Protein Alignment Set2 and set-25

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_499738.3
• Gene: set-25 / 3565129
• WormBaseID: WBGene00012802
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 715
• Identity: 149/715 - (20%)
• Similarity: 254/715 - (35%)
• Gaps: 163/715 - (22%)

  Fly   936 KNKKKLKKVPT-KVEAPPKVEPPTAVPVPGQKKSLSG----KTSLRRNTVYEDSPNLER----NS 991
            :.:::.:.|.| |.|.||:......     |::.:|.    ::|...|.:.:..|.:.|    ..
 Worm    56 QKRRRSESVRTLKPECPPEETQRLR-----QRRRISATDATQSSRTMNVIEDRKPRVNRARKSQD 115

  Fly   992 SPSSDSAQANTSAGKLKPSKVKKKINPRRST----ICEA--AKDLRSSSSSSTPTREVAASS--- 1047
            :||:.:....|..|..:.||......|.:.:    |.||  :|.:.:||.....|.:.|.:.
 Worm   116 APSTSTCGFETPVGTKRKSKAADSQKPPKQSKLRKIDEASTSKAVDNSSKDGKKTTKPAVTQSNR 180

  Fly  1048 ----------PVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFS 1102
                      |:.|....||.|..|....:|:....::::..      :.|...:.:||
 Worm   181 RRSGLSLRPVPIETIFSESSGRESSTEDEADVSHQQRVEKIA------KNPIMVVVLPL------ 233

  Fly  1103 MHPKASANPLHDTLLQTAGKKRGRKEGKES--LSRQNSLDSSSSASQGAPKKKALKSAEILSAAL 1165
             .|....|....|::.|. |.|..|...|:  ..|..|......|..|.|.||..|
 Worm   234 -GPGNYPNNERITVVSTY-KSRVNKNCNEARRAQRHGSWSRKGIAFPGIPTKKFTK--------- 287

  Fly  1166 LETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLK------------------ 1212
                 |:....|:..|.|..|.:...|.    |.|..:.|....|..
 Worm   288 -----SDLAKYGAHASNWPAQAAFRSEE----GKILIYYEGWTCLTLHRLSVEECARTAPTILEE 343

  Fly  1213 ---RDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKE 1274
               |||..|..:....:|.|...:..::...:...:.........|.| ||:||   :...:.::
 Worm   344 MSIRDKFIETVKSAAAEEAKLVVEKNQENGIELTLDEALKQIFIEPVP-QSSPE---NVFWIYQD 404

  Fly  1275 LETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAE-------------LANIEAIN 1326
            |.      ..|.:..:..|             |||:.......:             :.:::|..
 Worm   405 LS------YFHTMDNRDLG-------------LAPVFYISSYTQSVRPPCYAYTAINIVDVDAYK 450

  Fly  1327 EQFLRSEGLNTFQLLKENFYRCARQVSQEN-AEMQCDC---FLTGDEEAQGHLSCGA-GCI---- 1382
            ........::...|..:..:...|..:.|| .:.:||.   ||. |.....:|.|.. |.:
 Worm   451 RCLESRANMSFADLTGQKIWMPTRSKACENGTKCKCDARFMFLY-DPHDVTNLECTPDGKVDFTD 514

  Fly  1383 ----NRMLMIECGPLCSNGARCTNKRFQQHQCWPCRV-FRTEKKGCGITAELLIPPGEFIMEYVG 1442
                |..:::||...|.....|..:..|:.|..|..| :...:||.|:.|...|..||.:.||.|
 Worm   515 FKIDNARIVMECSDACGCSLDCPRRSLQRGQQHPLAVYYEGPEKGFGVRAAANIKAGELVCEYTG 579

  Fly  1443 EVI----------------DSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHS 1491
            :|.                |.||.|..:.....|.:....|.|:..:.:|.|...|||||:||||
 Worm   580 DVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSYDAAFNAMDTKIIISAKKTGNISRFINHS 644

  Fly  1492 CDPNA-----ETQKWTVNGEL-RIGFFSVKPIQPGEEITFDYQY--LRYGRDAQRCYCEAANCRG 1548
            |||::     .::::..:..: |:..:::|.|..|||||..|..  :.:.|.:.:|.|::..|.|
 Worm   645 CDPSSVFVEVYSRRFEEDPLIPRVAVYAIKDIALGEEITIAYYEPGIEWKRSSVKCRCKSTKCMG 709

  Fly  1549  1548
             Worm   710  709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	14/63 (22%)
		SET_SETD2	1410..1551	CDD:380949	48/164 (29%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
set-25	NP_499738.3	SET	<525..711	CDD:394802	54/185 (29%)