DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and phf20l1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_009290756.1	Gene:	phf20l1 / 327626	ZFINID:	ZDB-GENE-030131-5837	Length:	1116	Species:	Danio rerio

Alignment Length:	1017	Identity:	221/1017 - (21%)
Similarity:	351/1017 - (34%)	Gaps:	309/1017 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 VEPPALQDENAMDERPKQ---EQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEV 346
            :|.|||:.|...:|...:   |...||:                   .|.|...|..|:.:.:..
Zfish    68 LERPALRKEGLKEEEVSERLSEMRASRL-------------------RELPGSTESTEDQKDLPQ 113

  Fly   347 EPQDLIDIDMELAKQEPT---PDPEEDLDE---IMVEVLSG------PPSLWSADDEAEEEED-- 397
            :.|:|.|.:..||:....   |...|.:::   ..|:...|      ...:.|..::|:.::|
Zfish   114 QRQELRDGEEVLARWTDCRYYPAKIESINKEGTYTVQFYDGVIRCVKRIHIKSMPEDAKGQQDWI 178

  Fly   398 ATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQ 462
            |.|:.|:...|...    .:.||.|..|.......|:.::.||...:.|.|..    :.::..|.
Zfish   179 ALVKAASAAAKNKG----GNRPRTSANSNKDREDRREQRSDEEEDDDDADEDD----DDDDDDDG 235

  Fly   463 EEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSES 527
            ||:.      |:..||||..:.:..            ||......|:|:     |..|.|..|:.
Zfish   236 EEEE------EEEDSESEKLADLDS------------EEEDSKPPAEEL-----ESAIAKRRSKR 277

  Fly   528 DNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKL 592
            .....|:.:                                  :.|.|.|......||:.||||
Zfish   278 QGNQCSIKR----------------------------------SRLGKGAGCADTETELKAETK- 307

  Fly   593 SDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCT----LESV 653
              |:.:.|         |.:|..||..||..  ||:.: ||: :||.|...||.|..    |:..
Zfish   308 --ELPVTP---------QQKVPSPEPSPADE--KSQSV-SAQ-KTTPSLSNPPACKARSRRLKHD 357

  Fly   654 SGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVA 718
            ||            :|..:.:.||    ||.|.||..:|.:...:|:..............:::|
Zfish   358 SG------------ESASSCQNTP----AAPESSPLPSPTQTLPDSTHTAPSSSPQRRRRSQRLA 406

  Fly   719 EDEMMKCNNQKGQKQTPLPEMKEPEKPV-----AETVSKKEKAMENPARSSPAIVDKKVRAGEME 778
            ....:.|......:.|.......|:.|:     :.||.|.|...:.|...||:..
Zfish   407 TTSDLICPPSPHTRDTATHPTPPPDGPLIADEDSSTVVKTEAISQKPVSESPSTA---------- 461

  Fly   779 KKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDK 843
                                           .|..||:..|    |||||.:..|.|   |....
Zfish   462 -------------------------------TSTASAQAPI----TEKEKMNDVLPS---NQAAL 488

  Fly   844 KGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQP-APKEEQHAAKKGLSDNSPPSVLKAK 907
            :|...|.....:|.:|..:.|..:.:...:|:...|:.| ||.|    ....|..|.    .|.|
Zfish   489 EGNSPAVVPAAIQKVPSRTPKANKHAREPIINTKRSDDPLAPNE----CIIDLDHNK----FKCK 545

  Fly   908 EKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGK 972
               |||   |...|:...|.:..|:.....:|::   .|:|.:|.:         .|:.::.|
Zfish   546 ---VSG---CSKAFRKAKLLDYHLKYYHNTEKEM---DTEVCSPER---------EGRTRATS-- 590

  Fly   973 TSLRRNTVYEDSPNLERNSSPSSDSAQAN-------TSAGKLKPSKVKKKINPRRSTICEAAKDL 1030
            .|:..:|: .|.|:.:|..:.|:.|:.::       .|.|.::|||..||              .
Zfish   591 ASMPTSTL-SDVPDNKRRRTVSTSSSLSSQGFMLQMDSGGCVRPSKFCKK--------------K 640

  Fly  1031 RSSSSSSTPTREVAASSPV-STSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPV 1094
            |||:|.|:.:.||:...|. ....|...|::      ..|||          :|..
Zfish   641 RSSASMSSDSTEVSLPPPTFDNLHDKIIKKD------KHLDG----------LCIK--------- 680

  Fly  1095 PLTKRRFSMHPKASANPLHDTLLQTAGKKR--GRKEGKE-SLSRQNSLDSSSSASQGAPKKKALK 1156
              |:|:|.:..|.          |...|||  .|::.|| .|.|         ..|...|||..|
Zfish   681 --TERKFKLDDKC----------QLFVKKRDKDRRDRKEKDLFR---------IKQKKKKKKKKK 724

  Fly  1157 S-------AEILSAALLETESS---ESTSSGSKMSRWDVQ---TSPELEAANPFGDIAKFIEDGV 1208
            |       .:.:|.|.||..||   .|:||..|.|.:...   .|.:|...| ..|| .|:||..
Zfish   725 SKLHCYPDLDEMSLAYLERPSSPPHRSSSSAFKHSTFQYPRAILSVDLTGEN-LSDI-DFLEDST 787

  Fly  1209 N---LLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANME 1247
            .   |...|:.::|......::.:.|.|...||..:.:..|:
Zfish   788 TESLLFSGDEYNQDLDSITMEDFQDEDDDGADEIVRCICEMD 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
phf20l1	XP_009290756.1	MBT	3..68	CDD:327428	221/1017 (22%)
		TUDOR	121..165	CDD:119391	6/43 (14%)
		DUF3776	248..323	CDD:315317	24/137 (18%)
		Atrophin-1	<312..510	CDD:331285	58/274 (21%)
		PHD_PHF20L1	823..868	CDD:277103	1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030