DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setd2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_038937536.1	Gene:	Setd2 / 316013	RGDID:	1305576	Length:	2543	Species:	Rattus norvegicus

Alignment Length:	2882	Identity:	626/2882 - (21%)
Similarity:	1002/2882 - (34%)	Gaps:	989/2882 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SALGN----TPPHINPSLKHADA------EASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNK 83
            :||.|    ..|| :|:....|:      ||..|.|..::|...:.|....:  |.|
  Rat    98 TALSNEKQSDSPH-SPATPQVDSNPKAKMEAGDTFPATEESSPPKSRVELGR--IHF-------- 151

  Fly    84 NRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPP 148
              |.|.:.:         |...|..||....|:...|.....|.:.:||.        |..|.||
  Rat   152 --KKHLLHV---------TSRPQLATTTTVASLLPPTTQLPVAIAESTVD--------SPPSSPP 197

  Fly   149 PPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQT--MAGLPPVTPRKRGRPRKSQLADA 211
            |||||..:...:.|.|         .|||.|:  .||..|  |...|...|           .||
  Rat   198 PPPPPPQVSSPSPPAP---------ISEPVAL--PHPPVTALMTSTPGPLP-----------VDA 240

  Fly   212 AI-----IPTVIVPSCSDSD------TNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKL 265
            |:     .|...||...:.|      :||....|:....:..:   ..:||..|.:
  Rat   241 AVRAQKEPPMKSVPESLELDMKQDIVSNSLEEHTNQTLKEQAD---NALQKEDSHI--------- 293

  Fly   266 GGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETE 330
             |:.|....|:..|.||.:.           ..:.|..|.....:.:|.:.||        :.|.
  Rat   294 -GKEEEVSDGSKISLSSKKA-----------SSKKKSSQFEGTFLGSESDEDS--------VRTS 338

  Fly   331 SPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDE---- 391
            |.:...:.:....:|.| :|.        |:...|...|||.:       ...|....||:
  Rat   339 SSQRSHDLKSSTSIEKE-RDF--------KKSSAPSKSEDLGK-------SSRSKTERDDKYFSY 387

  Fly   392 -------------AEEEEDATVQRATPPGKEPAADSCS----------SAPRRSRRSAPLSGSSR 433
                         ...|.|....|:.......:..|.|          .:.||..||:|....:|
  Rat   388 SKLERDTRYVSTRCRSERDRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSERRYHRSSPYRERTR 452

  Fly   434 QGKTLEETFAEIAAESSKQILEAEESQDQEEQ-----------HILIDL--------------IE 473
            ..:...:.             .|.||.|.|::           |...||              .|
  Rat   453 YSRPYTDN-------------RARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTE 504

  Fly   474 DTLSESEVTSSVSP--------TIEHMVVEEVVVEENQL-------VDEADEILDSKQEFVIKKV 523
            .:..|.|.....|.        |.||..::......|:|       ..:.|....|:.:..:.|.
  Rat   505 TSYLEMERRGKYSSKLERESKRTSEHEAIKRCCSPPNELGFRRGSSYSKHDNNSTSRYKSALSKS 569

  Fly   524 FSESDNIAASL--------NKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVT 580
            .|:||....|.        ||......::|..:.|..:.....:.|    .|...:....:.:..
  Rat   570 ISKSDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIPE----REKTGSPSPSNQLND 630

  Fly   581 KPTTEMIAETKLSDEVVIEPP-LKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVP 644
            .||.:     ||.:..:::|. :..:|.....|:|||:.       |::::.:
  Rat   631 SPTFK-----KLDESPILKPEFIGHDSHESIKELELPKM-------KNDQLRN------------ 671

  Fly   645 PECCTLE-SVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLE 708
              .|::| :|:|....||.::|...|              |.|:.....::..:.|...|  |::
  Rat   672 --FCSIELNVNGSPETETDVATFRTS--------------KPDAISMTSDDSVTGSEVSP--LIK 718

  Fly   709 D--YESN--------QEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARS 763
            .  ..||        :|:.|:|...:.|..|    :|..|.:....|      ..:|.|..|
  Rat   719 GCVLSSNGFQSVGRCRERDADDACRQHNKSK----SPFRETEPLLSP------HHDKVMSLP--- 770

  Fly   764 SPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGK--SAKEAILKKETEK 826
                    |:..:..|.::|        :.:|.:.||     .|.|:|.:  |..|:   .|.|.
  Rat   771 --------VKTIDYSKTLIK--------EPVDKRHSC-----CKTKDSDRYCSPNES---SEAEN 811

  Fly   827 EKSSAK------LDS-----SSPNTLDKKGKDTAQWSPQ---------------LQTLPKSSTKP 865
            .:.|:.      |||     .:....|:..:.|.....|               |.....||...
  Rat   812 REISSNCFVNVHLDSKTVVCDNRELTDQHSEFTCDGYKQSIGSTSSASLNHFDDLYESVGSSGIS 876

  Fly   866 PQESAPSVISKTTSNQPAPKEEQHAAKKGL-------SDNSPPSVLKAKEKAVSGFVECDAMFKA 923
            ..:|.||.|....:..||....|  :|||:       .:....|.|....||.|.:.....|...
  Rat   877 SLQSLPSGIRCEENTSPALDTVQ--SKKGIDFLKYVGKETDVVSALPDSGKAFSSWENRHNMLSG 939

  Fly   924 MDLANAQ---------------LRLDEKNKKKLKKVPTKVEAPPKVEPP-----TAVPVPGQKKS 968
            ..|..:|               :.|||:.::.    .|.:....:|..|     |.....|...:
  Rat   940 QSLQESQEEGSSTLHERRGRSEVSLDEEEQRG----HTHISDDSEVVFPYDLNLTMEDSDGVTYT 1000

  Fly   969 L----SGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKK-KINPRRSTICEAAK 1028
            |    ||......:||:.|......:||..|||....:....:..::::. .:.|:.||:
  Rat  1001 LKCDSSGNAPEIVSTVHGDYSASSASSSDESDSEDTESDDSSIPRNRLQSVVVVPKNSTL----- 1060

  Fly  1029 DLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSD--LDGGSKLDQRRYTICEDRQPETA 1091
                               |:..:|..||:.:.|.|..||  .||   |:.||:.. |::....|
  Rat  1061 -------------------PMEETSPCSSRSSQSYRHYSDHWEDG---LESRRHAY-EEKFESMA 1102

  Fly  1092 IPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALK 1156
            ........:|.:|.....||  :|......:|......:.:.|:.:.:||:|.....:.....|.
  Rat  1103 SKGCSQTEKFFLHKGTERNP--ETSYSQFSRKIDNHLPEIAHSQSDGVDSTSHTDVKSDSVGHLN 1165

  Fly  1157 SAEILSAALL---------------------------ETESSE------STSSGSKMSRWD-VQT 1187
            |.:.:.|.:.                           ..:||.      |.||...:||.| :.:
  Rat  1166 SEDAIRAKMSRPQELPVYCDDFEDLPNTSRQQMIFSNRPDSSRLGKAELSFSSSCDISRMDGLHS 1230

  Fly  1188 SPEL---------------------------------EAANPFGDIAKFIEDGVNLLKRDKVDED 1219
            |.||                                 ::|..:|        |.:...:.....|
  Rat  1231 SEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSAEHYG--------GTHDYWQGNGYWD 1287

  Fly  1220 QRKEGQ--------DEVKREA------DPEEDEFAQRVANMETPATTPTPSPTQ----------- 1259
            .|..|:        |.::.:.      |.||:|      |.:..:.:...||:.
  Rat  1288 PRSAGRPPGTGVVYDRIQGQVPDSLTDDREEEE------NWDQRSGSHFSSPSNKFFFHQKDKGS 1346

  Fly  1260 -SNPEDSAST---TTVLKE-------------LETGGGVRRSHRIKQKPQGPRASQGR------- 1300
             ..||.|:::   :.|:.|             .|.|...:|...::...:.....|.|
  Rat  1347 VQAPEISSNSIKDSLVINERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEI 1411

  Fly  1301 --GVASV-----ALAP-ISMDE--------QLAELANIEAINEQFLRSEGLNTFQLLKENFYRCA 1349
              |.:||     .:.| .:||:        :.|:|..:...            |.|::||.|...
  Rat  1412 EQGQSSVPQHSELVGPSCAMDDFRDPQRWKEFAKLGKMPCY------------FDLIEENVYLTE 1464

  Fly  1350 RQVSQENAE---MQCDCF-LTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQC 1410
            |:.::.:.:   |||:|. |:.||.|||.::||..|:||:|||||...|.||..|:|:|||:.|.
  Rat  1465 RKKNKSHRDIKRMQCECTPLSKDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQH 1529

  Fly  1411 WPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAV 1475
            ....|..|||||.|:.|...:|...|::||.|||:|.:||:.|...|::::|.|||||||:.:.:
  Rat  1530 ADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEI 1594

  Fly  1476 IDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCY 1540
            ||||.|||.||::||||:||.|||||||||:||:|||:.|.:..|.|:|||||:.|||::||:|:
  Rat  1595 IDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCF 1659

  Fly  1541 CEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLA 1605
            |.:|||||::|||                                .|.|.:|            |
  Rat  1660 CGSANCRGYLGGE--------------------------------NRVSIRA------------A 1680

  Fly  1606 TGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGG 1670
            .|:.:||:::.||           |..|               :.:|::|:.:           |
  Rat  1681 GGKMKKERSRKKD-----------SVDG---------------ELEALMENGE-----------G 1708

  Fly  1671 LKNQQDTLRFSRCLVRAKLLKTRLALLRVL--THGELPCRRLFLDYHGLRLLHAWISENG----N 1729
            |.::...|..||.:||.:.|:.:|..|:::  ||.: .|.:.||:.|||.||..|::|.|    :
  Rat  1709 LSDKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQ-SCLKSFLERHGLSLLWIWMAELGDGRES 1772

  Fly  1730 DDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQ---------EKQAALH- 1784
            :.:|:|.::.|||.||||.:.||.:|:|...:|.||    |....|||         |..:..|
  Rat  1773 NQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWS----QTKTAVPQLSEGDGYSSENTSRAHT 1833

  Fly  1785 --------------------KRMV----------------------------------------- 1788
                                |:::
  Rat  1834 PLNTPDPSAKPSTEVDTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVE 1898

  Fly  1789 --ALLQKWQALP--------------EIFRIPKRE---------------RIEQM---------- 1812
              ..||..|.||              ::.::|..|               ::|:.
  Rat  1899 EDEELQSQQLLPSQLCESKVESESTIDVSKLPISEPEADTETEPKDSNGTKLEETIAEETPSQDE 1963

  Fly  1813 ------KEHEREADRQQKHVHAS---TALED---------------QRERESS-NDRFRQDRFRR 1852
                  .|.||..:...|.|..|   |.|.|               |.|:||: .:|.|.....|
  Rat  1964 EEGVSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVTERGRDTAAFR 2028

  Fly  1853 DTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRN--DNRRRSDIGPPS------------ 1903
            |.|:.:                 |..:.....||..::|  ..:||..:.|||
  Rat  2029 DQTAPK-----------------TPNRSREREPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDD 2076

  Fly  1904 -------------EQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADINTD-- 1953
                         :.|..||.|.||.|||::||..||:::......|.......|.....|..
  Rat  2077 RYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHH 2141

  Fly  1954 -----PKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLSPDIDVGQ---GATDVEYKLPPG 2010
                 |...|.....|.:. .|:..|.:|.|....:.:.|    ..|..|   |.:......||.
  Rat  2142 PFAGYPPGYPMQAYVDPSN-PNAGKVLLPTPSMDPVCSPA----PYDHAQPLVGHSTESLAAPPS 2201

  Fly  2011 VDPLP-PAWNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTTQQPLHELQIDPAVLEN 2074
            |..:| .|.:.:|:|.   .|....|.:...:...|...:||                 |..::.
  Rat  2202 VPVVPHGAASVEVSSS---QYAAQSESVVHQDSSVPGMPVQT-----------------PGPVQG 2246

  Fly  2075 ELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLES------- 2132
            :...|......|:|.:  .||                      ||.:.:..:|.|.::
  Rat  2247 QNYSVWDSNQQSVSVQ--PQY----------------------SPAQSQATIYYQGQTCSTVYGV 2287

  Fly  2133 ------------RKYKENKEKIRRRKELY--RRRKIEVLP-DAVDEIPVPGKALPIQP------- 2175
                        :.|.:...:..:.::::  ..:.:.|.| .||..|..||:..|:||
  Rat  2288 TSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPPEMVVTN 2352

  Fly  2176 ---------------------YLFSSDEEE--------TKVAAIEQPAAEEEQDSLNMAPSTSHA 2211
                                 :..:.|.|.        |:....:.|..|...|.    .|..|.
  Rat  2353 NLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDD----ASLEHE 2413

  Fly  2212 AMAALGKAVAQPTGLGTVGKRKLPMPPSVTVKKHRQEQRSKKVKSSQSPLTATSAREAHEKFRFE 2276
            |          ...|||....:.||            :.|||.|::::..::..|:::.|.||.|
  Rat  2414 A----------EMDLGTPTYDENPM------------KTSKKPKTAEADTSSELAKKSKEVFRKE 2456

  Fly  2277 ISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGNP--LSCTESVKHK 2339
            :|..:...|.||||..|.:||||:.||:|.|..:|::.:..||::||:   ||  |.|.|:||||
  Rat  2457 MSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCK---NPEDLECNENVKHK 2518

  Fly  2340 SYDFINQYMRQKGPVYKKPAEN 2361
            :.::|.:||::.|.|| ||.|:
  Rat  2519 TKEYIKKYMQKFGAVY-KPKED 2539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	28/55 (51%)
		SET	1414..1533	CDD:214614	66/118 (56%)
		PostSET	1535..1551	CDD:214703	9/15 (60%)
		WW	2014..2043	CDD:278809	6/29 (21%)
		SRI	2270..2348	CDD:285448	34/79 (43%)
Setd2	XP_038937536.1	AWS	1475..1529	CDD:197795	28/53 (53%)
		SET_SETD2	1529..1670	CDD:380949	77/140 (55%)
		WW	2370..2399	CDD:395320	3/28 (11%)
		SRI	2446..2534	CDD:400510	38/90 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352016
Domainoid	1	1.000	139	1.000	Domainoid score	I4680
eggNOG	1	0.900	-	-		E2759_KOG4442
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1447
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	1	1.000	-	-		FOG0002762
OrthoInspector	1	1.000	-	-		oto97962
orthoMCL	1	0.900	-	-		OOG6_102278
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.700