Protein Alignment Set2 and Ehmt2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_006256016.3
• Gene: Ehmt2 / 361798
• RGDID: 1302972
• Length: 1394
• Species: Rattus norvegicus
• Alignment Length: 1589
• Identity: 320/1589 - (20%)
• Similarity: 517/1589 - (32%)
• Gaps: 527/1589 - (33%)

  Fly   148 PPPPPP--TALEIFAKPRPTQSLIVAQVTSEPSAV-------GGAHPVQTMAGLPPVTPRKRGRP 203
            ||||||  .|.|:...|| .:.|:.|:.....:..       ||||             |.||||
  Rat   110 PPPPPPLLPAPEMRGLPR-GRGLMRARGRGRAAPTGGRGRGRGGAH-------------RGRGRP 160

  Fly   204 R------KSQLADAAIIPTVI----VPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRV 258
            |      ::|.:.|..:|..:    || |..|...:.:           |:....::|   :.|.
  Rat   161 RSLLSLPRAQASWAPQLPAGLTGPPVP-CLPSQGEAPA-----------EMGALLLEK---EPRG 210

  Fly   259 SLKRL--KLGGRLESSDSGNSPSSSSPEVEP-----PALQDENAMDERPKQEQNLSRMVDAE-EN 315
            :.:|:  .||....|.::  .|.::...:||     ||.......||........:.::..| ||
  Rat   211 AAERVHGSLGDTSHSEET--LPKANPDSLEPTGPSSPASVTVTVGDEGADTPVGATPLIGEEPEN 273

  Fly   316 SDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLS 380
            .:.|...|.:...|:|......:....|             ..||..            |.....
  Rat   274 LEGDGGRILLGHATKSFPSSPSKGGACP-------------SRAKMS------------MTGAGK 313

  Fly   381 GPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEI 445
            .|||:          :...::..:.||.:.||.:....|       |.:.:.::|:.......:.
  Rat   314 SPPSV----------QSLAMRLLSMPGAQGAATAGPEPP-------PATTAGQEGQPKVHRARKT 361

  Fly   446 AAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADE 510
            .::.|.......|.:..|.||.   .:.|.:...:|||.|:..
  Rat   362 MSKPSNGQPPVPEKRPPEVQHF---RMSDDMHLGKVTSDVAKR---------------------- 401

  Fly   511 ILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVV-----PRP-----EMVTEDVYI 565
                      :|:.|      .||::|:     .:....|||:     |||     .:|.:|..:
  Rat   402 ----------RKLTS------GSLSEDL-----GSAGGSGEVILEKGEPRPLEEWETVVGDDFSL 445

  Fly   566 TEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERI 630
            .....:..|:....:|...|.:||....:|...|...::|.:.::.|.|..|.:.:.|  :|:|.
  Rat   446 YYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGN--QSDRS 508

  Fly   631 LSA------EVETTSSPLV----------PPECCTLESV-----SGP-VLLETSLSTEEKSNENV 673
            .|:      :.....||.|          ||.......|     ||| ..:|..|.:.|..:|..
  Rat   509 GSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGT 573

  Fly   674 ----------ETTPLKTEAAKEDSPPAAPEEEA---SNSSEEPNFLLEDYESNQEQVAEDEMMKC 725
                      :|:.|:||...|:.|..:...||   ...||.........||     .:.|::.|
  Rat   574 LSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATES-----VDGELLGC 633

  Fly   726 NNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVK------- 783
            |                     ..:.|:| .|...:|.:..::.:..||     ::||
  Rat   634 N---------------------AAILKRE-TMRPSSRVALMVLCEAHRA-----RMVKHHCCPGC 671

  Fly   784 ---STKGTVPEKKMDSK------KSCAA------VTPAKQKESGKSAKEAILKKETEKEKSSAKL 833
               .|.||..|...|.:      |:|.:      ..|    ..|:.|.||       :|.:..:.
  Rat   672 GYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCP----HCGEDASEA-------QEVTIPRG 725

  Fly   834 DSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKP-PQESAPSVISKTTSNQPAPKEEQHAAKKGLSD 897
            |..:|                    |..:..| |...|.....:..::||:.:...|...:
  Rat   726 DGGTP--------------------PVGTVAPAPPPLAHDAPGRADTSQPSARMRGHGEPR---- 766

  Fly   898 NSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDE------------KNKKKLKKVPTKVEA 950
             .||               ||.:...:|.:...|.|..            ..::.|:|.....|:
  Rat   767 -RPP---------------CDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQES 815

  Fly   951 PPKVEPPTAVPVPGQKKS---------LSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGK 1006
            .....||   |.||::|.         ||.|....:..:.....||:.|......|.:....|..
  Rat   816 ESLPSPP---PSPGRRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAA 877

  Fly  1007 LKPSKVKKKINPRRSTIC----EAAKDLRS-SSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTT 1066
            .|.|          ..||    :|..::.: .....||..|...:
  Rat   878 QKGS----------VEICHVLLQAGANINAVDKQQRTPLMEAVVN-------------------- 912

  Fly  1067 SDLDGGSKLDQRRYTI----CEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRK 1127
                  :.|:..||.:    |...:.|..                      .|.|..|. |.|..
  Rat   913 ------NHLEVARYMVQLGGCVYSKEEDG----------------------STCLHHAA-KIGNL 948

  Fly  1128 EGKESLSRQNSLDSSSSASQG------APKKKALKSAEIL---SAALLETESSE-------STSS 1176
            |....|.....:|.::..|.|      |.:.|.:....:|   .|.:..|::.|       |.:.
  Rat   949 EMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTG 1013

  Fly  1177 GSKMSRWDVQTSPELEAANPFGDIAKFI------EDGVNL-LKRDKVDEDQRKEGQDEVKREADP 1234
            .:.::...:....:|.|.|..||....|      .|.|.| |.|....|.:.|||  :...:..|
  Rat  1014 SAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEG--DTAWDLTP 1076

  Fly  1235 EEDE--FAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVR--RSHRIKQKPQGPR 1295
            |..:  ||                 .|.|           ::|..|.|.|  |:.:|..:
  Rat  1077 ERSDVWFA-----------------LQLN-----------RKLRLGVGNRAVRTEKIICR----- 1108

  Fly  1296 ASQGRGVASVALAPIS-MD-EQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAE 1358
             ...||..:|.:..:: :| |...|                  .::.:.||.......:.:....
  Rat  1109 -DVARGYENVPIPCVNGVDGEPCPE------------------DYKYISENCETSTMNIDRNITH 1154

  Fly  1359 MQ-CDCFLTGDEEAQGHLSCGAGCI--------------NRM---LMIECGPLCSNGARCTNKRF 1405
            :| |.|.   |:.:..:..||...|              |::   |:.||...||....|.|:..
  Rat  1155 LQHCTCV---DDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVV 1216

  Fly  1406 QQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ---HLYSKDRNRHYYF 1467
            |.......:::||.|.|.|:.|...||.|.||.|||||:|...|.:.|:   :|:..|..
  Rat  1217 QSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNK----- 1276

  Fly  1468 MALRGEA-VIDATSKGNISRYINHSCDPN-AETQKWTVNGEL---RIGFFSVKPIQPGEEITFDY 1527
               .||. .|||...|||||:|||.|||| ...:.:.::.:|   ||.|||.:.|:.|||:.|||
  Rat  1277 ---DGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY 1338

  Fly  1528 ---------QYLRYGRDAQRCYCEAANCR 1547
                     :|.       .|.|.:..|:
  Rat  1339 GDRFWDIKSKYF-------TCQCGSEKCK 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	26/144 (18%)
		AWS	1358..1410	CDD:197795	16/69 (23%)
		SET_SETD2	1410..1551	CDD:380949	55/155 (35%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Ehmt2	XP_006256016.3	None