• Gaps: 362/1021 - (35%)

  Fly   664 STEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQ 728
            ||..|:...|:|...|.|..:..:   ...|..|.|      .:|..:|      :.::|:....
Mosquito    58 STVVKAISGVQTVRFKNELERNIT---IKLENLSKS------FIETLQS------DAKVMEAYLH 107

  Fly   729 KGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEK----KVVKSTKGTV 789
            |..:|...|...........|.|:|.|...|..::||      ...||.::    |::.....:.
Mosquito   108 KMHEQYKSPYNHGTSHSNKHTPSRKRKLSPNGLQTSP------TNNGETQRMKQAKIMDFFHMSP 166

  Fly   790 PE----------KKMDSKKSCAAVTPAKQ---------KESG----KSAKEAILKKETEKEKSSA 831
            ||          ::...:|||    ||.|         |.:|    .|.....:|||.::.:..:
Mosquito   167 PERITQPSLHASRERARRKSC----PAAQGNFSGTHIPKPNGFPKRMSCSIDKVKKEVDESEDGS 227

  Fly   832 KLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLS 896
            :.|                                   .|:.....|.||.....::...|...|
Mosquito   228 RFD-----------------------------------VPTDTRLATINQEQATPDKQNIKVECS 257

  Fly   897 DNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVP 961
            |.:|                 |||..:..:.|.            .:.| |..|..|||..|..|
Mosquito   258 DETP-----------------DAMSSSSQVENG------------TETP-KTTASVKVENGTDTP 292

  Fly   962 VP--------GQKKSLSG-----KTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVK 1013
            |.        |..|.:|.     |||..:.|.   |..:|..:...:.....::|.|.|   .||
Mosquito   293 VTPVARDNSNGLLKVMSAAKPSPKTSTPKTTA---SIKVENGTVSPATPVSRDSSKGLL---NVK 351

  Fly  1014 KKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQR 1078
            ....|...|.....::...|:..|||.|:       ||...|:||:.....|||          :
Mosquito   352 LAAKPSPKTPATGERNSSLSAGKSTPKRK-------STGGGSNSKQIKKSATTS----------K 399

  Fly  1079 RYTI--CEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNS--- 1138
            .||:  .||.|.....|..|.|                .|..|:     :....|.|:..||
Mosquito   400 EYTVENIEDIQLVGNSPFFLVK----------------WLGYTS-----KDNTWEPLNNVNSCAM 443

  Fly  1139 LDSSSSASQG------APKKKALKSA-EILSAALLETESSESTSS---GSKMSRWDVQTSPELEA 1193
            |||..||...      .|.::.::|: |.|.:  ||.:.|::...   ..|...||     :|.|
Mosquito   444 LDSFLSAQMSLLEEWVEPLQEKIRSSPEYLES--LERQGSKTYQEILLEHKEYDWD-----QLRA 501

  Fly  1194 ANPFGDIA------------KFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANM 1246
                 |:.            |.|.:.:..|...::...:|.|..:|::|        |.:.:
Mosquito   502 -----DLIIMAKLWMNRGRNKLIWERITRLMCRELSYAKRCEQLEELRR--------FEKHI--- 550

  Fly  1247 ETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPIS 1311
                            .|...|..|:.|.|        |.:...|......||
Mosquito   551 ----------------NDHEPTLRVVVENE--------HDLDAPPNNFTYLQG------------ 579

  Fly  1312 MDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCF-LTGDEEAQGHL 1375
                     ||.|        ||::.                ..:..:.|:|. .||.....|.|
Mosquito   580 ---------NIPA--------EGISI----------------PNDPPVGCECNPCTGRSTCCGKL 611

  Fly  1376 SCG--AGCINRMLMI-------ECGPLCSNGARCTNKRFQQHQCWPCRVFRTEK-KGCGITAELL 1430
            |.|  |..:.:.|::       ||...||.|..|.|:..|........:|:|.. :|.|:....:
Mosquito   612 SEGRFAYSVKKRLLLQPGAPIFECNKKCSCGPDCLNRVVQNGGKCNLTLFKTPNGRGWGVRTNTV 676

  Fly  1431 IPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRG---EAVIDATSKGNISRYINHSC 1492
            |..|::|.||.||||..:|.|:|...|......:.:.:...|   ...:||...||::|:.||||
Mosquito   677 IYEGQYISEYCGEVISYDEAEKRGREYDAVGRTYLFDLDFNGTDNPYTLDAARYGNVTRFFNHSC 741

  Fly  1493 DPNAETQKWTVNGEL------RIGFFSVKPIQPGEEITFDYQ----------------------- 1528
            |||...  |:|..:.      |:.||:.:.|:.|||:||:|.
Mosquito   742 DPNCGI--WSVWIDCLDPYLPRLAFFAQRRIEIGEELTFNYHAQVSPNNVSINGGSGGGGPPMDG 804

  Fly  1529 ------------------------YLRYGRDAQRCYCEAANCRGWI 1550
                                    .:|..:....|.|.:||||.:|
Mosquito   805 DSSTGGVVEEKPAENGDKATTANGSVRNTKGVTECLCGSANCRKFI 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	29/149 (19%)
		AWS	1358..1410	CDD:197795	18/61 (30%)
		SET_SETD2	1410..1551	CDD:380949	50/198 (25%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
LOC4577143	XP_313355.5	None