DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and ash1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster

Alignment Length:	1983	Identity:	405/1983 - (20%)
Similarity:	665/1983 - (33%)	Gaps:	705/1983 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 KQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQ----EEGRPVEVEPQDLIDIDMELAKQ 361
            :.|...:::::.:...:|.|:    ..||:|...:..|    :......|:..|...:.|.::..
  Fly     5 QNETAAAKVLETQRAQESGSE----NEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAI 65

  Fly   362 EPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRS---- 422
            .||         :.|.....||                  ::.....:.....||.|..|:
  Fly    66 RPT---------LGVVATKKPP------------------KSRKMSTQDTESGCSEAKNRAVSKK 103

  Fly   423 -----RRSAPLSGSSRQGKTLEETFAEIAAES--SKQILEAEESQDQEEQHILIDLIEDTLSESE 480
                 ::.|..||.|:..|..:...::|:|.|  |:..|..:..|.:..:.:|..:|:...|.|:
  Fly   104 VKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASK 168

  Fly   481 VTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVE- 544
            .|..:.                  :..:|..|.:..:..||:|.|:::           :..||
  Fly   169 PTLDIG------------------ISSSDNELPNLVQAAIKRVESDTE-----------DTTVEG 204

  Fly   545 --TKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS---DEVVIEP--PL 602
              .||...:.:|:        |.:..:...:||:.::.:.....:||.|::   :|.:::.  |.
  Fly   205 SFRKAAKDKNLPQ--------YQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPR 261

  Fly   603 KDESDPKQTEVELP---ESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLS 664
            |....||:....:|   .|.||:|    |...|..:.|||:                  .:::..
  Fly   262 KRRGRPKKVVPTVPAPGNSGPAIN----ESADSGVISTTST------------------TQSTTP 304

  Fly   665 TEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQK 729
            :.:..|||         |....|.|.|       ||.:|..         :....|:.|.. .::
  Fly   305 SPKMQNEN---------AVPTGSLPIA-------SSSKPKI---------DMAYLDKRMYA-TER 343

  Fly   730 GQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEME--------------KK 780
            .....|..:.::..|..|.:.|.||:...:|.... ..|:||.|...|.              .|
  Fly   344 VLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWRE-IDVNKKFRLRSMSVGAASGTGASTTICSK 407

  Fly   781 VVKSTKGTVPE-----------------------KKMDSKKSC-AAVTPAKQ-------KESGKS 814
            |:.:..|.|.:                       |...|.||| :..:.||.       ||||||
  Fly   408 VLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKS 472

  Fly   815 AKEAILKKETEKEKSSAKLDSSSPNTLDKK------GKDTAQWS---------PQLQTLPK---- 860
            .     .:...|.::|..|.||:.:|::.:      |....|.|         |.|::||.
  Fly   473 G-----LRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSAS 532

  Fly   861 ----------------------SSTKPPQESAPSVISKTTSNQ---PAPKEEQHAAKKGLSDNSP 900
                                  |:|.|     .:.|||..:.:   |||.:.....|...|
  Fly   533 KKYGEINRYVTTGQYFGRGGSLSATNP-----DNFISKMMNQRKETPAPSKSSCKIKSRRS---- 588

  Fly   901 PSVLKAKEKAVSGFVECDAMFKAMDLA-NAQLRLDEK---------------------------N 937
             |........|||........:....: |..|.:|.|                           .
  Fly   589 -SAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSG 652

  Fly   938 KKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSG-----------KTSLRRNTVYE--------- 982
            |:||.....|::|      ..|.|.|.|:.:|:|           |..|::..:.|
  Fly   653 KEKLLADANKLQA------TLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLS 711

  Fly   983 ----DSPNLERNS----------SPSSDSAQAN------------TSAGKLKPSKV---KKKINP 1018
                .:||...:|          |.|:||:..:            .:.|:..|::|   ..|:|.
  Fly   712 ASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNA 776

  Fly  1019 R------------RSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSD--- 1068
            .            .||..:|..:.||..|:.||.:......|.|.|...||..|...|...|
  Fly   777 EAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNS 841

  Fly  1069 LDGGSKLDQRRYTICEDRQP------------------------------------ETAIPVPLT 1097
            :.||..||....::|..:|.                                    |..|.:||:
  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLS 906

  Fly  1098 KRRFSMHPKASA-NPL------------------HDTLLQTAG------KKR-----------GR 1126
            |...|:..||.. :||                  .:|||...|      :||           .|
  Fly   907 KLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRR 971

  Fly  1127 KEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTS---------------- 1175
            |:.|.|:.:|.:........:..|..:.|:|       |.||.||.:.:
  Fly   972 KKRKVSVEQQTTAVIDEHEPEFDPDDEPLQS-------LRETRSSNNVNVQAAPNPPLDCERVPQ 1029

  Fly  1176 -----------SGSKMSRWDV------------------------------------QTSPELEA 1193
                       :..|..|..|                                    ::.||:..
  Fly  1030 AGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRP 1094

  Fly  1194 ANPFGDIAK------------------------FIEDGVN---------LLKRDK---VDEDQRK 1222
            |...|...|                        .:.||::         .|||.|   .....:|
  Fly  1095 AKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKK 1159

  Fly  1223 E-----------------GQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNP-------- 1262
            |                 .|:|:..||:      |:|:.::.| ...|.|:....||
  Fly  1160 EKPVQPVTVEEIPPEIPVSQEEIDAEAE------AKRLDSIPT-EHDPLPASESHNPGPQDYASC 1217

  Fly  1263 ----EDSASTTTV-----LKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQL-- 1316
                ||.||||::     :|:.....|:..:| .||....|       .|.|...| .::||:
  Fly  1218 SESSEDKASTTSLRKLSKVKKTYLVAGLFSNH-YKQSLMPP-------PAKVNKKP-GLEEQVGP 1273

  Fly  1317 AELANIEAINEQFLRSEGLN-------------------------TFQLLKENFYRCARQVSQEN 1356
            |.|.......|::||...::                         .::.::.|.|  |..|....
  Fly  1274 ASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVY--AESVRPNL 1336

  Fly  1357 AEMQ---CDCFLTGDEEAQGHLSCGAGCINRMLMIECGPL-CSNGARCTNKRFQQHQCWP-CRVF 1416
            |...   |:|      :.||..||...|:|||:..||.|. |..|.:|.|::.|:|...| ...|
  Fly  1337 AGFDHPTCNC------KNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERF 1395

  Fly  1417 RTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ-HLYSKDRNRHYYFMALRGEAVIDATS 1480
            .|..||.|:..:|.|..|.:|:||||||:..:||::|. .:|..|  .|:|.:.|.|..|||...
  Fly  1396 MTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND--THHYCLHLDGGLVIDGQR 1458

  Fly  1481 KGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYG-RDAQRCYCEAA 1544
            .|:..|::||||:||.|.|||:|||..|:..|:.:.|:.|||:|:||.:..:. .:.|.|.|...
  Fly  1459 MGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTP 1523

  Fly  1545 NCRGWIGGEPD----------SDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLK 1599
            .|||.|||:..          ...||.|...:....:...:: .|:.:.|:...||.|.||.:
  Fly  1524 QCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKK-HAQRQAGKDISSAVAVAKLQ-- 1585

  Fly  1600 AKLPLATGRKRKEQTK----------PKDREYKAGRWLKPSATGSS---------------SSAE 1639
               ||:  .|.|:..:          .|.|..||.|....:||.||               |:..
  Fly  1586 ---PLS--EKEKKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPS 1645

  Fly  1640 KP-----------PKKPKVNKFQAMLEDPDV--VEELSLLRRGGLKNQQDTLRFSRCLV-----R 1686
            .|           |:..|.......:.||::  :.:::::.| .:.:..:||:.|..|.     :
  Fly  1646 SPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLR-DICSAMETLKMSDLLTTVSSKK 1709

  Fly  1687 AKLLKTRL----------------ALLRVLTHGELPCRRLFLDYHGLRLLHAWISENGNDDQLRE 1735
            .|.:||.|                ::...:..|.....:.|.|:  ::.|.....:...||:.:|
  Fly  1710 KKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDH--MQQLFVEAKQQHGDDEGKE 1772

  Fly  1736 ----ALLDTLESLPIPNRT----MLSDSRVYQS 1760
                :|.|:.|...|.:..    :|.||...||
  Fly  1773 KALQSLKDSYEQQKIASYVQLVEILGDSESLQS 1805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	19/55 (35%)
		SET	1414..1533	CDD:214614	51/119 (43%)
		PostSET	1535..1551	CDD:214703	6/15 (40%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	19/53 (36%)
		SET	1392..1512	CDD:214614	51/121 (42%)
		Bromo_ASH1	1680..1787	CDD:99955	19/109 (17%)
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.880