Protein Alignment Set2 and Set1

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Alignment Length: 1651
• Identity: 306/1651 - (18%)
• Similarity: 539/1651 - (32%)
• Gaps: 501/1651 - (30%)

  Fly    16 RGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDL 80
            |||.|.|..::.....|        |||:                   |.|.|..:.|:.|||
  Fly   371 RGRDRDRSAEIDQRDRG--------SLKY-------------------CSRYSLHEYIETDVR-- 406

  Fly    81 LNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQS 145
                          |..:..|:.:|.|....||...::.:..:.......:..|.::.|:.....
  Fly   407 --------------RSSNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHP 457

  Fly   146 LPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLAD 210
            :.||||||..::.:.:....::.||      |:..|      .||.|.|..|        |.:..
  Fly   458 VQPPPPPPEEIDNWDEEEHDKNSIV------PTHYG------CMAKLQPPVP--------SNVNF 502

  Fly   211 AAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSG 275
            |..:.:|..|: ||..|....|                        |::|       ..:....|
  Fly   503 ATKLQSVTQPN-SDPGTVDLDT------------------------RIAL-------IFKGKTFG 535

  Fly   276 NSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQ-- 338
            |:         ||.||                 |..::..:|.....:|.::.::|...|.::
  Fly   536 NA---------PPFLQ-----------------MDSSDSETDQGKPEVFSDVNSDSNNSENKKRS 574

  Fly   339 -EEGRPVEVEPQDLIDI--DMEL-AKQEPTP-----DPEEDLDEIMVEVLSGPPSLWSADDEAEE 394
             |:...|..:|.:..||  |.|| .|::.:.     :.|.:.|.:.:..||      |.:|..:.
  Fly   575 CEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLS------SQEDPIQT 633

  Fly   395 EEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEES 459
            :|          |.|..:...|.....|.::.....:|..|..|    :.|.:||:.::......
  Fly   634 KE----------GAEYKSIMSSYMYSHSNQNPFYYHASGYGHYL----SGIPSESASRLFSNGAY 684

  Fly   460 QDQEEQHILIDLIEDTLSE---------SEVTSSVSPTIEHMVVEEVVVEENQLVDEADEIL--D 513
            ...|....:.....|:.|:         |:....:...::.::        ..:|:|..:||  |
  Fly   685 VHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVI--------GYIVEELKQILKRD 741

  Fly   514 SKQEFVIKKVFSE-----SDNIAASLNKDIFE---PKVETKATC------GEVVP--------RP 556
            ..:..:....|..     .::.:.:.:|.:||   ..|.|...|      .|..|        ..
  Fly   742 VNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHR 806

  Fly   557 EMVTEDVYITEGIAATLEKSAVVTK--------PTTEMIAETKLSDEVVIEPPLKDESDPKQTEV 613
            |:.....|.:.|:.|.:.|.....:        ||.....|..|||:.  |...:.:||.:.:.|
  Fly   807 EVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQE--EMVQRSDSDKEDSNV 869

  Fly   614 ELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPL 678
            |:.::                              ....:.|||.::.|.|....|..|
  Fly   870 EISDT------------------------------ARSKIKGPVPIQESDSKSHTSGLN------ 898

  Fly   679 KTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPE 743
               :.::.|..:.....:|::|.|               ||.|.:.|                .|
  Fly   899 ---SKRKGSASSFFSSSSSSTSSE---------------AEYEAIDC----------------VE 929

  Fly   744 KP-VAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAK 807
            |. .:|..|.:.....|..:.:..|.::.: .|.|:              .::.:..|:.
  Fly   930 KARTSEEDSPRGYGQRNLNQRTTTIRNRNL-VGTMD--------------VINVRNLCSG----- 974

  Fly   808 QKESGKSAKEAILKKETEKEKSSAKLDSSSPNTL--DKKGKDTAQWSPQLQTLPKSSTKPPQESA 870
               |.:..||.:.|:  .|:...:..|..:..||  ..|.|:.:.....|:.:.|.|.....|:.
  Fly   975 ---SNEFKKENVTKR--TKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENG 1034

  Fly   871 --PSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRL 933
              |:::.| ..|.|...||   .::.|:...||           |:
  Fly  1035 IEPTILRK-IPNTPKLNEE---CRRSLTPVPPP-----------GY------------------- 1065

  Fly   934 DEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPN----LERNSSPS 994
               |::::||                      |.....|.|...:.:|.||..    .||....:
  Fly  1066 ---NEEEIKK----------------------KVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNT 1105

  Fly   995 SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKR 1059
            ...||......:.:..:::|.::....:.....|:..|..:.:..||:.|.|
  Fly  1106 EYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAIS------------- 1157

  Fly  1060 NGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKR 1124
                :|.|..:..||:|.....|         |.|......|..|.:.      |.|.....|..
  Fly  1158 ----QTRSCFESASKVDTTLVNI---------ISVENDINEFGPHEEG------DVLTNGCNKMY 1203

  Fly  1125 GRKEG--KESLSRQNSLDSSSSASQGA--------------------PKKKALKSAEILSAALLE 1167
            ...:|  |.:.|...|...||.|||.:                    |..|..::..||.
  Fly  1204 TNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILK----- 1263

  Fly  1168 TESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREA 1232
             ..:|:.:..|:|:|    |.|.....:|.            .:::.|.|...|   ...||.:.
  Fly  1264 -REAENIAIVSQMTR----TGPGRPRKDPI------------CIQKKKRDLAPR---MSNVKSKM 1308

  Fly  1233 DPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLK---ELETGGGVRRSH--RIKQKPQ 1292
            .|..||:.. :|:............|:...|:.....|.|.   :.|....::.|:  .:.::|.
  Fly  1309 TPNGDEWPD-LAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPY 1372

  Fly  1293 G-------------------PRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTF 1338
            .                   |..|:.|          ..|::|.......|..|.|.:   |:..
  Fly  1373 AMFLNNTHWVDHCTTDRAFWPPPSKKR----------RKDDELIRHKTGCARTEGFYK---LDVR 1424

  Fly  1339 QLLKENFYRCARQVSQENAEMQCD--CFLTGD------EEAQGHLSCGAGCINRMLMIECGPLCS 1395
            :..|..::...........|.:.|  ..||..      .:.|| :|..|....|.|:...|.:..
  Fly  1425 EKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQG-ISREARSNQRRLLTAFGSMGE 1488

  Fly  1396 NGARCTNK-RFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSK 1459
            :.....|: :|::.|   .:..::.....|:.|...|...|.::||||::|.....:.|:..|..
  Fly  1489 SELLKFNQLKFRKKQ---LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEA 1550

  Fly  1460 DRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEIT 1524
            ......|...:..|.:||||..||::|:|||||:||...:..|:..|.:|..:|.:||...||||
  Fly  1551 IGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEIT 1615

  Fly  1525 FDYQYLRYGRDAQR--CYCEAANCRG 1548
            :||   ::..:.::  |.|.|..|||
  Fly  1616 YDY---KFPLEDEKIPCLCGAQGCRG 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	13/60 (22%)
		SET	1414..1533	CDD:214614	39/118 (33%)
		PostSET	1535..1551	CDD:214703	6/16 (38%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:240750
		DUF1777	255..>380	CDD:285811	5/8 (63%)
		PRP38_assoc	<318..388	CDD:289628	6/24 (25%)
		N-SET	1341..1492	CDD:288597	26/164 (16%)
		SET	<1463..1641	CDD:225491	55/183 (30%)
		SET	1504..1625	CDD:214614	39/123 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870