DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and ehmt1b

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_021324462.1	Gene:	ehmt1b / 402830	ZFINID:	ZDB-GENE-080515-3	Length:	1295	Species:	Danio rerio

Alignment Length:	1473	Identity:	284/1473 - (19%)
Similarity:	490/1473 - (33%)	Gaps:	473/1473 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 ELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPP-GKEPAADSCSSAPR 420
            |..|.|.|.:...|.:|             ..||:.::.....::.|... |.....|:     :
Zfish    29 ETMKSEGTKESRSDQEE-------------GGDDDHQDGRTGPLREAIEQNGTYENMDT-----K 75

  Fly   421 RSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSV 485
            |:.::....||..:..|:|...:|.......::        ....:||..:.|||:|....| :.
Zfish    76 RNEQNLSTQGSPARPSTMENGLSETEPPHGSKV--------GSNGYILSKVKEDTVSAPHRT-NW 131

  Fly   486 SP----TIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETK 546
            ||    |:.|..                   .|....|::.:...|.|..||....:.|.:.||:
Zfish   132 SPTGGTTLGHGT-------------------KSSPPSVLQSLDQGSSNSGASQGPSLTERRAETE 177

  Fly   547 ATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDES----- 606
            ...|.:...|.........|....|:.:...::.:...|.:.             :||:|
Zfish   178 TKNGIISKTPPPTVHRARKTMSRPASNQTLKLLNRENKEPVV-------------VKDDSAGKPE 229

  Fly   607 ----DPKQTEVELPESK-PAVNIP-----KSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
                .|...:.:||:|: .|.::|     |.:...|....|.....|.|....:.......:...
Zfish   230 AVQPQPSLIQNQLPQSQTDATSVPNTTPAKPQIEFSLYASTVEPRPVSPSVAAVSRKKKRKMGTY 294

  Fly   662 SLSTEEKSNENVETTPLKTEAAKEDSPP-AAPE-------EEASNSSEEPNFLLEDYESNQEQVA 718
            ||..::|:....:.|.|:.......||| ..|:       |:..|.|:|     |:.|..::...
Zfish   295 SLVPKKKNKVLKQRTVLEMFQQISQSPPNPKPKEIVRVNGEKMDNESDE-----EESEEGEDTED 354

  Fly   719 EDEMMKCNNQKGQKQTP-LPEMKEP---EKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEK 779
            |:|::..:..|...:.| :|.:.:|   |...::....:|:..|:...|.          ..::|
Zfish   355 EEELVTEDGAKASHEEPRIPSISQPLEEESEESQDCEGEEEGDESDLSSE----------SSLKK 409

  Fly   780 KVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDS-SSPNTLDK 843
            |..|..||           ..|.:.|::::                |.|..||.|. |:|.|
Zfish   410 KWKKKAKG-----------DHAWLRPSRKR----------------KRKWKAKTDKVSAPVT--- 444

  Fly   844 KGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKE 908
                      ::|:.|:|      :|||||   .|:::   ||.:......|:..:..::|.::.
Zfish   445 ----------EIQSRPES------QSAPSV---PTAHR---KEYKEVPLDSLNLAAQEALLTSQN 487

  Fly   909 KAVSGFVE-CDA-MFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSG 971
            .|.||.:: .|| |.:.:.|.:.::. ..|:::.|.....|..|               .:|:.|
Zfish   488 TAASGSLQSTDADMVQELPLCSCRME-TPKSREILTLADRKCMA---------------TESIDG 536

  Fly   972 KTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEA---------- 1026
            :.|..::.|      |:......|:|.|........:...||.:..|.....|.|
Zfish   537 QLSRCQSAV------LKHEMMRPSNSVQLLVLCEDHRTGMVKHQCCPGCGFFCRAGTFMECQPEV 595

  Fly  1027 -----------------------------AKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGS 1062
                                         ||::..:.:.:|.|..:..||.:.::|:      |.
Zfish   596 NISHRFHRTCASVLNGQSFCPHCGEEVSKAKEVTIAKADTTSTVPITHSSCIPSTSE------GK 654

  Fly  1063 KRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKK---- 1123
            ..||:   |||    .|.::..:.:..:.:|.|              :...||.|...|.|
Zfish   655 ADTTT---GGS----TRLSVLGEGKANSTLPKP--------------SESQDTSLSLVGSKARSV 698

  Fly  1124 -RGRKEG--------KESL-SRQNSLDSSSSASQGAPKK-----KAL----KSAEILSAALLETE 1169
             .....|        ||:| |...:||:..      |||     |.|    |..|:....|:..:
Zfish   699 AMAAAPGLPLPPGPPKETLQSVLLALDAEK------PKKLRFHPKQLYISAKQGELQKVLLMLVD 757

  Fly  1170 SSESTSSGSKMSRWDVQTSPELEAANPFGDIA-KFIEDGVNLLKRDKVDEDQRKEGQDEVKREAD 1233
            ..:   ...||...:.:|...:.|.....|:. ..::.|.||   |..|||||....:..:..
Zfish   758 GID---PNFKMESQNKRTPLHVAAEAGHQDVCHMLVQAGANL---DMCDEDQRTPLMEACENN-- 814

  Fly  1234 PEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTT----------TVLKELETGGGVRRSHRIK 1288
                       ::||...........|:.:...||.          ::::.|.:.|.|    .|.
Zfish   815 -----------HLETVRYLLRAGAIVSHKDVEGSTCLHLAAKNGHFSIVQHLLSAGLV----DIN 864

  Fly  1289 QKPQGP-----RASQGRGVASVAL-----APISM---DEQL----AELANIEAINEQFLRSE-GL 1335
            .:..|.     .|::.:.|..|.|     |.|::   :|.:    |..:....|.|.||.:: .|
Zfish   865 CQDDGGWTAMIWATEYKHVDQVKLLLSKGADINIRDKEENICLHWAAFSGCVEIAEIFLTAKCDL 929

  Fly  1336 NTFQL---------LKENFYRCAR-------QVSQENAE----MQCDCF---------------- 1364
            ||..:         .:|....|..       .|:.:|.|    |:| |.
Zfish   930 NTMNIHGDSPLHIASREGRLDCVNLFLSRGADVNLKNKEGETPMEC-CSHSSKVWNALQANKKQR 993

  Fly  1365 -----------LTGDEEAQGHLSCGAGCINRM--------------------------------- 1385
                       |...:.|:|:......|:|.:
Zfish   994 EANRKAGATEKLLNKDIARGYEKVPVPCVNAVDSEPCPDNYKYVPDSCVTSPLNIDKNITHLQYC 1058

  Fly  1386 --------------------------------------LMIECGPLCSNGARCTNKRFQQHQCWP 1412
                                                  |:.||...||....|.|:..|......
Zfish  1059 VCKDDCSSASCMCGQLSLRCWYDKESRLLPEFSNEEPPLIFECNHACSCWRTCKNRVVQNGLRTR 1123

  Fly  1413 CRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA 1474
            .::|:|:..|.|:.....||.|.|:.|||||:|...|.:.|:   :|:|.|..       :....
Zfish  1124 LQLFKTQMMGWGVKTLQDIPQGTFVCEYVGEIISDAEADVRENDSYLFSLDSK-------VGDMY 1181

  Fly  1475 VIDATSKGNISRYINHSCDPN-AETQKWTVNGELR---IGFFSVKPIQPGEEITFDY--QYLRYG 1533
            .:||...|||||:|||.|:|| ...:.:|.:.:||   |.||:.|.|..|:|:.|||  .:....
Zfish  1182 CVDARFYGNISRFINHHCEPNLLPCRVFTSHQDLRFPHIAFFACKNISAGDELGFDYGDHFWDVK 1246

  Fly  1534 RDAQRCYCEAANCRGWIGG----EPDSDEGEQ----LDEESDS 1568
            .....|.|.::.|:.....    :.||..|:|    |.:.|.|
Zfish  1247 GKLFNCKCGSSKCKHSAAAIAQTQADSTPGDQQPSALPDTSSS 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	17/153 (11%)
		SET	1414..1533	CDD:214614	45/127 (35%)
		PostSET	1535..1551	CDD:214703	3/15 (20%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
ehmt1b	XP_021324462.1	Atrophin-1	27..>278	CDD:331285	55/307 (18%)
		Ank_2	739..833	CDD:315466	21/112 (19%)
		ANK repeat	739..765	CDD:293786	4/28 (14%)
		ANK repeat	767..800	CDD:293786	7/35 (20%)
		ANK	797..923	CDD:238125	26/142 (18%)
		ANK repeat	802..833	CDD:293786	6/43 (14%)
		ANK repeat	835..867	CDD:293786	6/35 (17%)
		ANK repeat	869..900	CDD:293786	7/30 (23%)
		ANK repeat	902..933	CDD:293786	9/30 (30%)
		Ank_2	907..>980	CDD:315466	16/73 (22%)
		ANK repeat	935..966	CDD:293786	3/30 (10%)
		Pre-SET	1010..1114	CDD:309948	10/103 (10%)
		SET	1123..1244	CDD:214614	45/127 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840