DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and upSET

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster

Alignment Length:	1863	Identity:	346/1863 - (18%)
Similarity:	576/1863 - (30%)	Gaps:	679/1863 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SNPSPVASRGRG---RGRP---PKVALSALGNTP------------------PHINPSL-KHADA 47
            |.|||..::.:.   :..|   |:..||.|..:|                  |.::|.| |.|..
  Fly  1456 SIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPAQQ 1520

  Fly    48 EASPTAPEDQDSG------------------------------------QSECRRSSRKKIIKFD 76
            :|....|:.|.:.                                    |.:.::|.:.:.:...
  Fly  1521 QAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQ 1585

  Fly    77 VRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEM 141
            .:.::...::.|.:|.:.:.........::...:|..|..:..|:...|....|.|.:.....:.
  Fly  1586 QQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQ 1650

  Fly   142 SHQSLPPP--------------------PPPPTALEIFAKPRPTQ---SLIVA------------ 171
            ...:...|                    |..|.:.:...||:|.|   .::::
  Fly  1651 QQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATMPT 1715

  Fly   172 ------------------QVTSEPSAVGG-----AHP-VQTMAGLPPVTPRKRGRPRKSQLADAA 212
                              .|:::.|.|||     .|| .|......||||           ..||
  Fly  1716 KLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTP-----------VSAA 1769

  Fly   213 IIPTVIVPSCSDS---DTNSTSTTTSNMSSDSGELPGFPIQKPKS-----KLRVSLK-------- 261
            ..|.. .||.|:|   |.:::||||....:.:.:       |||.     ||...|:
  Fly  1770 TAPAA-TPSSSESKEDDVSASSTTTPTTRTPAKD-------KPKQSREDRKLEAILRAIEKMEKQ 1826

  Fly   262 --------RLKLGGRLESSDS------GNSPSSSSPEVEPPALQDE--NAMDERPKQEQNLSRMV 310
                    |...||:.::|:|      .||.:|.|.:||.|...:.  .|...|.|:::.:||.:
  Fly  1827 EARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSL 1891

  Fly   311 DAEEN--------SDSDSQIIFIEIETES---------PKGEEEQEEGRPVEVEPQDLIDIDMEL 358
            :...|        ::...:.|.:|.:.||         .:|:..|......|.:...|:   :.|
  Fly  1892 NNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLL---LAL 1953

  Fly   359 AKQEPTPDP--EEDLDE---------------IMVEVLSGP-----------PSL---------- 385
            |....:|:.  :..|.:               :::|...||           |||
  Fly  1954 AHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGA 2018

  Fly   386 ---------WSADDEAEEEE----DATVQRA-------------TPPGKE---PA---------- 411
                     |.  .:||::.    |:.||.|             .|.|:.   ||
  Fly  2019 KTKKSLMSSWF--QQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQ 2081

  Fly   412 ADSCSSAPRRSRRSAPLSGSS-------RQGKTLEETFAEIAAESSKQILEAEESQ--------- 460
            |:|.::.|.|.:...||..:|       ||..:.|.|..:...:|..|.:.|..|.
  Fly  2082 AESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPL 2146

  Fly   461 ----------------------DQEEQHILIDLIEDTLSESE----------------------- 480
                                  :.:|.|  ||:|.:...|:|
  Fly  2147 ANGFSTPLKKRRLVVVSNGTNVESDETH--IDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDV 2209

  Fly   481 -VTSSVSPTIEHMVVEEVVV--------------------EENQLVDEADEIL------DSKQEF 518
             :..|.||....:|.|:.:|                    ||:|..|:.:|::      :.::|.
  Fly  2210 DILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREK 2274

  Fly   519 VIKKVFSESDNIAASLNKDIFEPKVETKATCGE--VVPRPEMVTE----DVYITEGIAATLEKSA 577
            .||::....::....:.....|||:|......|  |.|..|:|::    .|....|.:.....:.
  Fly  2275 EIKQLQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTAT 2339

  Fly   578 VVTKPTTEMIAETKLSDEVVI----EPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETT 638
            |...||...||.|.|.|...:    .||||.|.:|::.:            ||.|.||.|.|.|
  Fly  2340 VTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKK------------PKLESILPAPVAT- 2391

  Fly   639 SSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEE- 702
                |||       ||.|.:...|         |..|:.:...||...:...|| ....|.:|.
  Fly  2392 ----VPP-------VSVPPIPAAS---------NATTSAVTNTAAASLTTTTAP-SSTKNLTEHD 2435

  Fly   703 -PNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPA 766
             ...||..:.:|                                ::...|:.:||......:||:
  Fly  2436 IQERLLSFHAAN--------------------------------ISYLQSRNKKATAALTSASPS 2468

  Fly   767 IVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSA 831
            ........|       ..|:.....|..|.|:.       |:|:..||.||....|:.||:|::.
  Fly  2469 QKSNSSSGG-------SGTESKKSSKDKDEKRD-------KEKQLKKSKKEKKKSKDKEKQKAAV 2519

  Fly   832 KLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKP-------PQESAPSVISKTTSNQPAPKEEQH 889
            .::|:| ..:|.|.|.|....|.    .|||..|       |..:|......|..|....:::|.
  Fly  2520 NVNSTS-QIVDTKKKTTQPSKPD----SKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQ 2579

  Fly   890 AAKKGLS-----------------DNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKN 937
            ..::.:|                 ..:|||..|.:                   .|.:..|.:.|
  Fly  2580 MRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQ-------------------TNFEQELTKPN 2625

  Fly   938 KKKL---------KKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP 993
            .:.|         |.:...:.||..|..||||.....:|.                 |..:.::|
  Fly  2626 SQILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKE-----------------NNHQEATP 2673

  Fly   994 SSD---SAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDS 1055
            :|.   |..|..::|||      ..|:.||.::|          .|......:||:.........
  Fly  2674 ASGGPMSLAAAIASGKL------NAISRRRESMC----------GSRQQQALIAAALKKEKKEKK 2722

  Fly  1056 SSKRNGSKRTTSDLDGGSKLDQRR-------------------YTICEDRQPETA-------IPV 1094
            .||:...::...|...|.:.::.:                   .|:..:..|.:|       :|.
  Fly  2723 KSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQKPAHPTTVPANSMPISAPAPVPVLVPT 2787

  Fly  1095 PLTKRRFSMHP----KASANPLHDT--LLQTAGKKRGRKEGKESLSRQNSL-----DSSSSASQG 1148
            |:|..:.:..|    :.:.:|:|.|  |:.....|      ..||...|::     |.|:..|..
  Fly  2788 PVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTK------VASLPFYNTIYGKLQDPSTPTSSP 2846

  Fly  1149 APKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNL--- 1210
            .|....:.|.    |..||:..|::|:..:.........:|...|..|    ||.....:.:
  Fly  2847 IPVTNTMPSL----AEYLESTKSKTTALSAVKPIGIAAVTPLSSAITP----AKVAPSSLEMPPP 2903

  Fly  1211 ----LK------------------RDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTP 1253
                ||                  .|.....:||....|.:....|..|. |.......|..|||
  Fly  2904 ATTPLKLYTRTASHDPRLNPMLTVPDPTPMPKRKLSISEYRMRHRPSVDT-APTTPTTPTTPTTP 2967

  Fly  1254 TPSPTQSNPEDSASTTTVLK-------ELETGGGVRRSHRIKQKPQ------------------- 1292
            |..|..:.....|...|:.|       ..:.....||:......||
  Fly  2968 TTPPGSNKDRSFAKPQTINKCSLQSPERFQAAIRERRNSISAHHPQQNAHHNLNNNKGGISNKSG 3032

  Fly  1293 ---GPRASQGRGVASVALAPIS--MDEQLAELANIEAINEQFLRSEGLNTFQLL-------KENF 1345
               |....|..|||...|...:  :|.....|:.:.:|         |:|.|.|       |...
  Fly  3033 SSSGNHLQQALGVAGGRLQSKNAIVDPAATTLSTVNSI---------LSTAQKLHMFDDKPKGGH 3088

  Fly  1346 YRCARQVSQENAEMQCD---CFLTGDEEAQGHLSCGAGCINRM 1385
            :..|..:.::..|...:   |.       |..:||.:..|.|:
  Fly  3089 FNAAPTLLEQQQEKMSERSRCL-------QRTISCDSRVIERL 3124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	7/31 (23%)
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030