Protein Alignment Set2 and KMT2A

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Alignment Length: 2052
• Identity: 381/2052 - (18%)
• Similarity: 637/2052 - (31%)
• Gaps: 709/2052 - (34%)

  Fly     6 PPSNPSPVASRGRGR------GRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSEC 64
            |||...|..|:..|.      .:.|::...:.  :|...:|..:...:..|||....:.....:
Human  2155 PPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY--SPTQRSPGCRPLPSAGSPTPTTHEIVTVGD- 2216

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKI---QIEARIDSNPSTGHSQSGTTAASTS----------- 115
                  .::...:|.:.::......:   :.:.||.|...||::.|....:|.|
Human  2217 ------PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS 2275

  Fly   116 ----------MSTATASAASASSAATVSRLF-------------SMFEMSHQSLPPPPPPPTALE 157
                      ::::|:...:.|:::.:.|..             |..||...|         |.:
Human  2276 AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSS---------ASD 2331

  Fly   158 IFAKP---RPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIV 219
            :.:|.   :..::.:::..:||.||...|:|     |:|.:.|:...  ..|:..:.:.|.:...
Human  2332 LVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP-----GIPKLAPQVHN--TTSRELNVSKIGSFAE 2389

  Fly   220 PSC--------------------SDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLK 264
            ||.                    :|.|.::.||.::|.|.|..               ..:|.||
Human  2390 PSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDED---------------TEVKTLK 2439

  Fly   265 LGGRLESSDSGNSPSSSSPE-----------------------VEP------------PALQDE- 293
            |.|....|...|....||..                       :||            |...||
Human  2440 LSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV 2504

  Fly   294 ---NAMDERPKQEQNLSRMVD--------------AEENSDSDSQI------------IFIEIET 329
               ..|.:||....:..::.|              ..|.|..:.|.            :.:|.|:
Human  2505 LTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES 2569

  Fly   330 ESPKGEEEQEEGRPVEVE---PQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSA-DD 390
            :|....:|.....|:::|   |.:.|.     |.:.|...|          |....|:..|. |.
Human  2570 QSKNALKESSPASPLQIESTSPTEPIS-----ASENPGDGP----------VAQPSPNNTSCQDS 2619

  Fly   391 EAEEEEDATVQRAT---PPGKEPAADSCSSA--PRRSRRS--------APLSG------------ 430
            ::...::..||...   |.|.:|..|.....  ||||.|:        .||.|
Human  2620 QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY 2684

  Fly   431 SSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVE 495
            ||..||...:..||...:.:..:..::|.          ||.....:.:.::|...   |.:...
Human  2685 SSSTGKKRGKRSAEGQVDGADDLSTSDED----------DLYYYNFTRTVISSGGE---ERLASH 2736

  Fly   496 EVVVEENQL----VDEADEILDSKQEFVIKKVFSESD-NIAASLNKDIFEPKVETKATCGE--VV 553
            .:..||.|.    :.:.|.:.|.          :||| ::.|:..|....||...|....|  .:
Human  2737 NLFREEEQCDLPKISQLDGVDDG----------TESDTSVTATTRKSSQIPKRNGKENGTENLKI 2791

  Fly   554 PRPEMVTEDVYITEGIAATLEKSAVVTKPTTEM-----IAETKLSDEVVIEPPLKDESDPKQTEV 613
            .|||...|..::|        ||:|..|...:|     ::..|...:..:|..|......::...
Human  2792 DRPEDAGEKEHVT--------KSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHT 2848

  Fly   614 ELPESKPAVNIPKSERILSAEVETTSSP----LVPPECCTLESVSGPVLLETSLSTEEKSNE--- 671
            ..|..|..::...:| :|.::.:..:|.    ::|.:.......:.|.:.....|.|..|:|
Human  2849 STPSDKNLLDTYNTE-LLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLN 2912

  Fly   672 ---------NVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNN 727
                     |.|......|...:..|...|.:.:.:||                ::.:|
Human  2913 LGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSS----------------ISAEE------ 2955

  Fly   728 QKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPAR---------SSPAIVDKKVRAGEMEKKVVK 783
                 |..|| ::.|......|........:||:|         ....|.:|.|.:.|.:..::.
Human  2956 -----QFELP-LELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLS 3014

  Fly   784 STKGTVPEKKMD--------------SKKSCAAVTPAKQKESGKSAKEAILKKET---------- 824
            ......||..|.              |...|.:|      |.|....:.:.:..:
Human  3015 PGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSV------EQGHGNNQDLTRNSSTPGLQVPVSP 3073

  Fly   825 ----EKEKSSAKLDSSSPNTLDKKGKD-----TAQWSPQ---------------------LQTLP 859
                :.:|       ..||:.|..|..     ..|.:|.                     |||||
Human  3074 TVPIQNQK-------YVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLP 3131

  Fly   860 KSSTKPPQ-----ESAPSVISKTTS---------------NQPAPKEEQ--HAAKKGLSDNSPPS 902
            ...|:..|     .|.|||:...||               |...|..:.  .:|.|||...|...
Human  3132 NGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQ 3196

  Fly   903 VLKAKEKAV-SGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPK-----VEPP---- 957
            .|.:...|. |.|                              |..:..||.     |:||
Human  3197 HLHSFPAATQSSF------------------------------PPNISNPPSGLLIGVQPPPDPQ 3231

  Fly   958 ---------------TAVPVPGQKKSLSGKTSLRRN---------------------TVYEDSPN 986
                           .|.|..|.||....:...|:|                     |:...:|:
Human  3232 LLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS 3296

  Fly   987 LERNSSPSSDSAQANTSAGKLKPSKVKKK-----------INPR-----------RSTICEAAKD 1029
            ...|.....|....|||:.:..|:.:|:.           :.|:           .|||.:....
Human  3297 QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH 3361

  Fly  1030 LRSSS----SSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDL----DGGS------KLDQRRY 1080
            |.|.|    :||:....|.:....:|.:.|:|.......|...|    |.||      |..|:..
Human  3362 LTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSL 3426

  Fly  1081 TICEDRQPETAIPVPLTKRRF-----SMHPKASA---------NPLHDTLLQTAGKKRGRKEGKE 1131
            .|.:  ||   :.:|.:...|     |..|..:|         .|...|...||....|..:...
Human  3427 GIQD--QP---VALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY 3486

  Fly  1132 SL--------------SRQNSLDSSSSA-------------SQGAPKKKALKSAEILS------- 1162
            .|              |.|..|||:|..             |.|..:.|||.||...|
Human  3487 QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGS 3551

  Fly  1163 -----------------------------------------AALLETESSES------TSS---- 1176
                                                     .:.|.|.|||:      |:|
Human  3552 PSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSG 3616

  Fly  1177 ----GSKMSRWD---VQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADP 1234
                |::..:.|   |:.|.:.|...|.|.:|        :|...:|.::...|.:....:..:.
Human  3617 TGTPGAEAEQQDTASVEQSSQKECGQPAGQVA--------VLPEVQVTQNPANEQESAEPKTVEE 3673

  Fly  1235 EEDEFAQRVANMETPATTPTPSPTQSNP---------------------EDS-ASTTTVLKELET 1277
            ||..|:..:............|.|:..|                     ||: .|.|..::|
Human  3674 EESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQE--- 3735

  Fly  1278 GGGVRRSHRIKQKP-QGPRASQGRGVASVALAPISMDEQLA---------------ELANIEAIN 1326
               .|.:.|:||.. .|....:..|:...|:  :.:.|||:               |.||...:|
Human  3736 ---ARSNARLKQLSFAGVNGLRMLGILHDAV--VFLIEQLSGAKHCRNYKFRFHKPEEANEPPLN 3795

  Fly  1327 -------EQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINR 1384
                   |..||....:.|..|....    ||..:.|.        ..:||.:..|.......:.
Human  3796 PHGSARAEVHLRKSAFDMFNFLASKH----RQPPEYNP--------NDEEEEEVQLKSARRATSM 3848

  Fly  1385 MLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEE 1449
            .|.:   |:.....:.|:|.       ...|:|:...|.|:..:..|..||.::||.|.||.|.:
Human  3849 DLPM---PMRFRHLKKTSKE-------AVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQ 3903

  Fly  1450 FERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSV 1514
            .::|:..|. .:....|...:....|:|||..||.:|:|||||:||..::...::|:..|..|::
Human  3904 TDKREKYYD-SKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM 3967

  Fly  1515 KPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRGWI 1550
            :.|..|||:|:||:: :....:...|.|.|..||.::
Human  3968 RKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFL 4004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	22/159 (14%)
		AWS	1358..1410	CDD:197795	7/51 (14%)
		SET_SETD2	1410..1551	CDD:380949	45/142 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:366873
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2060..2107	CDD:461787
		FYRC	3705..3788	CDD:197781	15/90 (17%)
		SET_KMT2A_2B	3852..4005	CDD:380947	48/164 (29%)