Protein Alignment Set2 and Kmt2d

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_017172163.1
• Gene: Kmt2d / 381022
• MGIID: 2682319
• Length: 5608
• Species: Mus musculus
• Alignment Length: 1835
• Identity: 354/1835 - (19%)
• Similarity: 549/1835 - (29%)
• Gaps: 740/1835 - (40%)

  Fly   153 PTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTV 217
            ||.|....:....::.:.::||..||...|..|....|..|                 .::.|..
Mouse  4076 PTLLLTGKEQNNAETALPSEVTEGPSTHQGGPPAVGTAPEP-----------------MSVEPGE 4123

  Fly   218 IVPSCS-DS-----DTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGN 276
            :.||.| ||     .:.:.|..||........|||.|  :|:..|..:     .||.......|:
Mouse  4124 VKPSISGDSQLLLVQSQAQSQATSVQLQPPLRLPGQP--QPQVNLLHT-----AGGGSHGQQLGS 4181

  Fly   277 SPSSSSPEVEPPALQDENAMDERP----------KQEQNLSRMVDAEENSDSDSQIIFIEIETES 331
            ..||.||.|.....|...::.|:|          :|...|.|.:  :.|:.|           :.
Mouse  4182 GSSSESPAVPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLDRPI--QNNTGS-----------QP 4233

  Fly   332 PKGEEEQEEGR------------PVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPS 384
            ||.....:.|:            .:..:.|.::..:.:|  :..:|..::.|..::::
Mouse  4234 PKSGPAPQSGQGPPGAGVMPTVGQLRAQLQGVLAKNPQL--RHLSPQQQQQLQALLMQ------- 4289

  Fly   385 LWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSG-----SSRQGKTLEET--F 442
                    .:.:.:...|.|||.:||..           :.:||.|     ....|.::.:|  .
Mouse  4290 --------RQLQQSQAVRQTPPFQEPGT-----------QPSPLQGLLGCQPQPGGFSVSQTGPL 4335

  Fly   443 AEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDE 507
            .|:.|.|..|            ....:.:.:..||...|.....||...
Mouse  4336 QELGAGSRPQ------------GPPRLPVPQGALSTGPVLGPAHPTPPP---------------- 4372

  Fly   508 ADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAAT 572
                 .|.||   .|..|:..:.:|.|          |....|  .|:|          :|.|..
Mouse  4373 -----SSPQE---PKRPSQLPSPSAQL----------TPTHPG--TPKP----------QGPALE 4407

  Fly   573 LEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVET 637
            |....|  .|....:|:|.....  :.|  .|.|| ..||.:.||
Mouse  4408 LPPGRV--SPAAAQLADTFFGKG--LGP--WDPSD-NLTEAQKPE-------------------- 4445

  Fly   638 TSSPLVPPECCTLESVSGPVLLETS-LSTEEKSNENVETTPLKTEAAKEDS---PPAAPEEE--- 695
             .|.|||..   |:.|:|.|:.|.| ||.:::..|  |...|..:..|.::   |..||...
Mouse  4446 -QSSLVPGH---LDQVNGQVVHEPSQLSIKQEPRE--EPCALGAQTVKREANGEPAGAPGTSNHL 4504

  Fly   696 --ASNSSEEPNFLLEDYESNQEQVAEDEMMKCNN-QKGQKQTPL-----------PEMKEPEKPV 746
              |.:.||..:.||:            ::::..| |.|..:.|.           .::...|:.:
Mouse  4505 LLAGSRSEAGHLLLQ------------KLLRAKNVQLGAGRGPEGLRAEINGHIDSKLSGLEQKL 4557

  Fly   747 AETVSKKE-KAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKE 810
            ..|.|.|| .|...|..:.|              |.|:.|...:|..:   ||        .:||
Mouse  4558 QGTSSNKEDAATRKPLPAKP--------------KRVQKTSDRLPSSR---KK--------LRKE 4597

  Fly   811 SGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVIS 875
            .|..|.||:||                            |...:|..||.:.        |::.:
Mouse  4598 DGVRANEALLK----------------------------QLKQELSQLPLTE--------PTITA 4626

  Fly   876 KTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKK 940
            ..:...|...                ..|.:.:..:.|.....|:....|..:..|     .|..
Mouse  4627 NFSLFAPFGS----------------GCLVSGQSQLRGAFGSGALHTGPDYYSQLL-----TKNN 4670

  Fly   941 LKKVPTKVEAPPKVEPPTAVPVPG-QKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSA 1004
            |...||    ||...|||  |.|. |:|.::|.|           |:.|....| .|:|.|..|.
Mouse  4671 LSNPPT----PPSSLPPT--PPPSVQQKMVNGVT-----------PSDELGERP-KDTASAQDSE 4717

  Fly  1005 GKLKPSKVKKKIN--------PRRSTICEAAKDLR--SSSSSSTPTREVAASSPVSTSSDSSSK- 1058
            |.|:.:...|.::        |...|     :|:|  |...|.:|...|.||||.|...:.:.:
Mouse  4718 GALRDAAEVKSLDLLAALPTPPHNQT-----EDVRMESDEDSDSPDSIVPASSPESILGEEAPRF 4777

  Fly  1059 -RNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPV-PLTKRRFSMHPKASANPLHDTLLQTAG 1121
             :.||        |..:.|.|..:......|.|.||| |.||            |.....|:..|
Mouse  4778 PQLGS--------GRWEQDNRALSPVIPIIPRTGIPVFPDTK------------PYGVLDLEVPG 4822

  Fly  1122 K------KRGRKEGKE-------SLSRQNSLDSSSSASQGAPKKKALKSAEIL-----SAALLET 1168
            |      ::|:  |.|       |.:...:|:....|.......|...|.|:|     :.|.||.
Mouse  4823 KLPATAWEKGK--GSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPDGPARAGLEP 4885

  Fly  1169 ESSESTSSGSK---MSRWDVQTSP----ELEAANPFGDIAKFIEDGVNLLKRD------------ 1214
            :..|:...|.|   :|.....|.|    :.:|..| |...|...|.::|||::
Mouse  4886 KKGEAEGPGGKEKGLSGKGPDTGPDWLKQFDAVLP-GYTLKSQLDILSLLKQESPAPEPSIQHSY 4949

  Fly  1215 -----KVDEDQRKEGQDEVKREADPEEDEFAQRVAN----------METPATTPTPS--PTQSNP 1262
                 .:|..|......|   |..|.....|...|:          .|.||..|.||  |..|:|
Mouse  4950 TYNVSNLDVRQLSAPPPE---EPSPPPSPLAPSPASPPAEPMVELQAERPAEPPIPSPLPLASSP 5011

  Fly  1263 EDSA---------------------------STTTVLKELETGGGVRRSHR-----IKQ-----K 1290
            |.:.                           ....:|..::.|.|.:...|     ::|     :
Mouse  5012 ESARPKPRARPPEESEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGHQEDEREVAEFMEQFGTALR 5076

  Fly  1291 P---------------QGPRASQG----------------------------------------R 1300
            |               :|..|:.|                                        |
Mouse  5077 PSKVPRDNRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHR 5141

  Fly  1301 GVAS---------------------------------------VALAPI-----SMDEQLAELA- 1320
            |:.:                                       ..|.|:     ..:::|:..|
Mouse  5142 GLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPVHKIKGPCEQELSSFAV 5206

  Fly  1321 ---------NIEAINEQFLRSEGLNTF-----------QLLKENF-------------------- 1345
                     .::.|.....|.|.|:.|           |||....
Mouse  5207 FRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIY 5271

  Fly  1346 -----------YRCARQVSQEN-----------------------------------AEMQCDC- 1363
                       |||:  :|:.|                                   |.|:.:.
Mouse  5272 WSLRTNNRRCCYRCS--ISENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEAD 5334

  Fly  1364 -------FLTGD--------------EEAQGHLSC--------------------GAGC------ 1381
                   :|.|:              |...|..||                    ..||
Mouse  5335 MLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPK 5399

  Fly  1382 --------------------------INRMLMIECGPLCSNGARCT--NKRFQQHQCWPCRVFRT 1418
                                      :|...|.:.......|...|  :|:|...:....|..||
Mouse  5400 ILTHYKRVFTSIISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRT 5464

  Fly  1419 EKK-----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRG 1472
            |.|           |.|:.|...:.....::||:|.:|.:|...||:.:| :::||..|...:..
Mouse  5465 EWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQNRGIYMFRINN 5528

  Fly  1473 EAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQ 1537
            |.|||||..|..:|||||||.||...:..|.:.|.:|...|.:.|..|||:|:|||: .:..|..
Mouse  5529 EHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQF-DFEDDQH 5592

  Fly  1538 R--CYCEAANCRGWI 1550
            :  |:|.|.|||.|:
Mouse  5593 KIPCHCGAWNCRKWM 5607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	26/135 (19%)
		AWS	1358..1410	CDD:197795	15/127 (12%)
		SET_SETD2	1410..1551	CDD:380949	55/154 (36%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Kmt2d	XP_017172163.1	ePHD1_KMT2D	134..217	CDD:277165
		PHD1_KMT2C_like	228..273	CDD:276984
		PHD_SF	275..320	CDD:473978
		PHA03247	<492..883	CDD:223021
		PHD3_KMT2D	1335..1385	CDD:277072
		PHD5_KMT2C_like	1386..1432	CDD:276988
		PHD5_KMT2D	1463..1513	CDD:277074
		HMG-box_KMT2D	1956..2039	CDD:438836
		PHA03247	<2071..2637	CDD:223021
		Med15	<4104..>4407	CDD:312941	75/425 (18%)
		ePHD2_KMT2D	5087..5193	CDD:277168	7/105 (7%)
		FYRN	5236..5287	CDD:461787	6/52 (12%)
		FYRC	5295..5382	CDD:197781	8/86 (9%)
		SET_KMT2D	5453..5607	CDD:380986	54/155 (35%)