Protein Alignment Set2 and Su(var)3-9

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 171/698 - (24%)
• Similarity: 258/698 - (36%)
• Gaps: 183/698 - (26%)

  Fly   909 KAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKT 973
            ||:||..  ...||.....|..::|:..::||:|.:.|..:...:.|..       |:..|....
  Fly    58 KAISGVQ--TVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIK-------QRSMLRHLA 113

  Fly   974 SLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSST 1038
            .|||::.:.     ...:.|:|.|..|:||:       |.:: ..||||          |.:|.:
  Fly   114 ELRRHSRFR-----RLCTKPASSSMPASTSS-------VDRR-TTRRST----------SQTSLS 155

  Fly  1039 PTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKR-RFS 1102
            |:......|..........|       ...|:|.:||.:|| :.|      ...|.|.:|| :.:
  Fly   156 PSNSSGYGSVFGCEEHDVDK-------IPSLNGFAKLKRRR-SSC------VGAPTPNSKRSKNN 206

  Fly  1103 MHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLE 1167
            |...|...|                :|:..:.|...::    ..|..|         :.....|.
  Fly   207 MGVIAKRPP----------------KGEYVVERIECVE----MDQYQP---------VFFVKWLG 242

  Fly  1168 TESSESTSSGSKMSRWD----VQTSPELEAANPFGDIAKFIEDGVNL--LKRDKVDEDQRKEGQD 1226
            ...||:|        |:    |....|:|         ||:|....|  :...|:..:..|:
  Fly   243 YHDSENT--------WESLANVADCAEME---------KFVERHQQLYEIYIAKITTELEKQ--- 287

  Fly  1227 EVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKP 1291
               .||.|    ..:.:...|..|..|.         :......:|.:....|.  ||.|..||
  Fly   288 ---LEALP----LMENITVAEVDAYEPL---------NLQIDLILLAQYRAAGS--RSQREPQK- 333

  Fly  1292 QGPRASQGRGVASVALAPISMDEQLAELANIEAINEQF------LRSEG---LNT----FQLLKE 1343
            .|.||.:.   ..:..|.....:|||:||..|......      :|.|.   |:|    |..:.:
  Fly   334 IGERALKS---MQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHD 395

  Fly  1344 NFY--------------RCARQVSQENAEMQCDCFLTGD----EEAQGHLSCGAGCINRMLMIEC 1390
            |..              :|.....:..|..:|.....|:    |.:...|....|    ..:.||
  Fly   396 NIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPG----SAIYEC 456

  Fly  1391 GPLCSNGARCTNKRFQQHQCWPCRVFRTEK-KGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ 1454
            ...||..:.|:|:..|..:..|..:|:|.. .|.|:.|...:..|||:.||:||:|.|:|...|.
  Fly   457 NSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERG 521

  Fly  1455 HLYSKDRNRHYYF-----MALRGEAVIDATSKGNISRYINHSCDPN-AETQKWT--VNGEL-RIG 1510
            ..|. |..|.|.|     .|...|..|||.:.||||.:|||||||| |....|.  :|..| .:.
  Fly   522 KAYD-DNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLV 585

  Fly  1511 FFSVKPIQPGEEITFDYQYLRYGRD---------AQR--CYCEAANCR 1547
            ||:::||:.|||::||  |:|...:         |.|  |.|.|.|||
  Fly   586 FFTLRPIKAGEELSFD--YIRADNEDVPYENLSTAVRVECRCGADNCR 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	12/55 (22%)
		SET_SETD2	1410..1551	CDD:380949	62/159 (39%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	7/23 (30%)
		Chromo	219..268	CDD:459793	13/78 (17%)
		SET_SUV39H	388..634	CDD:380940	78/251 (31%)