Protein Alignment Set2 and E(z)

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 930
• Identity: 185/930 - (19%)
• Similarity: 293/930 - (31%)
• Gaps: 316/930 - (33%)

  Fly   719 EDEMMKCNNQKGQKQTPLPEMKEP--------EKPVAETVSKKEKAMENPARSSPAIVDKKVRAG 775
            :.|.:|...||..|:.  .|:||.        ...|.:...:.:.....|  ..|..||...||.
  Fly    15 KSEYIKIRQQKRYKRA--DEIKEAWIRNWDEHNHNVQDLYCESKVWQAKP--YDPPHVDCVKRAE 75

  Fly   776 EMEKKVVKSTKGTVPEKKMDSKKSCA--AVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSP 838
            ......:.|....||        .|.  ||||.....:....::..:   .|.|.....:.....
  Fly    76 VTSYNGIPSGPQKVP--------ICVINAVTPIPTMYTWAPTQQNFM---VEDETVLHNIPYMGD 129

  Fly   839 NTLDKKGK----------------------DTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQ 881
            ..|||.||                      |.|.:...:..|.:|.:|..:|:||...:
  Fly   130 EVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTAT------ 188

  Fly   882 PAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPT 946
             |.|.|              ::.|:|:....|.|:.||              |.::..||:|..:
  Fly   189 -AIKTE--------------TLAKSKQGEDDGVVDVDA--------------DGESPMKLEKTDS 224

  Fly   947 KVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSS---PSSDSAQANTSAGKLK 1008
            |.:.....:..|..|:..:...:.......::.:...:|.:.:..|   |...:||      :||
  Fly   225 KGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQ------ELK 283

  Fly  1009 PSKVK--KKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLD- 1070
            ...::  :..:|.|...|             ||..:...:..||......|......|.....|
  Fly   284 EKYIELTEHQDPERPQEC-------------TPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDC 335

  Fly  1071 -------------GGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDT--LLQTA 1120
                         .|..|.:|||       ||.               |..|.|..::  :|...
  Fly   336 FLHRHHVQGLQGHAGPNLQKRRY-------PEL---------------KPFAEPCSNSCYMLIDG 378

  Fly  1121 GKKRGRKEGK----ESLSRQNSLDSSSSASQGAPK---------------KKALKSAEILSAALL 1166
            .|::...:.|    :|.:..:|.||:.|.||.:.|               ..|:.....:.|.::
  Fly   379 MKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMM 443

  Fly  1167 ETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKRE 1231
            ...|::...:|:..:.:.|.....|:         .:.....|:|.:.          ..:|...
  Fly   444 NITSTQCVWTGADQALYRVLHKVYLK---------NYCAIAHNMLTKT----------CRQVYEF 489

  Fly  1232 ADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRA 1296
            |..|:.||:.                     ||                      ::|....||.
  Fly   490 AQKEDAEFSF---------------------ED----------------------LRQDFTPPRK 511

  Fly  1297 SQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKE-------NFYRCARQVSQ 1354
            .:                           .:|.|.|......||.|:       |:..|..  ..
  Fly   512 KK---------------------------KKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDH--PG 547

  Fly  1355 ENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRV---- 1415
            ...:|.|.|..| ....:...:|.:.|.||.      |.|...|:|..|     || ||.:
  Fly   548 HPCDMNCSCIQT-QNFCEKFCNCSSDCQNRF------PGCRCKAQCNTK-----QC-PCYLAVRE 599

  Fly  1416 -------------FRTEKKGC-------GITAELLIPP----------------GEFIMEYVGEV 1444
                         |:..|..|       |:...||:.|                .|||.||.||:
  Fly   600 CDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEI 664

  Fly  1445 IDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRI 1509
            |..:|.:||..:|  |:....:...|..:.|:|||.|||..|:.|||.:||...:...|.|:.||
  Fly   665 ISQDEADRRGKVY--DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRI 727

  Fly  1510 GFFSVKPIQPGEEITFDYQY 1529
            |.|:.:.||||||:.|||:|
  Fly   728 GIFAKRAIQPGEELFFDYRY 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	25/122 (20%)
		AWS	1358..1410	CDD:197795	13/51 (25%)
		SET_SETD2	1410..1551	CDD:380949	53/160 (33%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	31/180 (17%)
		SANT	452..492	CDD:238096	7/58 (12%)
		preSET_CXC	579..610	CDD:408079	8/36 (22%)
		SET_EZH2	628..747	CDD:380995	46/120 (38%)