DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Ehmt1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_006233680.2	Gene:	Ehmt1 / 362078	RGDID:	1307588	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1468	Identity:	290/1468 - (19%)
Similarity:	482/1468 - (32%)	Gaps:	471/1468 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 RQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEV 497
            |.|.||... |..||::.:.:|..:|::            :|...::|
  Rat     5 RGGATLRAR-AMAAADAEQAVLAKQETK------------QDCCMKTE----------------- 39

  Fly   498 VVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKV------ETKATCGEVVPRP 556
            ::.|:.|: .|||....||............|.:...:.||..|..      .|:|:..|...|.
  Rat    40 LLREDTLM-AADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRV 103

  Fly   557 EMVTEDVYITEGIAATLEKSAVVTKP---TTEMIAETKL--SDEVVIEPPLKDESDPKQTEVELP 616
            ..|.|:     |::   |:...|.|.   |.:...:|.:  |:...:..|.. :..|.:|...|.
  Rat   104 SRVAEN-----GVS---ERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPAL-QGQPLRTPNTLN 159

  Fly   617 ESKP---AVNIPKSE---RILSAEVET-TSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVE 674
            .|.|   |..:|...   |..||..:| |::|.||.              |.|..||:: .....
  Rat   160 SSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPG--------------EGSADTEDR-KPTAS 209

  Fly   675 TTPLKTEAAKEDSP-------PAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMM--------- 723
            .|.::...|::..|       .|:.:.......:||.   ||...|..:....:::
  Rat   210 GTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPK---EDINRNISECGRQQLLPTFPALHQS 271

  Fly   724 ----KCNNQKGQKQTP-LPEMKEPEKPVAETVSKKEKAMEN-----PARSSPAIVDKKVRAGEME 778
                :|.....:.||. ||.:      :|..||:|:|....     |.:.:..:..:.|.  ||.
  Rat   272 LPQNQCYMATTKSQTACLPFV------LAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVI--EMF 328

  Fly   779 KKVVKSTKGTVPEK--------------KMDSKK--------------SCAAVTPAKQKESGKSA 815
            |.:..||.|...||              :|||::              ..||..|.   |..:::
  Rat   329 KSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPT---EDSRTS 390

  Fly   816 KEAILKKETEKEKSSAKLD------SSSPNT-LDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSV 873
            ||::  .||::   :||:|      ..||:| .|:.|.|.:..|.:.....|...:..:..:|.:
  Rat   391 KESM--SETDR---AAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWI 450

  Fly   874 ISKTTSNQPAPKEEQHAAKKGLS-------DNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQL 931
                   :||.|..:.:.||..|       .:||.|:.:|.....:|::|  ....::||....:
  Rat   451 -------KPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYME--VSLDSLDLRVRGI 506

  Fly   932 RLDEKNKKKLKKVPTKVEAPPKVEPPTA-----VPVPGQKKSLSGKTSLRRNTV----------- 980
            ...:...:.|...|..:|.....|.|..     .|...:..:|:....:...:|
  Rat   507 LSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSV 571

  Fly   981 --YEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSS------ 1037
              ||    |.|.|:.:..........|::    ||.:..|.....|.|...:.....||
  Rat   572 VKYE----LMRPSNKAPLLVLCEDHRGRM----VKHQCCPGCGYFCTAGNFMECQPESSISHRFH 628

  Fly  1038 --------------------TPTREVAASSPVSTSS-------DSSSKRNGSKRTTSDLDGGSKL 1075
                                :..:||..:...:||:       :.|....|...||:....|:..
  Rat   629 KDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPE 693

  Fly  1076 DQR-RYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESL-SRQNS 1138
            |:: :.|:.:  .||...|.         .|.....|       |:|..:|  .|||:| |...:
  Rat   694 DEKSQSTVTQ--APECFDPA---------GPAGFVRP-------TSGFSQG--PGKETLESALIA 738

  Fly  1139 LDSSSSASQGAPKK-----KAL----KSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAA 1194
            |||..      |||     |.|    :..|:....|:..:..:........|:    .|| |.||
  Rat   739 LDSEK------PKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSK----RSP-LHAA 792

  Fly  1195 NPFG--DIA-KFIEDGVNLLKRDKVDEDQR--------KEGQDEVK------READPEEDE---- 1238
            ...|  ||. ..::.|.|:   |...||||        ....|.||      .:.||::.|
  Rat   793 AEAGHVDICHMLVQAGANI---DTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTC 854

  Fly  1239 --FAQRVANMETPATTPTPSPTQSNPEDSASTTTVL-----------KELETGGG---------- 1280
              .|.:..:.:......:......|.:|....|.::           |.|.:.|.
  Rat   855 LHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEEN 919

  Fly  1281 --------------------------------------VRRSHR---------------IKQKPQ 1292
                                                  ..|.:|               :|.| :
  Rat   920 ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK-E 983

  Fly  1293 GPRASQGRGVASVALAPISMDEQLAELAN-------------------------IEAINEQFLRS 1332
            |....|...:.|...:.:.|.:.|.:.|.                         :.|::.:...:
  Rat   984 GETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPT 1048

  Fly  1333 EGLNTFQLLKENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGA----------------- 1379
                .::.:.:|.......:.:....:| |.|.   |:.:.....||.
  Rat  1049 ----NYKYVSQNCVTSPMNIDRNITHLQYCVCV---DDCSSSTCMCGQLSMRCWYDKDGRLLPEF 1106

  Fly  1380 GCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEV 1444
            ......|:.||...||....|.|:..|.......:::||:..|.|:.:...||.|.|:.|||||:
  Rat  1107 NMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGEL 1171

  Fly  1445 IDSEEFERRQ---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AETQKWTVN 1504
            |...|.:.|:   :|:..|..        .||. .|||...||:||:|||.|:|| ...:.:..:
  Rat  1172 ISDSEADVREEDSYLFDLDNK--------DGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSH 1228

  Fly  1505 GEL---RIGFFSVKPIQPGEEITFDYQYLRYGRDAQR----------CYCEAANCRGWIGGEPDS 1556
            .:|   ||.|||.:.||.||::.|||        .:|          |.|.:..||
  Rat  1229 QDLRFPRIAFFSTRLIQAGEQLGFDY--------GERFWDVKGKLFSCRCGSPKCR--------- 1276

  Fly  1557 DEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKA 1594
                   ..|.:.|:......:...|.|.|..|:.|.|
  Rat  1277 -------HSSAALAQRQASAAQEAQENGLPDTSSAAAA 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	14/69 (20%)
		SET	1414..1533	CDD:214614	46/126 (37%)
		PostSET	1535..1551	CDD:214703	5/25 (20%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Ehmt1	XP_006233680.2	Ank_2	754..848	CDD:289560	24/101 (24%)
		ANK repeat	786..815	CDD:293786	11/32 (34%)
		ANK	786..812	CDD:197603	10/29 (34%)
		ANK	812..938	CDD:238125	18/125 (14%)
		ANK repeat	817..848	CDD:293786	8/30 (27%)
		Ank_2	822..915	CDD:289560	13/92 (14%)
		ANK repeat	850..882	CDD:293786	3/31 (10%)
		ANK repeat	884..915	CDD:293786	4/30 (13%)
		Ank_2	890..981	CDD:289560	5/90 (6%)
		ANK repeat	917..948	CDD:293786	0/30 (0%)
		ANK repeat	950..981	CDD:293786	2/30 (7%)
		ANK	950..979	CDD:197603	2/28 (7%)
		Pre-SET	1026..1130	CDD:282838	14/110 (13%)
		SET	1138..1260	CDD:214614	47/137 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840