Protein Alignment Set2 and egg

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Alignment Length: 1531
• Identity: 283/1531 - (18%)
• Similarity: 492/1531 - (32%)
• Gaps: 535/1531 - (34%)

  Fly   269 LESS-----DSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIE 328
            ||||     |...:|:|.......|..:.||:::...:|   .::.|:.||.:.|::........
  Fly    11 LESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQ---AAKDVEIEELTHSEAIAATGSTR 72

  Fly   329 TESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAE 393
            .:.|.|.:..:       ||..|.| :.|..|.|.|            :.::..|.|.:.|
  Fly    73 KQCPYGGKAPD-------EPGKLAD-ESEDRKGENT------------KAIASSPVLVAVD---- 113

  Fly   394 EEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEE-TFAEIAAESSKQILEAE 457
              .|::|:....|.|..:|:.....|.:     |.:.:....|..|| |.:.|::.:|:...|.:
  Fly   114 --SDSSVELIESPVKFSSANESEKDPPK-----PDAVNEAAAKEAEEMTDSSISSPTSESFPEKD 171

  Fly   458 E----SQDQEEQHILIDL-IEDTLSESEVTSSVSPTIE-HMVVEEVVVEENQLVDEADEILDSKQ 516
            |    ..:||...:.:|. :|:::|.......:..|:: |..:....:||:::||:.|::|:.:.
  Fly   172 EKTNKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVEL 236

  Fly   517 EFVIKKVFSESDNIAASLNK-DIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVT 580
            |.......:|.:.:.|.|:. |:|..|......|.::        ...|:...: |||....|:.
  Fly   237 EKGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKL--------HKQYVLANM-ATLNFYQVLR 292

  Fly   581 KPT-----------TEMIAETKLSDEVVIEPP--LKD-----------ESDPKQTEVELPESKPA 621
            |.:           |.|....:.:.:::.:.|  |||           :|..::.|.:.||..
  Fly   293 KSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKS-- 355

  Fly   622 VNIPKSE-RILSAEVETTSSPLVPPECCTLE-SVSGPVL------LETSLSTEEKSNENVETTPL 678
             :..|:: :::..|::.....::.....|.: |.|..:|      ||...:..:...|.|:||..
  Fly   356 -DFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTAD 419

  Fly   679 KTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLP-EMKEP 742
            |...|..:|.|.|.:...:...|..:::.|                         .|.| |:..|
  Fly   420 KMHCALYNSCPVAHKHLPTLDIEPSDYVHE-------------------------VPPPGEIVRP 459

  Fly   743 EKPVAET-VSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGT-VPEKKMDSKKSCAAVTP 805
            ...:.|| .:.|.||:                |..:..||::.|:.| :....|.|.|.....||
  Fly   460 PIQLGETYYAVKNKAI----------------ASWVSIKVIEFTESTAINGNTMKSYKIRYLNTP 508

  Fly   806 AKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESA 870
            .:..::..:...|..:....:.....::.:....|...:|||                |...:||
  Fly   509 YQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKD----------------KGVVQSA 557

  Fly   871 --PSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRL 933
              |.:|:     :|..:..::.......|.....|.....:.|     |.|..|..:..:|..|
  Fly   558 FYPGIIA-----EPLKQANRYRYLIFYDDGYTQYVPHRDVRLV-----CQASEKVWEDVHAASR- 611

  Fly   934 DEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSG--------------------------- 971
             :..:|.::|.        .|:.|......||..:...
  Fly   612 -DFIQKYVEKY--------SVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNH 667

  Fly   972 -----KTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKP-----------SKVKKKIN--P 1018
                 :.|||...|:.::.|     :.:|.|||......:.:|           |||.:::.  .
  Fly   668 TEWIYRGSLRLGPVFRETQN-----NMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFA 727

  Fly  1019 RRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKR--NGSKRTTSD----------LDG 1071
            |:|:.......|.::||::||......:..||||:.:|:.|  |.|.....|          ...
  Fly   728 RKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTA 792

  Fly  1072 GSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESL-SR 1135
            ...|..:.|. |.:..|.....:        :|...|.:||...||          .|.|.| .|
  Fly   793 KRNLPPKMYK-CHECSPNCLFKI--------VHRLDSYSPLAKPLL----------SGWERLVMR 838

  Fly  1136 QNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDI 1200
            |.   :..|.....|..|:|:|...:...|..||:..:..        :...:|:|:.      :
  Fly   839 QK---TKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVD--------NFDFTPDLKC------L 886

  Fly  1201 AKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPA------TTPTPS--- 1256
            |::..| .:::|...:.:.|.|                       |..|.      |.|.|.
  Fly   887 AEYSID-PSIVKDTDISKGQEK-----------------------MAIPLVNYYDNTLPPPCTYA 927

  Fly  1257 ----PTQS-------------NPEDSASTTTVLKELE-TGGGVRRSHRIKQKPQGPRASQGRGVA 1303
                ||:.             :.||..|..:.....: |..|||..:     |:.|
  Fly   928 KQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCN-----PKKP--------- 978

  Fly  1304 SVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGD 1368
                              ||.|..|:.|         |.|:                   ..||.
  Fly   979 ------------------IEEIGYQYKR---------LHEH-------------------VPTGI 997

  Fly  1369 EEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPP 1433
            .|......|...|:||::...           ...:.|        ||:|..:|.|:.....||.
  Fly   998 YECNSRCKCKKNCLNRVVQFS-----------LEMKLQ--------VFKTSNRGWGLRCVNDIPK 1043

  Fly  1434 GEFIMEYVGEVI----------------------------------------------------- 1445
            |.||..|.|.::
  Fly  1044 GAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDA 1108

  Fly  1446 -DSEEFERRQH---------------------------------------------------LYS 1458
             |.::|....|                                                   |:.
  Fly  1109 EDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFG 1173

  Fly  1459 KDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVN-GELR---IGFFSVKPIQP 1519
            ||...:          ::||.:.||:.||.||||.||...|...|: .:||   :.|||...|:.
  Fly  1174 KDEAPY----------IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRS 1228

  Fly  1520 GEEITFDYQY--------LRYGRDAQRCYCEAANCR 1547
            |.|:|::|.|        :.|      |.|.|.|||
  Fly  1229 GTELTWNYNYEVGVVPGKVLY------CQCGAPNCR 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	20/125 (16%)
		AWS	1358..1410	CDD:197795	8/51 (16%)
		SET_SETD2	1410..1551	CDD:380949	50/255 (20%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	20/125 (16%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	6/53 (11%)
		HMT_MBD	823..879	CDD:238689	17/76 (22%)
		SET_SETDB1	900..1262	CDD:380915	83/477 (17%)